EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105821 (Gene tree)
Gene ID: 27000
Gene Symbol: DNAJC2
Alias: MPP11|MPHOSPH11|ZUO1|zuotin|ZRF1
Full Name: DnaJ heat shock protein family (Hsp40) member C2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 32,400 bases
Position: chr7:103,312,474-103,344,873
Accession: 13192
RBP type: non-canonical RBP
Summary: This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000379257	DNAJC2-202	942	-	ENSP00000368559	167 (aa)	-	F2Z3N9
ENST00000483637	DNAJC2-210	373	-	-	- (aa)	-	-
ENST00000379263	DNAJC2-203	2167	XM_005250269	ENSP00000368565	621 (aa)	XP_011514331	Q99543
ENST00000412522	DNAJC2-204	3033	-	ENSP00000406275	118 (aa)	-	F2Z3H0
ENST00000426036	DNAJC2-205	729	-	ENSP00000412611	243 (aa)	-	H7C3L7
ENST00000454277	DNAJC2-206	854	-	ENSP00000399058	188 (aa)	-	C9IZ83
ENST00000464253	DNAJC2-207	1809	-	-	- (aa)	-	-
ENST00000475090	DNAJC2-209	480	-	-	- (aa)	-	-
ENST00000249270	DNAJC2-201	1846	-	ENSP00000249270	568 (aa)	-	Q99543
ENST00000475065	DNAJC2-208	1952	-	-	- (aa)	-	-
ENST00000492497	DNAJC2-211	2167	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000105821's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105821's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105821	DNAJC2	100	97.340	ENSMUSG00000029014	Dnajc2	100	95.812	Mus_musculus
ENSG00000105821	DNAJC2	98	42.935	YGR285C	ZUO1	90	37.093	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	21179169.	IDA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	21179169.	IPI	Function
GO:0005634	nucleus	8885239.21179169.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	8885239.	IDA	Component
GO:0005829	cytosol	16002468.21179169.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006260	DNA replication	-	IEA	Process
GO:0006325	chromatin organization	-	IEA	Process
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0030544	Hsp70 protein binding	16002468.	IPI	Function
GO:0031965	nuclear membrane	-	IDA	Component
GO:0042393	histone binding	21179169.	IDA	Function
GO:0045893	positive regulation of transcription, DNA-templated	21179169.	IDA	Process
GO:0051083	'de novo' cotranslational protein folding	16002468.	TAS	Process
GO:0061649	ubiquitin modification-dependent histone binding	21179169.	IDA	Function
GO:1900034	regulation of cellular response to heat	-	TAS	Process
GO:2000279	negative regulation of DNA biosynthetic process	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29228320	Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma.	Carcinogenesis	2018 Feb 9	Imamura T	doi: 10.1093/carcin/bgx139.
22433847	M-phase phosphoprotein 11 is a highly immunogenic tumor antigen in patients with acute myeloid leukemia.	Acta Haematol	2012	Siegel S	doi: 10.1159/000335133

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr7	103337768	Missense_Mutation	novel	Y100C	0.06
BLCA	chr7	103322782	Silent	novel	R244R	0.31
BLCA	chr7	103319654	Silent	rs749456723	L399L	0.23
BLCA	chr7	103327692	Missense_Mutation	novel	E132K	0.24
BLCA	chr7	103319638	Missense_Mutation	novel	E405K	0.22
BRCA	chr7	103337654	Intron	novel		0.22
BRCA	chr7	103315830	Frame_Shift_Del	novel	*N518Kfs22**	0.18
BRCA	chr7	103319654	Frame_Shift_Del	NA	*L399Hfs21**	0.37
BRCA	chr7	103315767	Missense_Mutation	NA	E545Q	0.17
BRCA	chr7	103341805	Missense_Mutation	NA	E72Q	0.3
BRCA	chr7	103316920	Missense_Mutation	NA	G446V	0.17
BRCA	chr7	103322672	Intron	novel		0.03
BRCA	chr7	103322673	Intron	novel		0.03
BRCA	chr7	103344710	5'UTR	novel		0.1
CESC	chr7	103319617	Missense_Mutation	novel	E412Q	0.11
CESC	chr7	103326652	Nonsense_Mutation	NA	R155*	0.3
CESC	chr7	103337682	Intron	novel		0.32
CESC	chr7	103316089	Splice_Site	NA	X476_splice	0.4
COAD	chr7	103323649	Missense_Mutation	NA	S223Y	0.09
COAD	chr7	103316844	Silent	NA	A471A	0.35
COAD	chr7	103321974	Frame_Shift_Del	NA	*A348Pfs29**	0.27
COAD	chr7	103312575	Missense_Mutation	NA	K620N	0.14
COAD	chr7	103315783	Silent	rs781448899	T539T	0.33
COAD	chr7	103337727	Intron	NA		0.06
COAD	chr7	103324545	Frame_Shift_Del	NA	*N197Mfs8**	0.48
COAD	chr7	103313042	Silent	novel	L566L	0.1
COAD	chr7	103322642	Intron	novel		0.19
COAD	chr7	103322644	Intron	novel		0.19
COAD	chr7	103322730	Missense_Mutation	NA	E262K	0.31
COAD	chr7	103337665	Intron	novel		0.33
COAD	chr7	103312635	Silent	NA	V600V	0.17
ESCA	chr7	103324545	Frame_Shift_Del	NA	*N197Mfs8**	0.41
ESCA	chr7	103316982	Silent	NA	E425E	0.19
ESCA	chr7	103323602	In_Frame_Del	novel	A238del	0.46
GBM	chr7	103313079	Silent	rs759297684	P553P	0.28
GBM	chr7	103312940	Splice_Region	novel		0.37
GBM	chr7	103316860	Missense_Mutation	novel	V466A	0.19
GBM	chr7	103323641	Nonsense_Mutation	novel	E226*	0.24
GBM	chr7	103341925	Nonsense_Mutation	novel	G32*	0.19
GBM	chr7	103341828	Missense_Mutation	novel	E64V	0.15
GBM	chr7	103341780	Missense_Mutation	novel	D80V	0.06
HNSC	chr7	103313009	Missense_Mutation	novel	W577R	0.18
HNSC	chr7	103322578	Missense_Mutation	novel	A289V	0.39
HNSC	chr7	103341797	Silent	rs751657738	P74P	0.34
HNSC	chr7	103312994	Missense_Mutation	novel	E582K	0.17
HNSC	chr7	103344698	5'UTR	novel		0.21
HNSC	chr7	103327697	Missense_Mutation	novel	I130T	0.43
HNSC	chr7	103315858	Frame_Shift_Del	novel	*D515Mfs3**	0.62
KIRC	chr7	103341796	Missense_Mutation	NA	M75V	0.41
KIRC	chr7	103319642	Silent	NA	T403T	0.15
KIRC	chr7	103322663	Intron	novel		0.31
KIRP	chr7	103322605	Missense_Mutation	NA	I280K	0.55
KIRP	chr7	103322606	Missense_Mutation	NA	I280L	0.55
LAML	chr7	103316027	Frame_Shift_Ins	novel	*K497Qfs14**	0.18
LGG	chr7	103316915	Missense_Mutation	NA	G448R	0.14
LIHC	chr7	103313000	Frame_Shift_Del	novel	I580*	0.19
LIHC	chr7	103322031	Silent	rs142695020	E328E	0.35
LIHC	chr7	103312989	Silent	rs772238229	A583A	0.37
LUAD	chr7	103322579	Missense_Mutation	NA	A289T	0.41
LUAD	chr7	103316976	Silent	novel	E427E	0.1
LUAD	chr7	103316978	Missense_Mutation	rs751498127	E427K	0.1
LUAD	chr7	103319618	Silent	novel	L411L	0.08
LUAD	chr7	103327680	Missense_Mutation	NA	D136H	0.05
LUAD	chr7	103321939	Missense_Mutation	novel	S359L	0.09
LUAD	chr7	103326622	Missense_Mutation	novel	D165H	0.11
LUAD	chr7	103316089	Splice_Site	novel	X476_splice	0.08
LUSC	chr7	103341894	Missense_Mutation	rs189317813	R42K	0.38
LUSC	chr7	103312572	Frame_Shift_Del	novel	*R618Mfs11**	0.13
LUSC	chr7	103316886	Frame_Shift_Del	novel	*D457Efs6**	0.11
LUSC	chr7	103344671	5'UTR	novel		0.23
LUSC	chr7	103322592	Missense_Mutation	novel	K284N	0.1
LUSC	chr7	103312591	Missense_Mutation	novel	N615S	0.07
LUSC	chr7	103324545	Frame_Shift_Del	NA	*N197Mfs8**	0.33
LUSC	chr7	103319839	Missense_Mutation	novel	W363C	0.3
LUSC	chr7	103313022	Silent	novel	N572N	0.41
LUSC	chr7	103327682	Missense_Mutation	novel	N135T	0.47
OV	chr7	103322597	Missense_Mutation	novel	F283L	0.06
OV	chr7	103322034	Silent	rs747255126	E327E	0.04
PAAD	chr7	103326630	Missense_Mutation	novel	P162H	0.16
PRAD	chr7	103326567	Missense_Mutation	rs768898513	T183N	0.21
PRAD	chr7	103312602	Silent	rs756968406	E611E	0.06
PRAD	chr7	103324544	Frame_Shift_Ins	NA	*N197Kfs4**	0.32
READ	chr7	103316871	Silent	NA	L462L	0.23
READ	chr7	103322662	Intron	novel		0.28
READ	chr7	103326577	Missense_Mutation	NA	E180K	0.17
READ	chr7	103316064	Missense_Mutation	novel	M484I	0.19
SARC	chr7	103322578	Missense_Mutation	novel	A289D	0.07
SKCM	chr7	103315829	Missense_Mutation	NA	K524M	0.17
SKCM	chr7	103313057	Missense_Mutation	novel	L561F	0.69
SKCM	chr7	103341847	Missense_Mutation	novel	E58K	0.56
SKCM	chr7	103315774	Silent	NA	E542E	0.76
SKCM	chr7	103326589	Missense_Mutation	novel	D176N	0.38
SKCM	chr7	103326581	Silent	NA	F178F	0.14
STAD	chr7	103326643	Missense_Mutation	NA	N158Y	0.07
STAD	chr7	103313011	Missense_Mutation	NA	R576I	0.31
STAD	chr7	103341859	Missense_Mutation	rs770525647	E54K	0.32
STAD	chr7	103341956	Splice_Site	novel	X22_splice	0.09
STAD	chr7	103312985	Missense_Mutation	NA	P585S	0.14
STAD	chr7	103327678	Missense_Mutation	NA	D136E	0.09
STAD	chr7	103344718	5'UTR	novel		0.32
STAD	chr7	103322020	Missense_Mutation	NA	R332K	0.07
STAD	chr7	103322060	Missense_Mutation	NA	A319S	0.32
STAD	chr7	103322624	Missense_Mutation	NA	Y274H	0.24
STAD	chr7	103341942	Missense_Mutation	NA	C26Y	0.21
THCA	chr7	103337708	Intron	novel		0.31
UCEC	chr7	103337681	Intron	novel		0.44
UCEC	chr7	103312635	Silent	NA	V600V	0.36
UCEC	chr7	103312990	Missense_Mutation	NA	A583V	0.27
UCEC	chr7	103341839	Silent	rs371816384	S60S	0.33
UCEC	chr7	103321946	Nonsense_Mutation	NA	R357*	0.35
UCEC	chr7	103321946	Nonsense_Mutation	NA	R357*	0.39
UCEC	chr7	103337515	Intron	novel		0.43
UCEC	chr7	103315833	Missense_Mutation	novel	D523Y	0.12
UCEC	chr7	103319623	Missense_Mutation	NA	A410T	0.27
UCEC	chr7	103341839	Silent	rs371816384	S60S	0.22
UCEC	chr7	103337589	Intron	novel		0.27
UCEC	chr7	103327738	Silent	NA	L116L	0.33
UCEC	chr7	103315835	Missense_Mutation	novel	F522C	0.38
UCEC	chr7	103324488	Missense_Mutation	NA	S216Y	0.29
UCEC	chr7	103326578	Silent	rs748270951	F179F	0.28
UCEC	chr7	103327335	Intron	novel		0.31
UCEC	chr7	103337779	Silent	novel	G96G	0.41
UCEC	chr7	103312635	Silent	NA	V600V	0.56
UCEC	chr7	103312635	Silent	NA	V600V	0.42
UCEC	chr7	103324544	Frame_Shift_Ins	NA	*N197Kfs4**	0.51
UCEC	chr7	103316845	Missense_Mutation	NA	A471D	0.39
UCEC	chr7	103316059	Missense_Mutation	novel	I486K	0.34
UCEC	chr7	103316957	Nonsense_Mutation	novel	R434*	0.3
UCEC	chr7	103321946	Nonsense_Mutation	NA	R357*	0.1
UCEC	chr7	103326578	Silent	rs748270951	F179F	0.36
UCEC	chr7	103337589	Intron	novel		0.67
UCEC	chr7	103322570	Missense_Mutation	NA	E292Q	0.33
UCEC	chr7	103322580	Silent	novel	K288K	0.49
UCEC	chr7	103344590	Silent	novel	R11R	0.44
UCEC	chr7	103322693	Intron	novel		0.29
UCEC	chr7	103315853	Missense_Mutation	novel	D516G	0.54
UCEC	chr7	103322656	Intron	novel		0.3
UCEC	chr7	103316024	Missense_Mutation	novel	D498Y	0.19
UCEC	chr7	103322599	Frame_Shift_Del	novel	*K282Sfs36**	0.31
UCEC	chr7	103312955	Nonsense_Mutation	NA	R595*	0.3
UCEC	chr7	103324545	Frame_Shift_Del	NA	*N197Mfs8**	0.14
UCEC	chr7	103341857	Missense_Mutation	novel	E54D	0.28
UCEC	chr7	103323637	Missense_Mutation	NA	F227C	0.46
UCEC	chr7	103323649	Missense_Mutation	NA	S223Y	0.3
UCEC	chr7	103337661	Intron	novel		0.06
UCEC	chr7	103337681	Intron	novel		0.28
UCEC	chr7	103315869	Missense_Mutation	NA	P511S	0.05
UCEC	chr7	103327667	Missense_Mutation	NA	C140Y	0.31
UCEC	chr7	103321946	Nonsense_Mutation	NA	R357*	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0778	0.12261
DLBC	AMP	0.2917	0.13215
LGG	AMP	0.2943	1.5525e-07
LIHC	DEL	0.0595	0.24831
PAAD	DEL	0.0489	0.049388
PRAD	AMP	0.1382	0.012709
TGCT	AMP	0.6267	0.035574
THCA	DEL	0.002	0.27619

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.046	Kaplan-Meier Survival Analysis
MESO	0.0013	Kaplan-Meier Survival Analysis
ACC	0.00015	Kaplan-Meier Survival Analysis
SKCM	0.019	Kaplan-Meier Survival Analysis
PRAD	0.027	Kaplan-Meier Survival Analysis
LUSC	0.0033	Kaplan-Meier Survival Analysis
KIRP	0.011	Kaplan-Meier Survival Analysis
LAML	0.024	Kaplan-Meier Survival Analysis
KICH	0.0016	Kaplan-Meier Survival Analysis
UCEC	0.027	Kaplan-Meier Survival Analysis
LIHC	0.0013	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.015	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742