EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105849 (Gene tree)
Gene ID: 221830
Gene Symbol: TWISTNB
Alias: N
Full Name: TWIST neighbor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 13,626 bases
Position: chr7:19,695,462-19,709,087
Accession: 18027
RBP type: canonical RBP
Summary: (TWIST Neighbor) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Escape and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase I activity. An important paralog of this gene is POLR3H.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000222567	SHS2_Rpb7-N	PF03876.17	4e-09	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462263	TWISTNB-202	427	-	-	- (aa)	-	-
ENST00000222567	TWISTNB-201	3942	-	ENSP00000222567	338 (aa)	-	Q3B726

Gene Model

Click here to download ENSG00000105849's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105849's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105849	TWISTNB	92	41.471	ENSAPOG00000011796	twistnb	88	42.899	Acanthochromis_polyacanthus
ENSG00000105849	TWISTNB	98	68.848	ENSAMEG00000008558	TWISTNB	97	72.251	Ailuropoda_melanoleuca
ENSG00000105849	TWISTNB	86	40.823	ENSACIG00000020400	twistnb	80	43.226	Amphilophus_citrinellus
ENSG00000105849	TWISTNB	95	42.165	ENSAOCG00000024200	twistnb	51	56.122	Amphiprion_ocellaris
ENSG00000105849	TWISTNB	95	42.165	ENSAPEG00000016750	twistnb	92	43.305	Amphiprion_percula
ENSG00000105849	TWISTNB	89	46.037	ENSATEG00000017956	twistnb	88	45.562	Anabas_testudineus
ENSG00000105849	TWISTNB	50	65.089	ENSACAG00000011817	TWISTNB	86	65.089	Anolis_carolinensis
ENSG00000105849	TWISTNB	97	91.566	ENSANAG00000026418	TWISTNB	99	91.343	Aotus_nancymaae
ENSG00000105849	TWISTNB	58	54.315	ENSACLG00000022280	twistnb	78	46.178	Astatotilapia_calliptera
ENSG00000105849	TWISTNB	65	52.055	ENSAMXG00000035868	twistnb	69	49.174	Astyanax_mexicanus
ENSG00000105849	TWISTNB	98	78.743	ENSBTAG00000006721	TWISTNB	99	77.844	Bos_taurus
ENSG00000105849	TWISTNB	97	92.793	ENSCJAG00000001148	TWISTNB	99	92.262	Callithrix_jacchus
ENSG00000105849	TWISTNB	100	75.645	ENSCAFG00000002511	TWISTNB	100	77.364	Canis_familiaris
ENSG00000105849	TWISTNB	98	78.466	ENSCAFG00020002140	TWISTNB	92	79.941	Canis_lupus_dingo
ENSG00000105849	TWISTNB	98	77.679	ENSCHIG00000024078	TWISTNB	99	77.976	Capra_hircus
ENSG00000105849	TWISTNB	100	85.965	ENSTSYG00000001471	TWISTNB	100	86.257	Carlito_syrichta
ENSG00000105849	TWISTNB	99	81.306	ENSCPOG00000031651	TWISTNB	99	81.009	Cavia_porcellus
ENSG00000105849	TWISTNB	100	90.882	ENSCCAG00000026416	TWISTNB	100	92.353	Cebus_capucinus
ENSG00000105849	TWISTNB	100	97.633	ENSCATG00000035621	TWISTNB	100	97.633	Cercocebus_atys
ENSG00000105849	TWISTNB	99	82.544	ENSCLAG00000012696	TWISTNB	100	82.544	Chinchilla_lanigera
ENSG00000105849	TWISTNB	100	97.929	ENSCSAG00000013544	TWISTNB	100	97.929	Chlorocebus_sabaeus
ENSG00000105849	TWISTNB	79	90.152	ENSCHOG00000006034	TWISTNB	79	90.152	Choloepus_hoffmanni
ENSG00000105849	TWISTNB	91	61.022	ENSCPBG00000000367	TWISTNB	85	64.057	Chrysemys_picta_bellii
ENSG00000105849	TWISTNB	100	98.225	ENSCANG00000038759	TWISTNB	100	98.225	Colobus_angolensis_palliatus
ENSG00000105849	TWISTNB	96	75.684	ENSCGRG00001000499	Twistnb	99	76.364	Cricetulus_griseus_chok1gshd
ENSG00000105849	TWISTNB	64	52.609	ENSDARG00000024416	twistnb	55	54.630	Danio_rerio
ENSG00000105849	TWISTNB	98	81.737	ENSDNOG00000006438	-	99	82.036	Dasypus_novemcinctus
ENSG00000105849	TWISTNB	91	78.317	ENSDORG00000007795	Twistnb	95	77.994	Dipodomys_ordii
ENSG00000105849	TWISTNB	99	84.821	ENSEASG00005021702	TWISTNB	95	85.119	Equus_asinus_asinus
ENSG00000105849	TWISTNB	99	85.119	ENSECAG00000014563	TWISTNB	95	85.417	Equus_caballus
ENSG00000105849	TWISTNB	89	45.570	ENSELUG00000000098	TWISTNB	83	47.195	Esox_lucius
ENSG00000105849	TWISTNB	98	83.832	ENSFCAG00000025987	TWISTNB	99	83.533	Felis_catus
ENSG00000105849	TWISTNB	83	52.649	ENSFALG00000009761	TWISTNB	97	52.649	Ficedula_albicollis
ENSG00000105849	TWISTNB	97	82.530	ENSFDAG00000017368	TWISTNB	99	81.899	Fukomys_damarensis
ENSG00000105849	TWISTNB	57	56.995	ENSFHEG00000013318	twistnb	54	56.995	Fundulus_heteroclitus
ENSG00000105849	TWISTNB	92	55.096	ENSGALG00000010863	TWISTNB	77	55.096	Gallus_gallus
ENSG00000105849	TWISTNB	51	59.770	ENSGAFG00000018309	twistnb	53	56.995	Gambusia_affinis
ENSG00000105849	TWISTNB	66	48.548	ENSGACG00000006425	twistnb	66	55.747	Gasterosteus_aculeatus
ENSG00000105849	TWISTNB	100	98.817	ENSGGOG00000026888	TWISTNB	100	98.817	Gorilla_gorilla
ENSG00000105849	TWISTNB	55	56.216	ENSHBUG00000020155	twistnb	75	47.195	Haplochromis_burtoni
ENSG00000105849	TWISTNB	99	82.249	ENSHGLG00000010976	TWISTNB	99	82.738	Heterocephalus_glaber_female
ENSG00000105849	TWISTNB	97	83.082	ENSHGLG00100005410	TWISTNB	99	82.738	Heterocephalus_glaber_male
ENSG00000105849	TWISTNB	89	43.385	ENSIPUG00000004117	twistnb	90	42.683	Ictalurus_punctatus
ENSG00000105849	TWISTNB	99	81.361	ENSSTOG00000022702	TWISTNB	93	81.361	Ictidomys_tridecemlineatus
ENSG00000105849	TWISTNB	99	75.000	ENSJJAG00000015887	Twistnb	99	75.000	Jaculus_jaculus
ENSG00000105849	TWISTNB	54	57.609	ENSKMAG00000001591	twistnb	54	55.392	Kryptolebias_marmoratus
ENSG00000105849	TWISTNB	87	52.787	ENSLACG00000010508	TWISTNB	85	53.770	Latimeria_chalumnae
ENSG00000105849	TWISTNB	54	62.842	ENSLOCG00000011399	twistnb	56	62.234	Lepisosteus_oculatus
ENSG00000105849	TWISTNB	98	83.234	ENSLAFG00000008755	TWISTNB	99	82.934	Loxodonta_africana
ENSG00000105849	TWISTNB	100	97.929	ENSMFAG00000045328	TWISTNB	100	97.929	Macaca_fascicularis
ENSG00000105849	TWISTNB	99	97.904	ENSMMUG00000009609	TWISTNB	98	97.904	Macaca_mulatta
ENSG00000105849	TWISTNB	100	97.337	ENSMNEG00000041159	TWISTNB	100	97.337	Macaca_nemestrina
ENSG00000105849	TWISTNB	100	97.929	ENSMLEG00000042783	TWISTNB	100	97.929	Mandrillus_leucophaeus
ENSG00000105849	TWISTNB	58	54.315	ENSMZEG00005007561	twistnb	78	46.178	Maylandia_zebra
ENSG00000105849	TWISTNB	96	88.146	ENSMICG00000036489	TWISTNB	99	88.450	Microcebus_murinus
ENSG00000105849	TWISTNB	95	76.471	ENSMOCG00000003458	Twistnb	98	77.259	Microtus_ochrogaster
ENSG00000105849	TWISTNB	57	52.850	ENSMMOG00000020085	twistnb	50	52.850	Mola_mola
ENSG00000105849	TWISTNB	86	59.866	ENSMODG00000001402	-	68	58.974	Monodelphis_domestica
ENSG00000105849	TWISTNB	89	42.813	ENSMALG00000016407	twistnb	81	42.857	Monopterus_albus
ENSG00000105849	TWISTNB	96	75.529	MGP_CAROLIEiJ_G0017692	Twistnb	99	76.133	Mus_caroli
ENSG00000105849	TWISTNB	96	75.227	ENSMUSG00000020561	Twistnb	99	75.455	Mus_musculus
ENSG00000105849	TWISTNB	96	75.380	MGP_PahariEiJ_G0029450	Twistnb	99	75.380	Mus_pahari
ENSG00000105849	TWISTNB	96	75.529	MGP_SPRETEiJ_G0018534	Twistnb	99	75.758	Mus_spretus
ENSG00000105849	TWISTNB	98	84.132	ENSMPUG00000013948	TWISTNB	93	83.832	Mustela_putorius_furo
ENSG00000105849	TWISTNB	91	78.317	ENSMLUG00000008848	TWISTNB	99	78.317	Myotis_lucifugus
ENSG00000105849	TWISTNB	59	85.427	ENSNGAG00000022455	Twistnb	99	85.427	Nannospalax_galili
ENSG00000105849	TWISTNB	91	42.154	ENSNBRG00000008652	twistnb	92	42.286	Neolamprologus_brichardi
ENSG00000105849	TWISTNB	95	98.137	ENSNLEG00000035755	TWISTNB	95	98.137	Nomascus_leucogenys
ENSG00000105849	TWISTNB	100	75.581	ENSOPRG00000016109	TWISTNB	100	75.581	Ochotona_princeps
ENSG00000105849	TWISTNB	99	81.416	ENSODEG00000007222	TWISTNB	99	81.065	Octodon_degus
ENSG00000105849	TWISTNB	88	44.089	ENSORLG00000004005	twistnb	72	48.333	Oryzias_latipes
ENSG00000105849	TWISTNB	88	44.340	ENSORLG00020002579	twistnb	80	48.505	Oryzias_latipes_hni
ENSG00000105849	TWISTNB	88	44.025	ENSORLG00015013403	twistnb	71	49.000	Oryzias_latipes_hsok
ENSG00000105849	TWISTNB	100	87.135	ENSOGAG00000009189	TWISTNB	100	88.304	Otolemur_garnettii
ENSG00000105849	TWISTNB	98	78.209	ENSOARG00000009803	TWISTNB	98	78.507	Ovis_aries
ENSG00000105849	TWISTNB	100	99.408	ENSPPAG00000034623	TWISTNB	100	99.408	Pan_paniscus
ENSG00000105849	TWISTNB	98	82.934	ENSPPRG00000005877	TWISTNB	99	82.831	Panthera_pardus
ENSG00000105849	TWISTNB	87	83.446	ENSPTIG00000021539	TWISTNB	98	83.108	Panthera_tigris_altaica
ENSG00000105849	TWISTNB	100	99.704	ENSPTRG00000018962	TWISTNB	100	99.704	Pan_troglodytes
ENSG00000105849	TWISTNB	100	97.337	ENSPANG00000015736	TWISTNB	100	97.337	Papio_anubis
ENSG00000105849	TWISTNB	57	61.658	ENSPKIG00000025635	twistnb	53	61.658	Paramormyrops_kingsleyae
ENSG00000105849	TWISTNB	93	43.620	ENSPMGG00000019023	twistnb	50	56.853	Periophthalmus_magnuspinnatus
ENSG00000105849	TWISTNB	83	59.643	ENSPCIG00000017456	TWISTNB	96	56.740	Phascolarctos_cinereus
ENSG00000105849	TWISTNB	100	97.640	ENSPPYG00000017752	TWISTNB	100	97.640	Pongo_abelii
ENSG00000105849	TWISTNB	100	83.626	ENSPCOG00000017601	TWISTNB	100	87.135	Propithecus_coquereli
ENSG00000105849	TWISTNB	99	78.886	ENSPVAG00000015574	TWISTNB	99	79.179	Pteropus_vampyrus
ENSG00000105849	TWISTNB	58	54.315	ENSPNYG00000002674	twistnb	83	46.178	Pundamilia_nyererei
ENSG00000105849	TWISTNB	92	46.746	ENSPNAG00000011956	twistnb	93	46.746	Pygocentrus_nattereri
ENSG00000105849	TWISTNB	94	76.087	ENSRNOG00000010750	Twistnb	99	76.398	Rattus_norvegicus
ENSG00000105849	TWISTNB	99	97.313	ENSRBIG00000043007	TWISTNB	98	97.313	Rhinopithecus_bieti
ENSG00000105849	TWISTNB	100	97.041	ENSRROG00000040155	TWISTNB	100	97.041	Rhinopithecus_roxellana
ENSG00000105849	TWISTNB	97	91.566	ENSSBOG00000023188	TWISTNB	99	91.045	Saimiri_boliviensis_boliviensis
ENSG00000105849	TWISTNB	52	57.542	ENSSFOG00015012788	twistnb	63	51.163	Scleropages_formosus
ENSG00000105849	TWISTNB	99	41.061	ENSSMAG00000012792	twistnb	84	42.683	Scophthalmus_maximus
ENSG00000105849	TWISTNB	92	42.899	ENSSDUG00000007038	twistnb	81	46.774	Seriola_dumerili
ENSG00000105849	TWISTNB	93	51.220	ENSSPUG00000007595	TWISTNB	96	50.489	Sphenodon_punctatus
ENSG00000105849	TWISTNB	90	43.711	ENSSPAG00000005871	twistnb	83	45.484	Stegastes_partitus
ENSG00000105849	TWISTNB	98	80.357	ENSSSCG00000025298	TWISTNB	99	79.167	Sus_scrofa
ENSG00000105849	TWISTNB	91	42.857	ENSTNIG00000017778	twistnb	89	43.131	Tetraodon_nigroviridis
ENSG00000105849	TWISTNB	100	81.711	ENSTBEG00000003554	TWISTNB	100	82.647	Tupaia_belangeri
ENSG00000105849	TWISTNB	98	84.132	ENSUAMG00000017593	TWISTNB	99	83.832	Ursus_americanus
ENSG00000105849	TWISTNB	98	83.832	ENSUMAG00000022203	TWISTNB	99	83.533	Ursus_maritimus
ENSG00000105849	TWISTNB	98	79.056	ENSVVUG00000008386	TWISTNB	99	80.236	Vulpes_vulpes
ENSG00000105849	TWISTNB	65	53.604	ENSXCOG00000020199	twistnb	55	55.665	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001054	RNA polymerase I activity	21873635.	IBA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005736	RNA polymerase I complex	21873635.	IBA	Component
GO:0006361	transcription initiation from RNA polymerase I promoter	-	TAS	Process
GO:0006362	transcription elongation from RNA polymerase I promoter	-	TAS	Process
GO:0006363	termination of RNA polymerase I transcription	-	TAS	Process
GO:0045815	positive regulation of gene expression, epigenetic	-	TAS	Process
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	Process