EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105939 (Gene tree)
Gene ID: 56829
Gene Symbol: ZC3HAV1
Alias: ZAP|FLB6421|FLJ13288|MGC48898|ZC3HDC2|ZC3H2|PARP13
Full Name: zinc finger CCCH-type containing, antiviral 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 66,201 bases
Position: chr7:139,043,520-139,109,720
Accession: 23721
RBP type: canonical RBP
Summary: This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000242351	PARP	PF00644.20	7.1e-22	1	1
ENSP00000418385	PARP	PF00644.20	8.8e-22	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21203916	Analyses of SELEX-derived ZAP-binding RNA aptamers suggest that the binding specificity is determined by both structure and sequence of the RNA.	Protein Cell	2010 Aug	Huang Z	doi: 10.1007/s13238-010-0096-9
23836649	Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus.	Proc Natl Acad Sci U S A	2013 Jul 23	Lee H	doi: 10.1073/pnas.1310604110
15542630	The zinc finger antiviral protein directly binds to specific viral mRNAs through the CCCH zinc finger motifs.	J Virol	2004 Dec	Guo X	-
20451500	Expression and RNA-binding of human zinc-finger antiviral protein.	Biochem Biophys Res Commun	2010 Jun 4	Jeong MS	doi: 10.1016/j.bbrc.2010.04.164
25851173	Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer.	Trends Mol Med	2015 Jun	Todorova T	doi: 10.1016/j.molmed.2015.03.002
29117863	RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination.	BMC Biol	2017 Nov 8	Choudhury NR	doi: 10.1186/s12915-017-0444-9.
30016363	Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein.	PLoS Pathog	2018 Jul 17	Chiu HP	doi: 10.1371/journal.ppat.1007166
22407013	Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA.	Nat Struct Mol Biol	2012 Mar 11	Chen S	doi: 10.1038/nsmb.2243.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000460845	ZC3HAV1-202	1487	-	ENSP00000420107	264 (aa)	-	H7C5K1
ENST00000242351	ZC3HAV1-201	7100	-	ENSP00000242351	902 (aa)	-	Q7Z2W4
ENST00000471652	ZC3HAV1-204	3182	-	ENSP00000419855	699 (aa)	-	Q7Z2W4
ENST00000464606	ZC3HAV1-203	4776	XM_005250501	ENSP00000418385	1024 (aa)	XP_005250558	C9J6P4

Gene Model

Click here to download ENSG00000105939's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000105939	Intelligence Tests	1.0979300E-005	-
ENSG00000105939	Child Development Disorders, Pervasive	5.2169100E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105939	rs10273974	7	139050766	?	White blood cell count	30595370			EFO_0004308
ENSG00000105939	rs6945954	7	139102449	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105939's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000105939	ZC3HAV1	72	42.233	ENSG00000059378	PARP12	89	44.604

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105939	ZC3HAV1	99	62.777	ENSAMEG00000017936	ZC3HAV1	100	60.590	Ailuropoda_melanoleuca
ENSG00000105939	ZC3HAV1	95	82.051	ENSANAG00000025650	ZC3HAV1	100	82.051	Aotus_nancymaae
ENSG00000105939	ZC3HAV1	99	64.419	ENSBTAG00000021617	ZC3HAV1	100	63.286	Bos_taurus
ENSG00000105939	ZC3HAV1	100	84.406	ENSCJAG00000013080	ZC3HAV1	100	83.721	Callithrix_jacchus
ENSG00000105939	ZC3HAV1	99	67.551	ENSCAFG00000004102	ZC3HAV1	100	67.551	Canis_familiaris
ENSG00000105939	ZC3HAV1	99	66.763	ENSCAFG00020022308	ZC3HAV1	100	67.551	Canis_lupus_dingo
ENSG00000105939	ZC3HAV1	99	64.132	ENSCHIG00000025661	ZC3HAV1	100	62.967	Capra_hircus
ENSG00000105939	ZC3HAV1	100	63.429	ENSCPOG00000007709	ZC3HAV1	99	62.729	Cavia_porcellus
ENSG00000105939	ZC3HAV1	100	83.262	ENSCCAG00000028272	ZC3HAV1	100	82.927	Cebus_capucinus
ENSG00000105939	ZC3HAV1	99	93.469	ENSCATG00000040380	ZC3HAV1	99	86.497	Cercocebus_atys
ENSG00000105939	ZC3HAV1	99	63.845	ENSCLAG00000001337	ZC3HAV1	99	64.358	Chinchilla_lanigera
ENSG00000105939	ZC3HAV1	99	87.072	ENSCSAG00000008605	ZC3HAV1	100	83.786	Chlorocebus_sabaeus
ENSG00000105939	ZC3HAV1	91	59.970	ENSCHOG00000004588	ZC3HAV1	91	63.007	Choloepus_hoffmanni
ENSG00000105939	ZC3HAV1	99	85.714	ENSCANG00000030425	ZC3HAV1	100	84.556	Colobus_angolensis_palliatus
ENSG00000105939	ZC3HAV1	99	58.125	ENSCGRG00001014912	Zc3hav1	100	55.416	Cricetulus_griseus_chok1gshd
ENSG00000105939	ZC3HAV1	99	58.125	ENSCGRG00000014483	Zc3hav1	100	55.416	Cricetulus_griseus_crigri
ENSG00000105939	ZC3HAV1	100	61.039	ENSDNOG00000043117	ZC3HAV1	100	62.042	Dasypus_novemcinctus
ENSG00000105939	ZC3HAV1	100	60.870	ENSDORG00000026955	Zc3hav1	100	55.480	Dipodomys_ordii
ENSG00000105939	ZC3HAV1	100	48.230	ENSETEG00000001167	-	99	51.037	Echinops_telfairi
ENSG00000105939	ZC3HAV1	100	69.857	ENSEASG00005010064	ZC3HAV1	100	68.226	Equus_asinus_asinus
ENSG00000105939	ZC3HAV1	100	69.857	ENSECAG00000017394	ZC3HAV1	100	65.984	Equus_caballus
ENSG00000105939	ZC3HAV1	100	67.002	ENSFCAG00000026631	ZC3HAV1	100	62.938	Felis_catus
ENSG00000105939	ZC3HAV1	100	98.077	ENSGGOG00000000653	ZC3HAV1	100	98.047	Gorilla_gorilla
ENSG00000105939	ZC3HAV1	100	63.857	ENSHGLG00000006700	ZC3HAV1	98	65.173	Heterocephalus_glaber_female
ENSG00000105939	ZC3HAV1	100	63.714	ENSHGLG00100012010	ZC3HAV1	98	64.969	Heterocephalus_glaber_male
ENSG00000105939	ZC3HAV1	89	61.911	ENSSTOG00000005662	ZC3HAV1	99	61.985	Ictidomys_tridecemlineatus
ENSG00000105939	ZC3HAV1	99	61.881	ENSJJAG00000016894	Zc3hav1	100	53.547	Jaculus_jaculus
ENSG00000105939	ZC3HAV1	96	64.251	ENSLAFG00000013954	ZC3HAV1	99	56.536	Loxodonta_africana
ENSG00000105939	ZC3HAV1	99	94.286	ENSMFAG00000001484	ZC3HAV1	100	90.244	Macaca_fascicularis
ENSG00000105939	ZC3HAV1	99	87.452	ENSMNEG00000036256	ZC3HAV1	100	84.907	Macaca_nemestrina
ENSG00000105939	ZC3HAV1	99	93.469	ENSMLEG00000042609	ZC3HAV1	100	81.951	Mandrillus_leucophaeus
ENSG00000105939	ZC3HAV1	98	55.882	ENSMAUG00000008329	Zc3hav1	100	48.303	Mesocricetus_auratus
ENSG00000105939	ZC3HAV1	99	69.388	ENSMICG00000003101	ZC3HAV1	100	67.412	Microcebus_murinus
ENSG00000105939	ZC3HAV1	100	56.133	ENSMOCG00000004943	Zc3hav1	100	54.660	Microtus_ochrogaster
ENSG00000105939	ZC3HAV1	100	45.131	ENSMODG00000013769	-	100	39.943	Monodelphis_domestica
ENSG00000105939	ZC3HAV1	99	57.054	MGP_CAROLIEiJ_G0028233	Zc3hav1	100	53.630	Mus_caroli
ENSG00000105939	ZC3HAV1	100	56.846	ENSMUSG00000029826	Zc3hav1	99	57.025	Mus_musculus
ENSG00000105939	ZC3HAV1	99	55.785	MGP_PahariEiJ_G0021990	Zc3hav1	100	53.623	Mus_pahari
ENSG00000105939	ZC3HAV1	100	56.846	MGP_SPRETEiJ_G0029232	Zc3hav1	100	53.824	Mus_spretus
ENSG00000105939	ZC3HAV1	99	66.531	ENSMPUG00000003805	ZC3HAV1	100	60.330	Mustela_putorius_furo
ENSG00000105939	ZC3HAV1	97	67.026	ENSMLUG00000012040	ZC3HAV1	100	59.728	Myotis_lucifugus
ENSG00000105939	ZC3HAV1	100	59.126	ENSNGAG00000016695	Zc3hav1	100	59.223	Nannospalax_galili
ENSG00000105939	ZC3HAV1	100	91.501	ENSNLEG00000014005	ZC3HAV1	100	95.723	Nomascus_leucogenys
ENSG00000105939	ZC3HAV1	81	57.983	ENSOPRG00000008833	-	81	57.983	Ochotona_princeps
ENSG00000105939	ZC3HAV1	100	56.365	ENSODEG00000013337	ZC3HAV1	100	56.365	Octodon_degus
ENSG00000105939	ZC3HAV1	100	57.018	ENSOCUG00000017892	ZC3HAV1	99	62.410	Oryctolagus_cuniculus
ENSG00000105939	ZC3HAV1	100	68.066	ENSOGAG00000010481	ZC3HAV1	99	70.408	Otolemur_garnettii
ENSG00000105939	ZC3HAV1	100	59.146	ENSOARG00000011043	ZC3HAV1	100	62.919	Ovis_aries
ENSG00000105939	ZC3HAV1	100	98.540	ENSPPAG00000039112	ZC3HAV1	100	97.461	Pan_paniscus
ENSG00000105939	ZC3HAV1	100	66.801	ENSPPRG00000024556	ZC3HAV1	100	66.801	Panthera_pardus
ENSG00000105939	ZC3HAV1	99	58.779	ENSPTIG00000006337	ZC3HAV1	99	58.945	Panthera_tigris_altaica
ENSG00000105939	ZC3HAV1	100	98.540	ENSPTRG00000019750	ZC3HAV1	100	97.656	Pan_troglodytes
ENSG00000105939	ZC3HAV1	99	93.878	ENSPANG00000023963	ZC3HAV1	100	89.094	Papio_anubis
ENSG00000105939	ZC3HAV1	98	60.976	ENSPEMG00000015140	Zc3hav1	100	56.171	Peromyscus_maniculatus_bairdii
ENSG00000105939	ZC3HAV1	97	43.584	ENSPCIG00000021649	-	100	37.127	Phascolarctos_cinereus
ENSG00000105939	ZC3HAV1	99	93.874	ENSPPYG00000018044	ZC3HAV1	100	92.495	Pongo_abelii
ENSG00000105939	ZC3HAV1	88	56.736	ENSPCAG00000013260	-	89	56.218	Procavia_capensis
ENSG00000105939	ZC3HAV1	100	61.905	ENSPCOG00000020892	ZC3HAV1	100	59.047	Propithecus_coquereli
ENSG00000105939	ZC3HAV1	79	75.333	ENSPVAG00000017364	ZC3HAV1	79	75.333	Pteropus_vampyrus
ENSG00000105939	ZC3HAV1	82	71.471	ENSRNOG00000013948	Zc3hav1	100	54.114	Rattus_norvegicus
ENSG00000105939	ZC3HAV1	99	93.469	ENSRBIG00000030676	ZC3HAV1	100	86.257	Rhinopithecus_bieti
ENSG00000105939	ZC3HAV1	100	90.571	ENSRROG00000042287	ZC3HAV1	100	90.272	Rhinopithecus_roxellana
ENSG00000105939	ZC3HAV1	100	84.120	ENSSBOG00000027573	ZC3HAV1	100	83.278	Saimiri_boliviensis_boliviensis
ENSG00000105939	ZC3HAV1	91	35.618	ENSSHAG00000006732	-	100	36.705	Sarcophilus_harrisii
ENSG00000105939	ZC3HAV1	100	64.018	ENSSSCG00000016512	ZC3HAV1	100	64.018	Sus_scrofa
ENSG00000105939	ZC3HAV1	89	63.250	ENSTTRG00000006055	ZC3HAV1	100	63.250	Tursiops_truncatus
ENSG00000105939	ZC3HAV1	99	67.551	ENSUAMG00000015112	ZC3HAV1	100	63.592	Ursus_americanus
ENSG00000105939	ZC3HAV1	99	67.551	ENSUMAG00000015455	ZC3HAV1	100	63.689	Ursus_maritimus
ENSG00000105939	ZC3HAV1	78	71.875	ENSVPAG00000007462	-	90	61.089	Vicugna_pacos
ENSG00000105939	ZC3HAV1	99	65.007	ENSVVUG00000002633	ZC3HAV1	100	65.130	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	25635049.	IMP	Function
GO:0005515	protein binding	21102435.21204022.21876179.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006471	protein ADP-ribosylation	25043379.	IDA	Process
GO:0009615	response to virus	21876179.	IDA	Process
GO:0045071	negative regulation of viral genome replication	21876179.	IDA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0051607	defense response to virus	-	IEA	Process
GO:0061014	positive regulation of mRNA catabolic process	21876179.	IDA	Process
GO:0070212	protein poly-ADP-ribosylation	25635049.	IMP	Process
GO:0070403	NAD+ binding	25635049.	IMP	Function
GO:1990404	protein ADP-ribosylase activity	25043379.	IDA	Function