EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105953 (Gene tree)
Gene ID: 4967
Gene Symbol: OGDH
Alias: E1k
Full Name: oxoglutarate dehydrogenase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 102,549 bases
Position: chr7:44,606,522-44,709,070
Accession: 8124
RBP type: non-canonical RBP
Summary: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000439616	OGDH-203	2962	XM_024446783	ENSP00000398576	873 (aa)	XP_024302551	E9PFG7
ENST00000443864	OGDH-204	1744	-	ENSP00000388084	427 (aa)	-	Q02218
ENST00000449767	OGDH-207	3479	-	ENSP00000392878	1019 (aa)	-	Q02218
ENST00000497326	OGDH-209	554	-	-	- (aa)	-	-
ENST00000459672	OGDH-208	601	-	-	- (aa)	-	-
ENST00000444676	OGDH-205	3309	XM_005249759	ENSP00000414662	1038 (aa)	XP_005249816	E9PCR7
ENST00000631326	OGDH-210	4116	-	ENSP00000486854	1001 (aa)	-	A0A0D9SFS3
ENST00000419661	OGDH-202	789	-	ENSP00000411830	211 (aa)	-	C9J4G7
ENST00000222673	OGDH-201	4181	-	ENSP00000222673	1023 (aa)	-	Q02218
ENST00000447398	OGDH-206	3474	XM_005249761	ENSP00000388183	1034 (aa)	XP_005249818	E9PDF2

Gene Model

Click here to download ENSG00000105953's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00020	Citrate cycle (TCA cycle)	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000105953	Platelet Function Tests	2.1337000E-005	-
ENSG00000105953	Blood Pressure	3E-7	27980656

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105953	rs17133935	7	44698080	G	Systolic blood pressure change trajectories	27980656	[0.18-0.42] unit increase	0.3	EFO_0006944

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105953's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105953	OGDH	97	65.335	FBgn0010352	Nc73EF	98	62.287	Drosophila_melanogaster
ENSG00000105953	OGDH	100	96.209	ENSMUSG00000020456	Ogdh	100	97.619	Mus_musculus
ENSG00000105953	OGDH	99	45.507	YIL125W	KGD1	99	45.507	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	21873635.	IBA	Function
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	24495017.29211711.	IDA	Function
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	-	ISS	Function
GO:0005634	nucleus	29211711.	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	29211711.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006091	generation of precursor metabolites and energy	-	ISS	Process
GO:0006096	glycolytic process	-	IEA	Process
GO:0006099	tricarboxylic acid cycle	21873635.	IBA	Process
GO:0006099	tricarboxylic acid cycle	-	TAS	Process
GO:0006103	2-oxoglutarate metabolic process	24495017.29211711.	IDA	Process
GO:0006104	succinyl-CoA metabolic process	24495017.29211711.	IDA	Process
GO:0006554	lysine catabolic process	-	TAS	Process
GO:0006734	NADH metabolic process	-	IEA	Process
GO:0021695	cerebellar cortex development	-	IEA	Process
GO:0021756	striatum development	-	IEA	Process
GO:0021766	hippocampus development	-	IEA	Process
GO:0021794	thalamus development	-	IEA	Process
GO:0021860	pyramidal neuron development	-	IEA	Process
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	-	IEA	Process
GO:0030976	thiamine pyrophosphate binding	24495017.	IDA	Function
GO:0031072	heat shock protein binding	-	IEA	Function
GO:0031966	mitochondrial membrane	-	ISS	Component
GO:0034602	oxoglutarate dehydrogenase (NAD+) activity	-	IEA	Function
GO:0045252	oxoglutarate dehydrogenase complex	21873635.	IBA	Component
GO:0045252	oxoglutarate dehydrogenase complex	29211711.	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0051087	chaperone binding	-	IEA	Function
GO:0061034	olfactory bulb mitral cell layer development	-	IEA	Process
GO:0106077	histone succinylation	29211711.	IDA	Process