EuRBPDB

Description

Ensembl ID: ENSG00000105968 (Gene tree)
Gene ID: 94239
Gene Symbol: H2AFV
Alias: MGC10170|MGC10831|MGC1947|H2AV
Full Name: H2A histone family member V
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 21,336 bases
Position: chr7:44,826,791-44,848,126
Accession: 20664
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000308153	H2AFV-202	752	-	ENSP00000308405	128 (aa)	-	Q71UI9
ENST00000446531	H2AFV-207	1041	-	ENSP00000406901	122 (aa)	-	C9J0D1
ENST00000349299	H2AFV-203	596	-	ENSP00000342714	90 (aa)	-	Q71UI9
ENST00000222690	H2AFV-201	3804	-	ENSP00000222690	114 (aa)	-	Q71UI9
ENST00000437072	H2AFV-206	589	-	ENSP00000397115	76 (aa)	-	C9J386
ENST00000521529	H2AFV-208	439	-	ENSP00000430492	40 (aa)	-	E5RJU1
ENST00000350771	H2AFV-204	687	-	ENSP00000340708	102 (aa)	-	Q71UI9
ENST00000381124	H2AFV-205	628	-	ENSP00000370516	66 (aa)	-	Q71UI9

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04217	Necroptosis	KEGG
hsa05034	Alcoholism	KEGG
hsa05322	Systemic lupus erythematosus	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105968	rs10267576	7	44831334	C	Mean corpuscular volume	27863252	[0.025-0.039] unit increase	0.03245668	EFO_0004526
ENSG00000105968	rs12155039	7	44833526	A	Mean platelet volume	27863252	[0.017-0.031] unit decrease	0.02415063	EFO_0004584
ENSG00000105968	rs714543	7	44847477	G	Plateletcrit	27863252	[0.048-0.062] unit decrease	0.0549308	EFO_0007985
ENSG00000105968	rs7789162	7	44833301	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000105968	rs12155039	7	44833526	?	Red blood cell count	30595370			EFO_0004305
ENSG00000105968	rs12155038	7	44833378	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000105968	rs7789162	7	44833301	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105968	H2AFV	100	96.970	FBgn0001197	His2Av	87	98.361	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000786	nucleosome	-	IEA	Component
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0003674	molecular_function	-	ND	Function
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0005634	nucleus	16791210.21630459.	HDA	Component
GO:0005634	nucleus	16457589.	IDA	Component
GO:0006325	chromatin organization	21873635.	IBA	Process
GO:0008150	biological_process	-	ND	Process
GO:0046982	protein heterodimerization activity	-	IEA	Function
GO:0070062	extracellular exosome	23533145.	HDA	Component