EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000106560 (Gene tree)
Gene ID: 26157
Gene Symbol: GIMAP2
Alias: DKFZp586D0824|HIMAP2|IMAP2|IAN12
Full Name: GTPase, IMAP family member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 7,945 bases
Position: chr7:150,685,697-150,693,641
Accession: 21789
RBP type: canonical RBP
Summary: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000223293	MMR_HSR1	PF01926.23	1.4e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000487388	GIMAP2-203	556	-	-	- (aa)	-	-
ENST00000223293	GIMAP2-201	1449	-	ENSP00000223293	337 (aa)	-	Q9UG22
ENST00000474605	GIMAP2-202	309	-	ENSP00000420423	43 (aa)	-	C9JND7

Gene Model

Click here to download ENSG00000106560's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106560's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000106560	GIMAP2	83	69.751	ENSAMEG00000019645	GIMAP2	98	69.751	Ailuropoda_melanoleuca
ENSG00000106560	GIMAP2	100	87.834	ENSANAG00000030707	GIMAP2	100	87.834	Aotus_nancymaae
ENSG00000106560	GIMAP2	100	86.647	ENSCJAG00000043924	GIMAP2	100	86.647	Callithrix_jacchus
ENSG00000106560	GIMAP2	100	66.766	ENSCAFG00000032359	GIMAP2	100	66.766	Canis_familiaris
ENSG00000106560	GIMAP2	100	67.062	ENSCAFG00020006491	GIMAP2	100	67.062	Canis_lupus_dingo
ENSG00000106560	GIMAP2	99	72.836	ENSTSYG00000009562	GIMAP2	99	72.836	Carlito_syrichta
ENSG00000106560	GIMAP2	100	87.240	ENSCCAG00000037175	GIMAP2	100	87.240	Cebus_capucinus
ENSG00000106560	GIMAP2	100	92.285	ENSCATG00000040151	GIMAP2	100	92.285	Cercocebus_atys
ENSG00000106560	GIMAP2	100	91.988	ENSCSAG00000006873	GIMAP2	100	91.988	Chlorocebus_sabaeus
ENSG00000106560	GIMAP2	100	89.911	ENSCANG00000019169	GIMAP2	100	89.911	Colobus_angolensis_palliatus
ENSG00000106560	GIMAP2	100	70.326	ENSECAG00000037840	-	100	70.326	Equus_caballus
ENSG00000106560	GIMAP2	100	72.107	ENSECAG00000007598	-	92	72.107	Equus_caballus
ENSG00000106560	GIMAP2	99	67.857	ENSFCAG00000041167	GIMAP2	99	67.857	Felis_catus
ENSG00000106560	GIMAP2	99	98.512	ENSGGOG00000022230	GIMAP2	99	98.452	Gorilla_gorilla
ENSG00000106560	GIMAP2	100	92.285	ENSMFAG00000041785	GIMAP2	99	92.285	Macaca_fascicularis
ENSG00000106560	GIMAP2	100	91.988	ENSMMUG00000017008	GIMAP2	99	91.988	Macaca_mulatta
ENSG00000106560	GIMAP2	100	91.988	ENSMNEG00000029559	GIMAP2	99	91.988	Macaca_nemestrina
ENSG00000106560	GIMAP2	100	91.691	ENSMLEG00000033388	GIMAP2	100	91.691	Mandrillus_leucophaeus
ENSG00000106560	GIMAP2	100	68.249	ENSMICG00000008145	GIMAP2	100	68.249	Microcebus_murinus
ENSG00000106560	GIMAP2	99	71.726	ENSMLUG00000003659	GIMAP2	100	71.726	Myotis_lucifugus
ENSG00000106560	GIMAP2	100	95.549	ENSNLEG00000003839	GIMAP2	100	95.549	Nomascus_leucogenys
ENSG00000106560	GIMAP2	99	71.302	ENSOCUG00000029428	GIMAP2	98	71.302	Oryctolagus_cuniculus
ENSG00000106560	GIMAP2	95	72.100	ENSOGAG00000002649	GIMAP2	97	72.100	Otolemur_garnettii
ENSG00000106560	GIMAP2	99	64.793	ENSOARG00000001542	GIMAP2	99	64.793	Ovis_aries
ENSG00000106560	GIMAP2	96	97.833	ENSPPAG00000009720	GIMAP2	99	97.833	Pan_paniscus
ENSG00000106560	GIMAP2	98	68.580	ENSPPRG00000022402	GIMAP2	98	68.580	Panthera_pardus
ENSG00000106560	GIMAP2	98	68.278	ENSPTIG00000012381	GIMAP2	98	68.278	Panthera_tigris_altaica
ENSG00000106560	GIMAP2	100	98.813	ENSPTRG00000028357	GIMAP2	100	98.813	Pan_troglodytes
ENSG00000106560	GIMAP2	100	98.813	ENSPTRG00000052806	-	100	98.813	Pan_troglodytes
ENSG00000106560	GIMAP2	100	91.098	ENSPANG00000033198	GIMAP2	100	91.098	Papio_anubis
ENSG00000106560	GIMAP2	100	95.846	ENSPPYG00000018172	GIMAP2	100	95.846	Pongo_abelii
ENSG00000106560	GIMAP2	100	73.294	ENSPCOG00000024391	GIMAP2	100	73.294	Propithecus_coquereli
ENSG00000106560	GIMAP2	100	69.139	ENSPVAG00000013121	GIMAP2	100	69.139	Pteropus_vampyrus
ENSG00000106560	GIMAP2	100	90.801	ENSRBIG00000034688	GIMAP2	94	90.801	Rhinopithecus_bieti
ENSG00000106560	GIMAP2	100	90.801	ENSRROG00000036634	GIMAP2	94	90.801	Rhinopithecus_roxellana
ENSG00000106560	GIMAP2	96	58.967	ENSSARG00000006445	GIMAP2	97	58.967	Sorex_araneus
ENSG00000106560	GIMAP2	98	64.565	ENSSSCG00000016449	GIMAP2	96	64.565	Sus_scrofa
ENSG00000106560	GIMAP2	58	76.531	ENSTBEG00000013777	-	100	76.531	Tupaia_belangeri
ENSG00000106560	GIMAP2	100	65.000	ENSTTRG00000004927	GIMAP2	100	65.000	Tursiops_truncatus
ENSG00000106560	GIMAP2	85	69.123	ENSUAMG00000015307	-	96	69.123	Ursus_americanus
ENSG00000106560	GIMAP2	96	68.210	ENSUAMG00000011842	-	99	68.210	Ursus_americanus
ENSG00000106560	GIMAP2	100	67.953	ENSUMAG00000011148	-	100	67.953	Ursus_maritimus
ENSG00000106560	GIMAP2	100	67.656	ENSUMAG00000018156	-	86	67.656	Ursus_maritimus
ENSG00000106560	GIMAP2	77	71.648	ENSUMAG00000000549	-	97	71.648	Ursus_maritimus
ENSG00000106560	GIMAP2	100	67.656	ENSVVUG00000009149	GIMAP2	100	67.656	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	23454188.	IPI	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005811	lipid droplet	23454188.	IDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0042802	identical protein binding	21059949.	IPI	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr7	150693044	Frame_Shift_Ins	novel	*A255Pfs10**	0.3
BLCA	chr7	150692891	Missense_Mutation	rs138926685	I202T	0.38
BLCA	chr7	150693034	Nonsense_Mutation	NA	Q250*	0.47
BLCA	chr7	150692515	Missense_Mutation	novel	D77N	0.16	MMR_HSR1
BLCA	chr7	150692834	Missense_Mutation	novel	N183S	0.13
BLCA	chr7	150693087	Silent	novel	I267I	0.53
BLCA	chr7	150693372	3'UTR	novel		0.33
BRCA	chr7	150692524	Missense_Mutation	NA	D80H	0.19	MMR_HSR1
BRCA	chr7	150693081	Silent	novel	A265A	0.24
BRCA	chr7	150692409	Silent	NA	S41S	0.66
BRCA	chr7	150692852	Missense_Mutation	rs759125462	S189N	0.11
BRCA	chr7	150692853	Silent	novel	S189S	0.11
BRCA	chr7	150692746	Missense_Mutation	novel	G154S	0.08
BRCA	chr7	150692990	Missense_Mutation	novel	R235T	0.15
BRCA	chr7	150693012	Silent	NA	S242S	0.2
CESC	chr7	150692574	Silent	novel	Q96Q	0.39
CESC	chr7	150692431	Missense_Mutation	NA	E49K	0.26	MMR_HSR1
COAD	chr7	150692925	Missense_Mutation	NA	H213Q	0.2
COAD	chr7	150693218	Missense_Mutation	NA	S311N	0.43
COAD	chr7	150692818	Nonsense_Mutation	rs550994929	R178*	0.28
COAD	chr7	150692530	Missense_Mutation	novel	F82V	0.09	MMR_HSR1
ESCA	chr7	150692675	Missense_Mutation	rs754733684	K130T	0.29	MMR_HSR1
GBM	chr7	150692436	Silent	rs777336192	S50S	0.22
GBM	chr7	150693160	Missense_Mutation	NA	H292Y	0.08
HNSC	chr7	150693381	3'UTR	novel		0.29
HNSC	chr7	150692673	Silent	novel	V129V	0.38
HNSC	chr7	150692403	Silent	NA	G39G	0.23
KIRC	chr7	150692750	Missense_Mutation	NA	S155Y	0.2
LAML	chr7	150692970	Silent	novel	G228G	0.08
LGG	chr7	150693364	3'UTR	novel		0.23
LIHC	chr7	150692726	Missense_Mutation	novel	H147L	0.25
LIHC	chr7	150692976	Silent	NA	V230V	0.23
LUAD	chr7	150692692	Missense_Mutation	novel	D136Y	0.35
LUAD	chr7	150692598	Silent	NA	P104P	0.28
LUAD	chr7	150692816	Missense_Mutation	novel	G177V	0.32
LUAD	chr7	150692482	Nonsense_Mutation	novel	G66*	0.66	MMR_HSR1
LUAD	chr7	150692490	Missense_Mutation	novel	W68C	0.34	MMR_HSR1
LUAD	chr7	150692665	Missense_Mutation	novel	Q127K	0.16	MMR_HSR1
LUAD	chr7	150692571	Silent	novel	V95V	0.16
LUSC	chr7	150692758	Missense_Mutation	NA	D158H	0.3
LUSC	chr7	150692754	Silent	novel	L156L	0.1
LUSC	chr7	150692582	Missense_Mutation	novel	Y99C	0.2	MMR_HSR1
LUSC	chr7	150692403	Silent	novel	G39G	0.08
LUSC	chr7	150692990	Missense_Mutation	novel	R235T	0.23
LUSC	chr7	150692577	Missense_Mutation	novel	R97S	0.66	MMR_HSR1
LUSC	chr7	150692372	Missense_Mutation	NA	G29D	0.16	MMR_HSR1
OV	chr7	150692569	Missense_Mutation	NA	V95L	0.23	MMR_HSR1
OV	chr7	150692970	Silent	novel	G228G	0.06
READ	chr7	150693323	3'UTR	novel		0.27
READ	chr7	150693011	Missense_Mutation	NA	S242N	0.42
SARC	chr7	150692447	Missense_Mutation	novel	S54F	0.26	MMR_HSR1
SKCM	chr7	150692817	Silent	NA	G177G	0.41
SKCM	chr7	150693359	3'UTR	novel		0.39
SKCM	chr7	150692785	Missense_Mutation	rs150902506	A167T	0.5
SKCM	chr7	150693079	Missense_Mutation	novel	A265T	0.1
SKCM	chr7	150692402	Missense_Mutation	NA	G39E	0.12	MMR_HSR1
SKCM	chr7	150692875	Missense_Mutation	NA	E197K	0.26
SKCM	chr7	150693249	Missense_Mutation	NA	M321I	0.25
SKCM	chr7	150692381	Missense_Mutation	NA	G32E	0.31	MMR_HSR1
SKCM	chr7	150692998	Missense_Mutation	novel	E238K	0.37
SKCM	chr7	150692731	Missense_Mutation	NA	E149K	0.43
SKCM	chr7	150692403	Silent	NA	G39G	0.58
SKCM	chr7	150692482	Missense_Mutation	novel	G66R	0.25	MMR_HSR1
SKCM	chr7	150692849	Missense_Mutation	novel	G188E	0.33
SKCM	chr7	150693360	3'UTR	novel		0.29
SKCM	chr7	150692883	Missense_Mutation	rs376750400	M199I	0.18
SKCM	chr7	150692454	Silent	novel	T56T	0.46
SKCM	chr7	150692997	Silent	rs751294485	K237K	0.32
SKCM	chr7	150693135	Silent	novel	L283L	0.35
SKCM	chr7	150693235	Missense_Mutation	novel	P317S	0.16
SKCM	chr7	150692701	Missense_Mutation	rs372328919	G139R	0.27
SKCM	chr7	150692998	Missense_Mutation	novel	E238K	0.29
SKCM	chr7	150692955	Silent	NA	Q223Q	0.33
SKCM	chr7	150692492	Missense_Mutation	NA	G69E	0.32	MMR_HSR1
SKCM	chr7	150693077	Missense_Mutation	novel	G264E	0.15
SKCM	chr7	150693352	3'UTR	novel		0.45
SKCM	chr7	150692444	Missense_Mutation	NA	G53D	0.36	MMR_HSR1
SKCM	chr7	150693169	Missense_Mutation	NA	C295S	0.18
SKCM	chr7	150692447	Missense_Mutation	novel	S54F	0.46	MMR_HSR1
SKCM	chr7	150693309	3'UTR	novel		0.36
SKCM	chr7	150692770	Missense_Mutation	NA	D162N	0.58
SKCM	chr7	150692413	Missense_Mutation	NA	L43F	0.9	MMR_HSR1
SKCM	chr7	150692649	Silent	NA	Q121Q	0.27
SKCM	chr7	150692875	Missense_Mutation	NA	E197K	0.33
SKCM	chr7	150693293	Missense_Mutation	NA	R336K	0.31
SKCM	chr7	150692544	Silent	NA	D86D	0.48
SKCM	chr7	150692981	Missense_Mutation	novel	S232L	0.11
SKCM	chr7	150692394	Missense_Mutation	rs201164211	S36R	0.31	MMR_HSR1
SKCM	chr7	150692986	Missense_Mutation	NA	E234K	0.47
SKCM	chr7	150692381	Missense_Mutation	NA	G32E	0.18	MMR_HSR1
SKCM	chr7	150692859	Silent	NA	Q191Q	0.45
SKCM	chr7	150692904	Silent	NA	L206L	0.17
SKCM	chr7	150693344	3'UTR	novel		0.54
SKCM	chr7	150692403	Silent	NA	G39G	0.24
SKCM	chr7	150692660	Missense_Mutation	rs144149379	A125V	0.22	MMR_HSR1
SKCM	chr7	150692492	Missense_Mutation	NA	G69E	0.18	MMR_HSR1
SKCM	chr7	150692819	Missense_Mutation	rs141987826	R178Q	0.53
SKCM	chr7	150693142	Silent	novel	L286L	0.18
SKCM	chr7	150692697	Silent	NA	A137A	0.22
SKCM	chr7	150692823	Silent	rs370076034	I179I	0.16
SKCM	chr7	150692381	Missense_Mutation	NA	G32E	0.54	MMR_HSR1
SKCM	chr7	150692819	Missense_Mutation	rs141987826	R178Q	0.21
STAD	chr7	150692985	Silent	rs148143220	D233D	0.18
UCEC	chr7	150693327	3'UTR	novel		0.41
UCEC	chr7	150692583	Silent	novel	Y99Y	0.38
UCEC	chr7	150692899	Missense_Mutation	novel	L205M	0.24
UCEC	chr7	150692770	Missense_Mutation	NA	D162N	0.5
UCEC	chr7	150693170	Missense_Mutation	novel	C295Y	0.48
UCEC	chr7	150692874	Missense_Mutation	novel	K196N	0.33
UCEC	chr7	150692357	Missense_Mutation	novel	R24I	0.25	MMR_HSR1
UCEC	chr7	150692576	Missense_Mutation	NA	R97M	0.38	MMR_HSR1
UCEC	chr7	150692524	Missense_Mutation	novel	D80Y	0.14	MMR_HSR1
UCEC	chr7	150693282	Silent	novel	R332R	0.41
UCEC	chr7	150692758	Missense_Mutation	novel	D158Y	0.35
UCEC	chr7	150692611	Silent	novel	L109L	0.21
UCEC	chr7	150692390	Missense_Mutation	novel	K35T	0.37	MMR_HSR1
UCEC	chr7	150692484	Silent	novel	G66G	0.42
UCEC	chr7	150692507	Missense_Mutation	novel	V74A	0.57	MMR_HSR1
UCEC	chr7	150692992	Missense_Mutation	novel	V236I	0.16
UCEC	chr7	150692891	Missense_Mutation	rs138926685	I202T	0.39
UCEC	chr7	150693349	3'UTR	novel		0.27
UCEC	chr7	150692436	Silent	rs777336192	S50S	0.34
UCEC	chr7	150692914	Missense_Mutation	novel	N210D	0.53

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0778	0.12261
CESC	DEL	0.1831	0.0016147
DLBC	DEL	0.0833	0.03486
HNSC	DEL	0.2031	1.1399e-22
KIRC	AMP	0.2898	0.075418
LAML	DEL	0.1309	3.4101e-05
LGG	AMP	0.3119	1.5525e-07
LIHC	DEL	0.0784	0.24831
OV	AMP	0.4767	1.5763e-13
PAAD	DEL	0.0652	0.049388
TGCT	DEL	0.0733	0.11738
THCA	DEL	0	0.27619
UCEC	DEL	0.0965	0.0001859
UCS	DEL	0.3393	0.10142

Survival Analysis

Cancer	P-value	Q-value
THYM	0.012	Kaplan-Meier Survival Analysis
KIRC	0.036	Kaplan-Meier Survival Analysis
SARC	0.00015	Kaplan-Meier Survival Analysis
MESO	0.0054	Kaplan-Meier Survival Analysis
HNSC	0.015	Kaplan-Meier Survival Analysis
BRCA	0.0064	Kaplan-Meier Survival Analysis
PAAD	0.021	Kaplan-Meier Survival Analysis
UCEC	0.0005	Kaplan-Meier Survival Analysis
LIHC	0.037	Kaplan-Meier Survival Analysis
THCA	0.037	Kaplan-Meier Survival Analysis
LUAD	0.016	Kaplan-Meier Survival Analysis