EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000106591 (Gene tree)
Gene ID: 64983
Gene Symbol: MRPL32
Alias: HSPC283|L32mt|MRP-L32|bMRP-59b
Full Name: mitochondrial ribosomal protein L32
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 16,759 bases
Position: chr7:42,932,200-42,948,958
Accession: 14035
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000223324	Ribosomal_L32p	PF01783.23	8e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000432845	MRPL32-203	2734	-	ENSP00000415581	107 (aa)	-	B3KQX1
ENST00000413995	MRPL32-202	730	-	ENSP00000391562	42 (aa)	-	H7BZU9
ENST00000496564	MRPL32-204	488	-	-	- (aa)	-	-
ENST00000223324	MRPL32-201	1035	-	ENSP00000223324	188 (aa)	-	Q9BYC8

Gene Model

Click here to download ENSG00000106591's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000106591	Cholesterol, HDL	8.2660000E-005	-
ENSG00000106591	Cholesterol, HDL	1.7670000E-005	-
ENSG00000106591	Platelet Function Tests	2.2532972E-007	-
ENSG00000106591	Platelet Function Tests	2.6992373E-007	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000106591	rs10486743	7	42940343	A	Cognitive empathy	28584286	[0.2-0.45] unit increase	0.3241	EFO_0009183

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106591's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000106591	MRPL32	88	72.973	ENSAPOG00000004637	mrpl32	82	62.162	Acanthochromis_polyacanthus
ENSG00000106591	MRPL32	100	87.766	ENSAMEG00000009422	MRPL32	100	87.766	Ailuropoda_melanoleuca
ENSG00000106591	MRPL32	86	72.222	ENSACIG00000019897	mrpl32	77	62.500	Amphilophus_citrinellus
ENSG00000106591	MRPL32	88	72.973	ENSAOCG00000009691	mrpl32	82	61.486	Amphiprion_ocellaris
ENSG00000106591	MRPL32	88	72.973	ENSAPEG00000018363	mrpl32	82	62.162	Amphiprion_percula
ENSG00000106591	MRPL32	86	72.222	ENSATEG00000024446	mrpl32	81	61.905	Anabas_testudineus
ENSG00000106591	MRPL32	88	75.676	ENSAPLG00000004159	MRPL32	96	68.707	Anas_platyrhynchos
ENSG00000106591	MRPL32	90	84.211	ENSACAG00000017508	MRPL32	100	61.828	Anolis_carolinensis
ENSG00000106591	MRPL32	100	92.021	ENSANAG00000036260	MRPL32	100	92.021	Aotus_nancymaae
ENSG00000106591	MRPL32	83	80.000	ENSACLG00000021664	mrpl32	81	64.583	Astatotilapia_calliptera
ENSG00000106591	MRPL32	88	81.081	ENSAMXG00000037068	mrpl32	81	63.636	Astyanax_mexicanus
ENSG00000106591	MRPL32	100	84.574	ENSBTAG00000000991	MRPL32	100	84.574	Bos_taurus
ENSG00000106591	MRPL32	100	91.489	ENSCJAG00000007749	MRPL32	100	91.489	Callithrix_jacchus
ENSG00000106591	MRPL32	100	87.766	ENSCAFG00000003507	MRPL32	100	87.766	Canis_familiaris
ENSG00000106591	MRPL32	100	87.766	ENSCAFG00020023577	MRPL32	100	87.766	Canis_lupus_dingo
ENSG00000106591	MRPL32	100	84.574	ENSCHIG00000026167	MRPL32	100	84.574	Capra_hircus
ENSG00000106591	MRPL32	100	86.702	ENSTSYG00000014296	MRPL32	100	86.702	Carlito_syrichta
ENSG00000106591	MRPL32	95	87.500	ENSCAPG00000005855	MRPL32	100	86.111	Cavia_aperea
ENSG00000106591	MRPL32	90	92.105	ENSCPOG00000034853	MRPL32	100	77.717	Cavia_porcellus
ENSG00000106591	MRPL32	100	89.362	ENSCCAG00000021732	MRPL32	100	89.362	Cebus_capucinus
ENSG00000106591	MRPL32	100	94.149	ENSCATG00000038411	MRPL32	100	94.149	Cercocebus_atys
ENSG00000106591	MRPL32	100	80.319	ENSCLAG00000016308	MRPL32	100	80.319	Chinchilla_lanigera
ENSG00000106591	MRPL32	100	95.745	ENSCSAG00000015403	-	100	95.745	Chlorocebus_sabaeus
ENSG00000106591	MRPL32	100	93.617	ENSCSAG00000000306	-	100	93.617	Chlorocebus_sabaeus
ENSG00000106591	MRPL32	100	84.574	ENSCHOG00000000649	MRPL32	100	84.574	Choloepus_hoffmanni
ENSG00000106591	MRPL32	88	78.378	ENSCPBG00000024797	MRPL32	76	63.636	Chrysemys_picta_bellii
ENSG00000106591	MRPL32	100	95.213	ENSCANG00000034535	MRPL32	100	95.213	Colobus_angolensis_palliatus
ENSG00000106591	MRPL32	90	84.211	ENSCGRG00001016443	Mrpl32	96	71.809	Cricetulus_griseus_chok1gshd
ENSG00000106591	MRPL32	88	83.784	ENSCGRG00000002784	Mrpl32	100	70.745	Cricetulus_griseus_crigri
ENSG00000106591	MRPL32	86	72.222	ENSCSEG00000011393	mrpl32	82	59.441	Cynoglossus_semilaevis
ENSG00000106591	MRPL32	90	68.421	ENSCVAG00000003751	mrpl32	81	63.194	Cyprinodon_variegatus
ENSG00000106591	MRPL32	90	85.000	ENSDARG00000060489	mrpl32	91	59.877	Danio_rerio
ENSG00000106591	MRPL32	100	84.043	ENSDNOG00000042619	MRPL32	100	84.043	Dasypus_novemcinctus
ENSG00000106591	MRPL32	100	80.319	ENSDORG00000011748	Mrpl32	100	80.319	Dipodomys_ordii
ENSG00000106591	MRPL32	86	97.222	ENSETEG00000015832	MRPL32	100	82.979	Echinops_telfairi
ENSG00000106591	MRPL32	79	70.588	ENSEBUG00000009789	mrpl32	80	48.592	Eptatretus_burgeri
ENSG00000106591	MRPL32	95	77.500	ENSEASG00005017108	-	99	68.280	Equus_asinus_asinus
ENSG00000106591	MRPL32	100	86.702	ENSEASG00005017681	-	95	86.702	Equus_asinus_asinus
ENSG00000106591	MRPL32	93	82.051	ENSECAG00000002903	-	99	69.892	Equus_caballus
ENSG00000106591	MRPL32	100	86.702	ENSECAG00000009052	-	95	86.702	Equus_caballus
ENSG00000106591	MRPL32	100	73.016	ENSEEUG00000007707	MRPL32	100	73.016	Erinaceus_europaeus
ENSG00000106591	MRPL32	83	65.714	ENSELUG00000022019	mrpl32	82	58.333	Esox_lucius
ENSG00000106591	MRPL32	90	94.737	ENSFCAG00000041230	MRPL32	88	88.304	Felis_catus
ENSG00000106591	MRPL32	90	76.316	ENSFALG00000005069	MRPL32	100	65.054	Ficedula_albicollis
ENSG00000106591	MRPL32	90	89.474	ENSFDAG00000016940	MRPL32	99	80.000	Fukomys_damarensis
ENSG00000106591	MRPL32	93	74.359	ENSFHEG00000002357	mrpl32	85	63.226	Fundulus_heteroclitus
ENSG00000106591	MRPL32	86	66.667	ENSGMOG00000009575	mrpl32	91	61.111	Gadus_morhua
ENSG00000106591	MRPL32	98	60.870	ENSGALG00000037258	MRPL32	100	60.870	Gallus_gallus
ENSG00000106591	MRPL32	90	73.684	ENSGAFG00000000128	mrpl32	81	64.626	Gambusia_affinis
ENSG00000106591	MRPL32	95	55.000	ENSGACG00000005754	mrpl32	95	51.648	Gasterosteus_aculeatus
ENSG00000106591	MRPL32	88	78.378	ENSGAGG00000012516	MRPL32	80	62.567	Gopherus_agassizii
ENSG00000106591	MRPL32	100	98.404	ENSGGOG00000027492	MRPL32	100	98.404	Gorilla_gorilla
ENSG00000106591	MRPL32	83	80.000	ENSHBUG00000011435	mrpl32	82	63.514	Haplochromis_burtoni
ENSG00000106591	MRPL32	90	84.211	ENSHGLG00000002039	-	92	77.070	Heterocephalus_glaber_female
ENSG00000106591	MRPL32	95	90.000	ENSHGLG00000017398	MRPL32	100	81.915	Heterocephalus_glaber_female
ENSG00000106591	MRPL32	90	92.105	ENSHGLG00000010570	-	94	83.951	Heterocephalus_glaber_female
ENSG00000106591	MRPL32	95	90.000	ENSHGLG00100009179	MRPL32	100	81.915	Heterocephalus_glaber_male
ENSG00000106591	MRPL32	90	92.105	ENSHGLG00100016561	-	94	83.951	Heterocephalus_glaber_male
ENSG00000106591	MRPL32	83	74.286	ENSHCOG00000009839	mrpl32	81	63.448	Hippocampus_comes
ENSG00000106591	MRPL32	88	86.486	ENSIPUG00000022592	mrpl32	81	66.197	Ictalurus_punctatus
ENSG00000106591	MRPL32	100	81.383	ENSSTOG00000013340	MRPL32	99	81.383	Ictidomys_tridecemlineatus
ENSG00000106591	MRPL32	95	80.000	ENSJJAG00000010906	Mrpl32	100	81.944	Jaculus_jaculus
ENSG00000106591	MRPL32	83	77.143	ENSKMAG00000021643	mrpl32	94	56.250	Kryptolebias_marmoratus
ENSG00000106591	MRPL32	86	72.222	ENSLBEG00000006081	mrpl32	82	61.644	Labrus_bergylta
ENSG00000106591	MRPL32	95	77.500	ENSLACG00000013631	MRPL32	92	58.929	Latimeria_chalumnae
ENSG00000106591	MRPL32	100	84.574	ENSLAFG00000011427	MRPL32	100	84.574	Loxodonta_africana
ENSG00000106591	MRPL32	100	95.745	ENSMFAG00000041218	MRPL32	100	95.745	Macaca_fascicularis
ENSG00000106591	MRPL32	100	95.745	ENSMNEG00000042550	MRPL32	100	95.745	Macaca_nemestrina
ENSG00000106591	MRPL32	100	95.213	ENSMLEG00000025401	MRPL32	100	95.213	Mandrillus_leucophaeus
ENSG00000106591	MRPL32	86	66.667	ENSMAMG00000000634	mrpl32	82	63.448	Mastacembelus_armatus
ENSG00000106591	MRPL32	83	80.000	ENSMZEG00005006966	mrpl32	82	63.514	Maylandia_zebra
ENSG00000106591	MRPL32	98	60.215	ENSMGAG00000012299	MRPL32	98	60.215	Meleagris_gallopavo
ENSG00000106591	MRPL32	95	82.500	ENSMAUG00000019188	Mrpl32	98	73.224	Mesocricetus_auratus
ENSG00000106591	MRPL32	97	83.654	ENSMICG00000031524	-	92	85.882	Microcebus_murinus
ENSG00000106591	MRPL32	100	87.766	ENSMICG00000045915	-	100	87.766	Microcebus_murinus
ENSG00000106591	MRPL32	100	73.936	ENSMOCG00000000157	Mrpl32	100	73.936	Microtus_ochrogaster
ENSG00000106591	MRPL32	86	69.444	ENSMMOG00000006725	mrpl32	80	62.838	Mola_mola
ENSG00000106591	MRPL32	93	71.795	ENSMALG00000004178	mrpl32	91	62.963	Monopterus_albus
ENSG00000106591	MRPL32	95	90.000	MGP_CAROLIEiJ_G0018238	Mrpl32	100	72.872	Mus_caroli
ENSG00000106591	MRPL32	95	90.000	ENSMUSG00000015672	Mrpl32	100	72.340	Mus_musculus
ENSG00000106591	MRPL32	90	92.105	MGP_PahariEiJ_G0019288	Mrpl32	98	72.678	Mus_pahari
ENSG00000106591	MRPL32	95	90.000	MGP_SPRETEiJ_G0019096	Mrpl32	100	72.872	Mus_spretus
ENSG00000106591	MRPL32	100	83.511	ENSMPUG00000018146	-	100	83.511	Mustela_putorius_furo
ENSG00000106591	MRPL32	96	76.111	ENSMPUG00000018427	-	100	76.111	Mustela_putorius_furo
ENSG00000106591	MRPL32	98	84.324	ENSMLUG00000010108	MRPL32	98	84.324	Myotis_lucifugus
ENSG00000106591	MRPL32	95	87.500	ENSNGAG00000014806	Mrpl32	98	75.956	Nannospalax_galili
ENSG00000106591	MRPL32	83	80.000	ENSNBRG00000009648	mrpl32	82	63.514	Neolamprologus_brichardi
ENSG00000106591	MRPL32	100	96.277	ENSNLEG00000027404	MRPL32	100	96.277	Nomascus_leucogenys
ENSG00000106591	MRPL32	99	69.519	ENSMEUG00000015597	MRPL32	98	69.519	Notamacropus_eugenii
ENSG00000106591	MRPL32	100	75.532	ENSOPRG00000011804	MRPL32	100	75.532	Ochotona_princeps
ENSG00000106591	MRPL32	95	85.000	ENSODEG00000008658	MRPL32	99	79.144	Octodon_degus
ENSG00000106591	MRPL32	83	77.143	ENSONIG00000007276	mrpl32	81	64.336	Oreochromis_niloticus
ENSG00000106591	MRPL32	90	78.947	ENSOANG00000010696	MRPL32	100	64.021	Ornithorhynchus_anatinus
ENSG00000106591	MRPL32	95	92.500	ENSOCUG00000012098	-	100	80.319	Oryctolagus_cuniculus
ENSG00000106591	MRPL32	95	87.500	ENSOCUG00000022702	-	100	78.836	Oryctolagus_cuniculus
ENSG00000106591	MRPL32	86	77.778	ENSORLG00000006185	mrpl32	82	63.758	Oryzias_latipes
ENSG00000106591	MRPL32	86	80.556	ENSORLG00020000568	mrpl32	77	65.101	Oryzias_latipes_hni
ENSG00000106591	MRPL32	86	77.778	ENSORLG00015003501	mrpl32	82	64.430	Oryzias_latipes_hsok
ENSG00000106591	MRPL32	86	77.778	ENSOMEG00000017332	mrpl32	86	61.783	Oryzias_melastigma
ENSG00000106591	MRPL32	95	95.000	ENSOGAG00000016806	MRPL32	100	85.638	Otolemur_garnettii
ENSG00000106591	MRPL32	100	84.043	ENSOARG00000017330	MRPL32	100	84.043	Ovis_aries
ENSG00000106591	MRPL32	100	98.404	ENSPPAG00000039260	MRPL32	100	98.404	Pan_paniscus
ENSG00000106591	MRPL32	100	87.766	ENSPPRG00000011233	MRPL32	100	87.766	Panthera_pardus
ENSG00000106591	MRPL32	100	87.766	ENSPTIG00000019413	MRPL32	100	87.766	Panthera_tigris_altaica
ENSG00000106591	MRPL32	100	98.404	ENSPTRG00000019121	MRPL32	100	98.404	Pan_troglodytes
ENSG00000106591	MRPL32	100	95.745	ENSPANG00000023966	MRPL32	100	95.745	Papio_anubis
ENSG00000106591	MRPL32	88	81.081	ENSPKIG00000018407	mrpl32	81	65.278	Paramormyrops_kingsleyae
ENSG00000106591	MRPL32	95	80.000	ENSPSIG00000017913	MRPL32	92	71.233	Pelodiscus_sinensis
ENSG00000106591	MRPL32	88	67.568	ENSPMGG00000016922	mrpl32	81	62.162	Periophthalmus_magnuspinnatus
ENSG00000106591	MRPL32	90	68.421	ENSPMAG00000001920	mrpl32	99	55.484	Petromyzon_marinus
ENSG00000106591	MRPL32	90	84.211	ENSPCIG00000008901	MRPL32	99	69.474	Phascolarctos_cinereus
ENSG00000106591	MRPL32	93	71.795	ENSPFOG00000018949	mrpl32	79	64.626	Poecilia_formosa
ENSG00000106591	MRPL32	93	71.795	ENSPLAG00000017871	mrpl32	81	64.626	Poecilia_latipinna
ENSG00000106591	MRPL32	93	71.795	ENSPMEG00000012112	mrpl32	81	63.946	Poecilia_mexicana
ENSG00000106591	MRPL32	93	69.231	ENSPREG00000013918	mrpl32	81	64.626	Poecilia_reticulata
ENSG00000106591	MRPL32	100	98.404	ENSPPYG00000017611	MRPL32	100	98.404	Pongo_abelii
ENSG00000106591	MRPL32	95	92.500	ENSPCOG00000020168	MRPL32	100	87.234	Propithecus_coquereli
ENSG00000106591	MRPL32	99	54.545	ENSPVAG00000011730	-	99	54.545	Pteropus_vampyrus
ENSG00000106591	MRPL32	83	80.000	ENSPNYG00000013630	mrpl32	82	63.514	Pundamilia_nyererei
ENSG00000106591	MRPL32	88	83.784	ENSPNAG00000015235	mrpl32	99	58.286	Pygocentrus_nattereri
ENSG00000106591	MRPL32	90	92.105	ENSRNOG00000015989	Mrpl32	100	72.872	Rattus_norvegicus
ENSG00000106591	MRPL32	100	95.745	ENSRBIG00000038406	MRPL32	100	95.745	Rhinopithecus_bieti
ENSG00000106591	MRPL32	96	86.740	ENSRBIG00000033368	-	100	86.740	Rhinopithecus_bieti
ENSG00000106591	MRPL32	96	86.188	ENSRROG00000037937	-	98	87.931	Rhinopithecus_roxellana
ENSG00000106591	MRPL32	100	95.213	ENSRROG00000037173	MRPL32	100	95.213	Rhinopithecus_roxellana
ENSG00000106591	MRPL32	100	89.894	ENSSBOG00000029277	MRPL32	100	89.894	Saimiri_boliviensis_boliviensis
ENSG00000106591	MRPL32	90	78.947	ENSSFOG00015005707	mrpl32	82	67.586	Scleropages_formosus
ENSG00000106591	MRPL32	93	64.103	ENSSMAG00000007141	mrpl32	82	60.000	Scophthalmus_maximus
ENSG00000106591	MRPL32	86	69.444	ENSSDUG00000011693	mrpl32	83	59.868	Seriola_dumerili
ENSG00000106591	MRPL32	86	66.667	ENSSLDG00000013498	mrpl32	83	58.553	Seriola_lalandi_dorsalis
ENSG00000106591	MRPL32	93	79.487	ENSSPUG00000015517	MRPL32	89	67.665	Sphenodon_punctatus
ENSG00000106591	MRPL32	90	60.526	ENSSPAG00000018061	mrpl32	82	57.534	Stegastes_partitus
ENSG00000106591	MRPL32	95	77.500	ENSSSCG00000038274	-	100	63.830	Sus_scrofa
ENSG00000106591	MRPL32	100	84.574	ENSSSCG00000025060	-	100	84.574	Sus_scrofa
ENSG00000106591	MRPL32	90	73.684	ENSTGUG00000001824	MRPL32	100	68.142	Taeniopygia_guttata
ENSG00000106591	MRPL32	95	60.000	ENSTRUG00000014307	mrpl32	81	60.563	Takifugu_rubripes
ENSG00000106591	MRPL32	88	75.676	ENSTNIG00000018412	mrpl32	81	64.336	Tetraodon_nigroviridis
ENSG00000106591	MRPL32	100	56.915	ENSTBEG00000015226	MRPL32	100	56.915	Tupaia_belangeri
ENSG00000106591	MRPL32	100	85.106	ENSTTRG00000005645	MRPL32	100	85.106	Tursiops_truncatus
ENSG00000106591	MRPL32	100	86.702	ENSUAMG00000025882	MRPL32	100	86.702	Ursus_americanus
ENSG00000106591	MRPL32	100	86.170	ENSUMAG00000009855	MRPL32	100	86.170	Ursus_maritimus
ENSG00000106591	MRPL32	86	91.667	ENSVPAG00000006819	MRPL32	100	85.417	Vicugna_pacos
ENSG00000106591	MRPL32	95	90.000	ENSVVUG00000006632	MRPL32	85	85.294	Vulpes_vulpes
ENSG00000106591	MRPL32	86	80.556	ENSXETG00000001852	mrpl32	81	65.306	Xenopus_tropicalis
ENSG00000106591	MRPL32	90	65.789	ENSXCOG00000016862	mrpl32	81	62.585	Xiphophorus_couchianus
ENSG00000106591	MRPL32	83	71.429	ENSXMAG00000008933	mrpl32	81	62.585	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	11543634.	NAS	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	21873635.	IBA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005761	mitochondrial ribosome	11543634.	NAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0006412	translation	11543634.	NAS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process