EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000106628 (Gene tree)
Gene ID: 5425
Gene Symbol: POLD2
Alias: N
Full Name: DNA polymerase delta 2, accessory subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 9,679 bases
Position: chr7:44,114,680-44,124,358
Accession: 9176
RBP type: non-canonical RBP
Summary: This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000481104	POLD2-214	541	-	-	- (aa)	-	-
ENST00000461116	POLD2-209	420	-	-	- (aa)	-	-
ENST00000433715	POLD2-204	765	-	ENSP00000389816	220 (aa)	-	C9JLE1
ENST00000223361	POLD2-201	1597	-	ENSP00000223361	455 (aa)	-	F8W8R3
ENST00000456038	POLD2-208	665	-	ENSP00000397461	155 (aa)	-	C9J8Z7
ENST00000496539	POLD2-217	571	-	-	- (aa)	-	-
ENST00000436400	POLD2-205	249	-	ENSP00000399447	83 (aa)	-	H7C1B3
ENST00000470867	POLD2-213	678	-	-	- (aa)	-	-
ENST00000463464	POLD2-210	707	-	-	- (aa)	-	-
ENST00000467469	POLD2-212	528	-	-	- (aa)	-	-
ENST00000452185	POLD2-207	1659	XM_024446802	ENSP00000395231	469 (aa)	XP_024302570	P49005
ENST00000464871	POLD2-211	580	-	-	- (aa)	-	-
ENST00000489883	POLD2-216	528	-	-	- (aa)	-	-
ENST00000406581	POLD2-202	2158	-	ENSP00000386105	469 (aa)	-	P49005
ENST00000436844	POLD2-206	854	-	ENSP00000416203	257 (aa)	-	C9JHC7
ENST00000610533	POLD2-218	1619	-	ENSP00000480186	504 (aa)	-	A0A087WWF6
ENST00000418438	POLD2-203	556	-	ENSP00000406702	148 (aa)	-	C9IZD2
ENST00000481763	POLD2-215	810	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000106628's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG
hsa03410	Base excision repair	KEGG
hsa03420	Nucleotide excision repair	KEGG
hsa03430	Mismatch repair	KEGG
hsa03440	Homologous recombination	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000106628	Gastrointestinal Neoplasms	3.0320000E-005	23504502
ENSG00000106628	Gastrointestinal Neoplasms	3.6200000E-005	23504502

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000106628	rs3087367	7	44116547	G	Blood protein levels	30072576	[0.17-0.26] unit increase	0.213	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106628's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000723	telomere maintenance	-	TAS	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003887	DNA-directed DNA polymerase activity	21873635.	IBA	Function
GO:0005515	protein binding	12403614.15670210.16000169.16510448.26496610.	IPI	Function
GO:0005634	nucleus	8530069.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006260	DNA replication	8530069.	TAS	Process
GO:0006271	DNA strand elongation involved in DNA replication	21873635.	IBA	Process
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	Process
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	Process
GO:0006298	mismatch repair	-	TAS	Process
GO:0019985	translesion synthesis	-	TAS	Process
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	Process
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	Process
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	Process
GO:0043625	delta DNA polymerase complex	21873635.	IBA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr7	44116494	Missense_Mutation	novel	K266R	0.17
BLCA	chr7	44116969	Missense_Mutation	rs568159170	E210K	0.36
BLCA	chr7	44118023	Missense_Mutation	NA	E88K	0.21
BLCA	chr7	44118004	Missense_Mutation	NA	V94E	0.37
BRCA	chr7	44116475	Silent	rs749854320	S272S	0.12
BRCA	chr7	44116913	Silent	rs144701499	D228D	0.39
BRCA	chr7	44116219	Silent	rs145093588	T305T	0.15
BRCA	chr7	44122099	5'UTR	novel		0.5
BRCA	chr7	44117940	Splice_Region	novel		0.16
CESC	chr7	44117235	Missense_Mutation	novel	A160V	0.34
CESC	chr7	44116998	Missense_Mutation	NA	S200F	0.35
CESC	chr7	44118013	Frame_Shift_Del	novel	*C91Sfs54**	0.07
COAD	chr7	44118001	Missense_Mutation	novel	G95A	0.18
COAD	chr7	44116245	Missense_Mutation	novel	G297C	0.18
COAD	chr7	44116913	Silent	rs144701499	D228D	0.32
COAD	chr7	44116243	Silent	rs368138685	G297G	0.13
COAD	chr7	44116868	Silent	rs762376881	L243L	0.48
COAD	chr7	44117155	Missense_Mutation	rs768064825	A187T	0.27
COAD	chr7	44114817	Missense_Mutation	rs752936314	D460N	0.37
COAD	chr7	44121860	Frame_Shift_Del	novel	*F64Wfs15**	0.12
COAD	chr7	44115878	Silent	novel	S345S	0.07
COAD	chr7	44122149	5'UTR	novel		0.14
COAD	chr7	44115895	Splice_Site	novel	X340_splice	0.3
ESCA	chr7	44115875	Silent	novel	G346G	0.48
ESCA	chr7	44117229	Missense_Mutation	novel	F162Y	0.08
ESCA	chr7	44122078	5'UTR	novel		0.26
GBM	chr7	44117737	Silent	novel	N116N	0.48
KIRP	chr7	44116453	Missense_Mutation	novel	D280N	0.36
LGG	chr7	44114796	Missense_Mutation	novel	L467M	0.17
LIHC	chr7	44121905	Missense_Mutation	novel	Y50C	0.29
LUAD	chr7	44114806	Silent	novel	G463G	0.32
LUAD	chr7	44118005	Frame_Shift_Del	novel	*V94Wfs51**	0.09
LUAD	chr7	44117704	Silent	novel	I127I	0.19
LUAD	chr7	44116944	Missense_Mutation	novel	L218R	0.15
LUAD	chr7	44114940	Missense_Mutation	novel	E419K	0.2
LUAD	chr7	44116880	Silent	novel	S239S	0.25
LUAD	chr7	44115348	Missense_Mutation	novel	P399Q	0.25
LUAD	chr7	44116979	Silent	rs757035691	G206G	0.48
LUAD	chr7	44117729	Missense_Mutation	novel	P119R	0.11
LUSC	chr7	44117179	Missense_Mutation	novel	A179S	0.36
LUSC	chr7	44114760	3'UTR	novel		0.11
LUSC	chr7	44116867	Missense_Mutation	novel	A244S	0.15
LUSC	chr7	44116189	Missense_Mutation	NA	M315I	0.28
MESO	chr7	44118002	Missense_Mutation	novel	G95S	0.27
OV	chr7	44115327	Missense_Mutation	NA	N406S	0.31
OV	chr7	44122249	Intron	novel		0.13
OV	chr7	44121902	Missense_Mutation	NA	A51G	0.25
OV	chr7	44116139	Missense_Mutation	NA	Y332C	0.38
PAAD	chr7	44114942	Missense_Mutation	novel	P418H	0.11
PCPG	chr7	44114860	Silent	novel	L445L	0.33
PRAD	chr7	44115343	Missense_Mutation	novel	V401I	0.12
READ	chr7	44115881	Silent	novel	T344T	0.24
SKCM	chr7	44116856	Silent	rs142289447	L247L	0.27
SKCM	chr7	44116881	Missense_Mutation	NA	S239F	0.39
STAD	chr7	44117963	Silent	NA	L108L	0.13
STAD	chr7	44122018	Silent	rs554456369	T12T	0.15
STAD	chr7	44115781	Missense_Mutation	novel	A378T	0.47
STAD	chr7	44122099	5'UTR	novel		0.11
STAD	chr7	44116875	Missense_Mutation	NA	V241G	0.19
STAD	chr7	44117959	Missense_Mutation	rs149066641	R109Q	0.44
STAD	chr7	44116203	Frame_Shift_Del	novel	*L311Sfs39**	0.2
STAD	chr7	44116256	Missense_Mutation	NA	D293G	0.26
STAD	chr7	44116162	Silent	rs757435023	T324T	0.18
TGCT	chr7	44122150	5'UTR	novel		0.36
UCEC	chr7	44116474	Missense_Mutation	rs778303040	V273M	0.41
UCEC	chr7	44117644	Silent	novel	T147T	0.13
UCEC	chr7	44115830	Missense_Mutation	novel	H361Q	0.17
UCEC	chr7	44121948	Missense_Mutation	novel	S36T	0.4
UCEC	chr7	44116886	Silent	rs144295402	H237H	0.39
UCEC	chr7	44114925	Missense_Mutation	NA	L424M	0.18
UCEC	chr7	44116469	Missense_Mutation	NA	E274D	0.13
UCEC	chr7	44118012	Nonsense_Mutation	NA	C91*	0.28
UCEC	chr7	44121911	Missense_Mutation	rs753677894	R48Q	0.2
UCEC	chr7	44122113	5'UTR	novel		0.39
UCEC	chr7	44122188	5'UTR	novel		0.2
UCEC	chr7	44117664	Missense_Mutation	rs372336011	R141C	0.43
UCEC	chr7	44115880	Missense_Mutation	NA	S345T	0.37
UCEC	chr7	44116979	Silent	rs757035691	G206G	0.3
UCEC	chr7	44114830	Silent	rs751003958	F455F	0.5
UCEC	chr7	44115398	Splice_Site	novel	X383_splice	0.15
UCEC	chr7	44121885	Missense_Mutation	rs770459450	R57C	0.35
UCEC	chr7	44118001	Missense_Mutation	novel	G95D	0.46
UCEC	chr7	44116256	Missense_Mutation	NA	D293G	0.44
UCEC	chr7	44116248	Missense_Mutation	NA	P296T	0.27
UCEC	chr7	44114755	3'UTR	novel		0.5
UCEC	chr7	44117244	Missense_Mutation	novel	T157I	0.36
UCEC	chr7	44116814	Splice_Region	rs757787653		0.42
UCEC	chr7	44114755	3'UTR	novel		0.19
UCEC	chr7	44117986	Missense_Mutation	NA	A100D	0.35
UCEC	chr7	44116129	Silent	rs148680081	T335T	0.27
UCS	chr7	44115348	Missense_Mutation	novel	P399L	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.27619

Survival Analysis

Cancer	P-value	Q-value
SARC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.0053	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.0023	Kaplan-Meier Survival Analysis
SKCM	0.0047	Kaplan-Meier Survival Analysis
BLCA	0.0074	Kaplan-Meier Survival Analysis
KICH	0.0054	Kaplan-Meier Survival Analysis
UCEC	0.0028	Kaplan-Meier Survival Analysis
LIHC	0.0018	Kaplan-Meier Survival Analysis
DLBC	0.0085	Kaplan-Meier Survival Analysis
LUAD	0.00038	Kaplan-Meier Survival Analysis
OV	0.00042	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742