EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000106638 (Gene tree)
Gene ID: 26608
Gene Symbol: TBL2
Alias: WS-betaTRP|WBSCR13|DKFZP43N024
Full Name: transducin beta like 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 11,259 bases
Position: chr7:73,567,533-73,578,791
Accession: 11586
RBP type: non-canonical RBP
Summary: This gene encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000469518	TBL2-216	583	-	-	- (aa)	-	-
ENST00000458466	TBL2-212	673	-	ENSP00000406418	43 (aa)	-	F2Z3G3
ENST00000452475	TBL2-211	1262	-	-	- (aa)	-	-
ENST00000476136	TBL2-217	559	-	-	- (aa)	-	-
ENST00000496056	TBL2-221	579	-	-	- (aa)	-	-
ENST00000432538	TBL2-205	1573	XM_006715923	ENSP00000413979	411 (aa)	XP_006715986	E9PF19
ENST00000488915	TBL2-219	708	-	-	- (aa)	-	-
ENST00000452125	TBL2-210	576	-	ENSP00000414865	64 (aa)	-	F8WBD9
ENST00000426966	TBL2-204	1196	-	ENSP00000410737	75 (aa)	-	F8WB62
ENST00000417008	TBL2-202	1717	-	ENSP00000407503	43 (aa)	-	F2Z3G3
ENST00000495885	TBL2-220	543	-	-	- (aa)	-	-
ENST00000468669	TBL2-215	575	-	-	- (aa)	-	-
ENST00000305632	TBL2-201	4560	XM_011516027	ENSP00000307260	447 (aa)	-	Q9Y4P3
ENST00000450285	TBL2-209	2209	-	ENSP00000409820	176 (aa)	-	F8WDI9
ENST00000424598	TBL2-203	2276	-	ENSP00000398195	46 (aa)	-	F8WBP2
ENST00000465279	TBL2-214	762	-	-	- (aa)	-	-
ENST00000433464	TBL2-206	1423	-	ENSP00000404242	107 (aa)	-	F8WCR3
ENST00000610724	TBL2-222	2165	-	ENSP00000484750	446 (aa)	-	Q96E41
ENST00000479892	TBL2-218	494	-	ENSP00000480898	96 (aa)	-	A0A087WXC6
ENST00000459913	TBL2-213	2358	-	-	- (aa)	-	-
ENST00000437521	TBL2-208	834	-	ENSP00000400569	39 (aa)	-	F8WCC7
ENST00000435792	TBL2-207	1109	-	ENSP00000408255	54 (aa)	-	F8WEC3

Gene Model

Click here to download ENSG00000106638's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000106638	Triglycerides	6.547e-006	19060910
ENSG00000106638	Triglycerides	4.38e-005	19060910
ENSG00000106638	Insulin-Like Growth Factor Binding Protein 3	6E-6	23251661
ENSG00000106638	Triglycerides	2E-12	18193043
ENSG00000106638	Triglycerides	7E-22	18193044
ENSG00000106638	Cholesterol, HDL	5E-13	24097068
ENSG00000106638	Hypertriglyceridemia	8E-9	27599772
ENSG00000106638	Triglycerides	9E-99	24097068
ENSG00000106638	Triglycerides	9E-59	20686565
ENSG00000106638	Hypertriglyceridemia	2E-13	27599772
ENSG00000106638	Triglycerides	2E-6	23505323
ENSG00000106638	Cholesterol, HDL	1E-9	20686565
ENSG00000106638	Triglycerides	1E-15	21909109

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000106638	rs17145738	7	73568544	C	Hypertriglyceridemia	27599772	[1.41-2.38]	1.82	EFO_0004211
ENSG00000106638	rs2286276	7	73573024	?	Hypertriglyceridemia	23505323	[1.25-1.53]	1.39	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	T	HDL cholesterol	24097068	[NR] unit increase	0.041	EFO_0004612
ENSG00000106638	rs17145738	7	73568544	T	Triglycerides	24097068	[NR] mg/dL decrease	0.115	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	?	Low density lipoprotein cholesterol levels	29403010	[0.033-0.067] unit increase novel	0.04998	EFO_0004611
ENSG00000106638	rs2286276	7	73573024	T	Triglycerides	21909109	[0.049-0.081] mg/dL decrease	0.0652	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	T	HDL cholesterol	20686565	[0.33-0.81] mg/dL increase	0.57	EFO_0004612
ENSG00000106638	rs17145738	7	73568544	G	Triglycerides	20686565	[6.93-8.89] mg/dL decrease	7.91	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	T	Triglycerides	18193044	[0.25-0.53] unit decrease	0.14	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	C	Triglycerides	18193043	[NR] mg/dl increase	8.21	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	T	Triglyceride levels	28334899	[0.1-0.13] unit decrease (EA Beta values)	0.115	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	T	Triglyceride levels	28334899	[0.09-0.144] unit decrease	0.117	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	C	High density lipoprotein cholesterol levels	29507422	unit decrease	0.035	EFO_0004612
ENSG00000106638	rs17145738	7	73568544	C	High density lipoprotein cholesterol levels	29507422	unit decrease	0.035	EFO_0004612
ENSG00000106638	rs17145738	7	73568544	C	Triglycerides	29507422	unit increase	0.135	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	C	Triglycerides	29507422	unit increase	0.15	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	C	Triglycerides	29507422	unit increase	0.13	EFO_0004530
ENSG00000106638	rs17145738	7	73568544	C	Triglycerides	29507422	unit increase	0.135	EFO_0004530

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106638's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000106638	TBL2	100	96.875	ENSMUSG00000005374	Tbl2	100	88.601	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005783	endoplasmic reticulum	25393282.	IDA	Component
GO:0019901	protein kinase binding	25393282.	IPI	Function
GO:0030176	integral component of endoplasmic reticulum membrane	25393282.	NAS	Component
GO:0030968	endoplasmic reticulum unfolded protein response	25393282.	IMP	Process
GO:0031369	translation initiation factor binding	25393282.	IPI	Function
GO:0042149	cellular response to glucose starvation	25393282.	IMP	Process
GO:0051219	phosphoprotein binding	25393282.	IDA	Function
GO:0071456	cellular response to hypoxia	25393282.	IMP	Process