EuRBPDB

Description

Ensembl ID: ENSG00000106803 (Gene tree)
Gene ID: 10952
Gene Symbol: SEC61B
Alias: N
Full Name: Sec61 translocon beta subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 8,556 bases
Position: chr9:99,222,064-99,230,619
Accession: 16993
RBP type: non-canonical RBP
Summary: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498603	SEC61B-203	587	-	ENSP00000474122	42 (aa)	-	S4R3B5
ENST00000223641	SEC61B-201	545	-	ENSP00000223641	96 (aa)	-	P60468
ENST00000481573	SEC61B-202	687	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03060	Protein export	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04145	Phagosome	KEGG
hsa05110	Vibrio cholerae infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000106803	Platelet Function Tests	1.1673600E-005	-
ENSG00000106803	Maximal Midexpiratory Flow Rate	1E-6	24023788

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000106803	SEC61B	100	98.958	ENSMUSG00000053317	Sec61b	100	98.958	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005086	ARF guanyl-nucleotide exchange factor activity	21873635.	IBA	Function
GO:0005515	protein binding	9792704.18555783.19675567.21866104.	IPI	Function
GO:0005783	endoplasmic reticulum	18555783.	IDA	Component
GO:0005784	Sec61 translocon complex	-	IEA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006616	SRP-dependent cotranslational protein targeting to membrane, translocation	21873635.	IBA	Process
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	21873635.	IBA	Function
GO:0016020	membrane	22375059.	IDA	Component
GO:0016021	integral component of membrane	8107851.	NAS	Component
GO:0030433	ubiquitin-dependent ERAD pathway	8945469.	IDA	Process
GO:0030970	retrograde protein transport, ER to cytosol	17215517.	IMP	Process
GO:0031204	posttranslational protein targeting to membrane, translocation	21873635.	IBA	Process
GO:0031205	endoplasmic reticulum Sec complex	21873635.	IBA	Component
GO:0031205	endoplasmic reticulum Sec complex	-	ISS	Component
GO:0048408	epidermal growth factor binding	19602593.	IPI	Function