EuRBPDB

Description

Ensembl ID: ENSG00000107223 (Gene tree)
Gene ID: 8721
Gene Symbol: EDF1
Alias: EDF-1|CFAP280
Full Name: endothelial differentiation related factor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 4,223 bases
Position: chr9:136,862,114-136,866,336
Accession: 3164
RBP type: non-canonical RBP
Summary: This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23636942	Quantitative proteomic analysis reveals concurrent RNA-protein interactions and identifies new RNA-binding proteins in Saccharomyces cerevisiae.	Genome Res	2013 Jun	Klass DM	doi: 10.1101/gr.153031.112
17321087	Proteomic analysis of cisplatin-induced cochlear damage: methods and early changes in protein expression.	Hear Res	2007 Apr	Coling DE	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000371648	EDF1-202	809	-	ENSP00000360711	139 (aa)	-	O60869
ENST00000371649	EDF1-203	790	-	ENSP00000360712	141 (aa)	-	O60869
ENST00000224073	EDF1-201	640	-	ENSP00000224073	148 (aa)	-	O60869

Gene Model

Protein-Protein Interaction (PPI)

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000107223	EDF1	96	85.211	ENSDARG00000009950	edf1	97	85.211	Danio_rerio
ENSG00000107223	EDF1	93	65.942	FBgn0262732	mbf1	95	65.942	Drosophila_melanogaster
ENSG00000107223	EDF1	100	98.649	ENSMUSG00000015092	Edf1	100	98.649	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001094	TFIID-class transcription factor complex binding	12040021.	IDA	Function
GO:0003713	transcription coactivator activity	10567391.12040021.	IMP	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	10567391.12040021.24008843.25416956.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10567391.	IDA	Component
GO:0005634	nucleus	8164657.	NAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	10567391.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	8164657.12040021.	TAS	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0019216	regulation of lipid metabolic process	12040021.	TAS	Process
GO:0043388	positive regulation of DNA binding	10567391.	IDA	Process
GO:0043565	sequence-specific DNA binding	-	IEA	Function
GO:0045446	endothelial cell differentiation	12040021.	TAS	Process
GO:0045893	positive regulation of transcription, DNA-templated	8164657.	TAS	Process