EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000107625 (Gene tree)
Gene ID: 79009
Gene Symbol: DDX50
Alias: GU2|MGC3199|GUB|RH-II/GuB
Full Name: DExD-box helicase 50
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 47,876 bases
Position: chr10:68,898,972-68,946,847
Accession: 17906
RBP type: canonical RBP
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000362687	GUCT	PF08152.12	2.3e-27	1	1
ENSP00000479336	GUCT	PF08152.12	9.6e-22	1	1
ENSP00000479336	ResIII	PF04851.15	1.4e-09	1	1
ENSP00000362687	ResIII	PF04851.15	1.4e-09	1	1
ENSP00000479336	DEAD	PF00270.29	6.6e-47	1	1
ENSP00000362687	DEAD	PF00270.29	6.8e-47	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000483593	DDX50-205	1067	-	ENSP00000474785	39 (aa)	-	S4R3V4
ENST00000373585	DDX50-201	2538	XM_005270148	ENSP00000362687	737 (aa)	XP_005270205	Q9BQ39
ENST00000460470	DDX50-202	531	-	-	- (aa)	-	-
ENST00000466265	DDX50-203	744	-	-	- (aa)	-	-
ENST00000610822	DDX50-206	2510	-	ENSP00000479336	730 (aa)	-	A0A087WVC1
ENST00000471475	DDX50-204	888	-	ENSP00000474314	51 (aa)	-	S4R3G6

Gene Model

Click here to download ENSG00000107625's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000107625	Depressive Disorder	9E-6	20800221

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000107625's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000107625	DDX50	50	32.533	ENSG00000161960	EIF4A1	99	34.731
ENSG00000107625	DDX50	59	31.448	ENSG00000178105	DDX10	62	31.222
ENSG00000107625	DDX50	50	31.635	ENSG00000123064	DDX54	96	34.928
ENSG00000107625	DDX50	50	35.279	ENSG00000088205	DDX18	97	34.156
ENSG00000107625	DDX50	50	31.536	ENSG00000156976	EIF4A2	90	30.904
ENSG00000107625	DDX50	50	34.417	ENSG00000100201	DDX17	73	48.780
ENSG00000107625	DDX50	50	32.888	ENSG00000141543	EIF4A3	86	32.888
ENSG00000107625	DDX50	52	32.500	ENSG00000213782	DDX47	79	32.095
ENSG00000107625	DDX50	55	33.255	ENSG00000124228	DDX27	84	32.520
ENSG00000107625	DDX50	93	62.536	ENSG00000165732	DDX21	84	65.372

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000107625	DDX50	100	97.425	ENSAMEG00000017992	DDX50	100	97.425	Ailuropoda_melanoleuca
ENSG00000107625	DDX50	74	100.000	ENSANAG00000017785	-	91	79.161	Aotus_nancymaae
ENSG00000107625	DDX50	100	97.422	ENSBTAG00000033413	DDX50	100	97.422	Bos_taurus
ENSG00000107625	DDX50	100	99.729	ENSCJAG00000018844	DDX50	100	99.729	Callithrix_jacchus
ENSG00000107625	DDX50	100	97.832	ENSCAFG00000013776	DDX50	100	97.832	Canis_familiaris
ENSG00000107625	DDX50	100	97.832	ENSCAFG00020025977	DDX50	99	97.832	Canis_lupus_dingo
ENSG00000107625	DDX50	100	97.151	ENSCHIG00000000285	DDX50	99	97.151	Capra_hircus
ENSG00000107625	DDX50	100	98.372	ENSTSYG00000004192	DDX50	100	98.372	Carlito_syrichta
ENSG00000107625	DDX50	91	76.855	ENSCAPG00000007230	-	87	79.231	Cavia_aperea
ENSG00000107625	DDX50	100	96.608	ENSCPOG00000002131	-	100	96.608	Cavia_porcellus
ENSG00000107625	DDX50	91	90.476	ENSCCAG00000030543	DDX50	100	90.476	Cebus_capucinus
ENSG00000107625	DDX50	99	96.739	ENSCATG00000032463	DDX50	99	96.739	Cercocebus_atys
ENSG00000107625	DDX50	99	67.703	ENSCATG00000039259	-	89	69.016	Cercocebus_atys
ENSG00000107625	DDX50	95	86.486	ENSCATG00000035153	-	89	90.282	Cercocebus_atys
ENSG00000107625	DDX50	97	71.208	ENSCLAG00000001938	-	91	71.822	Chinchilla_lanigera
ENSG00000107625	DDX50	50	87.534	ENSCLAG00000001553	-	79	88.710	Chinchilla_lanigera
ENSG00000107625	DDX50	100	97.829	ENSCLAG00000012957	-	100	97.829	Chinchilla_lanigera
ENSG00000107625	DDX50	100	99.729	ENSCSAG00000007703	DDX50	100	99.729	Chlorocebus_sabaeus
ENSG00000107625	DDX50	90	95.796	ENSCHOG00000000233	DDX50	100	95.796	Choloepus_hoffmanni
ENSG00000107625	DDX50	86	72.713	ENSCANG00000018820	-	88	73.565	Colobus_angolensis_palliatus
ENSG00000107625	DDX50	100	85.753	ENSCANG00000036450	-	100	85.753	Colobus_angolensis_palliatus
ENSG00000107625	DDX50	95	81.081	ENSCANG00000028077	-	91	69.839	Colobus_angolensis_palliatus
ENSG00000107625	DDX50	92	96.165	ENSCGRG00001020223	Ddx50	92	96.165	Cricetulus_griseus_chok1gshd
ENSG00000107625	DDX50	92	96.296	ENSCGRG00000015884	Ddx50	92	96.165	Cricetulus_griseus_crigri
ENSG00000107625	DDX50	88	90.895	ENSDNOG00000001675	DDX50	100	90.895	Dasypus_novemcinctus
ENSG00000107625	DDX50	100	97.286	ENSDORG00000007310	Ddx50	100	97.286	Dipodomys_ordii
ENSG00000107625	DDX50	90	97.566	ENSETEG00000014069	DDX50	90	97.566	Echinops_telfairi
ENSG00000107625	DDX50	100	97.558	ENSEASG00005015595	DDX50	99	97.558	Equus_asinus_asinus
ENSG00000107625	DDX50	100	97.693	ENSECAG00000023044	DDX50	99	97.693	Equus_caballus
ENSG00000107625	DDX50	89	96.166	ENSEEUG00000005782	DDX50	81	98.589	Erinaceus_europaeus
ENSG00000107625	DDX50	100	98.238	ENSFCAG00000012678	DDX50	99	98.238	Felis_catus
ENSG00000107625	DDX50	92	90.413	ENSFDAG00000016109	-	91	90.413	Fukomys_damarensis
ENSG00000107625	DDX50	52	71.354	ENSGGOG00000022568	-	90	79.814	Gorilla_gorilla
ENSG00000107625	DDX50	100	100.000	ENSGGOG00000010100	DDX50	100	100.000	Gorilla_gorilla
ENSG00000107625	DDX50	51	82.804	ENSGGOG00000041063	-	82	85.580	Gorilla_gorilla
ENSG00000107625	DDX50	92	96.018	ENSHGLG00000013466	DDX50	92	96.018	Heterocephalus_glaber_female
ENSG00000107625	DDX50	82	88.298	ENSHGLG00100006568	-	92	88.298	Heterocephalus_glaber_male
ENSG00000107625	DDX50	92	96.018	ENSHGLG00100017191	DDX50	92	96.018	Heterocephalus_glaber_male
ENSG00000107625	DDX50	100	95.935	ENSSTOG00000021852	-	100	95.935	Ictidomys_tridecemlineatus
ENSG00000107625	DDX50	100	94.980	ENSJJAG00000023928	-	92	94.838	Jaculus_jaculus
ENSG00000107625	DDX50	100	73.549	ENSJJAG00000019626	-	91	74.135	Jaculus_jaculus
ENSG00000107625	DDX50	100	97.965	ENSLAFG00000006186	DDX50	100	97.965	Loxodonta_africana
ENSG00000107625	DDX50	95	86.486	ENSMFAG00000045339	-	89	89.342	Macaca_fascicularis
ENSG00000107625	DDX50	100	99.729	ENSMFAG00000044067	DDX50	100	99.729	Macaca_fascicularis
ENSG00000107625	DDX50	92	66.814	ENSMMUG00000045343	-	90	66.568	Macaca_mulatta
ENSG00000107625	DDX50	100	99.729	ENSMMUG00000001006	DDX50	100	99.851	Macaca_mulatta
ENSG00000107625	DDX50	92	92.773	ENSMNEG00000031664	DDX50	100	93.351	Macaca_nemestrina
ENSG00000107625	DDX50	95	86.486	ENSMNEG00000045530	-	89	90.596	Macaca_nemestrina
ENSG00000107625	DDX50	100	97.829	ENSMLEG00000037313	DDX50	100	97.829	Mandrillus_leucophaeus
ENSG00000107625	DDX50	95	86.486	ENSMLEG00000041988	-	89	88.114	Mandrillus_leucophaeus
ENSG00000107625	DDX50	74	100.000	ENSMAUG00000022192	Ddx50	100	94.673	Mesocricetus_auratus
ENSG00000107625	DDX50	100	90.773	ENSMICG00000017539	DDX50	100	90.773	Microcebus_murinus
ENSG00000107625	DDX50	92	95.735	ENSMOCG00000001676	Ddx50	92	95.735	Microtus_ochrogaster
ENSG00000107625	DDX50	92	80.205	ENSMODG00000010741	DDX50	92	80.758	Monodelphis_domestica
ENSG00000107625	DDX50	92	94.395	MGP_CAROLIEiJ_G0015389	Ddx50	92	95.133	Mus_caroli
ENSG00000107625	DDX50	92	94.838	ENSMUSG00000020076	Ddx50	92	95.575	Mus_musculus
ENSG00000107625	DDX50	92	94.985	MGP_PahariEiJ_G0030805	Ddx50	92	95.723	Mus_pahari
ENSG00000107625	DDX50	92	94.838	MGP_SPRETEiJ_G0016200	Ddx50	92	95.575	Mus_spretus
ENSG00000107625	DDX50	88	97.068	ENSMPUG00000004589	DDX50	99	97.068	Mustela_putorius_furo
ENSG00000107625	DDX50	100	96.336	ENSMLUG00000017590	DDX50	100	96.336	Myotis_lucifugus
ENSG00000107625	DDX50	100	96.879	ENSNGAG00000004283	Ddx50	100	96.879	Nannospalax_galili
ENSG00000107625	DDX50	98	66.944	ENSNLEG00000035506	-	88	78.505	Nomascus_leucogenys
ENSG00000107625	DDX50	100	99.864	ENSNLEG00000011631	DDX50	100	99.864	Nomascus_leucogenys
ENSG00000107625	DDX50	92	93.953	ENSOPRG00000001619	DDX50	92	94.690	Ochotona_princeps
ENSG00000107625	DDX50	100	96.472	ENSODEG00000014597	-	100	96.472	Octodon_degus
ENSG00000107625	DDX50	93	67.192	ENSOANG00000004776	DDX50	79	69.968	Ornithorhynchus_anatinus
ENSG00000107625	DDX50	100	95.664	ENSOCUG00000002879	DDX50	100	95.664	Oryctolagus_cuniculus
ENSG00000107625	DDX50	100	98.372	ENSOGAG00000001844	DDX50	100	98.372	Otolemur_garnettii
ENSG00000107625	DDX50	100	97.151	ENSOARG00000005264	DDX50	99	97.151	Ovis_aries
ENSG00000107625	DDX50	100	99.864	ENSPPAG00000040723	DDX50	100	99.864	Pan_paniscus
ENSG00000107625	DDX50	52	71.316	ENSPPAG00000026788	-	89	79.874	Pan_paniscus
ENSG00000107625	DDX50	100	98.238	ENSPPRG00000015826	DDX50	100	98.238	Panthera_pardus
ENSG00000107625	DDX50	100	98.238	ENSPTIG00000008454	DDX50	100	98.238	Panthera_tigris_altaica
ENSG00000107625	DDX50	52	71.316	ENSPTRG00000044913	-	99	72.368	Pan_troglodytes
ENSG00000107625	DDX50	100	99.864	ENSPTRG00000002562	DDX50	100	99.864	Pan_troglodytes
ENSG00000107625	DDX50	92	91.888	ENSPANG00000022143	-	92	91.888	Papio_anubis
ENSG00000107625	DDX50	92	94.985	ENSPEMG00000020899	-	92	94.985	Peromyscus_maniculatus_bairdii
ENSG00000107625	DDX50	92	80.147	ENSPCIG00000016036	DDX50	93	81.402	Phascolarctos_cinereus
ENSG00000107625	DDX50	91	100.000	ENSPPYG00000002390	DDX50	100	100.000	Pongo_abelii
ENSG00000107625	DDX50	84	83.929	ENSPCAG00000009692	DDX50	100	83.929	Procavia_capensis
ENSG00000107625	DDX50	79	93.939	ENSPCOG00000012574	DDX50	91	93.939	Propithecus_coquereli
ENSG00000107625	DDX50	86	96.143	ENSPVAG00000009519	DDX50	78	96.143	Pteropus_vampyrus
ENSG00000107625	DDX50	92	94.248	ENSRNOG00000000396	Ddx50	98	98.396	Rattus_norvegicus
ENSG00000107625	DDX50	95	81.081	ENSRBIG00000039673	-	90	67.695	Rhinopithecus_bieti
ENSG00000107625	DDX50	87	97.823	ENSRBIG00000042841	-	98	99.141	Rhinopithecus_bieti
ENSG00000107625	DDX50	99	68.895	ENSRBIG00000036573	-	92	68.991	Rhinopithecus_bieti
ENSG00000107625	DDX50	99	66.576	ENSRROG00000022853	-	91	66.174	Rhinopithecus_roxellana
ENSG00000107625	DDX50	52	71.540	ENSRROG00000031940	-	87	75.692	Rhinopithecus_roxellana
ENSG00000107625	DDX50	100	99.457	ENSRROG00000032158	DDX50	100	99.457	Rhinopithecus_roxellana
ENSG00000107625	DDX50	100	88.874	ENSSBOG00000014441	DDX50	100	88.874	Saimiri_boliviensis_boliviensis
ENSG00000107625	DDX50	88	81.307	ENSSHAG00000005690	DDX50	91	81.364	Sarcophilus_harrisii
ENSG00000107625	DDX50	84	65.463	ENSSHAG00000005334	-	80	67.492	Sarcophilus_harrisii
ENSG00000107625	DDX50	100	80.461	ENSSARG00000013553	DDX50	88	88.217	Sorex_araneus
ENSG00000107625	DDX50	100	96.336	ENSSSCG00000010246	DDX50	99	96.336	Sus_scrofa
ENSG00000107625	DDX50	96	75.809	ENSTBEG00000001085	DDX50	92	75.369	Tupaia_belangeri
ENSG00000107625	DDX50	100	91.180	ENSTTRG00000012408	DDX50	99	91.180	Tursiops_truncatus
ENSG00000107625	DDX50	100	97.696	ENSUAMG00000010976	DDX50	99	98.976	Ursus_americanus
ENSG00000107625	DDX50	100	97.696	ENSUMAG00000007726	DDX50	99	97.696	Ursus_maritimus
ENSG00000107625	DDX50	100	97.286	ENSVPAG00000000626	DDX50	100	97.286	Vicugna_pacos
ENSG00000107625	DDX50	82	92.371	ENSVVUG00000020366	DDX50	98	99.198	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component