EuRBPDB

Description

Ensembl ID: ENSG00000107651 (Gene tree)
Gene ID: 11196
Gene Symbol: SEC23IP
Alias: p125
Full Name: SEC23 interacting protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 52,086 bases
Position: chr10:119,892,573-119,944,658
Accession: 17018
RBP type: non-canonical RBP
Summary: This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462222	SEC23IP-204	552	-	-	- (aa)	-	-
ENST00000543134	SEC23IP-208	1461	-	ENSP00000438773	486 (aa)	-	A0A0C4DH82
ENST00000475542	SEC23IP-206	552	-	-	- (aa)	-	-
ENST00000470478	SEC23IP-205	285	-	-	- (aa)	-	-
ENST00000483890	SEC23IP-207	457	-	-	- (aa)	-	-
ENST00000442952	SEC23IP-202	782	-	ENSP00000416723	153 (aa)	-	H7C4C4
ENST00000446561	SEC23IP-203	582	-	ENSP00000396906	194 (aa)	-	H7C0V8
ENST00000369075	SEC23IP-201	7168	XM_005269469	ENSP00000358071	1000 (aa)	XP_005269526	Q9Y6Y8

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000107651	Blood Pressure	4.5810000E-005	-
ENSG00000107651	Platelet Function Tests	1.3653700E-005	-
ENSG00000107651	Clusterin	5E-6	26545630
ENSG00000107651	Menarche	3E-10	25231870

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000107651	rs2456721	10	119906261	?	Cerebrospinal fluid clusterin levels	26545630	[NR] unit decrease	0.266	EFO_0007657

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004620	phospholipase activity	21873635.	IBA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005737	cytoplasm	10400679.	TAS	Component
GO:0005783	endoplasmic reticulum	-	IEA	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	10400679.	TAS	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	10400679.	TAS	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0007030	Golgi organization	10400679.	TAS	Process
GO:0012507	ER to Golgi transport vesicle membrane	-	IEA	Component
GO:0030134	COPII-coated ER to Golgi transport vesicle	21873635.	IBA	Component
GO:0030134	COPII-coated ER to Golgi transport vesicle	-	TAS	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0048208	COPII vesicle coating	-	TAS	Process