EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000107854 (Gene tree)
Gene ID: 80351
Gene Symbol: TNKS2
Alias: TNKL|TANK2|PARP-5b|PARP-5c|PARP5B|PARP5C|pART6
Full Name: tankyrase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 67,164 bases
Position: chr10:91,798,312-91,865,475
Accession: 15677
RBP type: canonical RBP
Summary: TNKS2 (Tankyrase 2) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and T41 mutants of beta-catenin arent phosphorylated. Gene Ontology (GO) annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is TNKS.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000360689	PARP	PF00644.20	6.6e-25	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000371627	TNKS2-201	6157	XM_005270185	ENSP00000360689	1166 (aa)	XP_005270242	Q9H2K2

Gene Model

Click here to download ENSG00000107854's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000107854's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000107854	TNKS2	99	82.038	ENSAPOG00000021973	-	94	83.707	Acanthochromis_polyacanthus
ENSG00000107854	TNKS2	99	98.277	ENSAMEG00000014261	TNKS2	95	98.277	Ailuropoda_melanoleuca
ENSG00000107854	TNKS2	99	83.759	ENSACIG00000021200	-	93	85.175	Amphilophus_citrinellus
ENSG00000107854	TNKS2	99	76.561	ENSAOCG00000015355	-	99	77.738	Amphiprion_ocellaris
ENSG00000107854	TNKS2	93	94.942	ENSAPLG00000011056	TNKS2	100	94.942	Anas_platyrhynchos
ENSG00000107854	TNKS2	98	93.772	ENSACAG00000007762	TNKS2	96	93.386	Anolis_carolinensis
ENSG00000107854	TNKS2	100	98.286	ENSANAG00000037727	TNKS2	100	98.286	Aotus_nancymaae
ENSG00000107854	TNKS2	99	81.617	ENSACLG00000018157	-	97	82.895	Astatotilapia_calliptera
ENSG00000107854	TNKS2	99	77.943	ENSAMXG00000004975	-	97	73.818	Astyanax_mexicanus
ENSG00000107854	TNKS2	100	99.057	ENSBTAG00000009279	TNKS2	100	99.057	Bos_taurus
ENSG00000107854	TNKS2	100	99.657	ENSCJAG00000008230	TNKS2	100	99.657	Callithrix_jacchus
ENSG00000107854	TNKS2	100	99.228	ENSCAFG00000007302	TNKS2	99	99.121	Canis_familiaris
ENSG00000107854	TNKS2	100	98.886	ENSCAFG00020000625	TNKS2	99	98.886	Canis_lupus_dingo
ENSG00000107854	TNKS2	100	98.885	ENSCHIG00000021316	TNKS2	100	98.885	Capra_hircus
ENSG00000107854	TNKS2	99	99.295	ENSTSYG00000009856	TNKS2	99	98.509	Carlito_syrichta
ENSG00000107854	TNKS2	96	73.925	ENSCAPG00000013060	TNKS2	100	74.866	Cavia_aperea
ENSG00000107854	TNKS2	100	97.341	ENSCPOG00000002254	TNKS2	100	97.341	Cavia_porcellus
ENSG00000107854	TNKS2	100	99.485	ENSCCAG00000027247	TNKS2	100	99.485	Cebus_capucinus
ENSG00000107854	TNKS2	100	99.657	ENSCATG00000035054	TNKS2	100	96.915	Cercocebus_atys
ENSG00000107854	TNKS2	100	98.456	ENSCLAG00000013558	TNKS2	100	98.456	Chinchilla_lanigera
ENSG00000107854	TNKS2	100	99.657	ENSCSAG00000006602	TNKS2	100	99.657	Chlorocebus_sabaeus
ENSG00000107854	TNKS2	92	100.000	ENSCHOG00000005660	TNKS2	72	100.000	Choloepus_hoffmanni
ENSG00000107854	TNKS2	99	93.837	ENSCPBG00000026533	TNKS2	98	94.376	Chrysemys_picta_bellii
ENSG00000107854	TNKS2	99	99.826	ENSCANG00000036484	TNKS2	100	99.826	Colobus_angolensis_palliatus
ENSG00000107854	TNKS2	100	94.683	ENSCGRG00001008529	Tnks2	100	94.683	Cricetulus_griseus_chok1gshd
ENSG00000107854	TNKS2	98	98.187	ENSCGRG00000002702	Tnks2	98	98.187	Cricetulus_griseus_crigri
ENSG00000107854	TNKS2	98	73.125	ENSDORG00000015121	Tnks2	96	85.585	Dipodomys_ordii
ENSG00000107854	TNKS2	98	95.833	ENSETEG00000006736	TNKS2	90	97.436	Echinops_telfairi
ENSG00000107854	TNKS2	100	99.400	ENSEASG00005011073	TNKS2	89	99.400	Equus_asinus_asinus
ENSG00000107854	TNKS2	99	99.313	ENSECAG00000012810	TNKS2	89	99.313	Equus_caballus
ENSG00000107854	TNKS2	93	95.117	ENSEEUG00000005974	TNKS2	99	95.117	Erinaceus_europaeus
ENSG00000107854	TNKS2	98	81.882	ENSELUG00000003897	TNKS2	97	74.126	Esox_lucius
ENSG00000107854	TNKS2	100	99.228	ENSFCAG00000014953	TNKS2	87	99.228	Felis_catus
ENSG00000107854	TNKS2	99	94.293	ENSFALG00000007782	TNKS2	100	94.208	Ficedula_albicollis
ENSG00000107854	TNKS2	98	98.692	ENSFDAG00000006471	TNKS2	99	98.692	Fukomys_damarensis
ENSG00000107854	TNKS2	98	94.677	ENSGALG00000014614	TNKS2	98	94.644	Gallus_gallus
ENSG00000107854	TNKS2	98	95.010	ENSGAGG00000018575	-	100	93.996	Gopherus_agassizii
ENSG00000107854	TNKS2	100	100.000	ENSGGOG00000009781	TNKS2	100	100.000	Gorilla_gorilla
ENSG00000107854	TNKS2	100	98.285	ENSHGLG00000018423	TNKS2	100	98.285	Heterocephalus_glaber_female
ENSG00000107854	TNKS2	100	98.285	ENSHGLG00100003237	TNKS2	100	98.285	Heterocephalus_glaber_male
ENSG00000107854	TNKS2	99	84.426	ENSIPUG00000011046	Tnks2	98	78.139	Ictalurus_punctatus
ENSG00000107854	TNKS2	99	99.134	ENSSTOG00000002349	TNKS2	100	99.134	Ictidomys_tridecemlineatus
ENSG00000107854	TNKS2	99	96.996	ENSJJAG00000024121	Tnks2	99	96.996	Jaculus_jaculus
ENSG00000107854	TNKS2	100	90.213	ENSLACG00000002950	TNKS2	97	91.243	Latimeria_chalumnae
ENSG00000107854	TNKS2	100	86.849	ENSLOCG00000005988	TNKS2	97	88.246	Lepisosteus_oculatus
ENSG00000107854	TNKS2	100	98.799	ENSLAFG00000018705	TNKS2	100	98.799	Loxodonta_africana
ENSG00000107854	TNKS2	100	99.743	ENSMFAG00000001030	TNKS2	100	97.001	Macaca_fascicularis
ENSG00000107854	TNKS2	98	99.825	ENSMMUG00000007478	TNKS2	100	99.825	Macaca_mulatta
ENSG00000107854	TNKS2	100	99.743	ENSMNEG00000036136	TNKS2	100	99.743	Macaca_nemestrina
ENSG00000107854	TNKS2	100	96.496	ENSMLEG00000038022	TNKS2	100	96.915	Mandrillus_leucophaeus
ENSG00000107854	TNKS2	100	76.585	ENSMAMG00000009801	-	97	80.017	Mastacembelus_armatus
ENSG00000107854	TNKS2	99	81.511	ENSMZEG00005025991	-	99	75.789	Maylandia_zebra
ENSG00000107854	TNKS2	98	74.818	ENSMZEG00005028533	-	98	76.294	Maylandia_zebra
ENSG00000107854	TNKS2	99	94.995	ENSMGAG00000008555	TNKS2	100	94.909	Meleagris_gallopavo
ENSG00000107854	TNKS2	100	98.113	ENSMAUG00000002675	Tnks2	84	98.113	Mesocricetus_auratus
ENSG00000107854	TNKS2	99	99.565	ENSMICG00000014154	TNKS2	99	99.565	Microcebus_murinus
ENSG00000107854	TNKS2	100	98.113	ENSMOCG00000014956	Tnks2	100	98.113	Microtus_ochrogaster
ENSG00000107854	TNKS2	100	95.979	ENSMODG00000006738	TNKS2	98	96.754	Monodelphis_domestica
ENSG00000107854	TNKS2	100	97.599	MGP_CAROLIEiJ_G0022907	Tnks2	100	97.599	Mus_caroli
ENSG00000107854	TNKS2	100	97.256	ENSMUSG00000024811	Tnks2	100	97.256	Mus_musculus
ENSG00000107854	TNKS2	98	90.078	MGP_SPRETEiJ_G0023826	Tnks2	98	94.293	Mus_spretus
ENSG00000107854	TNKS2	99	98.730	ENSMPUG00000017232	TNKS2	100	98.730	Mustela_putorius_furo
ENSG00000107854	TNKS2	100	98.628	ENSMLUG00000004297	TNKS2	100	98.628	Myotis_lucifugus
ENSG00000107854	TNKS2	98	93.164	ENSNGAG00000018372	Tnks2	98	93.152	Nannospalax_galili
ENSG00000107854	TNKS2	99	81.138	ENSNBRG00000002340	-	97	82.265	Neolamprologus_brichardi
ENSG00000107854	TNKS2	100	99.828	ENSNLEG00000012457	TNKS2	100	99.828	Nomascus_leucogenys
ENSG00000107854	TNKS2	92	99.545	ENSMEUG00000013423	-	72	99.545	Notamacropus_eugenii
ENSG00000107854	TNKS2	100	98.628	ENSODEG00000004816	TNKS2	100	98.628	Octodon_degus
ENSG00000107854	TNKS2	99	83.333	ENSONIG00000019061	-	97	84.629	Oreochromis_niloticus
ENSG00000107854	TNKS2	99	92.000	ENSOANG00000000256	TNKS2	100	92.000	Ornithorhynchus_anatinus
ENSG00000107854	TNKS2	100	98.885	ENSOCUG00000012010	TNKS2	91	98.885	Oryctolagus_cuniculus
ENSG00000107854	TNKS2	100	99.142	ENSOGAG00000001988	TNKS2	100	99.142	Otolemur_garnettii
ENSG00000107854	TNKS2	99	98.110	ENSOARG00000016303	TNKS2	99	98.110	Ovis_aries
ENSG00000107854	TNKS2	100	99.914	ENSPPAG00000040339	TNKS2	100	99.914	Pan_paniscus
ENSG00000107854	TNKS2	100	99.314	ENSPPRG00000019676	TNKS2	100	99.314	Panthera_pardus
ENSG00000107854	TNKS2	99	98.756	ENSPTIG00000013504	TNKS2	100	98.756	Panthera_tigris_altaica
ENSG00000107854	TNKS2	100	100.000	ENSPTRG00000002749	TNKS2	100	100.000	Pan_troglodytes
ENSG00000107854	TNKS2	100	99.743	ENSPANG00000021618	TNKS2	100	99.743	Papio_anubis
ENSG00000107854	TNKS2	100	84.031	ENSPKIG00000006010	TNKS2	97	85.451	Paramormyrops_kingsleyae
ENSG00000107854	TNKS2	99	93.340	ENSPSIG00000016490	TNKS2	100	93.006	Pelodiscus_sinensis
ENSG00000107854	TNKS2	99	97.222	ENSPEMG00000002166	Tnks2	100	97.222	Peromyscus_maniculatus_bairdii
ENSG00000107854	TNKS2	100	93.750	ENSPCIG00000016784	TNKS2	98	94.379	Phascolarctos_cinereus
ENSG00000107854	TNKS2	100	98.628	ENSPCAG00000012924	TNKS2	100	98.628	Procavia_capensis
ENSG00000107854	TNKS2	98	86.212	ENSPCOG00000024373	TNKS2	98	86.064	Propithecus_coquereli
ENSG00000107854	TNKS2	100	99.142	ENSPVAG00000012070	TNKS2	100	99.142	Pteropus_vampyrus
ENSG00000107854	TNKS2	98	85.854	ENSPNAG00000002397	TNKS2	99	84.284	Pygocentrus_nattereri
ENSG00000107854	TNKS2	100	97.256	ENSRNOG00000052664	Tnks2	100	97.256	Rattus_norvegicus
ENSG00000107854	TNKS2	100	97.256	ENSRNOG00000059776	Tnks2	100	97.256	Rattus_norvegicus
ENSG00000107854	TNKS2	100	98.885	ENSRBIG00000003573	TNKS2	100	98.885	Rhinopithecus_bieti
ENSG00000107854	TNKS2	100	99.657	ENSRROG00000036681	TNKS2	100	99.657	Rhinopithecus_roxellana
ENSG00000107854	TNKS2	100	99.400	ENSSBOG00000022355	TNKS2	100	99.400	Saimiri_boliviensis_boliviensis
ENSG00000107854	TNKS2	99	83.205	ENSSFOG00015012708	TNKS2	96	83.961	Scleropages_formosus
ENSG00000107854	TNKS2	100	82.293	ENSSDUG00000014995	-	96	84.460	Seriola_dumerili
ENSG00000107854	TNKS2	98	77.057	ENSSLDG00000017021	-	100	78.770	Seriola_lalandi_dorsalis
ENSG00000107854	TNKS2	91	98.974	ENSSARG00000001847	TNKS2	91	98.974	Sorex_araneus
ENSG00000107854	TNKS2	99	89.871	ENSSPUG00000000832	TNKS2	97	91.005	Sphenodon_punctatus
ENSG00000107854	TNKS2	99	75.024	ENSSPAG00000009863	-	99	73.403	Stegastes_partitus
ENSG00000107854	TNKS2	100	99.571	ENSSSCG00000010465	TNKS2	89	99.571	Sus_scrofa
ENSG00000107854	TNKS2	98	94.809	ENSTGUG00000008510	-	100	94.809	Taeniopygia_guttata
ENSG00000107854	TNKS2	98	90.331	ENSTBEG00000015297	TNKS2	98	90.342	Tupaia_belangeri
ENSG00000107854	TNKS2	100	99.315	ENSTTRG00000006222	TNKS2	100	99.315	Tursiops_truncatus
ENSG00000107854	TNKS2	98	99.281	ENSUAMG00000016213	TNKS2	100	99.281	Ursus_americanus
ENSG00000107854	TNKS2	99	98.909	ENSUMAG00000001139	TNKS2	98	98.909	Ursus_maritimus
ENSG00000107854	TNKS2	100	97.942	ENSVPAG00000010887	TNKS2	100	97.942	Vicugna_pacos
ENSG00000107854	TNKS2	100	99.142	ENSVVUG00000021474	TNKS2	99	99.142	Vulpes_vulpes
ENSG00000107854	TNKS2	94	75.623	ENSXETG00000020983	-	97	75.799	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0000209	protein polyubiquitination	19759537.21478859.	IDA	Process
GO:0000242	pericentriolar material	11454873.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	11739745.	IC	Component
GO:0003950	NAD+ ADP-ribosyltransferase activity	21873635.	IBA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	11739745.19759537.21478859.	IDA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	-	TAS	Function
GO:0005515	protein binding	11854288.12080061.19759537.21251231.21478859.22153076.22153077.23414517.26774128.26972000.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11739745.	IDA	Component
GO:0005635	nuclear envelope	11454873.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	11278563.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006471	protein ADP-ribosylation	21873635.	IBA	Process
GO:0006471	protein ADP-ribosylation	11739745.	IDA	Process
GO:0016055	Wnt signaling pathway	-	IEA	Process
GO:0019899	enzyme binding	21251231.	IPI	Function
GO:0032212	positive regulation of telomere maintenance via telomerase	11739745.	IC	Process
GO:0035264	multicellular organism growth	-	IEA	Process
GO:0040014	regulation of multicellular organism growth	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048471	perinuclear region of cytoplasm	11454873.	IDA	Component
GO:0070198	protein localization to chromosome, telomeric region	21873635.	IBA	Process
GO:0070198	protein localization to chromosome, telomeric region	11739745.	IMP	Process
GO:0070212	protein poly-ADP-ribosylation	25043379.	IDA	Process
GO:0070213	protein auto-ADP-ribosylation	19759537.21478859.	IDA	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	21873635.	IBA	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	19759537.25939383.	IMP	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1904355	positive regulation of telomere capping	21873635.	IBA	Process
GO:1904355	positive regulation of telomere capping	21531765.	IDA	Process
GO:1904355	positive regulation of telomere capping	25939383.	IMP	Process
GO:1904357	negative regulation of telomere maintenance via telomere lengthening	25939383.	IMP	Process
GO:1990404	protein ADP-ribosylase activity	25043379.	IDA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27506313	miR-490-3p inhibits the growth and invasiveness in triple-negative breast cancer by repressing the expression of TNKS2.	Gene	2016 Nov 15	Jia Z	doi: 10.1016/j.gene.2016.08.014
27485113	Identification of novel biomarkers associated with poor patient outcomes in invasive breast carcinoma.	Tumour Biol	2016 Oct	Canevari RA	-
22449978	miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells.	FEBS Lett	2012 Mar 23	Kang HW	doi: 10.1016/j.febslet.2012.02.020
16151859	Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue.	Cell Tissue Res	2006 Jan	Sidorova N	-
18026951	Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients.	Cancer Immunol Immunother	2008 Jun	Shebzukhov YV	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr10	91862034	Missense_Mutation	novel	S1106C	0.36	PARP
BLCA	chr10	91851217	Missense_Mutation	novel	I899N	0.45
BLCA	chr10	91833877	Missense_Mutation	novel	Q434E	0.2
BLCA	chr10	91859577	Silent	rs759381857	Q1070Q	0.51
BLCA	chr10	91845816	Missense_Mutation	NA	A745G	0.11
BLCA	chr10	91813082	Missense_Mutation	NA	S100C	0.18
BLCA	chr10	91822300	Missense_Mutation	NA	L245V	0.25
BLCA	chr10	91828386	Missense_Mutation	novel	Q362E	0.59
BLCA	chr10	91813165	Missense_Mutation	novel	L128V	0.2
BLCA	chr10	91842236	Missense_Mutation	novel	G635E	0.18
BLCA	chr10	91848435	Missense_Mutation	novel	P804L	0.22
BRCA	chr10	91845833	Missense_Mutation	rs758437700	E751K	0.31
BRCA	chr10	91813048	Missense_Mutation	NA	D89N	0.32
BRCA	chr10	91813143	Silent	NA	R120R	0.1
BRCA	chr10	91831131	Missense_Mutation	NA	E409Q	0.4
BRCA	chr10	91864462	3'UTR	novel		0.33
BRCA	chr10	91819285	Missense_Mutation	NA	D179V	0.33
BRCA	chr10	91828371	Frame_Shift_Ins	novel	*N357Ifs16**	0.12
BRCA	chr10	91863055	3'UTR	novel		0.1
BRCA	chr10	91845924	Missense_Mutation	NA	P781L	0.4
BRCA	chr10	91830987	Missense_Mutation	novel	G390E	0.05
CESC	chr10	91840654	Missense_Mutation	rs771829801	V541M	0.29
CESC	chr10	91842189	Frame_Shift_Del	rs749004712	*N622Tfs29**	0.53
CESC	chr10	91812989	Missense_Mutation	novel	G69V	0.08
CESC	chr10	91863218	3'UTR	novel		0.43
CESC	chr10	91864324	3'UTR	novel		0.16
CESC	chr10	91833943	Missense_Mutation	NA	G456W	0.4
CESC	chr10	91851307	Missense_Mutation	NA	G929E	0.45
CESC	chr10	91848452	Missense_Mutation	rs767450342	Q810E	0.2
COAD	chr10	91813191	Missense_Mutation	NA	K136N	0.34
COAD	chr10	91819508	Missense_Mutation	NA	A195V	0.35
COAD	chr10	91842189	Frame_Shift_Del	rs749004712	*N622Tfs29**	0.33
COAD	chr10	91855629	Nonsense_Mutation	NA	R977*	0.28	PARP
COAD	chr10	91851219	Missense_Mutation	novel	T900A	0.29
COAD	chr10	91857447	Missense_Mutation	novel	K1004T	0.41	PARP
COAD	chr10	91833958	In_Frame_Del	novel	I462del	0.36
COAD	chr10	91845851	Nonsense_Mutation	rs747817039	R757*	0.3
COAD	chr10	91859541	Silent	NA	G1058G	0.2
COAD	chr10	91833976	Missense_Mutation	NA	F467V	0.2
COAD	chr10	91812991	Missense_Mutation	novel	R70W	0.35
COAD	chr10	91819540	Missense_Mutation	NA	A206T	0.46
COAD	chr10	91813168	Missense_Mutation	NA	H129Y	0.3
COAD	chr10	91855630	Missense_Mutation	novel	R977Q	0.14	PARP
COAD	chr10	91828344	Frame_Shift_Del	NA	*K349Nfs8**	0.47
COAD	chr10	91863079	3'UTR	novel		0.39
COAD	chr10	91863080	3'UTR	novel		0.22
COAD	chr10	91833926	Missense_Mutation	rs747895530	R450H	0.18
COAD	chr10	91831145	Silent	NA	N413N	0.3
COAD	chr10	91833932	Missense_Mutation	NA	L452R	0.17
COAD	chr10	91855629	Nonsense_Mutation	NA	R977*	0.2	PARP
COAD	chr10	91819496	Frame_Shift_Del	NA	M193*	0.31
COAD	chr10	91819964	Missense_Mutation	novel	G220A	0.54
COAD	chr10	91828313	Missense_Mutation	novel	Q337H	0.13
COAD	chr10	91855629	Nonsense_Mutation	NA	R977*	0.07	PARP
COAD	chr10	91833884	Missense_Mutation	NA	S436F	0.21
COAD	chr10	91848535	Silent	NA	A837A	0.28
ESCA	chr10	91820018	In_Frame_Del	novel	A239_D241del	0.33
ESCA	chr10	91862038	Missense_Mutation	novel	F1107L	0.08	PARP
ESCA	chr10	91864676	3'UTR	novel		0.13
ESCA	chr10	91849579	Missense_Mutation	novel	I893M	0.32
GBM	chr10	91819975	Missense_Mutation	NA	V224I	0.35
GBM	chr10	91817144	Silent	novel	Q145Q	0.42
GBM	chr10	91840564	Missense_Mutation	novel	L511M	0.39
GBM	chr10	91855059	Missense_Mutation	novel	S949Y	0.43
GBM	chr10	91857479	Nonsense_Mutation	novel	E1015*	0.2	PARP
GBM	chr10	91862015	Missense_Mutation	rs768080166	R1100W	0.7	PARP
GBM	chr10	91859509	Missense_Mutation	novel	H1048Y	0.38	PARP
HNSC	chr10	91827033	Missense_Mutation	novel	N271S	0.15
HNSC	chr10	91842362	Missense_Mutation	novel	G677D	0.05
HNSC	chr10	91822304	Missense_Mutation	novel	V246E	0.51
HNSC	chr10	91842348	Silent	novel	C672C	0.08
HNSC	chr10	91841398	Missense_Mutation	novel	H597N	0.24
HNSC	chr10	91859552	Missense_Mutation	novel	A1062V	0.27	PARP
HNSC	chr10	91819961	Missense_Mutation	NA	A219V	0.47
KIRC	chr10	91844997	Missense_Mutation	NA	L713P	0.22
KIRC	chr10	91862946	Frame_Shift_Del	novel	*E1150Sfs3**	0.23	PARP
KIRP	chr10	91828339	Missense_Mutation	novel	R346Q	0.25
KIRP	chr10	91833903	Nonsense_Mutation	novel	Y442*	0.38
KIRP	chr10	91833929	Missense_Mutation	novel	L451P	0.33
KIRP	chr10	91840558	Splice_Region	novel		0.17
LAML	chr10	91827037	Frame_Shift_Ins	novel	*M273Dfs11**	0.07
LAML	chr10	91827038	Frame_Shift_Ins	novel	*M273Ifs26**	0.07
LAML	chr10	91819937	Splice_Site	novel	X212_splice	0.13
LGG	chr10	91830963	Missense_Mutation	novel	I382T	0.09
LGG	chr10	91859625	Silent	novel	D1086D	0.3
LGG	chr10	91863095	3'UTR	novel		0.36
LGG	chr10	91831015	Splice_Site	novel	X399_splice	0.08
LIHC	chr10	91798890	Splice_Site	NA	X67_splice	0.15
LIHC	chr10	91798847	Missense_Mutation	novel	D53Y	0.3
LIHC	chr10	91819982	Missense_Mutation	novel	I226T	0.26
LIHC	chr10	91859527	Missense_Mutation	novel	M1054V	0.32	PARP
LIHC	chr10	91798867	Silent	NA	S59S	0.45
LIHC	chr10	91849562	Missense_Mutation	rs556843721	E888K	0.33
LUAD	chr10	91863092	3'UTR	novel		0.67
LUAD	chr10	91836937	Missense_Mutation	novel	N489I	0.12
LUAD	chr10	91848470	Nonsense_Mutation	NA	R816*	0.1
LUAD	chr10	91827040	Missense_Mutation	novel	M273I	0.19
LUAD	chr10	91851312	Missense_Mutation	novel	E931Q	0.23
LUAD	chr10	91849595	Splice_Site	novel	X898_splice	0.2
LUAD	chr10	91845026	Missense_Mutation	NA	G723W	0.22
LUAD	chr10	91840684	Missense_Mutation	novel	D551N	0.1
LUAD	chr10	91813191	Missense_Mutation	NA	K136N	0.16
LUAD	chr10	91862117	Missense_Mutation	NA	L1134V	0.12	PARP
LUAD	chr10	91859621	Missense_Mutation	NA	K1085R	0.58	PARP
LUAD	chr10	91833852	Splice_Site	novel	X426_splice	0.1
LUAD	chr10	91863028	3'UTR	novel		0.21
LUAD	chr10	91836962	Silent	novel	L497L	0.1
LUAD	chr10	91848595	Silent	novel	S857S	0.05
LUAD	chr10	91817179	Missense_Mutation	NA	G157V	0.21
LUSC	chr10	91833966	Silent	novel	S463S	0.31
LUSC	chr10	91848545	Missense_Mutation	NA	L841V	0.17
LUSC	chr10	91848398	Missense_Mutation	novel	A792S	0.39
LUSC	chr10	91840657	Missense_Mutation	NA	V542L	0.15
LUSC	chr10	91798854	Missense_Mutation	novel	A55V	0.18
LUSC	chr10	91828303	Missense_Mutation	novel	S334L	0.2
LUSC	chr10	91813069	Frame_Shift_Del	novel	*H96Cfs8**	0.45
LUSC	chr10	91848616	Silent	novel	S864S	0.4
LUSC	chr10	91844987	Missense_Mutation	novel	K710Q	0.38
LUSC	chr10	91851296	Missense_Mutation	novel	K925N	0.15
LUSC	chr10	91813039	Missense_Mutation	novel	A86S	0.32
LUSC	chr10	91857464	Missense_Mutation	novel	T1010S	0.18	PARP
OV	chr10	91807245	Intron	NA		0.09
OV	chr10	91842334	Missense_Mutation	NA	D668H	0.38
OV	chr10	91841418	Silent	novel	G603G	0.11
OV	chr10	91841419	Missense_Mutation	novel	K604E	0.1
OV	chr10	91859563	Missense_Mutation	novel	S1066A	0.07	PARP
OV	chr10	91833984	Silent	rs369522806	A469A	0.08
OV	chr10	91855082	Missense_Mutation	novel	D957H	0.07
OV	chr10	91827049	Nonsense_Mutation	novel	W276*	0.15
PAAD	chr10	91848540	Missense_Mutation	rs774046359	S839N	0.15
PRAD	chr10	91830980	Silent	novel	R388R	0.14
PRAD	chr10	91813000	Missense_Mutation	NA	V73I	0.1
READ	chr10	91862070	Missense_Mutation	NA	S1118Y	0.3	PARP
READ	chr10	91828339	Missense_Mutation	novel	R346Q	0.41
READ	chr10	91851253	Missense_Mutation	NA	E911A	0.28
READ	chr10	91855629	Nonsense_Mutation	NA	R977*	0.45	PARP
SARC	chr10	91848597	Missense_Mutation	novel	S858I	0.07
SKCM	chr10	91851218	Splice_Region	rs751359159	I899I	0.17
SKCM	chr10	91822364	Splice_Site	NA	X265_splice	0.43
SKCM	chr10	91813041	Silent	novel	A86A	0.26
SKCM	chr10	91813042	Missense_Mutation	rs749487107	R87C	0.25
SKCM	chr10	91855056	Missense_Mutation	novel	T948I	0.22
SKCM	chr10	91855057	Silent	rs61756247	T948T	0.24
SKCM	chr10	91848509	Missense_Mutation	novel	P829S	0.41
SKCM	chr10	91819274	Missense_Mutation	NA	E175D	0.32
SKCM	chr10	91830948	Missense_Mutation	NA	P377L	0.29
SKCM	chr10	91813141	Nonsense_Mutation	novel	R120*	0.13
SKCM	chr10	91855117	Silent	novel	V968V	0.41
STAD	chr10	91822326	Silent	NA	S253S	0.22
STAD	chr10	91819540	Missense_Mutation	NA	A206T	0.32
STAD	chr10	91851240	Frame_Shift_Ins	novel	*M907Ifs17**	0.34
STAD	chr10	91842189	Frame_Shift_Del	rs749004712	*N622Tfs29**	0.42
STAD	chr10	91842342	Silent	NA	V670V	0.12
STAD	chr10	91862988	Missense_Mutation	NA	V1164I	0.33
STAD	chr10	91831119	Missense_Mutation	NA	H405Y	0.14
STAD	chr10	91842365	Missense_Mutation	novel	R678T	0.08
STAD	chr10	91851263	Missense_Mutation	NA	E914D	0.76
STAD	chr10	91859606	Missense_Mutation	novel	G1080E	0.24	PARP
STAD	chr10	91848384	Missense_Mutation	rs758827793	A787V	0.14
STAD	chr10	91840676	Missense_Mutation	rs764051162	H548R	0.31
STAD	chr10	91857528	Missense_Mutation	NA	H1031R	0.37	PARP
STAD	chr10	91849591	Silent	NA	E897E	0.08
STAD	chr10	91828320	Nonsense_Mutation	novel	R340*	0.2
STAD	chr10	91840606	Missense_Mutation	rs755266752	R525C	0.21
THYM	chr10	91831114	Missense_Mutation	novel	P403H	0.22
UCEC	chr10	91833958	In_Frame_Del	novel	I462del	0.25
UCEC	chr10	91841326	Nonsense_Mutation	NA	E573*	0.3
UCEC	chr10	91859468	Missense_Mutation	NA	P1034H	0.28	PARP
UCEC	chr10	91822351	Missense_Mutation	novel	L262I	0.21
UCEC	chr10	91849543	Silent	rs200020202	F881F	0.15
UCEC	chr10	91864239	3'UTR	novel		0.17
UCEC	chr10	91863132	3'UTR	rs534968932		0.66
UCEC	chr10	91842221	Missense_Mutation	novel	D630G	0.2
UCEC	chr10	91864939	3'UTR	novel		0.44
UCEC	chr10	91813107	Silent	novel	N108N	0.28
UCEC	chr10	91864717	3'UTR	novel		0.46
UCEC	chr10	91827196	Silent	novel	R325R	0.51
UCEC	chr10	91851323	Silent	novel	I934I	0.17
UCEC	chr10	91833896	Missense_Mutation	novel	A440D	0.33
UCEC	chr10	91842189	Frame_Shift_Del	rs749004712	*N622Tfs29**	0.44
UCEC	chr10	91842349	Missense_Mutation	rs771677211	R673C	0.39
UCEC	chr10	91842351	Silent	rs751558431	R673R	0.38
UCEC	chr10	91865254	3'UTR	novel		0.2
UCEC	chr10	91864757	3'UTR	novel		0.31
UCEC	chr10	91833967	Missense_Mutation	NA	L464I	0.13
UCEC	chr10	91848397	Silent	rs142783979	S791S	0.21
UCEC	chr10	91863001	3'UTR	novel		0.06
UCEC	chr10	91863003	3'UTR	novel		0.04
UCEC	chr10	91813061	Missense_Mutation	novel	I93N	0.27
UCEC	chr10	91845833	Missense_Mutation	rs758437700	E751K	0.5
UCEC	chr10	91827107	Missense_Mutation	novel	L296I	0.13
UCEC	chr10	91840595	Missense_Mutation	rs147855760	D521G	0.38
UCEC	chr10	91864641	3'UTR	novel		0.36
UCEC	chr10	91862149	Silent	novel	G1144G	0.3
UCEC	chr10	91864611	3'UTR	novel		0.42
UCEC	chr10	91828351	Frame_Shift_Ins	novel	*E354Wfs4**	0.33
UCEC	chr10	91848384	Missense_Mutation	rs758827793	A787V	0.38
UCEC	chr10	91865002	3'UTR	novel		0.24
UCEC	chr10	91859573	Missense_Mutation	novel	N1069S	0.44	PARP
UCEC	chr10	91813117	Nonsense_Mutation	rs372595864	R112*	0.25
UCEC	chr10	91848458	Missense_Mutation	novel	L812I	0.44
UCEC	chr10	91857521	Missense_Mutation	novel	L1029I	0.43	PARP
UCEC	chr10	91863195	3'UTR	novel		0.11
UCEC	chr10	91864158	3'UTR	novel		0.44
UCEC	chr10	91865192	3'UTR	novel		0.26
UCEC	chr10	91841341	Missense_Mutation	novel	L578I	0.52
UCEC	chr10	91849543	Silent	rs200020202	F881F	0.58
UCEC	chr10	91855031	Missense_Mutation	novel	L940I	0.46
UCEC	chr10	91862138	Frame_Shift_Ins	novel	*I1141Tfs10**	0.06	PARP
UCEC	chr10	91862140	Nonsense_Mutation	novel	*Y1142Pfs2**	0.04	PARP
UCEC	chr10	91828381	Nonsense_Mutation	novel	*P361Kfs6**	0.11
UCEC	chr10	91855688	Missense_Mutation	NA	K996N	0.37	PARP
UCEC	chr10	91849543	Silent	rs200020202	F881F	0.51
UCEC	chr10	91863457	3'UTR	novel		0.16
UCEC	chr10	91863119	3'UTR	novel		0.14
UCEC	chr10	91836987	Missense_Mutation	rs755521324	E506K	0.32
UCEC	chr10	91822328	Missense_Mutation	novel	Y254C	0.56
UCEC	chr10	91842189	Frame_Shift_Del	rs749004712	*N622Tfs29**	0.4
UCEC	chr10	91842189	Frame_Shift_Del	rs749004712	*N622Tfs29**	0.36
UCEC	chr10	91842349	Missense_Mutation	rs771677211	R673C	0.42
UCEC	chr10	91828343	Frame_Shift_Ins	NA	*H350Tfs16**	0.41
UCEC	chr10	91842189	Frame_Shift_Del	novel	*N622Qfs11**	0.27
UCEC	chr10	91840661	Missense_Mutation	novel	E543G	0.38
UCEC	chr10	91851312	Missense_Mutation	rs759260364	E931K	0.43
UCEC	chr10	91813117	Nonsense_Mutation	rs372595864	R112*	0.16
UCEC	chr10	91836987	Missense_Mutation	rs755521324	E506K	0.45
UCEC	chr10	91819481	Splice_Site	NA	X186_splice	0.55
UCEC	chr10	91828370	Silent	novel	V356V	0.24
UCEC	chr10	91842229	Missense_Mutation	novel	K633Q	0.21
UCEC	chr10	91842223	Missense_Mutation	novel	L631I	0.17
UCEC	chr10	91848414	Missense_Mutation	novel	A797V	0.31
UCEC	chr10	91859514	Silent	rs773164571	A1049A	0.19
UCEC	chr10	91864263	3'UTR	novel		0.35
UCEC	chr10	91841443	Missense_Mutation	novel	L612F	0.05
UCEC	chr10	91863111	3'UTR	novel		0.1
UCEC	chr10	91863194	3'UTR	novel		0.33
UCEC	chr10	91864380	3'UTR	novel		0.29
UCEC	chr10	91830933	Missense_Mutation	NA	A372V	0.11
UCEC	chr10	91842351	Silent	rs751558431	R673R	0.39
UCEC	chr10	91819278	Missense_Mutation	novel	K177E	0.26
UCEC	chr10	91833871	Missense_Mutation	novel	L432I	0.31
UCEC	chr10	91817175	Missense_Mutation	novel	D156Y	0.13
UCEC	chr10	91830925	Missense_Mutation	novel	H369Q	0.45
UCEC	chr10	91833925	Missense_Mutation	novel	R450S	0.22
UCEC	chr10	91841386	Missense_Mutation	novel	F593I	0.37
UCEC	chr10	91828371	Frame_Shift_Ins	novel	*N357Ifs11**	0.04
UCEC	chr10	91828373	Silent	novel	N357N	0.02
UCEC	chr10	91842189	Frame_Shift_Del	rs749004712	*N622Tfs29**	0.41
UCEC	chr10	91863080	3'UTR	novel		0.32
UCEC	chr10	91849576	Silent	novel	D892D	0.08
UCEC	chr10	91859609	Missense_Mutation	NA	C1081F	0.44	PARP
UCEC	chr10	91842322	Missense_Mutation	novel	L664V	0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
CHOL	DEL	0.1667	0.048655
MESO	DEL	0.2644	0.00015289
PAAD	DEL	0.125	0.169
READ	DEL	0.2485	0.014135
THCA	DEL	0.02	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.3393	0.1218

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00014	Kaplan-Meier Survival Analysis
ACC	0.00037	Kaplan-Meier Survival Analysis
HNSC	0.015	Kaplan-Meier Survival Analysis
SKCM	0.014	Kaplan-Meier Survival Analysis
PRAD	0.026	Kaplan-Meier Survival Analysis
UCEC	0.041	Kaplan-Meier Survival Analysis
GBM	0.023	Kaplan-Meier Survival Analysis
LGG	0.00012	Kaplan-Meier Survival Analysis
CHOL	0.021	Kaplan-Meier Survival Analysis
LUAD	0.0094	Kaplan-Meier Survival Analysis
UVM	0.025	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742