EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000107862 (Gene tree)
Gene ID: 8729
Gene Symbol: GBF1
Alias: KIAA0248|ARF1GEF
Full Name: golgi brefeldin A resistant guanine nucleotide exchange factor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 137,402 bases
Position: chr10:102,245,498-102,382,899
Accession: 4181
RBP type: non-canonical RBP
Summary: This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000476019	GBF1-202	503	-	-	- (aa)	-	-
ENST00000369983	GBF1-201	6403	XM_005270261	ENSP00000359000	1859 (aa)	XP_005270318	Q92538

Gene Model

Click here to download ENSG00000107862's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000107862	Echocardiography	1.00875727110608E-6	17903301
ENSG00000107862	Echocardiography	1.14091622155842E-5	17903301
ENSG00000107862	Adiponectin	3.8610000E-005	-
ENSG00000107862	Electrocardiography	3E-8	24952745
ENSG00000107862	Education	2E-8	27225129

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000107862	rs12354486	10	102364298	C	Educational attainment (college completion)	27225129	[NR]	1.0427477	EFO_0004784
ENSG00000107862	rs2485376	10	102290249	A	QT interval	24952745	[0.36-0.76] unit decrease	0.56	EFO_0004682
ENSG00000107862	rs2273555	10	102367414	A	Hand grip strength	29313844	[0.092-0.18] kg increase	0.1361	EFO_0006941
ENSG00000107862	rs2296887	10	102245653	C	Parkinson's disease	28892059	[1.05-1.11]	1.084	EFO_0002508
ENSG00000107862	rs11191270	10	102364848	T	Intelligence (MTAG)	29326435	[0.021-0.036] unit decrease	0.028393682	EFO_0004337
ENSG00000107862	rs12772375	10	102322931	T	Intelligence (MTAG)	29326435	[0.012-0.024] unit decrease	0.018256338	EFO_0004337
ENSG00000107862	rs72845660	10	102312216	C	Intelligence (MTAG)	29326435	[0.015-0.03] unit decrease	0.022791114	EFO_0004337
ENSG00000107862	rs12772375	10	102322931	T	Cognitive performance	30038396	[0.013-0.024] unit decrease	0.0184	EFO_0008354
ENSG00000107862	rs4919624	10	102261328	A	Educational attainment (MTAG)	30038396	[0.016-0.023] unit increase	0.0196	EFO_0004784
ENSG00000107862	rs72845663	10	102321592	C	Highest math class taken	30038396	[0.01-0.019] unit decrease	0.0145	EFO_0004875
ENSG00000107862	rs72845663	10	102321592	T	Self-reported math ability (MTAG)	30038396	[0.01-0.017] unit increase	0.0138	EFO_0004875
ENSG00000107862	rs4919624	10	102261328	A	Highest math class taken (MTAG)	30038396	[0.017-0.025] unit increase	0.021	EFO_0004875
ENSG00000107862	rs12772375	10	102322931	T	Cognitive performance (MTAG)	30038396	[0.014-0.023] unit decrease	0.0189	EFO_0008354
ENSG00000107862	rs11191270	10	102364848	T	General cognitive ability	29844566	z-score decrease	6.688	EFO_0004337
ENSG00000107862	rs2485371	10	102274330	T	Intelligence	29942086	z-score decrease	7.513	EFO_0004337
ENSG00000107862	rs72845660	10	102312216	C	Intelligence	29942086	z-score decrease	6.149	EFO_0004337
ENSG00000107862	rs11191270	10	102364848	T	Intelligence	29942086	z-score decrease	6.943	EFO_0004337
ENSG00000107862	rs12772375	10	102322931	T	Intelligence	29942086	z-score decrease	6.388	EFO_0004337
ENSG00000107862	rs4919624	10	102261328	A	Educational attainment (years of education)	30038396	[0.016-0.023] unit increase	0.0193	EFO_0004784
ENSG00000107862	rs772031	10	102261784	?	Body mass index	30595370			EFO_0004340
ENSG00000107862	rs72845655	10	102284277	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000107862	rs11191269	10	102360765	G	Smoking initiation (ever regular vs never regular)	30643251	[0.011-0.024] unit increase	0.017642591	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000107862's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	TAS	Component
GO:0002263	cell activation involved in immune response	22573891.	IMP	Process
GO:0005085	guanyl-nucleotide exchange factor activity	-	TAS	Function
GO:0005086	ARF guanyl-nucleotide exchange factor activity	-	TAS	Function
GO:0005515	protein binding	17956946.19039328.	IPI	Function
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	22573891.	IDA	Function
GO:0005739	mitochondrion	-	IEA	Component
GO:0005777	peroxisome	-	IEA	Component
GO:0005788	endoplasmic reticulum lumen	-	IEA	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	12047556.	IDA	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005795	Golgi stack	-	IEA	Component
GO:0005801	cis-Golgi network	12047556.	IDA	Component
GO:0005802	trans-Golgi network	23386609.	IDA	Component
GO:0005811	lipid droplet	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	12047556.	IMP	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0006892	post-Golgi vesicle-mediated transport	-	TAS	Process
GO:0006895	Golgi to endosome transport	23386609.	IMP	Process
GO:0007030	Golgi organization	12808027.	IMP	Process
GO:0007346	regulation of mitotic cell cycle	23418352.	IMP	Process
GO:0015031	protein transport	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0030593	neutrophil chemotaxis	22573891.	IMP	Process
GO:0031252	cell leading edge	22573891.	IDA	Component
GO:0032012	regulation of ARF protein signal transduction	-	IEA	Process
GO:0034067	protein localization to Golgi apparatus	17956946.	IMP	Process
GO:0042147	retrograde transport, endosome to Golgi	12808027.	IMP	Process
GO:0048205	COPI coating of Golgi vesicle	12047556.17956946.	IMP	Process
GO:0061162	establishment of monopolar cell polarity	22573891.	IMP	Process
GO:0070973	protein localization to endoplasmic reticulum exit site	17956946.	IMP	Process
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	22573891.	IDA	Function
GO:0090166	Golgi disassembly	23418352.	IMP	Process
GO:0097111	endoplasmic reticulum-Golgi intermediate compartment organization	17956946.	IMP	Process
GO:0098586	cellular response to virus	28389568.	IMP	Process
GO:1903409	reactive oxygen species biosynthetic process	22573891.	IMP	Process
GO:1903420	protein localization to endoplasmic reticulum tubular network	17956946.	IMP	Process
GO:2000008	regulation of protein localization to cell surface	17956946.	IMP	Process