EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000107951 (Gene tree)
Gene ID: 55149
Gene Symbol: MTPAP
Alias: FLJ10486|mtPAP|SPAX4|TENT6|PAPD1
Full Name: mitochondrial poly(A) polymerase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 64,648 bases
Position: chr10:30,309,801-30,374,448
Accession: 25532
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000263063	PAP_assoc	PF03828.19	1.8e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21292163	Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase.	Mol Cell	2011 Feb 4	Bai Y	doi: 10.1016/j.molcel.2011.01.013.
25008111	A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.	Hum Mol Genet	2014 Dec 1	Wilson WC	doi: 10.1093/hmg/ddu352
24770417	Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes.	J Biol Chem	2014 Jun 13	Wang DD	doi: 10.1074/jbc.M113.536540

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000471055	MTPAP-204	2071	-	-	- (aa)	-	-
ENST00000488290	MTPAP-205	4103	-	-	- (aa)	-	-
ENST00000417581	MTPAP-202	816	-	ENSP00000404392	219 (aa)	-	Q5T852
ENST00000421701	MTPAP-203	695	-	ENSP00000394118	150 (aa)	-	Q5T851
ENST00000263063	MTPAP-201	5601	-	ENSP00000263063	582 (aa)	-	Q9NVV4

Gene Model

Click here to download ENSG00000107951's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000107951's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000107951	MTPAP	77	33.333	ENSG00000149016	TUT1	55	41.026

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000107951	MTPAP	99	80.239	ENSAMEG00000017072	MTPAP	99	80.239	Ailuropoda_melanoleuca
ENSG00000107951	MTPAP	100	47.534	ENSATEG00000018649	mtpap	87	55.769	Anabas_testudineus
ENSG00000107951	MTPAP	100	52.703	ENSAPLG00000008962	MTPAP	100	59.693	Anas_platyrhynchos
ENSG00000107951	MTPAP	100	89.041	ENSANAG00000028210	-	100	88.660	Aotus_nancymaae
ENSG00000107951	MTPAP	100	49.776	ENSAMXG00000043393	mtpap	96	53.641	Astyanax_mexicanus
ENSG00000107951	MTPAP	100	80.171	ENSBTAG00000004387	MTPAP	100	80.171	Bos_taurus
ENSG00000107951	MTPAP	100	89.498	ENSCJAG00000013270	MTPAP	100	88.316	Callithrix_jacchus
ENSG00000107951	MTPAP	100	80.513	ENSCAFG00000003984	MTPAP	100	80.513	Canis_familiaris
ENSG00000107951	MTPAP	100	80.513	ENSCAFG00020026734	MTPAP	100	80.513	Canis_lupus_dingo
ENSG00000107951	MTPAP	100	79.829	ENSCHIG00000025725	MTPAP	100	79.829	Capra_hircus
ENSG00000107951	MTPAP	100	84.234	ENSTSYG00000010888	MTPAP	100	84.103	Carlito_syrichta
ENSG00000107951	MTPAP	100	74.775	ENSCAPG00000008656	MTPAP	99	76.967	Cavia_aperea
ENSG00000107951	MTPAP	100	74.775	ENSCPOG00000004018	MTPAP	91	75.652	Cavia_porcellus
ENSG00000107951	MTPAP	100	88.316	ENSCCAG00000031189	MTPAP	100	88.316	Cebus_capucinus
ENSG00000107951	MTPAP	100	77.027	ENSCLAG00000006536	MTPAP	97	75.500	Chinchilla_lanigera
ENSG00000107951	MTPAP	100	91.324	ENSCSAG00000011662	MTPAP	100	90.550	Chlorocebus_sabaeus
ENSG00000107951	MTPAP	100	78.378	ENSCHOG00000009091	MTPAP	99	80.603	Choloepus_hoffmanni
ENSG00000107951	MTPAP	100	60.360	ENSCPBG00000015871	MTPAP	97	65.589	Chrysemys_picta_bellii
ENSG00000107951	MTPAP	100	91.324	ENSCANG00000035641	MTPAP	100	90.550	Colobus_angolensis_palliatus
ENSG00000107951	MTPAP	100	75.556	ENSCGRG00001017262	-	100	75.726	Cricetulus_griseus_chok1gshd
ENSG00000107951	MTPAP	100	70.940	ENSCGRG00001001905	-	100	71.111	Cricetulus_griseus_chok1gshd
ENSG00000107951	MTPAP	100	72.973	ENSCGRG00000005450	-	99	76.836	Cricetulus_griseus_crigri
ENSG00000107951	MTPAP	100	70.940	ENSCGRG00000006147	-	100	71.111	Cricetulus_griseus_crigri
ENSG00000107951	MTPAP	100	45.455	ENSCSEG00000007072	mtpap	91	54.386	Cynoglossus_semilaevis
ENSG00000107951	MTPAP	100	53.182	ENSDARG00000076155	mtpap	88	57.036	Danio_rerio
ENSG00000107951	MTPAP	100	79.730	ENSDNOG00000041149	MTPAP	100	76.923	Dasypus_novemcinctus
ENSG00000107951	MTPAP	100	76.320	ENSDORG00000008425	Mtpap	100	76.320	Dipodomys_ordii
ENSG00000107951	MTPAP	77	33.049	FBgn0024360	MTPAP	76	33.049	Drosophila_melanogaster
ENSG00000107951	MTPAP	100	63.514	ENSETEG00000008496	MTPAP	98	71.429	Echinops_telfairi
ENSG00000107951	MTPAP	99	37.387	ENSEBUG00000005514	-	79	44.748	Eptatretus_burgeri
ENSG00000107951	MTPAP	100	80.684	ENSEASG00005007214	MTPAP	100	80.684	Equus_asinus_asinus
ENSG00000107951	MTPAP	100	80.684	ENSECAG00000000001	MTPAP	100	80.684	Equus_caballus
ENSG00000107951	MTPAP	56	74.603	ENSEEUG00000008652	-	82	74.603	Erinaceus_europaeus
ENSG00000107951	MTPAP	100	54.054	ENSELUG00000004043	mtpap	92	57.482	Esox_lucius
ENSG00000107951	MTPAP	100	82.432	ENSFCAG00000019348	MTPAP	100	81.197	Felis_catus
ENSG00000107951	MTPAP	100	51.802	ENSFALG00000007132	MTPAP	98	60.076	Ficedula_albicollis
ENSG00000107951	MTPAP	100	75.225	ENSFDAG00000013934	MTPAP	93	78.024	Fukomys_damarensis
ENSG00000107951	MTPAP	100	49.558	ENSGMOG00000002498	mtpap	94	57.255	Gadus_morhua
ENSG00000107951	MTPAP	100	52.252	ENSGALG00000007351	MTPAP	97	56.757	Gallus_gallus
ENSG00000107951	MTPAP	100	49.550	ENSGACG00000001658	mtpap	99	56.944	Gasterosteus_aculeatus
ENSG00000107951	MTPAP	55	99.377	ENSGGOG00000009335	-	98	99.377	Gorilla_gorilla
ENSG00000107951	MTPAP	99	74.208	ENSHGLG00000016439	MTPAP	99	75.174	Heterocephalus_glaber_female
ENSG00000107951	MTPAP	98	75.000	ENSHGLG00100012930	MTPAP	99	75.000	Heterocephalus_glaber_male
ENSG00000107951	MTPAP	99	50.000	ENSHCOG00000017475	mtpap	96	58.717	Hippocampus_comes
ENSG00000107951	MTPAP	100	51.802	ENSIPUG00000011455	Mtpap	88	59.144	Ictalurus_punctatus
ENSG00000107951	MTPAP	100	85.586	ENSSTOG00000000734	MTPAP	100	83.077	Ictidomys_tridecemlineatus
ENSG00000107951	MTPAP	100	78.632	ENSJJAG00000023931	Mtpap	99	78.632	Jaculus_jaculus
ENSG00000107951	MTPAP	100	48.858	ENSKMAG00000015120	mtpap	89	57.031	Kryptolebias_marmoratus
ENSG00000107951	MTPAP	100	47.489	ENSLBEG00000026965	mtpap	87	57.455	Labrus_bergylta
ENSG00000107951	MTPAP	80	59.664	ENSLACG00000010030	MTPAP	100	59.664	Latimeria_chalumnae
ENSG00000107951	MTPAP	100	54.955	ENSLOCG00000007357	mtpap	89	60.700	Lepisosteus_oculatus
ENSG00000107951	MTPAP	100	79.545	ENSLAFG00000013452	MTPAP	100	80.603	Loxodonta_africana
ENSG00000107951	MTPAP	100	89.954	ENSMFAG00000036179	MTPAP	100	89.347	Macaca_fascicularis
ENSG00000107951	MTPAP	100	89.498	ENSMMUG00000003001	MTPAP	100	89.175	Macaca_mulatta
ENSG00000107951	MTPAP	100	89.175	ENSMNEG00000039635	MTPAP	100	89.175	Macaca_nemestrina
ENSG00000107951	MTPAP	100	89.954	ENSMLEG00000043590	MTPAP	100	89.175	Mandrillus_leucophaeus
ENSG00000107951	MTPAP	92	55.823	ENSMAMG00000013994	mtpap	91	55.823	Mastacembelus_armatus
ENSG00000107951	MTPAP	100	52.703	ENSMGAG00000006525	MTPAP	98	58.555	Meleagris_gallopavo
ENSG00000107951	MTPAP	100	76.621	ENSMAUG00000006874	Mtpap	100	76.621	Mesocricetus_auratus
ENSG00000107951	MTPAP	100	84.685	ENSMICG00000026621	MTPAP	97	84.589	Microcebus_murinus
ENSG00000107951	MTPAP	100	76.923	ENSMOCG00000002437	Mtpap	100	77.094	Microtus_ochrogaster
ENSG00000107951	MTPAP	100	49.776	ENSMMOG00000005629	mtpap	90	58.580	Mola_mola
ENSG00000107951	MTPAP	98	64.870	ENSMODG00000007924	MTPAP	99	64.870	Monodelphis_domestica
ENSG00000107951	MTPAP	99	48.869	ENSMALG00000018046	mtpap	93	54.845	Monopterus_albus
ENSG00000107951	MTPAP	100	80.342	ENSMPUG00000016413	MTPAP	100	80.342	Mustela_putorius_furo
ENSG00000107951	MTPAP	100	81.982	ENSMLUG00000000214	MTPAP	100	81.197	Myotis_lucifugus
ENSG00000107951	MTPAP	100	77.928	ENSNGAG00000017051	Mtpap	100	77.949	Nannospalax_galili
ENSG00000107951	MTPAP	82	68.817	ENSODEG00000003767	-	100	68.817	Octodon_degus
ENSG00000107951	MTPAP	97	63.652	ENSOANG00000006046	MTPAP	97	63.652	Ornithorhynchus_anatinus
ENSG00000107951	MTPAP	100	74.775	ENSOCUG00000007276	MTPAP	100	68.889	Oryctolagus_cuniculus
ENSG00000107951	MTPAP	100	80.342	ENSOARG00000014807	MTPAP	100	80.342	Ovis_aries
ENSG00000107951	MTPAP	100	99.087	ENSPPAG00000038626	MTPAP	100	98.969	Pan_paniscus
ENSG00000107951	MTPAP	100	81.532	ENSPPRG00000015326	MTPAP	100	81.026	Panthera_pardus
ENSG00000107951	MTPAP	100	81.081	ENSPTIG00000011190	MTPAP	100	80.855	Panthera_tigris_altaica
ENSG00000107951	MTPAP	100	99.087	ENSPTRG00000033794	MTPAP	100	98.969	Pan_troglodytes
ENSG00000107951	MTPAP	100	90.411	ENSPANG00000022927	MTPAP	100	89.863	Papio_anubis
ENSG00000107951	MTPAP	99	49.315	ENSPKIG00000009397	mtpap	98	51.767	Paramormyrops_kingsleyae
ENSG00000107951	MTPAP	100	59.009	ENSPSIG00000015809	MTPAP	98	64.381	Pelodiscus_sinensis
ENSG00000107951	MTPAP	100	46.606	ENSPMGG00000014361	mtpap	88	55.248	Periophthalmus_magnuspinnatus
ENSG00000107951	MTPAP	100	77.928	ENSPEMG00000019906	Mtpap	100	76.923	Peromyscus_maniculatus_bairdii
ENSG00000107951	MTPAP	99	65.517	ENSPCIG00000018263	MTPAP	99	65.517	Phascolarctos_cinereus
ENSG00000107951	MTPAP	100	95.434	ENSPPYG00000002184	MTPAP	99	96.364	Pongo_abelii
ENSG00000107951	MTPAP	100	80.180	ENSPVAG00000007804	MTPAP	99	81.524	Pteropus_vampyrus
ENSG00000107951	MTPAP	100	52.511	ENSPNAG00000003023	mtpap	89	59.332	Pygocentrus_nattereri
ENSG00000107951	MTPAP	58	80.415	ENSRNOG00000016578	Mtpap	100	80.415	Rattus_norvegicus
ENSG00000107951	MTPAP	100	90.868	ENSRROG00000033147	MTPAP	99	90.206	Rhinopithecus_roxellana
ENSG00000107951	MTPAP	100	88.584	ENSSBOG00000034390	MTPAP	98	87.457	Saimiri_boliviensis_boliviensis
ENSG00000107951	MTPAP	100	64.384	ENSSHAG00000001222	MTPAP	99	58.520	Sarcophilus_harrisii
ENSG00000107951	MTPAP	98	53.217	ENSSFOG00015017121	mtpap	97	53.217	Scleropages_formosus
ENSG00000107951	MTPAP	100	49.558	ENSSMAG00000003235	mtpap	96	52.793	Scophthalmus_maximus
ENSG00000107951	MTPAP	100	49.561	ENSSDUG00000003515	mtpap	91	57.198	Seriola_dumerili
ENSG00000107951	MTPAP	100	46.847	ENSSLDG00000013858	mtpap	91	56.711	Seriola_lalandi_dorsalis
ENSG00000107951	MTPAP	100	54.955	ENSSPUG00000017558	MTPAP	99	55.649	Sphenodon_punctatus
ENSG00000107951	MTPAP	100	46.903	ENSSPAG00000004661	mtpap	92	54.151	Stegastes_partitus
ENSG00000107951	MTPAP	100	79.829	ENSSSCG00000011018	MTPAP	97	80.171	Sus_scrofa
ENSG00000107951	MTPAP	100	51.802	ENSTGUG00000001048	MTPAP	99	60.630	Taeniopygia_guttata
ENSG00000107951	MTPAP	100	45.045	ENSTRUG00000002765	mtpap	97	52.110	Takifugu_rubripes
ENSG00000107951	MTPAP	100	46.396	ENSTNIG00000008709	mtpap	100	55.253	Tetraodon_nigroviridis
ENSG00000107951	MTPAP	78	85.390	ENSTBEG00000006583	MTPAP	86	85.390	Tupaia_belangeri
ENSG00000107951	MTPAP	89	79.293	ENSTTRG00000016657	MTPAP	72	78.947	Tursiops_truncatus
ENSG00000107951	MTPAP	100	80.513	ENSUAMG00000011155	MTPAP	100	80.513	Ursus_americanus
ENSG00000107951	MTPAP	100	80.631	ENSUMAG00000015907	MTPAP	100	80.513	Ursus_maritimus
ENSG00000107951	MTPAP	65	100.000	ENSVPAG00000002130	MTPAP	85	85.670	Vicugna_pacos
ENSG00000107951	MTPAP	100	80.855	ENSVVUG00000002094	MTPAP	100	80.855	Vulpes_vulpes
ENSG00000107951	MTPAP	100	51.142	ENSXETG00000002656	mtpap	100	58.904	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	21292163.	IDA	Function
GO:0002134	UTP binding	21292163.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004652	polynucleotide adenylyltransferase activity	21292163.	IDA	Function
GO:0005515	protein binding	21903422.	IPI	Function
GO:0005524	ATP binding	21292163.	IDA	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0006378	mRNA polyadenylation	21292163.	IDA	Process
GO:0030145	manganese ion binding	21292163.	IDA	Function
GO:0042802	identical protein binding	21292163.	IPI	Function
GO:0042803	protein homodimerization activity	21292163.	IPI	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0071044	histone mRNA catabolic process	18172165.	IMP	Process