EuRBPDB

Description

Ensembl ID: ENSG00000107959 (Gene tree)
Gene ID: 10531
Gene Symbol: PITRM1
Alias: MP1|KIAA1104|hMP1|PreP
Full Name: pitrilysin metallopeptidase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 35,115 bases
Position: chr10:3,137,727-3,172,841
Accession: 17663
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000464395	PITRM1-209	3240	-	-	- (aa)	-	-
ENST00000224949	PITRM1-201	3450	-	ENSP00000224949	1037 (aa)	-	Q5JRX3
ENST00000490510	PITRM1-211	778	-	-	- (aa)	-	-
ENST00000455371	PITRM1-208	673	-	ENSP00000399307	184 (aa)	-	B1APQ0
ENST00000488065	PITRM1-210	851	-	-	- (aa)	-	-
ENST00000380989	PITRM1-202	3487	-	ENSP00000370377	1038 (aa)	-	Q5JRX3
ENST00000451454	PITRM1-207	875	-	ENSP00000413687	259 (aa)	-	H0Y7L7
ENST00000430362	PITRM1-205	718	-	ENSP00000391526	233 (aa)	-	H0Y4F7
ENST00000451104	PITRM1-206	3183	-	ENSP00000401201	939 (aa)	-	Q5JRX3
ENST00000380994	PITRM1-203	2579	-	ENSP00000370382	595 (aa)	-	A0A0A0MRX9
ENST00000424714	PITRM1-204	482	-	ENSP00000402072	86 (aa)	-	B1APQ1

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000107959	Waist-Hip Ratio	5.7080000E-005	-
ENSG00000107959	Waist-Hip Ratio	4.0790000E-005	-
ENSG00000107959	Insulin Resistance	8.3810000E-006	-
ENSG00000107959	Insulin	5.0580000E-006	-
ENSG00000107959	Insulin	4.7980000E-005	-
ENSG00000107959	Insulin	5.3070000E-005	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000107959	PITRM1	97	39.010	FBgn0033005	CG3107	94	39.010	Drosophila_melanogaster
ENSG00000107959	PITRM1	100	86.596	ENSMUSG00000021193	Pitrm1	100	86.596	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004222	metalloendopeptidase activity	21873635.	IBA	Function
GO:0004222	metalloendopeptidase activity	10360838.19196155.	IDA	Function
GO:0004222	metalloendopeptidase activity	16849325.24931469.	IMP	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	16849325.19196155.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006508	proteolysis	10360838.19196155.	IDA	Process
GO:0006508	proteolysis	16849325.24931469.	IMP	Process
GO:0006626	protein targeting to mitochondrion	-	TAS	Process
GO:0008047	enzyme activator activity	9733512.	TAS	Function
GO:0008237	metallopeptidase activity	19962426.26697887.	EXP	Function
GO:0008270	zinc ion binding	24931469.	IDA	Function
GO:0016485	protein processing	21873635.	IBA	Process
GO:0043085	positive regulation of catalytic activity	-	IEA	Process