EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000107960 (Gene tree)
Gene ID: 79991
Gene Symbol: STN1
Alias: FLJ22559|bA541N10.2|OBFC1
Full Name: STN1 subunit of CST complex
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 48,030 bases
Position: chr10:103,870,258-103,918,287
Accession: 26200
RBP type: canonical RBP
Summary: OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000224950	tRNA_anti-codon	PF01336.25	1.9e-07	1	1
ENSP00000358779	tRNA_anti-codon	PF01336.25	1.9e-07	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27259814	Short Telomere Length and Ischemic Heart Disease: Observational and Genetic Studies in 290 022 Individuals.	Clin Chem	2016 Aug	Scheller Madrid A	doi: 10.1373/clinchem.2016.258566

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000224950	STN1-201	1417	-	ENSP00000224950	368 (aa)	-	Q9H668
ENST00000369764	STN1-202	1311	-	ENSP00000358779	368 (aa)	-	Q9H668
ENST00000466828	STN1-203	1414	-	-	- (aa)	-	-
ENST00000472951	STN1-204	783	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000107960's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000107960	Lung Diseases, Interstitial	4.6460730E-007	-
ENSG00000107960	Lung Diseases, Interstitial	4.7251010E-007	-
ENSG00000107960	Lung Diseases, Interstitial	2.8198680E-007	-
ENSG00000107960	Telomere	9E-11	23001564
ENSG00000107960	Lung Diseases, Interstitial	2E-8	23583980
ENSG00000107960	Diagnostic Techniques, Cardiovascular	9E-7	17903301
ENSG00000107960	Melanoma	2E-9	28212542
ENSG00000107960	Telomere	7E-11	23535734
ENSG00000107960	Telomere	2E-11	20421499
ENSG00000107960	Thyroid Neoplasms	5E-11	28195142
ENSG00000107960	Carcinoma, Basal Cell	5E-9	27539887
ENSG00000107960	Melanoma	2E-9	26237428

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000107960	rs11191852	10	103896584	T	Nicotine dependence symptom count	29532581	[0.39-0.97] unit decrease	0.68	EFO_0009262
ENSG00000107960	rs4387287	10	103918139	C	Diastolic blood pressure	28739976	[0.16-0.39] unit decrease	0.273	EFO_0006336
ENSG00000107960	rs11191865	10	103913084	A	Interstitial lung disease	23583980	[1.15-1.35]	1.25	EFO_0004244
ENSG00000107960	rs2995264	10	103909085	G	Cutaneous malignant melanoma	26237428	[NR] unit increase	0.16	EFO_0000389
ENSG00000107960	rs9419958	10	103916188	T	Telomere length	23001564	[0.057-0.108] unit increase	0.0829	EFO_0004505
ENSG00000107960	rs9420907	10	103916707	A	Telomere length	23535734	[0.049-0.089] unit decrease	0.069	EFO_0004505
ENSG00000107960	rs4387287	10	103918139	A	Telomere length	20421499	[0.06-0.14] kb increase	0.1	EFO_0004505
ENSG00000107960	rs12765878	10	103909864	T	Coronary artery disease	29212778	[0.022-0.043] unit decrease	0.0327	EFO_0000378
ENSG00000107960	rs4387287	10	103918139	A	Diastolic blood pressure	27618447	[0.15-0.29] mmHg increase	0.2243	EFO_0006336
ENSG00000107960	rs4387287	10	103918139	A	Systolic blood pressure	27618447	mmHg increase	0.361	EFO_0006335
ENSG00000107960	rs4387287	10	103918139	A	Hypertension	27618447	z score increase	5.583	EFO_0000537
ENSG00000107960	rs11598018	10	103901557	C	Non-glioblastoma glioma	28346443	1.09-1.20	1.14	EFO_0000326\|EFO_0005543
ENSG00000107960	rs2995264	10	103909085	G	Melanoma	28212542	[NR]	1.17	EFO_0000756
ENSG00000107960	rs3814219	10	103887337	?	Endothelial function traits	17903301			EFO_0004298
ENSG00000107960	rs11191847	10	103890868	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000107960	rs10786774	10	103884565	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000107960's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000107960	STN1	100	80.323	ENSAMEG00000017971	STN1	98	80.323	Ailuropoda_melanoleuca
ENSG00000107960	STN1	100	58.266	ENSAPLG00000006661	STN1	100	58.266	Anas_platyrhynchos
ENSG00000107960	STN1	100	47.838	ENSACAG00000004954	STN1	100	47.838	Anolis_carolinensis
ENSG00000107960	STN1	100	95.652	ENSANAG00000038147	STN1	100	95.652	Aotus_nancymaae
ENSG00000107960	STN1	100	82.749	ENSBTAG00000015019	STN1	100	82.749	Bos_taurus
ENSG00000107960	STN1	100	94.293	ENSCJAG00000040388	STN1	100	94.293	Callithrix_jacchus
ENSG00000107960	STN1	100	82.086	ENSCAFG00000010483	STN1	100	82.086	Canis_familiaris
ENSG00000107960	STN1	100	81.452	ENSCAFG00020010650	STN1	100	81.452	Canis_lupus_dingo
ENSG00000107960	STN1	100	69.293	ENSCHIG00000003253	-	98	72.507	Capra_hircus
ENSG00000107960	STN1	100	81.892	ENSCHIG00000019425	-	100	82.480	Capra_hircus
ENSG00000107960	STN1	88	78.769	ENSCAPG00000016278	STN1	100	78.769	Cavia_aperea
ENSG00000107960	STN1	100	79.404	ENSCPOG00000006273	STN1	98	79.404	Cavia_porcellus
ENSG00000107960	STN1	100	94.565	ENSCCAG00000020507	STN1	100	94.565	Cebus_capucinus
ENSG00000107960	STN1	100	97.283	ENSCATG00000043103	STN1	100	97.283	Cercocebus_atys
ENSG00000107960	STN1	100	81.843	ENSCLAG00000001617	STN1	98	81.843	Chinchilla_lanigera
ENSG00000107960	STN1	100	97.011	ENSCSAG00000005318	STN1	100	97.011	Chlorocebus_sabaeus
ENSG00000107960	STN1	100	60.163	ENSCPBG00000024481	STN1	100	60.163	Chrysemys_picta_bellii
ENSG00000107960	STN1	100	97.011	ENSCANG00000029004	STN1	100	97.011	Colobus_angolensis_palliatus
ENSG00000107960	STN1	100	63.342	ENSCGRG00001023175	Stn1	98	63.342	Cricetulus_griseus_chok1gshd
ENSG00000107960	STN1	100	71.429	ENSCGRG00000004324	Stn1	98	71.429	Cricetulus_griseus_crigri
ENSG00000107960	STN1	97	44.959	ENSDARG00000007734	stn1	96	44.959	Danio_rerio
ENSG00000107960	STN1	86	84.326	ENSDNOG00000011022	STN1	99	84.326	Dasypus_novemcinctus
ENSG00000107960	STN1	96	82.203	ENSDORG00000005994	Stn1	100	81.793	Dipodomys_ordii
ENSG00000107960	STN1	98	73.889	ENSETEG00000013967	STN1	98	73.889	Echinops_telfairi
ENSG00000107960	STN1	100	86.559	ENSEASG00005015134	STN1	100	86.559	Equus_asinus_asinus
ENSG00000107960	STN1	100	85.984	ENSECAG00000023477	STN1	100	87.062	Equus_caballus
ENSG00000107960	STN1	96	82.535	ENSFCAG00000030378	STN1	100	82.114	Felis_catus
ENSG00000107960	STN1	100	58.065	ENSFALG00000008791	STN1	100	58.065	Ficedula_albicollis
ENSG00000107960	STN1	100	78.591	ENSFDAG00000007528	STN1	98	78.591	Fukomys_damarensis
ENSG00000107960	STN1	100	56.873	ENSGALG00000008304	STN1	100	56.873	Gallus_gallus
ENSG00000107960	STN1	79	58.703	ENSGAGG00000003673	STN1	89	58.703	Gopherus_agassizii
ENSG00000107960	STN1	100	99.185	ENSGGOG00000008979	STN1	100	99.185	Gorilla_gorilla
ENSG00000107960	STN1	100	82.927	ENSHGLG00000002775	OBFC1	98	82.927	Heterocephalus_glaber_female
ENSG00000107960	STN1	100	82.656	ENSHGLG00100012701	STN1	98	82.656	Heterocephalus_glaber_male
ENSG00000107960	STN1	98	41.144	ENSHCOG00000002048	stn1	98	41.144	Hippocampus_comes
ENSG00000107960	STN1	100	81.572	ENSSTOG00000011905	STN1	98	81.572	Ictidomys_tridecemlineatus
ENSG00000107960	STN1	99	74.054	ENSJJAG00000020389	Stn1	99	74.054	Jaculus_jaculus
ENSG00000107960	STN1	99	44.086	ENSLACG00000012381	STN1	99	44.086	Latimeria_chalumnae
ENSG00000107960	STN1	97	84.298	ENSLAFG00000004232	STN1	98	84.000	Loxodonta_africana
ENSG00000107960	STN1	100	97.283	ENSMFAG00000041817	STN1	100	97.283	Macaca_fascicularis
ENSG00000107960	STN1	100	97.283	ENSMMUG00000015323	STN1	100	97.283	Macaca_mulatta
ENSG00000107960	STN1	100	96.739	ENSMNEG00000031906	STN1	100	96.739	Macaca_nemestrina
ENSG00000107960	STN1	100	97.011	ENSMLEG00000040619	STN1	100	97.011	Mandrillus_leucophaeus
ENSG00000107960	STN1	100	57.447	ENSMGAG00000010550	STN1	98	57.447	Meleagris_gallopavo
ENSG00000107960	STN1	100	73.046	ENSMAUG00000015671	Stn1	98	73.046	Mesocricetus_auratus
ENSG00000107960	STN1	100	84.054	ENSMICG00000012547	STN1	100	86.486	Microcebus_murinus
ENSG00000107960	STN1	100	65.239	ENSMOCG00000009637	Stn1	98	65.239	Microtus_ochrogaster
ENSG00000107960	STN1	100	69.705	ENSMODG00000011003	STN1	100	69.705	Monodelphis_domestica
ENSG00000107960	STN1	100	71.968	MGP_CAROLIEiJ_G0023057	Stn1	98	71.968	Mus_caroli
ENSG00000107960	STN1	100	70.350	ENSMUSG00000042694	Stn1	98	70.350	Mus_musculus
ENSG00000107960	STN1	100	71.968	MGP_PahariEiJ_G0014547	Stn1	98	71.968	Mus_pahari
ENSG00000107960	STN1	100	70.081	MGP_SPRETEiJ_G0023978	Stn1	98	70.081	Mus_spretus
ENSG00000107960	STN1	100	73.585	ENSMPUG00000016800	STN1	100	73.585	Mustela_putorius_furo
ENSG00000107960	STN1	100	81.818	ENSMLUG00000002037	STN1	98	81.818	Myotis_lucifugus
ENSG00000107960	STN1	100	79.784	ENSNGAG00000023986	Stn1	98	79.784	Nannospalax_galili
ENSG00000107960	STN1	100	98.641	ENSNLEG00000015282	STN1	100	98.641	Nomascus_leucogenys
ENSG00000107960	STN1	100	78.320	ENSOPRG00000010707	STN1	100	78.320	Ochotona_princeps
ENSG00000107960	STN1	98	73.611	ENSODEG00000007270	STN1	96	73.611	Octodon_degus
ENSG00000107960	STN1	100	66.307	ENSOANG00000001628	STN1	100	66.307	Ornithorhynchus_anatinus
ENSG00000107960	STN1	100	81.941	ENSOCUG00000003028	STN1	98	83.019	Oryctolagus_cuniculus
ENSG00000107960	STN1	98	42.120	ENSORLG00000002353	stn1	99	42.120	Oryzias_latipes
ENSG00000107960	STN1	98	42.391	ENSORLG00020012935	stn1	98	42.391	Oryzias_latipes_hni
ENSG00000107960	STN1	98	42.120	ENSORLG00015012154	stn1	98	42.120	Oryzias_latipes_hsok
ENSG00000107960	STN1	100	83.378	ENSOGAG00000008722	STN1	98	83.378	Otolemur_garnettii
ENSG00000107960	STN1	100	81.600	ENSOARG00000004883	STN1	98	81.600	Ovis_aries
ENSG00000107960	STN1	100	99.185	ENSPPAG00000030947	STN1	100	99.185	Pan_paniscus
ENSG00000107960	STN1	96	82.817	ENSPPRG00000010476	STN1	100	82.385	Panthera_pardus
ENSG00000107960	STN1	96	81.111	ENSPTIG00000017333	STN1	100	80.749	Panthera_tigris_altaica
ENSG00000107960	STN1	100	99.185	ENSPTRG00000002919	STN1	100	99.185	Pan_troglodytes
ENSG00000107960	STN1	100	97.283	ENSPANG00000020926	STN1	100	97.283	Papio_anubis
ENSG00000107960	STN1	97	41.622	ENSPKIG00000000721	stn1	97	41.622	Paramormyrops_kingsleyae
ENSG00000107960	STN1	100	57.412	ENSPSIG00000010802	STN1	100	57.412	Pelodiscus_sinensis
ENSG00000107960	STN1	100	73.387	ENSPEMG00000013944	Stn1	98	73.387	Peromyscus_maniculatus_bairdii
ENSG00000107960	STN1	100	70.190	ENSPCIG00000024497	STN1	100	70.190	Phascolarctos_cinereus
ENSG00000107960	STN1	100	98.098	ENSPPYG00000002628	STN1	100	98.098	Pongo_abelii
ENSG00000107960	STN1	100	86.757	ENSPCOG00000017648	STN1	100	86.757	Propithecus_coquereli
ENSG00000107960	STN1	100	83.967	ENSPVAG00000004187	STN1	100	83.967	Pteropus_vampyrus
ENSG00000107960	STN1	100	70.081	ENSRNOG00000020376	Stn1	98	70.081	Rattus_norvegicus
ENSG00000107960	STN1	100	97.554	ENSRBIG00000039819	STN1	100	97.554	Rhinopithecus_bieti
ENSG00000107960	STN1	100	97.826	ENSRROG00000013903	STN1	100	97.826	Rhinopithecus_roxellana
ENSG00000107960	STN1	100	96.196	ENSSBOG00000031516	STN1	100	96.196	Saimiri_boliviensis_boliviensis
ENSG00000107960	STN1	100	68.022	ENSSHAG00000017550	STN1	100	68.022	Sarcophilus_harrisii
ENSG00000107960	STN1	100	42.408	ENSSFOG00015004107	stn1	100	42.408	Scleropages_formosus
ENSG00000107960	STN1	100	84.595	ENSSSCG00000010605	STN1	85	84.595	Sus_scrofa
ENSG00000107960	STN1	100	55.585	ENSTGUG00000010354	STN1	100	55.585	Taeniopygia_guttata
ENSG00000107960	STN1	98	43.443	ENSTNIG00000014162	stn1	96	43.443	Tetraodon_nigroviridis
ENSG00000107960	STN1	66	88.235	ENSTBEG00000000659	STN1	66	88.235	Tupaia_belangeri
ENSG00000107960	STN1	100	84.282	ENSTTRG00000003375	STN1	100	84.282	Tursiops_truncatus
ENSG00000107960	STN1	100	76.011	ENSUMAG00000023647	STN1	100	76.011	Ursus_maritimus
ENSG00000107960	STN1	100	86.992	ENSVPAG00000002530	STN1	100	86.992	Vicugna_pacos
ENSG00000107960	STN1	100	80.697	ENSVVUG00000004636	-	60	80.697	Vulpes_vulpes
ENSG00000107960	STN1	96	49.725	ENSXETG00000011402	STN1	100	48.942	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000723	telomere maintenance	19854130.	IMP	Process
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000784	nuclear chromosome, telomeric region	21873635.	IBA	Component
GO:0000784	nuclear chromosome, telomeric region	19648609.19854130.	IDA	Component
GO:0001650	fibrillar center	-	IDA	Component
GO:0003697	single-stranded DNA binding	-	ISS	Function
GO:0005515	protein binding	19648609.19854130.22763445.25416956.25910212.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	19854130.	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0010833	telomere maintenance via telomere lengthening	21873635.	IBA	Process
GO:0010833	telomere maintenance via telomere lengthening	19648609.	IMP	Process
GO:0016233	telomere capping	21873635.	IBA	Process
GO:0016233	telomere capping	22763445.	TAS	Process
GO:0032211	negative regulation of telomere maintenance via telomerase	21873635.	IBA	Process
GO:0032211	negative regulation of telomere maintenance via telomerase	22763445.	IDA	Process
GO:0042162	telomeric DNA binding	21873635.	IBA	Function
GO:0042162	telomeric DNA binding	19854130.	IDA	Function
GO:0043047	single-stranded telomeric DNA binding	21873635.	IBA	Function
GO:0043047	single-stranded telomeric DNA binding	19648609.	IDA	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0045740	positive regulation of DNA replication	-	ISS	Process
GO:1990879	CST complex	21873635.	IBA	Component
GO:1990879	CST complex	19854130.22763445.	IDA	Component