EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108010 (Gene tree)
Gene ID: 10539
Gene Symbol: GLRX3
Alias: PICOT|bA500G10.4|GRX3|GLRX4|GRX4|TXNL2
Full Name: glutaredoxin 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 48,147 bases
Position: chr10:130,136,375-130,184,521
Accession: 15987
RBP type: non-canonical RBP
Summary: This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000486974	GLRX3-204	242	-	-	- (aa)	-	-
ENST00000368644	GLRX3-202	3827	XM_017015474	ENSP00000357633	335 (aa)	XP_016870963	O76003
ENST00000619341	GLRX3-206	496	-	-	- (aa)	-	-
ENST00000331244	GLRX3-201	1302	-	ENSP00000330836	335 (aa)	-	O76003
ENST00000496195	GLRX3-205	317	-	-	- (aa)	-	-
ENST00000481034	GLRX3-203	1921	-	ENSP00000435445	335 (aa)	-	O76003

Gene Model

Click here to download ENSG00000108010's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000108010	Uric Acid	4.80916660096385E-12	17903292
ENSG00000108010	Stroke	1.9730084E-004	19369658
ENSG00000108010	Blood Pressure	9.028e-005	19060910
ENSG00000108010	Cholesterol	7.982e-005	-
ENSG00000108010	Respiratory Function Tests	3.1260000E-005	-
ENSG00000108010	Antihypertensive Agents	9.2200000E-005	-
ENSG00000108010	Antihypertensive Agents	7.8400000E-005	-
ENSG00000108010	Antihypertensive Agents	1.2810000E-005	-
ENSG00000108010	Antihypertensive Agents	5.3010000E-005	-
ENSG00000108010	Antihypertensive Agents	3.7420000E-005	-
ENSG00000108010	Hypertrophy, Left Ventricular	8.6000000E-005	-
ENSG00000108010	Cardiovascular Physiological Phenomena	7.0660000E-005	-
ENSG00000108010	Cardiovascular Physiological Phenomena	3.6660000E-005	-
ENSG00000108010	Cardiovascular Physiological Phenomena	4.9280000E-005	-
ENSG00000108010	Cardiovascular Physiological Phenomena	4.2430000E-005	-
ENSG00000108010	Cardiovascular Physiological Phenomena	7.2710000E-005	-
ENSG00000108010	Cardiovascular Physiological Phenomena	4.5870000E-005	-
ENSG00000108010	Smoking	6.0800000E-006	-
ENSG00000108010	Smoking	1.0300000E-007	-
ENSG00000108010	Smoking	1.0100000E-005	-
ENSG00000108010	Smoking	9.4500000E-006	-
ENSG00000108010	Platelet Function Tests	1.8318200E-005	-
ENSG00000108010	Platelet Function Tests	2.2400000E-006	-
ENSG00000108010	Platelet Function Tests	5.6166277E-006	-
ENSG00000108010	Platelet Function Tests	1.0108000E-005	-
ENSG00000108010	Platelet Function Tests	2.5619904E-006	-
ENSG00000108010	Autistic Disorder	1.5934000E-005	-
ENSG00000108010	Testosterone	4.3250000E-005	-
ENSG00000108010	Folic Acid	2.7980000E-005	-
ENSG00000108010	Folic Acid	2.2380000E-005	-
ENSG00000108010	alpha-Tocopherol	4.7310000E-005	-
ENSG00000108010	Alcoholism	9E-6	26365420
ENSG00000108010	HIV-1	7E-6	21160409
ENSG00000108010	Conotruncal cardiac defects	3E-7	24800985
ENSG00000108010	Speech Perception	7E-6	19786962
ENSG00000108010	Body Weight	4E-6	23251661
ENSG00000108010	Insulin Resistance	3E-8	22791750
ENSG00000108010	Body Composition	9E-6	23251661
ENSG00000108010	dimethylarginine	6E-6	24159190
ENSG00000108010	Migraine Disorders	1E-7	23793025
ENSG00000108010	Insulin	1E-7	22791750

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108010's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108010	GLRX3	91	47.264	FBgn0032509	CG6523	93	47.264	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002026	regulation of the force of heart contraction	18258855.	ISS	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005080	protein kinase C binding	-	IEA	Function
GO:0005515	protein binding	10636891.15846844.16189514.21516116.25416956.25910212.26302480.26871637.27107012.27519415.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005938	cell cortex	-	IEA	Component
GO:0006879	cellular iron ion homeostasis	21873635.	IBA	Process
GO:0009055	electron transfer activity	-	IEA	Function
GO:0010614	negative regulation of cardiac muscle hypertrophy	-	ISS	Process
GO:0015035	protein disulfide oxidoreductase activity	-	IEA	Function
GO:0015038	glutathione disulfide oxidoreductase activity	21873635.	IBA	Function
GO:0022900	electron transport chain	-	IEA	Process
GO:0030018	Z disc	-	IEA	Component
GO:0030425	dendrite	-	IEA	Component
GO:0042802	identical protein binding	25416956.26302480.	IPI	Function
GO:0044571	[2Fe-2S] cluster assembly	27519415.	IDA	Process
GO:0045454	cell redox homeostasis	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051536	iron-sulfur cluster binding	-	IEA	Function
GO:0097428	protein maturation by iron-sulfur cluster transfer	27519415.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18528843	Identification and distribution of thioredoxin-like 2 as the antigen for the monoclonal antibody MC3 specific to colorectal cancer.	Proteomics	2008 Jun	Lu Y	doi: 10.1002/pmic.200700770.
21123948	Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-??B signaling.	J Clin Invest	2011 Jan	Qu Y	doi: 10.1172/JCI43144
19797004	Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma.	Cancer Epidemiol	2009 Oct	Cha MK	doi: 10.1016/j.canep.2009.08.006

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	130160859	Nonsense_Mutation	rs769979468	R114*	0.28
BLCA	chr10	130171614	Missense_Mutation	NA	L268V	0.19
BLCA	chr10	130166578	Missense_Mutation	NA	D184N	0.2
BRCA	chr10	130166639	Missense_Mutation	rs373775553	Y204C	0.23
BRCA	chr10	130160933	Missense_Mutation	novel	K138N	0.1
CESC	chr10	130145281	Nonsense_Mutation	novel	E55*	0.31
CESC	chr10	130166961	Missense_Mutation	novel	A232T	0.35
COAD	chr10	130160983	Missense_Mutation	novel	Q155P	0.22
COAD	chr10	130179381	Missense_Mutation	NA	G333R	0.34
COAD	chr10	130160860	Missense_Mutation	rs775786978	R114Q	0.3
COAD	chr10	130179376	Missense_Mutation	novel	L331P	0.36
COAD	chr10	130175020	Silent	novel	Y296Y	0.47
COAD	chr10	130145293	Nonsense_Mutation	NA	E59*	0.2
COAD	chr10	130174886	Missense_Mutation	rs751236022	D282N	0.05
COAD	chr10	130145314	Missense_Mutation	rs753162172	V66M	0.13
COAD	chr10	130145269	Missense_Mutation	rs188360612	E51K	0.37
COAD	chr10	130174872	Missense_Mutation	novel	E277G	0.37
ESCA	chr10	130166551	Nonsense_Mutation	novel	Q175*	0.65
HNSC	chr10	130175000	Missense_Mutation	rs755871807	R290W	0.15
KIRC	chr10	130166576	Frame_Shift_Ins	novel	D184*	0.04
KIRP	chr10	130166558	Missense_Mutation	NA	S177I	0.24
KIRP	chr10	130179507	3'UTR	novel		0.07
KIRP	chr10	130179509	3'UTR	novel		0.05
LIHC	chr10	130179493	3'UTR	novel		0.32
LUAD	chr10	130174881	Missense_Mutation	NA	T280I	0.1
LUAD	chr10	130166930	Silent	NA	A221A	0.28
LUAD	chr10	130160918	Silent	novel	L133L	0.16
LUAD	chr10	130166595	Missense_Mutation	NA	Q189H	0.4
LUAD	chr10	130174865	Splice_Site	NA	X275_splice	0.59
LUSC	chr10	130169466	Missense_Mutation	NA	M249I	0.45
LUSC	chr10	130171582	Splice_Site	novel	X258_splice	0.52
LUSC	chr10	130160004	Missense_Mutation	NA	E71K	0.19
LUSC	chr10	130175001	Missense_Mutation	rs370646206	R290Q	0.05
OV	chr10	130160004	Missense_Mutation	NA	E71K	0.09
PAAD	chr10	130160810	Silent	rs748966258	I97I	0.32
PAAD	chr10	130175072	Missense_Mutation	novel	G314R	0.13
PRAD	chr10	130179534	3'UTR	novel		0.25
READ	chr10	130160994	Missense_Mutation	novel	C159R	0.59
READ	chr10	130166937	Nonsense_Mutation	NA	E224*	0.08
SKCM	chr10	130160813	Silent	novel	D98D	0.22
SKCM	chr10	130160814	Nonsense_Mutation	novel	R99*	0.22
SKCM	chr10	130166919	Missense_Mutation	novel	E218K	0.58
SKCM	chr10	130166551	Nonsense_Mutation	novel	Q175*	0.49
SKCM	chr10	130160049	Missense_Mutation	NA	P86S	0.37
SKCM	chr10	130160810	Silent	rs748966258	I97I	0.63
STAD	chr10	130145293	Nonsense_Mutation	NA	E59*	0.28
STAD	chr10	130160047	Missense_Mutation	novel	V85A	0.26
STAD	chr10	130175058	Missense_Mutation	novel	G309E	0.42
STAD	chr10	130160951	Silent	novel	A144A	0.2
STAD	chr10	130169457	Frame_Shift_Ins	novel	*F251Cfs26**	0.11
STAD	chr10	130160033	Nonsense_Mutation	NA	Y80*	0.25
STAD	chr10	130179557	3'UTR	novel		0.33
STAD	chr10	130160061	Frame_Shift_Del	novel	*F91Sfs10**	0.16
STAD	chr10	130175000	Missense_Mutation	rs755871807	R290W	0.32
THYM	chr10	130179566	3'UTR	novel		0.12
UCEC	chr10	130179544	3'UTR	novel		0.38
UCEC	chr10	130166676	Silent	novel	I216I	0.15
UCEC	chr10	130174886	Missense_Mutation	NA	D282Y	0.3
UCEC	chr10	130179384	Nonsense_Mutation	NA	E334*	0.43
UCEC	chr10	130174886	Missense_Mutation	rs751236022	D282N	0.31
UCEC	chr10	130166937	Nonsense_Mutation	NA	E224*	0.19
UCEC	chr10	130160958	Missense_Mutation	rs141914058	M147V	0.2
UCEC	chr10	130160974	Missense_Mutation	NA	G152E	0.45
UCEC	chr10	130160811	Missense_Mutation	rs754777393	D98N	0.33
UCEC	chr10	130160052	Frame_Shift_Ins	novel	*L89Sfs30**	0.16
UCEC	chr10	130171591	Missense_Mutation	novel	K260T	0.37
UCEC	chr10	130160973	Nonsense_Mutation	NA	G152*	0.39
UCEC	chr10	130166650	Missense_Mutation	novel	E208K	0.75
UCEC	chr10	130160859	Nonsense_Mutation	rs769979468	R114*	0.32
UCEC	chr10	130171634	Splice_Region	NA	T274T	0.27
UCEC	chr10	130166525	Missense_Mutation	novel	V166A	0.44
UCEC	chr10	130171618	Missense_Mutation	novel	E269V	0.18
UCEC	chr10	130179513	3'UTR	novel		0.28
UCEC	chr10	130145269	Missense_Mutation	rs188360612	E51K	0.29
UCEC	chr10	130174870	Silent	rs765784800	V276V	0.21
UCEC	chr10	130145269	Missense_Mutation	rs188360612	E51K	0.31
UCEC	chr10	130171614	Missense_Mutation	NA	L268M	0.17
UCEC	chr10	130179351	Nonsense_Mutation	NA	E323*	0.29
UCEC	chr10	130145269	Missense_Mutation	rs188360612	E51K	0.15
UCEC	chr10	130179346	Missense_Mutation	novel	L321P	0.34
UCEC	chr10	130145225	Missense_Mutation	novel	V36A	0.17
UCEC	chr10	130179534	3'UTR	novel		0.26
UCEC	chr10	130169438	Missense_Mutation	novel	K240T	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1111	0.19593
BRCA	DEL	0.2296	9.4498e-14
CHOL	DEL	0.2222	0.048655
COAD	DEL	0.1619	9.4741e-07
LGG	DEL	0.2671	4.3789e-20
LIHC	DEL	0.2541	5.7505e-06
LUAD	DEL	0.186	0.032471
MESO	DEL	0.2644	0.00015289
PAAD	DEL	0.1196	0.169
READ	DEL	0.2061	0.014135
THYM	DEL	0.0488	0.10563
UCS	DEL	0.2679	0.1218

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0081	Kaplan-Meier Survival Analysis
SARC	0.0096	Kaplan-Meier Survival Analysis
MESO	0.014	Kaplan-Meier Survival Analysis
ACC	0.0023	Kaplan-Meier Survival Analysis
PRAD	0.024	Kaplan-Meier Survival Analysis
LUSC	0.039	Kaplan-Meier Survival Analysis
BRCA	0.014	Kaplan-Meier Survival Analysis
ESCA	0.0066	Kaplan-Meier Survival Analysis
KIRP	0.016	Kaplan-Meier Survival Analysis
PAAD	0.00064	Kaplan-Meier Survival Analysis
KICH	0.048	Kaplan-Meier Survival Analysis
UCEC	0.043	Kaplan-Meier Survival Analysis
LIHC	0.00017	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.015	Kaplan-Meier Survival Analysis
OV	0.02	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742