EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108055 (Gene tree)
Gene ID: 9126
Gene Symbol: SMC3
Alias: HCAP|BAM|SMC3L1|bamacan|CSPG6
Full Name: structural maintenance of chromosomes 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 36,946 bases
Position: chr10:110,567,691-110,604,636
Accession: 2468
RBP type: non-canonical RBP
Summary: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22163028	Differential roles of HOW in male and female Drosophila germline differentiation.	PLoS One	2011	Monk AC	doi: 10.1371/journal.pone.0028508

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000361804	SMC3-201	4114	-	ENSP00000354720	1217 (aa)	-	Q9UQE7
ENST00000462899	SMC3-202	777	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000108055's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04114	Oocyte meiosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000108055	Platelet Function Tests	3.1086240E-015	-
ENSG00000108055	Warfarin	6.3170000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108055's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108055	SMC3	100	99.918	ENSMUSG00000024974	Smc3	100	99.918	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	9506951.	TAS	Process
GO:0000775	chromosome, centromeric region	-	TAS	Component
GO:0000785	chromatin	16682347.19907496.	IDA	Component
GO:0000800	lateral element	-	IEA	Component
GO:0003682	chromatin binding	-	IEA	Function
GO:0003777	microtubule motor activity	11590136.	NAS	Function
GO:0005515	protein binding	9506951.11590136.11983169.15656913.15737063.15837422.15855230.16682347.16802858.17105772.17112726.17113138.17349791.17962804.18235444.18832153.19444697.19629043.19907496.20818333.22293751.22540012.22628566.22885700.23242214.24299456.26496610.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005604	basement membrane	8621634.	TAS	Component
GO:0005634	nucleus	9506951.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006275	regulation of DNA replication	19907496.	IMP	Process
GO:0006281	DNA repair	-	IEA	Process
GO:0007062	sister chromatid cohesion	15917200.	IMP	Process
GO:0007062	sister chromatid cohesion	11590136.	NAS	Process
GO:0008278	cohesin complex	11590136.22628566.	IDA	Component
GO:0008278	cohesin complex	9506951.	NAS	Component
GO:0016363	nuclear matrix	11590136.	IDA	Component
GO:0019827	stem cell population maintenance	-	IEA	Process
GO:0030893	meiotic cohesin complex	21242291.	IDA	Component
GO:0032876	negative regulation of DNA endoreduplication	15917200.	IMP	Process
GO:0034991	nuclear meiotic cohesin complex	-	IEA	Component
GO:0036033	mediator complex binding	-	IEA	Function
GO:0044791	positive regulation by host of viral release from host cell	19444697.	IDA	Process
GO:0046982	protein heterodimerization activity	11590136.	IPI	Function
GO:0048487	beta-tubulin binding	11590136.	IDA	Function
GO:0051301	cell division	-	IEA	Process
GO:0051321	meiotic cell cycle	12498344.	IDA	Process
GO:0051702	interaction with symbiont	19444697.	IDA	Process
GO:0070840	dynein complex binding	11590136.	IDA	Function
GO:0097431	mitotic spindle pole	11590136.	IDA	Component
GO:1901673	regulation of mitotic spindle assembly	11590136.	IMP	Process