EuRBPDB

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  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000108312 (Gene tree)
Gene ID
7343
Gene Symbol
UBTF
Alias
UBF|NOR-90|UBF1|UBF2
Full Name
upstream binding transcription factor
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
16,594 bases
Position
chr17:44,205,033-44,221,626
Accession
12511
RBP type
non-canonical RBP
Summary
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
1940801Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor.J Exp Med1991 Nov 1Chan EK-
15970593TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.J Biol Chem2005 Aug 19Friedrich JK-
22426501Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription.Int J Mol Med2012 JunDieriks Bdoi: 10.3892/ijmm.2012.937
20713446Regulation of nucleolar chromatin by B23/nucleophosmin jointly depends upon its RNA binding activity and transcription factor UBF.Mol Cell Biol2010 OctHisaoka Mdoi: 10.1128/MCB.00299-10
9843972Phosphorylation of the rRNA transcription factor upstream binding factor promotes its association with TATA binding protein.Proc Natl Acad Sci U S A1998 Dec 8Kihm AJ-
20720019Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis.J Biol Chem2010 Nov 19Jimenez-Vidal Mdoi: 10.1074/jbc.M110.165555
26512942Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.Brain Pathol2016 SepHernandez-Ortega Kdoi: 10.1111/bpa.12335
14585813Expression of nucleolar-related proteins in porcine preimplantation embryos produced in vivo and in vitro.Biol Reprod2004 AprBjerregaard B-
21418567Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin.Epigenetics Chromatin2011 Mar 18Stixova Ldoi: 10.1186/1756-8935-4-5.
7491500Coactivator and promoter-selective properties of RNA polymerase I TAFs.Science1995 Dec 1Beckmann H-
2330041Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.Nature1990 Apr 26Jantzen HM-
9688843Regulation of ribosomal DNA transcription by insulin.Am J Physiol1998 JulHannan KMdoi: 10.1152/ajpcell.1998.275.1.C130.
9588897Nucleolar function and size in cancer cells.Am J Pathol1998 MayDerenzini M-
9211969Experimental induction of prenucleolar bodies (PNBs) in interphase cells: interphase PNBs show similar characteristics as those typically observed at telophase of mitosis in untreated cells.Chromosoma1997 JunZatsepina OV-
9211974Relative distribution of rDNA and proteins of the RNA polymerase I transcription machinery at chromosomal NORs.Chromosoma1997 JunSuja JA-
7877691Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product.Nature1995 Mar 9Cavanaugh AH-
11319160Immunolocalization of nucleolar proteins during bovine oocyte growth, meiotic maturation, and fertilization.Biol Reprod2001 MayFair T-
10882521Functional and molecular reorganization of the nucleolar apparatus in maturing mouse oocytes.Dev Biol2000 Jul 15Zatsepina OV-
15533945Regulation of upstream binding factor 1 activity by insulin-like growth factor I receptor signaling.J Biol Chem2005 Jan 28Wu A-
19718949In vitro expression and redistribution of nucleolar proteins following the treatment with cis-dichloro-1,2-propylenediamine-N,N,N',N'-tetraacetato ruthenium (III) (RAP).Oncol Res2009Delmani FA-
17443674Dual regulation of upstream binding factor 1 levels by IRS-1 and ERKs in IGF-1-receptor signaling.J Cell Physiol2007 SepSun H-
21059229CTCF regulates the local epigenetic state of ribosomal DNA repeats.Epigenetics Chromatin2010 Nov 8van de Nobelen Sdoi: 10.1186/1756-8935-3-19.
27589844The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription.Oncotarget2016 Oct 18Johnston Rdoi: 10.18632/oncotarget.11770.
26317157Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells.Oncotarget2015 Sep 29Hamdane Ndoi: 10.18632/oncotarget.4823.
29300972A recurrent de novo missense mutation in UBTF causes developmental neuroregression.Hum Mol Genet2018 Feb 15Toro Cdoi: 10.1093/hmg/ddx435.
29591153-----
31217076Ectopically expressed pNO40 suppresses ribosomal RNA synthesis by inhibiting UBF-dependent transcription activation.Biochem Biophys Res Commun2019 Aug 20Lin YMdoi: 10.1016/j.bbrc.2019.06.057
9819223Cisplatin-DNA adducts inhibit ribosomal RNA synthesis by hijacking the transcription factor human upstream binding factor.Biochemistry1998 Nov 17Zhai X-
1579451Analysis of the rat ribosomal DNA promoter: characterization of linker-scanning mutants and of the binding of UBF.Nucleic Acids Res1992 Apr 11Xie W-
9126496Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping.Genomics1997 Apr 1Matera AG-
8607848The dimerization domain upstream binding factor contains multiple helical structures.Biochem Biophys Res Commun1996 Mar 27Lai YS-
8041627The RNA polymerase I transcription factor UBF is a sequence-tolerant HMG-box protein that can recognize structured nucleic acids.Nucleic Acids Res1994 Jul 11Copenhaver GP-
7935371The RNA polymerase I transactivator upstream binding factor requires its dimerization domain and high-mobility-group (HMG) box 1 to bend, wrap, and positively supercoil enhancer DNA.Mol Cell Biol1994 OctPutnam CD-
21177859hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF).J Biol Chem2011 Mar 4Kong Rdoi: 10.1074/jbc.M110.173393
23591814Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription.J Cell Sci2013 Jun 15Yildirim Sdoi: 10.1242/jcs.123661
10230738The DNA binding domains of UBF represent major human autoepitopes conserved in vertebrates species.Cell Mol Biol (Noisy-le-grand)1999 MarBolivar J-
10082553Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation.Mol Cell Biol1999 AprTuan JC-
3413483Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis.Science1988 Sep 2Bell SP-
2384215Assembly of alternative multiprotein complexes directs rRNA promoter selectivity.Genes Dev1990 JunBell SP-
2035027Similarity of human mitochondrial transcription factor 1 to high mobility group proteins.Science1991 May 17Parisi MA-
1561086Analysis of the phosphorylation, DNA-binding and dimerization properties of the RNA polymerase I transcription factors UBF1 and UBF2.Nucleic Acids Res1992 Mar 25O'Mahony DJ-
1502143Dual role of the nucleolar transcription factor UBF: trans-activator and antirepressor.Proc Natl Acad Sci U S A1992 Aug 15Kuhn A-
1398072Multiple domains of the RNA polymerase I activator hUBF interact with the TATA-binding protein complex hSL1 to mediate transcription.Genes Dev1992 OctJantzen HM-
9639561The first high-mobility-group box of upstream binding factor assembles across-over DNA junction by basic residues.Biochem J1998 Jul 1Hu CH-
9566304Differential effects of heavy metals on the binding of Xenopus upstream binding factor(xUBF) to DNA.Chemosphere1998 AprHsu T-
9378756Association of the nucleolar transcription factor UBF with the transcriptionally inactive rRNA genes of pronuclei and early Xenopus embryos.J Cell Sci1997 SepBell P-
9315641Nucleosome binding by the polymerase I transactivator upstream binding factor displaces linker histone H1.Mol Cell Biol1997 OctKermekchiev M-
9112227The behavior of the coiled body in cells infected with adenovirus in vitro.Mol Biol Rep1996Rodrigues SH-
9112231Antinuclear autoantibodies: probes for defining proteolytic events associated with apoptosis.Mol Biol Rep1996Casiano CA-
9017602Involvement of in situ conformation of ribosomal genes and selective distribution of upstream binding factor in rRNA transcription.Mol Biol Cell1997 JanJunera HR-
9029158The Xenopus RNA polymerase I transcription factor, UBF, has a role in transcriptional enhancement distinct from that at the promoter.EMBO J1997 Jan 15McStay B-
8816469Upstream binding factor stabilizes Rib 1, the TATA-binding-protein-containing Xenopus laevis RNA polymerase I transcription factor, by multiple protein interactions in a DNA-independent manner.Mol Cell Biol1996 OctBodeker M-
10413677Nucleolar localization of murine nuclear DNA helicase II (RNA helicase A).J Cell Sci1999 AugZhang S-
8760832Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis.J Exp Med1996 Aug 1Casiano CA-
8593693Regulation of rDNA transcription during endothelin-1-induced hypertrophy of neonatal cardiomyocytes. Hyperphosphorylation of upstream binding factor, an rDNA transcription factor.Circ Res1996 MarLuyken J-
8609157In vivo evidence that TATA-binding protein/SL1 colocalizes with UBF and RNA polymerase I when rRNA synthesis is either active or inactive.J Cell Biol1996 AprJordan P-
8552083The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor.Mol Cell Biol1996 FebHempel WM-
8411210Phylogenetic relationships of HMG box DNA-binding domains.J Mol Evol1993 AugGriess EA-
8396256Coordinated decreases in rRNA gene transcription factors and rRNA synthesis during muscle cell differentiation.Proc Natl Acad Sci U S A1993 Sep 1Larson DE-
8306961The HMG box-containing nucleolar transcription factor UBF interacts with a specific subunit of RNA polymerase I.EMBO J1994 Jan 1Schnapp G-
8202546Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor).Proc Natl Acad Sci U S A1994 Jun 7Treiber DK-
7982918The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein.J Biol Chem1994 Dec 2Kwon H-
16626289A role for upstream binding factor in organizing ribosomal gene chromatin.Biochem Soc Symp2006Wright JE-
16582105Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I.Nucleic Acids Res2006 Mar 31Meraner J-
12590579Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor.Biochemistry2003 Feb 25Yang W-
11891919Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from granulosa cells.Mol Reprod Dev2002 AprLaurincik J-
11900641Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from embryonic cells.Cloning2001Hyttel P-
11874979Upstream binding factor up-regulated in hepatocellular carcinoma is related to the survival and cisplatin-sensitivity of cancer cells.FASEB J2002 MarHuang R-
11470882DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules.Nucleic Acids Res2001 Aug 1Stefanovsky VY-
11036095Immunohistochemical detection of ribosomal transcription factor UBF and AgNOR staining identify apoptotic events in neoplastic cells of Hodgkin's disease and in other lymphoid cells.J Histochem Cytochem2000 NovTorres-Montaner A-
10930464Initiation of nucleolar assembly is independent of RNA polymerase I transcription.Mol Biol Cell2000 AugDousset T-
10727273Nucleolar proteins and nuclear ultrastructure in preimplantation bovine embryos produced in vitro.Biol Reprod2000 AprLaurincik J-
10653582Nonrandom distribution of metaphase AgNOR staining patterns on human acrocentric chromosomes.J Histochem Cytochem2000 JanHeliot L-
16246141Nucleolar biogenesis: the first small steps.Biochem Soc Trans2005 DecPrieto JL-
16187064Re-localization of nuclear DNA helicase II during the growth period of bovine oocytes.Histochem Cell Biol2006 JanBaran V-
16079186mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators.Am J Physiol Cell Physiol2005 DecNader GA-
15598984UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery.Genes Dev2005 Jan 1Mais C-
15477594Upstream binding factor association induces large-scale chromatin decondensation.Proc Natl Acad Sci U S A2004 Oct 19Chen D-
15197263Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase.Proc Natl Acad Sci U S A2004 Jun 22Drakas R-
15112326Nucleolar ultrastructure and protein allocation in in vitro produced porcine embryos.Mol Reprod Dev2004 JulLaurincik J-
16777843Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription.Hum Mol Genet2006 Jul 15Becherel OJ-
14989163[Activation of transcription of ribosome genes following human embryo fibroblast infection with cytomegalovirus in vitro].Tsitologiia2003Zharskaia OO-
14613906Immunolocalization of upstream binding factor and pocket protein p130 during final stages of bovine oocyte growth.Biol Reprod2004 AprBaran V-
14627545Regulation of ribosomal RNA synthesis during the final phases of porcine oocyte growth.Biol Reprod2004 AprBjerregaard B-
20147409Relocalization of upstream binding factor to viral replication compartments is UL24 independent and follows the onset of herpes simplex virus 1 DNA synthesis.J Virol2010 MayLymberopoulos MHdoi: 10.1128/JVI.02437-09
18502146Asymmetrical distribution of the transcriptionally competent NORs in mitosis.J Struct Biol2008 JulKalmarova Mdoi: 10.1016/j.jsb.2008.04.002
17505112Structure of human upstream binding factor HMG box 5 and site for binding of the cell-cycle regulatory factor TAF1.Acta Crystallogr D Biol Crystallogr2007 JunRong H-
17182730Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor.Am J Physiol Cell Physiol2007 MayLin CH-
17145851A mechanism for cell size regulation by the insulin and insulin-like growth factor-I receptors.Cancer Res2006 Dec 1Sun H-
17063482Downregulation of the upstream binding factor1 by glycogen synthase kinase3beta in myeloid cells induced to differentiate.J Cell Biochem2007 Apr 1Liu M-
22731742Histopathological study comparing upstream binding factor expression and AgNOR staining.Cell Prolif2012 AugTorres-Montaner Adoi: 10.1111/j.1365-2184.2012.00829.x.
21930779Identification of DHX33 as a mediator of rRNA synthesis and cell growth.Mol Cell Biol2011 DecZhang Ydoi: 10.1128/MCB.05832-11
23229552PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis.J Biol Chem2013 Feb 1Wang Jdoi: 10.1074/jbc.M112.414839
25452314A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.Genome Res2015 FebSanij Edoi: 10.1101/gr.176115.114
25121932Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body.PLoS Genet2014 Aug 14Hamdane Ndoi: 10.1371/journal.pgen.1004505
24787739The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis.PLoS One2014 May 1Ponti Ddoi: 10.1371/journal.pone.0096037
24798431Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF.PLoS One2014 May 5Dichamp Idoi: 10.1371/journal.pone.0096136
24662969Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.PLoS One2014 Mar 24Stimpson KMdoi: 10.1371/journal.pone.0092432
26484160Genome wide mapping of UBF binding-sites in mouse and human cell lines.Genom Data2015 Jan 5Diesch Jdoi: 10.1016/j.gdata.2014.12.005
26089203The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development.Hum Mol Genet2015 Sep 1Sun Xdoi: 10.1093/hmg/ddv213
28775694Aging in Rats Differentially Affects Markers of Transcriptional and Translational Capacity in Soleus and Plantaris Muscle.Front Physiol2017 Jul 20Mobley CBdoi: 10.3389/fphys.2017.00518
28806394SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.Oncogene2017 Dec 14Gonyo Pdoi: 10.1038/onc.2017.280
28994181Age-associated dysregulation of protein metabolism in the mammalian oocyte.Aging Cell2017 DecDuncan FEdoi: 10.1111/acel.12676
31068593Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.Nat Commun2019 May 8Prakash Vdoi: 10.1038/s41467-019-10100-8.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000537550UBTF-2141085--- (aa)--
ENST00000529383UBTF-2092570-ENSP00000435708764 (aa)-P17480
ENST00000393606UBTF-2032683XM_017025001ENSP00000377231727 (aa)XP_016880490P17480
ENST00000533177UBTF-2133011XM_017025003ENSP00000437180727 (aa)XP_016880492P17480
ENST00000529042UBTF-207535--- (aa)--
ENST00000529373UBTF-208674-ENSP00000431295194 (aa)-E9PLT2
ENST00000527034UBTF-2063010-ENSP00000431539745 (aa)-E9PKP7
ENST00000343638UBTF-2024684XM_017025000ENSP00000345297727 (aa)XP_016880489P17480
ENST00000302904UBTF-2014997XM_006722059ENSP00000302640764 (aa)XP_006722122P17480
ENST00000526094UBTF-2052459-ENSP00000432925727 (aa)-P17480
ENST00000530828UBTF-211721-ENSP00000433046149 (aa)-E9PMM2
ENST00000436088UBTF-2042738XM_006722060ENSP00000390669764 (aa)XP_006722123P17480
ENST00000529947UBTF-210685-ENSP0000043362536 (aa)-H0YDH7
ENST00000531368UBTF-212431--- (aa)--
Gene Model
Click here to download ENSG00000108312's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000108312Erythrocyte Indices1E-828017375
ENSG00000108312Erythrocyte Indices4E-728017375
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000108312rs22699061744216969?Mean corpuscular hemoglobin concentration28017375EFO_0004528
ENSG00000108312rs22699061744216969?Mean corpuscular hemoglobin concentration28017375EFO_0004528
ENSG00000108312rs99100551744205669TTotal body bone mineral density29304378unit increase0.0442EFO_0003923
ENSG00000108312rs99100551744205669TTotal body bone mineral density29304378unit increase0.0441EFO_0003923
ENSG00000108312rs20711671744210151TBody fat distribution (leg fat ratio)30664634NR unit decrease (replication)0.01332EFO_0004341
ENSG00000108312rs20711671744210151TBody fat distribution (trunk fat ratio)30664634NR unit increase (replication)0.01801EFO_0004341
ENSG00000108312rs20711671744210151TBody fat distribution (trunk fat ratio)30664634NR unit increase (replication)0.01132EFO_0004341
ENSG00000108312rs20711671744210151TBody fat distribution (leg fat ratio)30664634NR unit decrease (replication)0.02265EFO_0004341
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108312's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000108312UBTF100100.000ENSMUSG00000020923Ubtf99100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.ISMFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.NASFunction
GO:0001164RNA polymerase I CORE element sequence-specific DNA binding22368283.IDAFunction
GO:0001165RNA polymerase I upstream control element sequence-specific DNA binding22368283.IDAFunction
GO:0001188RNA polymerase I preinitiation complex assembly-IEAProcess
GO:0001650fibrillar center-IDAComponent
GO:0003682chromatin binding26089203.IDAFunction
GO:0003723RNA binding22681889.HDAFunction
GO:0005515protein binding12498690.16777843.17251981.17318177.19174463.20075868.20160071.20195357.20208542.21150319.21930779.26089203.27729611.IPIFunction
GO:0005634nucleus22368283.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus12498690.22368283.IDAComponent
GO:0005730nucleolus-ISSComponent
GO:0006356regulation of transcription by RNA polymerase I12498690.NASProcess
GO:0006357regulation of transcription by RNA polymerase II-IEAProcess
GO:0006360transcription by RNA polymerase I28777933.IMPProcess
GO:0006361transcription initiation from RNA polymerase I promoter-TASProcess
GO:0006362transcription elongation from RNA polymerase I promoter-TASProcess
GO:0006363termination of RNA polymerase I transcription-TASProcess
GO:0045943positive regulation of transcription by RNA polymerase I-ISSProcess
GO:0097110scaffold protein binding23203802.IPIFunction
GO:1902659regulation of glucose mediated signaling pathway22368283.IDAProcess

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