EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108349 (Gene tree)
Gene ID: 22794
Gene Symbol: CASC3
Alias: MLN51|BTZ
Full Name: CASC3 exon junction complex subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 31,930 bases
Position: chr17:40,140,254-40,172,183
Accession: 17040
RBP type: canonical RBP
Summary: The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000264645	Btz	PF09405.10	4.3e-23	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24360960	Interactome of two diverse RNA granules links mRNA localization to translational repression in neurons.	Cell Rep	2013 Dec 26	Fritzsche R	doi: 10.1016/j.celrep.2013.11.023
16775137	Dendritic localization of the translational repressor Pumilio 2 and its contribution to dendritic stress granules.	J Neurosci	2006 Jun 14	Vessey JP	-
27475226	Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.	Cell Rep	2016 Aug 9	Hauer C	doi: 10.1016/j.celrep.2016.06.096
16797590	The three-dimensional arcitecture of the EJC core.	J Mol Biol	2006 Jul 21	Stroupe ME	-
15166247	Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.	J Biol Chem	2004 Aug 6	Degot S	-
23530232	EJC core component MLN51 interacts with eIF3 and activates translation.	Proc Natl Acad Sci U S A	2013 Apr 9	Chazal PE	doi: 10.1073/pnas.1218732110
27071313	Two highly similar DEAD box proteins, OsRH2 and OsRH34, homologous to eukaryotic initiation factor 4AIII, play roles of the exon junction complex in regulating growth and development in rice.	BMC Plant Biol	2016 Apr 12	Huang CK	doi: 10.1186/s12870-016-0769-5.
29791316	Roles of the exon junction complex components in the central nervous system: a mini review.	Rev Neurosci	2018 Nov 27	Bartkowska K	doi: 10.1515/revneuro-2017-0113.
17652158	The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly.	J Cell Sci	2007 Aug 15	Baguet A	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000581849	CASC3-207	580	-	-	- (aa)	-	-
ENST00000577605	CASC3-205	714	-	ENSP00000464626	129 (aa)	-	J3QSC4
ENST00000584997	CASC3-210	543	-	ENSP00000467654	66 (aa)	-	K7EQ38
ENST00000474190	CASC3-204	908	-	ENSP00000462713	223 (aa)	-	J3KSY7
ENST00000394114	CASC3-202	2792	-	-	- (aa)	-	-
ENST00000264645	CASC3-201	4116	XM_005257163	ENSP00000264645	703 (aa)	XP_005257220	O15234
ENST00000418132	CASC3-203	1986	-	-	- (aa)	-	-
ENST00000583649	CASC3-208	577	-	-	- (aa)	-	-
ENST00000579238	CASC3-206	517	-	-	- (aa)	-	-
ENST00000583902	CASC3-209	557	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000108349's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108349's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108349	CASC3	63	68.085	ENSAPOG00000008467	casc3	73	51.475	Acanthochromis_polyacanthus
ENSG00000108349	CASC3	100	95.875	ENSAMEG00000007764	CASC3	100	95.875	Ailuropoda_melanoleuca
ENSG00000108349	CASC3	63	67.606	ENSACIG00000000720	casc3	83	50.179	Amphilophus_citrinellus
ENSG00000108349	CASC3	83	52.751	ENSAOCG00000016676	casc3	76	51.485	Amphiprion_ocellaris
ENSG00000108349	CASC3	63	67.376	ENSAPEG00000006787	casc3	76	51.485	Amphiprion_percula
ENSG00000108349	CASC3	73	55.172	ENSATEG00000017196	casc3	69	53.226	Anabas_testudineus
ENSG00000108349	CASC3	89	77.966	ENSACAG00000002674	CASC3	99	66.758	Anolis_carolinensis
ENSG00000108349	CASC3	99	85.014	ENSANAG00000034820	-	99	89.971	Aotus_nancymaae
ENSG00000108349	CASC3	89	98.305	ENSANAG00000031954	-	100	97.170	Aotus_nancymaae
ENSG00000108349	CASC3	68	66.234	ENSACLG00000016198	casc3	80	54.098	Astatotilapia_calliptera
ENSG00000108349	CASC3	100	93.314	ENSBTAG00000006250	CASC3	100	93.314	Bos_taurus
ENSG00000108349	CASC3	100	95.164	ENSCJAG00000016032	CASC3	100	95.164	Callithrix_jacchus
ENSG00000108349	CASC3	100	95.448	ENSCAFG00000016141	CASC3	100	95.448	Canis_familiaris
ENSG00000108349	CASC3	100	94.460	ENSCAFG00020018882	CASC3	100	94.460	Canis_lupus_dingo
ENSG00000108349	CASC3	100	91.892	ENSCHIG00000006338	CASC3	100	91.892	Capra_hircus
ENSG00000108349	CASC3	100	88.762	ENSTSYG00000002975	CASC3	89	95.345	Carlito_syrichta
ENSG00000108349	CASC3	88	89.123	ENSCAPG00000010514	CASC3	100	89.123	Cavia_aperea
ENSG00000108349	CASC3	100	88.478	ENSCPOG00000015139	CASC3	100	88.336	Cavia_porcellus
ENSG00000108349	CASC3	100	95.739	ENSCCAG00000033620	CASC3	100	95.312	Cebus_capucinus
ENSG00000108349	CASC3	100	97.585	ENSCATG00000033593	CASC3	100	97.585	Cercocebus_atys
ENSG00000108349	CASC3	100	90.327	ENSCLAG00000013730	CASC3	100	89.900	Chinchilla_lanigera
ENSG00000108349	CASC3	100	97.585	ENSCSAG00000002777	CASC3	100	97.585	Chlorocebus_sabaeus
ENSG00000108349	CASC3	99	75.281	ENSCPBG00000004750	CASC3	99	74.579	Chrysemys_picta_bellii
ENSG00000108349	CASC3	100	97.443	ENSCANG00000008814	CASC3	100	97.443	Colobus_angolensis_palliatus
ENSG00000108349	CASC3	100	92.461	ENSCGRG00001014706	Casc3	100	92.319	Cricetulus_griseus_chok1gshd
ENSG00000108349	CASC3	100	85.206	ENSCGRG00000001952	Casc3	96	92.135	Cricetulus_griseus_crigri
ENSG00000108349	CASC3	88	48.424	ENSCSEG00000010047	casc3	59	59.563	Cynoglossus_semilaevis
ENSG00000108349	CASC3	98	35.075	ENSCVAG00000014935	casc3	77	53.226	Cyprinodon_variegatus
ENSG00000108349	CASC3	100	93.883	ENSDNOG00000017249	CASC3	96	93.883	Dasypus_novemcinctus
ENSG00000108349	CASC3	100	85.064	ENSETEG00000013720	CASC3	100	84.922	Echinops_telfairi
ENSG00000108349	CASC3	99	36.627	ENSEBUG00000010654	casc3	82	42.806	Eptatretus_burgeri
ENSG00000108349	CASC3	100	93.333	ENSEASG00005002909	CASC3	100	93.791	Equus_asinus_asinus
ENSG00000108349	CASC3	100	94.595	ENSECAG00000019947	CASC3	88	94.595	Equus_caballus
ENSG00000108349	CASC3	85	95.238	ENSEEUG00000014253	CASC3	100	88.672	Erinaceus_europaeus
ENSG00000108349	CASC3	100	95.590	ENSFCAG00000014998	CASC3	100	95.590	Felis_catus
ENSG00000108349	CASC3	87	77.551	ENSFALG00000000412	CASC3	98	72.756	Ficedula_albicollis
ENSG00000108349	CASC3	93	86.758	ENSFDAG00000020696	CASC3	100	86.454	Fukomys_damarensis
ENSG00000108349	CASC3	69	65.806	ENSFHEG00000015793	casc3	77	52.258	Fundulus_heteroclitus
ENSG00000108349	CASC3	60	66.917	ENSGMOG00000004046	-	75	56.522	Gadus_morhua
ENSG00000108349	CASC3	87	81.122	ENSGALG00000031813	CASC3	99	69.744	Gallus_gallus
ENSG00000108349	CASC3	74	64.286	ENSGAFG00000017148	casc3	53	60.963	Gambusia_affinis
ENSG00000108349	CASC3	53	69.748	ENSGACG00000015032	-	77	56.667	Gasterosteus_aculeatus
ENSG00000108349	CASC3	85	82.632	ENSGAGG00000008432	CASC3	94	77.706	Gopherus_agassizii
ENSG00000108349	CASC3	100	99.289	ENSGGOG00000005067	CASC3	100	99.289	Gorilla_gorilla
ENSG00000108349	CASC3	68	66.883	ENSHBUG00000013155	casc3	80	54.098	Haplochromis_burtoni
ENSG00000108349	CASC3	100	89.758	ENSHGLG00000012117	CASC3	100	89.758	Heterocephalus_glaber_female
ENSG00000108349	CASC3	89	89.457	ENSHGLG00100002268	CASC3	99	89.406	Heterocephalus_glaber_male
ENSG00000108349	CASC3	100	93.741	ENSSTOG00000006374	CASC3	100	93.741	Ictidomys_tridecemlineatus
ENSG00000108349	CASC3	100	90.341	ENSJJAG00000023525	Casc3	100	90.483	Jaculus_jaculus
ENSG00000108349	CASC3	80	60.112	ENSKMAG00000019507	casc3	81	48.511	Kryptolebias_marmoratus
ENSG00000108349	CASC3	63	67.606	ENSLBEG00000005435	casc3	57	60.112	Labrus_bergylta
ENSG00000108349	CASC3	98	56.783	ENSLACG00000013200	CASC3	99	55.785	Latimeria_chalumnae
ENSG00000108349	CASC3	73	73.430	ENSLOCG00000013518	casc3	71	70.531	Lepisosteus_oculatus
ENSG00000108349	CASC3	100	92.319	ENSLAFG00000000606	CASC3	100	92.319	Loxodonta_africana
ENSG00000108349	CASC3	100	97.585	ENSMFAG00000041496	CASC3	100	99.338	Macaca_fascicularis
ENSG00000108349	CASC3	100	97.585	ENSMMUG00000045187	CASC3	100	97.585	Macaca_mulatta
ENSG00000108349	CASC3	100	96.970	ENSMLEG00000029049	CASC3	99	97.448	Mandrillus_leucophaeus
ENSG00000108349	CASC3	72	64.417	ENSMAMG00000005235	casc3	69	54.724	Mastacembelus_armatus
ENSG00000108349	CASC3	68	66.234	ENSMZEG00005003815	casc3	80	54.098	Maylandia_zebra
ENSG00000108349	CASC3	87	80.612	ENSMGAG00000013247	CASC3	99	72.683	Meleagris_gallopavo
ENSG00000108349	CASC3	82	85.849	ENSMAUG00000006023	Casc3	80	90.637	Mesocricetus_auratus
ENSG00000108349	CASC3	100	92.898	ENSMICG00000003321	CASC3	100	93.040	Microcebus_murinus
ENSG00000108349	CASC3	100	91.465	ENSMOCG00000013644	Casc3	100	90.327	Microtus_ochrogaster
ENSG00000108349	CASC3	78	53.704	ENSMMOG00000014339	casc3	67	53.623	Mola_mola
ENSG00000108349	CASC3	100	78.187	ENSMODG00000013044	CASC3	92	78.612	Monodelphis_domestica
ENSG00000108349	CASC3	100	90.896	MGP_CAROLIEiJ_G0017099	Casc3	100	89.900	Mus_caroli
ENSG00000108349	CASC3	100	90.185	ENSMUSG00000078676	Casc3	100	89.189	Mus_musculus
ENSG00000108349	CASC3	100	90.185	MGP_SPRETEiJ_G0017943	Casc3	100	89.189	Mus_spretus
ENSG00000108349	CASC3	100	94.452	ENSMPUG00000014903	CASC3	100	94.452	Mustela_putorius_furo
ENSG00000108349	CASC3	100	92.199	ENSMLUG00000010520	CASC3	100	91.206	Myotis_lucifugus
ENSG00000108349	CASC3	100	91.323	ENSNGAG00000023121	Casc3	100	90.327	Nannospalax_galili
ENSG00000108349	CASC3	100	97.866	ENSNLEG00000001598	CASC3	100	97.866	Nomascus_leucogenys
ENSG00000108349	CASC3	89	86.441	ENSMEUG00000015662	CASC3	100	91.463	Notamacropus_eugenii
ENSG00000108349	CASC3	85	94.709	ENSOPRG00000007240	-	79	100.000	Ochotona_princeps
ENSG00000108349	CASC3	100	89.518	ENSODEG00000017858	CASC3	100	89.802	Octodon_degus
ENSG00000108349	CASC3	71	65.432	ENSONIG00000009337	casc3	91	51.562	Oreochromis_niloticus
ENSG00000108349	CASC3	89	81.667	ENSOANG00000003499	-	80	70.000	Ornithorhynchus_anatinus
ENSG00000108349	CASC3	100	93.741	ENSOCUG00000002954	CASC3	100	93.457	Oryctolagus_cuniculus
ENSG00000108349	CASC3	99	94.993	ENSOGAG00000034486	CASC3	98	94.993	Otolemur_garnettii
ENSG00000108349	CASC3	100	93.172	ENSOARG00000013239	CASC3	100	93.172	Ovis_aries
ENSG00000108349	CASC3	100	99.858	ENSPPAG00000035069	CASC3	100	99.858	Pan_paniscus
ENSG00000108349	CASC3	100	95.590	ENSPPRG00000023670	CASC3	100	95.590	Panthera_pardus
ENSG00000108349	CASC3	91	95.290	ENSPTIG00000010891	CASC3	91	95.290	Panthera_tigris_altaica
ENSG00000108349	CASC3	100	97.585	ENSPANG00000021708	CASC3	100	97.585	Papio_anubis
ENSG00000108349	CASC3	100	92.034	ENSPEMG00000009774	Casc3	100	91.607	Peromyscus_maniculatus_bairdii
ENSG00000108349	CASC3	100	81.135	ENSPCIG00000025678	CASC3	100	82.553	Phascolarctos_cinereus
ENSG00000108349	CASC3	90	48.844	ENSPFOG00000017632	casc3	100	45.964	Poecilia_formosa
ENSG00000108349	CASC3	75	64.706	ENSPLAG00000005268	casc3	61	62.903	Poecilia_latipinna
ENSG00000108349	CASC3	61	67.143	ENSPMEG00000010299	casc3	73	48.451	Poecilia_mexicana
ENSG00000108349	CASC3	64	67.143	ENSPREG00000011856	casc3	82	50.987	Poecilia_reticulata
ENSG00000108349	CASC3	100	97.866	ENSPPYG00000008467	CASC3	100	97.866	Pongo_abelii
ENSG00000108349	CASC3	100	92.330	ENSPCOG00000008183	CASC3	100	93.466	Propithecus_coquereli
ENSG00000108349	CASC3	100	94.168	ENSPVAG00000008556	CASC3	100	94.168	Pteropus_vampyrus
ENSG00000108349	CASC3	68	66.883	ENSPNYG00000011962	casc3	80	54.098	Pundamilia_nyererei
ENSG00000108349	CASC3	92	92.715	ENSRNOG00000009716	Casc3	53	90.560	Rattus_norvegicus
ENSG00000108349	CASC3	100	97.727	ENSRBIG00000033289	CASC3	100	96.449	Rhinopithecus_bieti
ENSG00000108349	CASC3	100	97.727	ENSRROG00000022337	CASC3	100	97.727	Rhinopithecus_roxellana
ENSG00000108349	CASC3	88	96.278	ENSSBOG00000031406	CASC3	98	96.278	Saimiri_boliviensis_boliviensis
ENSG00000108349	CASC3	87	87.437	ENSSHAG00000013338	CASC3	99	84.160	Sarcophilus_harrisii
ENSG00000108349	CASC3	65	66.667	ENSSMAG00000016096	casc3	55	65.563	Scophthalmus_maximus
ENSG00000108349	CASC3	61	75.424	ENSSLDG00000020308	casc3	68	70.229	Seriola_lalandi_dorsalis
ENSG00000108349	CASC3	84	80.303	ENSSARG00000010378	CASC3	98	80.303	Sorex_araneus
ENSG00000108349	CASC3	68	66.447	ENSSPAG00000023008	casc3	77	51.466	Stegastes_partitus
ENSG00000108349	CASC3	100	90.909	ENSSSCG00000017477	CASC3	98	92.295	Sus_scrofa
ENSG00000108349	CASC3	74	73.624	ENSTGUG00000002300	CASC3	99	73.333	Taeniopygia_guttata
ENSG00000108349	CASC3	89	79.661	ENSTBEG00000017459	CASC3	67	97.170	Tupaia_belangeri
ENSG00000108349	CASC3	82	88.679	ENSTTRG00000016896	CASC3	98	83.333	Tursiops_truncatus
ENSG00000108349	CASC3	100	94.318	ENSUAMG00000015116	CASC3	100	94.426	Ursus_americanus
ENSG00000108349	CASC3	100	93.939	ENSUMAG00000017697	CASC3	100	94.330	Ursus_maritimus
ENSG00000108349	CASC3	75	100.000	ENSVPAG00000000799	CASC3	75	100.000	Vicugna_pacos
ENSG00000108349	CASC3	100	95.448	ENSVVUG00000000997	CASC3	100	95.448	Vulpes_vulpes
ENSG00000108349	CASC3	84	64.894	ENSXETG00000024395	casc3	98	56.662	Xenopus_tropicalis
ENSG00000108349	CASC3	74	64.286	ENSXMAG00000013937	casc3	60	61.749	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0000398	mRNA splicing, via spliceosome	29301961.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	14973490.16170325.16209946.16601204.16923391.18066079.19410547.19478851.20479275.22522823.23084401.	IPI	Function
GO:0005634	nucleus	29301961.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006417	regulation of translation	-	IEA	Process
GO:0008150	biological_process	-	ND	Process
GO:0008298	intracellular mRNA localization	-	IEA	Process
GO:0010494	cytoplasmic stress granule	-	IEA	Component
GO:0016607	nuclear speck	-	IEA	Component
GO:0019899	enzyme binding	21478859.	IPI	Function
GO:0030425	dendrite	-	IEA	Component
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0031625	ubiquitin protein ligase binding	21478859.	IPI	Function
GO:0031965	nuclear membrane	-	IDA	Component
GO:0035145	exon-exon junction complex	21873635.	IBA	Component
GO:0035145	exon-exon junction complex	16601204.	IDA	Component
GO:0042802	identical protein binding	12080473.	IDA	Function
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0071006	U2-type catalytic step 1 spliceosome	29301961.	IDA	Component