EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Description

Ensembl ID: ENSG00000108387 (Gene tree)
Gene ID: 5414
Gene Symbol: SEPT4
Alias: H5|CE5B3|hucep-7|ARTS|hCDCREL-2|MART|FLJ40121|PNUTL2|C17orf47
Full Name: septin 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 20,569 bases
Position: chr17:58,520,250-58,540,818
Accession: 9165
RBP type: canonical RBP
Summary: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000463671	MMR_HSR1	PF01926.23	6.4e-07	1	1
ENSP00000464373	MMR_HSR1	PF01926.23	1.5e-06	1	1
ENSP00000462727	MMR_HSR1	PF01926.23	1.6e-06	1	1
ENSP00000463768	MMR_HSR1	PF01926.23	2.3e-06	1	1
ENSP00000321071	MMR_HSR1	PF01926.23	2.6e-06	1	1
ENSP00000376801	MMR_HSR1	PF01926.23	2.6e-06	1	1
ENSP00000414779	MMR_HSR1	PF01926.23	2.6e-06	1	1
ENSP00000321674	MMR_HSR1	PF01926.23	2.8e-06	1	1
ENSP00000402000	MMR_HSR1	PF01926.23	2.9e-06	1	1
ENSP00000464382	MMR_HSR1	PF01926.23	4e-06	1	1
ENSP00000402348	MMR_HSR1	PF01926.23	1.2e-05	1	1
ENSP00000463461	MMR_HSR1	PF01926.23	5.4e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000584488	SEPT4-226	1731	-	-	- (aa)	-	-
ENST00000317256	SEPT4-201	1530	XM_006721949	ENSP00000321071	459 (aa)	XP_006722012	O43236
ENST00000580844	SEPT4-216	1396	XM_006721951	ENSP00000462727	379 (aa)	XP_006722014	J3KSZ7
ENST00000581921	SEPT4-219	235	-	-	- (aa)	-	-
ENST00000582248	SEPT4-220	604	-	-	- (aa)	-	-
ENST00000583273	SEPT4-224	2151	NR_037155	-	- (aa)	-	-
ENST00000585170	SEPT4-229	3544	-	-	- (aa)	-	-
ENST00000426861	SEPT4-205	1906	-	ENSP00000402348	274 (aa)	-	O43236
ENST00000577729	SEPT4-208	724	-	ENSP00000463671	207 (aa)	-	J3QLR2
ENST00000457347	SEPT4-206	1795	-	ENSP00000402000	493 (aa)	-	O43236
ENST00000581607	SEPT4-217	676	-	ENSP00000464360	72 (aa)	-	J3QRS4
ENST00000583291	SEPT4-225	789	-	ENSP00000463461	225 (aa)	-	J3QLA8
ENST00000412945	SEPT4-204	1597	-	ENSP00000414779	470 (aa)	-	O43236
ENST00000579371	SEPT4-211	1362	-	ENSP00000464373	332 (aa)	-	J3QRT6
ENST00000584528	SEPT4-227	559	-	-	- (aa)	-	-
ENST00000317268	SEPT4-202	1784	-	ENSP00000321674	478 (aa)	-	O43236
ENST00000578747	SEPT4-210	564	-	-	- (aa)	-	-
ENST00000393086	SEPT4-203	1556	XM_006721954	ENSP00000376801	459 (aa)	XP_006722017	O43236
ENST00000582270	SEPT4-221	2195	-	-	- (aa)	-	-
ENST00000577440	SEPT4-207	1792	-	-	- (aa)	-	-
ENST00000581615	SEPT4-218	632	-	ENSP00000462278	55 (aa)	-	J3KS26
ENST00000584789	SEPT4-228	963	-	-	- (aa)	-	-
ENST00000583114	SEPT4-223	1709	XM_011524912	ENSP00000463768	331 (aa)	XP_011523214	O43236
ENST00000580740	SEPT4-212	549	-	-	- (aa)	-	-
ENST00000582976	SEPT4-222	1707	-	-	- (aa)	-	-
ENST00000580791	SEPT4-213	566	-	-	- (aa)	-	-
ENST00000578131	SEPT4-209	508	-	ENSP00000462362	36 (aa)	-	J3KS85
ENST00000580796	SEPT4-214	2790	-	-	- (aa)	-	-
ENST00000580809	SEPT4-215	952	-	ENSP00000464382	175 (aa)	-	J3QRU3

Gene Model

Click here to download ENSG00000108387's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000108387	rs113162402	17	58522103	?	Tenofovir clearance in HIV infection	26148204			EFO_0009279\|EFO_0000764
ENSG00000108387	rs740605	17	58527450	T	Intelligence	29942086	z-score increase	6.357	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108387's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108387	SEPT4	96	75.625	ENSAPOG00000017596	sept4a	91	67.436	Acanthochromis_polyacanthus
ENSG00000108387	SEPT4	99	88.379	ENSAPOG00000004169	SEPT4	98	88.757	Acanthochromis_polyacanthus
ENSG00000108387	SEPT4	100	97.281	ENSAMEG00000011592	SEPT4	79	93.886	Ailuropoda_melanoleuca
ENSG00000108387	SEPT4	95	76.899	ENSACIG00000018748	sept4a	96	70.868	Amphilophus_citrinellus
ENSG00000108387	SEPT4	95	86.624	ENSACIG00000002675	SEPT4	83	87.683	Amphilophus_citrinellus
ENSG00000108387	SEPT4	96	88.050	ENSAOCG00000008228	SEPT4	92	88.986	Amphiprion_ocellaris
ENSG00000108387	SEPT4	96	75.625	ENSAOCG00000015851	sept4a	98	66.846	Amphiprion_ocellaris
ENSG00000108387	SEPT4	96	75.312	ENSAPEG00000017422	sept4a	91	67.206	Amphiprion_percula
ENSG00000108387	SEPT4	99	86.626	ENSAPEG00000013889	SEPT4	92	87.640	Amphiprion_percula
ENSG00000108387	SEPT4	99	89.297	ENSATEG00000010484	SEPT4	98	89.297	Anabas_testudineus
ENSG00000108387	SEPT4	99	74.174	ENSATEG00000007945	sept4a	88	71.463	Anabas_testudineus
ENSG00000108387	SEPT4	99	71.515	ENSACAG00000010754	-	98	72.500	Anolis_carolinensis
ENSG00000108387	SEPT4	99	99.425	ENSANAG00000032288	-	99	99.425	Aotus_nancymaae
ENSG00000108387	SEPT4	100	91.667	ENSANAG00000028439	-	100	82.135	Aotus_nancymaae
ENSG00000108387	SEPT4	96	78.056	ENSACLG00000007242	sept4a	78	75.130	Astatotilapia_calliptera
ENSG00000108387	SEPT4	99	89.297	ENSACLG00000020556	SEPT4	98	89.297	Astatotilapia_calliptera
ENSG00000108387	SEPT4	100	77.177	ENSAMXG00000020058	sept4a	85	77.922	Astyanax_mexicanus
ENSG00000108387	SEPT4	100	88.922	ENSAMXG00000037346	SEPT4	100	88.922	Astyanax_mexicanus
ENSG00000108387	SEPT4	94	63.344	ENSAMXG00000031256	zgc:162239	96	63.344	Astyanax_mexicanus
ENSG00000108387	SEPT4	100	96.073	ENSBTAG00000015368	SEPT4	100	95.515	Bos_taurus
ENSG00000108387	SEPT4	81	91.803	ENSCJAG00000043546	-	99	90.811	Callithrix_jacchus
ENSG00000108387	SEPT4	98	97.853	ENSCAFG00020025931	SEPT4	100	93.404	Canis_lupus_dingo
ENSG00000108387	SEPT4	100	96.073	ENSCHIG00000024623	SEPT4	100	91.004	Capra_hircus
ENSG00000108387	SEPT4	99	100.000	ENSTSYG00000007856	SEPT4	100	97.625	Carlito_syrichta
ENSG00000108387	SEPT4	99	96.951	ENSCPOG00000003438	SEPT4	99	98.077	Cavia_porcellus
ENSG00000108387	SEPT4	100	98.945	ENSCCAG00000033722	SEPT4	100	98.945	Cebus_capucinus
ENSG00000108387	SEPT4	100	97.281	ENSCLAG00000012112	SEPT4	99	98.397	Chinchilla_lanigera
ENSG00000108387	SEPT4	100	100.000	ENSCSAG00000005775	SEPT4	100	98.745	Chlorocebus_sabaeus
ENSG00000108387	SEPT4	100	91.541	ENSCPBG00000015911	SEPT4	100	81.838	Chrysemys_picta_bellii
ENSG00000108387	SEPT4	72	72.222	ENSCPBG00000005809	-	82	73.387	Chrysemys_picta_bellii
ENSG00000108387	SEPT4	100	98.489	ENSCANG00000043093	SEPT4	100	98.417	Colobus_angolensis_palliatus
ENSG00000108387	SEPT4	100	98.489	ENSCGRG00001020635	Sept4	99	99.359	Cricetulus_griseus_chok1gshd
ENSG00000108387	SEPT4	100	98.489	ENSCGRG00000016009	Sept4	100	93.515	Cricetulus_griseus_crigri
ENSG00000108387	SEPT4	95	89.490	ENSCSEG00000009655	SEPT4	89	89.846	Cynoglossus_semilaevis
ENSG00000108387	SEPT4	96	77.429	ENSCVAG00000005954	-	98	73.900	Cyprinodon_variegatus
ENSG00000108387	SEPT4	99	88.379	ENSCVAG00000021688	SEPT4	99	88.379	Cyprinodon_variegatus
ENSG00000108387	SEPT4	86	66.480	ENSDARG00000019651	zgc:162239	90	57.364	Danio_rerio
ENSG00000108387	SEPT4	100	76.877	ENSDARG00000010385	sept4a	98	66.667	Danio_rerio
ENSG00000108387	SEPT4	97	86.997	ENSDARG00000105271	SEPT4	87	85.286	Danio_rerio
ENSG00000108387	SEPT4	100	98.187	ENSDORG00000001966	Sept4	99	99.359	Dipodomys_ordii
ENSG00000108387	SEPT4	100	96.677	ENSETEG00000013398	SEPT4	100	96.936	Echinops_telfairi
ENSG00000108387	SEPT4	86	68.000	ENSEBUG00000003857	zgc:162239	97	55.278	Eptatretus_burgeri
ENSG00000108387	SEPT4	100	97.281	ENSEASG00005002775	SEPT4	100	94.118	Equus_asinus_asinus
ENSG00000108387	SEPT4	93	67.097	ENSELUG00000006608	-	90	68.950	Esox_lucius
ENSG00000108387	SEPT4	100	88.623	ENSELUG00000007982	SEPT4	100	88.623	Esox_lucius
ENSG00000108387	SEPT4	99	77.711	ENSELUG00000006509	sept4a	88	71.461	Esox_lucius
ENSG00000108387	SEPT4	100	97.583	ENSFCAG00000004488	SEPT4	100	97.583	Felis_catus
ENSG00000108387	SEPT4	98	88.923	ENSFALG00000013797	SEPT4	99	78.913	Ficedula_albicollis
ENSG00000108387	SEPT4	100	96.979	ENSFDAG00000014745	SEPT4	100	96.042	Fukomys_damarensis
ENSG00000108387	SEPT4	99	87.768	ENSFHEG00000021445	SEPT4	98	87.768	Fundulus_heteroclitus
ENSG00000108387	SEPT4	96	76.489	ENSFHEG00000000567	sept4a	98	71.111	Fundulus_heteroclitus
ENSG00000108387	SEPT4	95	88.535	ENSGMOG00000011574	SEPT4	75	86.921	Gadus_morhua
ENSG00000108387	SEPT4	83	82.192	ENSGMOG00000007005	sept4a	99	63.702	Gadus_morhua
ENSG00000108387	SEPT4	90	54.545	ENSGMOG00000007022	-	98	52.098	Gadus_morhua
ENSG00000108387	SEPT4	100	90.332	ENSGALG00000035185	SEPT4	96	80.260	Gallus_gallus
ENSG00000108387	SEPT4	99	87.768	ENSGAFG00000010509	SEPT4	98	87.768	Gambusia_affinis
ENSG00000108387	SEPT4	95	76.433	ENSGAFG00000001757	sept4a	80	72.222	Gambusia_affinis
ENSG00000108387	SEPT4	99	88.685	ENSGACG00000008792	SEPT4	81	84.772	Gasterosteus_aculeatus
ENSG00000108387	SEPT4	95	76.656	ENSGACG00000020488	sept4a	96	70.083	Gasterosteus_aculeatus
ENSG00000108387	SEPT4	94	91.961	ENSGAGG00000005922	SEPT4	70	86.849	Gopherus_agassizii
ENSG00000108387	SEPT4	100	74.096	ENSHBUG00000005988	sept4a	98	74.006	Haplochromis_burtoni
ENSG00000108387	SEPT4	99	89.297	ENSHBUG00000001102	SEPT4	98	89.297	Haplochromis_burtoni
ENSG00000108387	SEPT4	100	97.583	ENSHGLG00000007661	SEPT4	99	98.397	Heterocephalus_glaber_female
ENSG00000108387	SEPT4	100	95.770	ENSHGLG00100011068	SEPT4	100	94.987	Heterocephalus_glaber_male
ENSG00000108387	SEPT4	95	88.217	ENSHCOG00000016706	SEPT4	88	88.580	Hippocampus_comes
ENSG00000108387	SEPT4	84	68.707	ENSHCOG00000009438	sept4a	90	61.093	Hippocampus_comes
ENSG00000108387	SEPT4	99	71.299	ENSIPUG00000008070	SEPT4a	72	74.151	Ictalurus_punctatus
ENSG00000108387	SEPT4	89	89.899	ENSIPUG00000007470	SEPT4	88	90.411	Ictalurus_punctatus
ENSG00000108387	SEPT4	88	69.481	ENSIPUG00000007941	zgc:162239	88	70.073	Ictalurus_punctatus
ENSG00000108387	SEPT4	100	97.889	ENSSTOG00000028582	SEPT4	100	97.889	Ictidomys_tridecemlineatus
ENSG00000108387	SEPT4	100	98.489	ENSJJAG00000022351	Sept4	99	99.359	Jaculus_jaculus
ENSG00000108387	SEPT4	96	76.250	ENSKMAG00000006586	sept4a	92	76.471	Kryptolebias_marmoratus
ENSG00000108387	SEPT4	99	86.239	ENSKMAG00000015750	SEPT4	97	85.912	Kryptolebias_marmoratus
ENSG00000108387	SEPT4	99	75.000	ENSLBEG00000000185	sept4a	98	74.255	Labrus_bergylta
ENSG00000108387	SEPT4	100	88.623	ENSLBEG00000026675	SEPT4	100	88.623	Labrus_bergylta
ENSG00000108387	SEPT4	99	88.991	ENSLACG00000018670	SEPT4	94	87.728	Latimeria_chalumnae
ENSG00000108387	SEPT4	85	92.617	ENSLOCG00000004398	sept4a	76	88.163	Lepisosteus_oculatus
ENSG00000108387	SEPT4	100	97.281	ENSLAFG00000003381	SEPT4	100	93.933	Loxodonta_africana
ENSG00000108387	SEPT4	99	90.214	ENSMAMG00000009320	SEPT4	98	90.214	Mastacembelus_armatus
ENSG00000108387	SEPT4	96	78.997	ENSMAMG00000020986	sept4a	79	72.356	Mastacembelus_armatus
ENSG00000108387	SEPT4	96	78.056	ENSMZEG00005024888	sept4a	98	73.757	Maylandia_zebra
ENSG00000108387	SEPT4	99	89.297	ENSMZEG00005015238	SEPT4	98	89.297	Maylandia_zebra
ENSG00000108387	SEPT4	96	90.252	ENSMGAG00000002059	SEPT4	99	88.636	Meleagris_gallopavo
ENSG00000108387	SEPT4	100	98.489	ENSMAUG00000018468	Sept4	99	99.359	Mesocricetus_auratus
ENSG00000108387	SEPT4	100	97.885	ENSMICG00000016062	SEPT4	100	97.714	Microcebus_murinus
ENSG00000108387	SEPT4	100	98.489	ENSMOCG00000022414	Sept4	99	99.038	Microtus_ochrogaster
ENSG00000108387	SEPT4	98	82.407	ENSMMOG00000004005	-	96	82.303	Mola_mola
ENSG00000108387	SEPT4	99	71.254	ENSMMOG00000011577	sept4a	98	68.194	Mola_mola
ENSG00000108387	SEPT4	100	88.922	ENSMMOG00000011919	SEPT4	100	89.275	Mola_mola
ENSG00000108387	SEPT4	99	85.321	ENSMALG00000004418	SEPT4	96	87.288	Monopterus_albus
ENSG00000108387	SEPT4	100	98.489	MGP_CAROLIEiJ_G0016931	Sept4	100	98.153	Mus_caroli
ENSG00000108387	SEPT4	100	98.489	ENSMUSG00000020486	Sept4	99	99.359	Mus_musculus
ENSG00000108387	SEPT4	100	98.187	MGP_PahariEiJ_G0018060	Sept4	100	97.361	Mus_pahari
ENSG00000108387	SEPT4	100	98.489	MGP_SPRETEiJ_G0017778	Sept4	99	99.359	Mus_spretus
ENSG00000108387	SEPT4	100	96.979	ENSMLUG00000029785	SEPT4	82	90.062	Myotis_lucifugus
ENSG00000108387	SEPT4	100	98.187	ENSNGAG00000000527	Sept4	99	99.359	Nannospalax_galili
ENSG00000108387	SEPT4	97	88.438	ENSNBRG00000008584	SEPT4	87	79.398	Neolamprologus_brichardi
ENSG00000108387	SEPT4	93	78.571	ENSNBRG00000002328	sept4a	97	78.571	Neolamprologus_brichardi
ENSG00000108387	SEPT4	100	97.583	ENSODEG00000011244	SEPT4	99	98.397	Octodon_degus
ENSG00000108387	SEPT4	96	77.429	ENSONIG00000008732	sept4a	99	74.611	Oreochromis_niloticus
ENSG00000108387	SEPT4	99	89.602	ENSONIG00000008130	SEPT4	88	88.251	Oreochromis_niloticus
ENSG00000108387	SEPT4	100	97.281	ENSOCUG00000009757	SEPT4	100	94.351	Oryctolagus_cuniculus
ENSG00000108387	SEPT4	96	73.668	ENSORLG00000002766	sept4a	92	65.661	Oryzias_latipes
ENSG00000108387	SEPT4	99	87.156	ENSORLG00000007856	SEPT4	98	87.156	Oryzias_latipes
ENSG00000108387	SEPT4	96	73.354	ENSORLG00020016855	sept4a	90	68.828	Oryzias_latipes_hni
ENSG00000108387	SEPT4	99	87.156	ENSORLG00020000643	SEPT4	98	87.156	Oryzias_latipes_hni
ENSG00000108387	SEPT4	96	73.981	ENSORLG00015001204	sept4a	90	69.327	Oryzias_latipes_hsok
ENSG00000108387	SEPT4	99	87.156	ENSORLG00015002602	SEPT4	98	87.156	Oryzias_latipes_hsok
ENSG00000108387	SEPT4	99	87.768	ENSOMEG00000016432	SEPT4	98	87.768	Oryzias_melastigma
ENSG00000108387	SEPT4	95	76.115	ENSOMEG00000009047	sept4a	85	66.893	Oryzias_melastigma
ENSG00000108387	SEPT4	99	98.485	ENSOGAG00000004928	SEPT4	99	96.646	Otolemur_garnettii
ENSG00000108387	SEPT4	100	96.979	ENSPPRG00000022781	SEPT4	100	96.834	Panthera_pardus
ENSG00000108387	SEPT4	100	96.979	ENSPTIG00000014205	SEPT4	100	96.979	Panthera_tigris_altaica
ENSG00000108387	SEPT4	100	99.472	ENSPANG00000022286	SEPT4	100	99.472	Papio_anubis
ENSG00000108387	SEPT4	100	88.323	ENSPKIG00000005907	SEPT4	100	88.696	Paramormyrops_kingsleyae
ENSG00000108387	SEPT4	96	77.358	ENSPKIG00000018498	sept4a	82	74.387	Paramormyrops_kingsleyae
ENSG00000108387	SEPT4	84	95.238	ENSPSIG00000014354	-	100	69.972	Pelodiscus_sinensis
ENSG00000108387	SEPT4	100	67.169	ENSPMGG00000021141	SEPT4	83	69.251	Periophthalmus_magnuspinnatus
ENSG00000108387	SEPT4	99	73.636	ENSPMGG00000005528	sept4a	98	74.085	Periophthalmus_magnuspinnatus
ENSG00000108387	SEPT4	100	98.489	ENSPEMG00000015994	Sept4	99	99.359	Peromyscus_maniculatus_bairdii
ENSG00000108387	SEPT4	86	76.966	ENSPMAG00000003139	zgc:162239	99	65.617	Petromyzon_marinus
ENSG00000108387	SEPT4	99	88.788	ENSPCIG00000015596	SEPT4	99	78.959	Phascolarctos_cinereus
ENSG00000108387	SEPT4	99	86.707	ENSPFOG00000015200	SEPT4	95	76.096	Poecilia_formosa
ENSG00000108387	SEPT4	96	76.250	ENSPFOG00000010456	sept4a	78	73.506	Poecilia_formosa
ENSG00000108387	SEPT4	96	76.250	ENSPLAG00000019026	sept4a	94	81.132	Poecilia_latipinna
ENSG00000108387	SEPT4	99	87.156	ENSPLAG00000000023	SEPT4	98	87.156	Poecilia_latipinna
ENSG00000108387	SEPT4	79	82.014	ENSPLAG00000018091	sept4a	93	82.609	Poecilia_latipinna
ENSG00000108387	SEPT4	96	76.250	ENSPMEG00000014050	sept4a	81	73.506	Poecilia_mexicana
ENSG00000108387	SEPT4	99	87.462	ENSPMEG00000014632	SEPT4	98	87.462	Poecilia_mexicana
ENSG00000108387	SEPT4	96	76.562	ENSPREG00000008912	sept4a	75	73.766	Poecilia_reticulata
ENSG00000108387	SEPT4	99	86.850	ENSPREG00000022047	SEPT4	98	86.850	Poecilia_reticulata
ENSG00000108387	SEPT4	100	100.000	ENSPPYG00000008229	SEPT4	100	99.163	Pongo_abelii
ENSG00000108387	SEPT4	100	98.286	ENSPCOG00000024780	SEPT4	100	98.286	Propithecus_coquereli
ENSG00000108387	SEPT4	100	89.124	ENSPVAG00000002325	SEPT4	100	88.075	Pteropus_vampyrus
ENSG00000108387	SEPT4	95	89.809	ENSPNYG00000016710	SEPT4	95	80.471	Pundamilia_nyererei
ENSG00000108387	SEPT4	96	78.056	ENSPNYG00000018040	sept4a	93	81.019	Pundamilia_nyererei
ENSG00000108387	SEPT4	100	76.577	ENSPNAG00000015089	sept4a	99	79.532	Pygocentrus_nattereri
ENSG00000108387	SEPT4	88	71.429	ENSPNAG00000015185	zgc:162239	95	60.831	Pygocentrus_nattereri
ENSG00000108387	SEPT4	95	89.524	ENSPNAG00000007157	SEPT4	95	89.877	Pygocentrus_nattereri
ENSG00000108387	SEPT4	100	97.892	ENSRNOG00000007367	Sept4	100	97.892	Rattus_norvegicus
ENSG00000108387	SEPT4	100	98.857	ENSRBIG00000027007	SEPT4	100	98.857	Rhinopithecus_bieti
ENSG00000108387	SEPT4	100	98.857	ENSRROG00000031893	SEPT4	100	98.857	Rhinopithecus_roxellana
ENSG00000108387	SEPT4	100	98.945	ENSSBOG00000021401	SEPT4	100	98.945	Saimiri_boliviensis_boliviensis
ENSG00000108387	SEPT4	100	89.728	ENSSHAG00000010070	SEPT4	99	78.914	Sarcophilus_harrisii
ENSG00000108387	SEPT4	100	79.940	ENSSFOG00015006345	sept4a	99	70.626	Scleropages_formosus
ENSG00000108387	SEPT4	100	88.922	ENSSFOG00015002137	SEPT4	87	88.750	Scleropages_formosus
ENSG00000108387	SEPT4	96	76.803	ENSSMAG00000019627	sept4a	75	73.177	Scophthalmus_maximus
ENSG00000108387	SEPT4	99	88.073	ENSSMAG00000016821	SEPT4	96	85.511	Scophthalmus_maximus
ENSG00000108387	SEPT4	99	89.602	ENSSDUG00000020367	SEPT4	98	89.602	Seriola_dumerili
ENSG00000108387	SEPT4	98	76.380	ENSSDUG00000017913	sept4a	98	75.069	Seriola_dumerili
ENSG00000108387	SEPT4	96	77.188	ENSSLDG00000015580	sept4a	74	70.000	Seriola_lalandi_dorsalis
ENSG00000108387	SEPT4	99	88.788	ENSSLDG00000021047	SEPT4	98	89.118	Seriola_lalandi_dorsalis
ENSG00000108387	SEPT4	99	97.273	ENSSARG00000012784	SEPT4	100	89.937	Sorex_araneus
ENSG00000108387	SEPT4	100	92.145	ENSSPUG00000000871	-	97	92.758	Sphenodon_punctatus
ENSG00000108387	SEPT4	95	89.490	ENSSPAG00000004946	SEPT4	87	89.490	Stegastes_partitus
ENSG00000108387	SEPT4	96	75.312	ENSSPAG00000008751	sept4a	91	76.974	Stegastes_partitus
ENSG00000108387	SEPT4	100	97.098	ENSSSCG00000017643	SEPT4	100	97.098	Sus_scrofa
ENSG00000108387	SEPT4	100	87.725	ENSTRUG00000015731	SEPT4	96	82.576	Takifugu_rubripes
ENSG00000108387	SEPT4	98	71.345	ENSTRUG00000010944	sept4a	99	71.345	Takifugu_rubripes
ENSG00000108387	SEPT4	95	75.873	ENSTNIG00000003311	sept4a	95	72.324	Tetraodon_nigroviridis
ENSG00000108387	SEPT4	100	86.647	ENSTNIG00000005815	SEPT4	100	86.945	Tetraodon_nigroviridis
ENSG00000108387	SEPT4	99	98.165	ENSTBEG00000010153	SEPT4	68	98.165	Tupaia_belangeri
ENSG00000108387	SEPT4	100	85.498	ENSTTRG00000006853	SEPT4	100	84.716	Tursiops_truncatus
ENSG00000108387	SEPT4	100	96.979	ENSUAMG00000005181	SEPT4	100	93.933	Ursus_americanus
ENSG00000108387	SEPT4	100	97.098	ENSUMAG00000022793	SEPT4	100	97.098	Ursus_maritimus
ENSG00000108387	SEPT4	93	91.542	ENSVPAG00000001810	SEPT4	78	91.914	Vicugna_pacos
ENSG00000108387	SEPT4	100	97.281	ENSVVUG00000012618	SEPT4	99	96.636	Vulpes_vulpes
ENSG00000108387	SEPT4	99	75.904	ENSXETG00000030625	SEPT4	99	76.440	Xenopus_tropicalis
ENSG00000108387	SEPT4	92	90.850	ENSXCOG00000012748	SEPT4	90	90.000	Xiphophorus_couchianus
ENSG00000108387	SEPT4	100	75.000	ENSXCOG00000007196	sept4a	97	78.105	Xiphophorus_couchianus
ENSG00000108387	SEPT4	99	75.000	ENSXMAG00000011277	sept4a	90	70.732	Xiphophorus_maculatus
ENSG00000108387	SEPT4	99	87.462	ENSXMAG00000008630	SEPT4	98	87.462	Xiphophorus_maculatus

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21952823	Involvement of SEPT4_i1 in hepatocellular carcinoma: SEPT4_i1 regulates susceptibility to apoptosis in hepatocellular carcinoma cells.	Mol Biol Rep	2012 Apr	Shen S	doi: 10.1007/s11033-011-1242-z
22503047	Bradeion (SEPT4) as a urinary marker of transitional cell bladder cancer: a real-time polymerase chain reaction study of gene expression.	J Urol	2012 Jun	Bongiovanni L	doi: 10.1016/j.juro.2012.01.031
15122323	Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients.	Oncogene	2004 Jul 15	Elhasid R	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr17	58521280	Missense_Mutation	novel	R363P	0.25
BLCA	chr17	58521086	Missense_Mutation	novel	D397N	0.48
BLCA	chr17	58521015	Silent	novel	V420V	0.4
BLCA	chr17	58529263	5'UTR	novel		0.55
BLCA	chr17	58520795	Missense_Mutation	novel	P442L	0.2
BLCA	chr17	58529135	Missense_Mutation	NA	E14K	0.18
BLCA	chr17	58526948	Missense_Mutation	novel	D31N	0.33
BLCA	chr17	58521081	Silent	novel	V398V	0.32
BLCA	chr17	58520961	Intron	novel		0.47
BLCA	chr17	58525694	Splice_Site	novel	X180_splice	0.25
BRCA	chr17	58526981	Splice_Region	novel		0.14
BRCA	chr17	58520337	3'UTR	novel		0.14
BRCA	chr17	58520914	Intron	novel		0.39
BRCA	chr17	58521900	Intron	novel		0.1
BRCA	chr17	58526389	Intron	novel		0.07
BRCA	chr17	58525715	Missense_Mutation	rs772182274	R173Q	0.21	MMR_HSR1
BRCA	chr17	58520908	Intron	novel		0.07
BRCA	chr17	58529123	Missense_Mutation	novel	E18K	0.06
BRCA	chr17	58521415	Intron	novel		0.33
BRCA	chr17	58526722	Missense_Mutation	NA	R106H	0.17
BRCA	chr17	58521205	Intron	novel		0.22
BRCA	chr17	58525202	Splice_Site	novel	X180_splice	0.09
CESC	chr17	58529286	5'UTR	novel		0.33
CESC	chr17	58520477	Silent	novel	R462R	0.1
CESC	chr17	58520422	3'UTR	novel		0.35
CESC	chr17	58521008	Missense_Mutation	rs759153104	R423W	0.31
COAD	chr17	58521478	Intron	novel		0.33
COAD	chr17	58526579	Intron	novel		0.39
COAD	chr17	58521948	Intron	novel		0.1
COAD	chr17	58521325	Missense_Mutation	NA	G348D	0.38
COAD	chr17	58520414	3'UTR	rs759858107		0.42
COAD	chr17	58526845	Missense_Mutation	novel	R65M	0.11
COAD	chr17	58521415	Intron	novel		0.4
COAD	chr17	58526614	Intron	novel		0.8
COAD	chr17	58520889	Intron	rs375706047		0.29
DLBC	chr17	58521996	Silent	rs144640338	C256C	0.27
ESCA	chr17	58526686	Missense_Mutation	novel	S118C	0.13
GBM	chr17	58520784	Missense_Mutation	novel	D446H	0.28
GBM	chr17	58529302	5'UTR	novel		0.13
GBM	chr17	58520968	Intron	novel		0.1
GBM	chr17	58520849	Splice_Region	novel		0.09
GBM	chr17	58520415	3'UTR	novel		0.33
GBM	chr17	58521879	Intron	novel		0.15
GBM	chr17	58526916	Missense_Mutation	novel	F41L	0.05
GBM	chr17	58522035	Silent	NA	L243L	0.13
GBM	chr17	58521564	Missense_Mutation	novel	L333S	0.08
GBM	chr17	58521891	Intron	novel		0.24
HNSC	chr17	58526953	Missense_Mutation	rs755554839	T29M	0.1
HNSC	chr17	58520980	Intron	novel		0.3
HNSC	chr17	58520901	Intron	novel		0.24
HNSC	chr17	58526699	Missense_Mutation	novel	P114A	0.06
HNSC	chr17	58521693	Intron	novel		0.05
KIRC	chr17	58525720	Silent	NA	R171R	0.11
KIRC	chr17	58521770	Missense_Mutation	NA	L294Q	0.05
LAML	chr17	58527145	Intron	novel		0.06
LIHC	chr17	58521678	Intron	novel		0.24
LIHC	chr17	58526943	Silent	novel	G32G	0.25
LUAD	chr17	58520417	3'UTR	novel		0.12
LUAD	chr17	58521272	Missense_Mutation	NA	P366S	0.24
LUAD	chr17	58525140	Silent	novel	V200V	0.07
LUAD	chr17	58521373	Intron	novel		0.31
LUAD	chr17	58522005	Silent	NA	V253V	0.42
LUAD	chr17	58525162	Missense_Mutation	rs112657072	V193A	0.12	MMR_HSR1
LUAD	chr17	58526397	Intron	novel		0.71
LUAD	chr17	58521902	Intron	novel		0.21
LUAD	chr17	58521447	Intron	novel		0.21
LUAD	chr17	58529116	Missense_Mutation	NA	G20V	0.06
LUSC	chr17	58527201	Intron	novel		0.23
LUSC	chr17	58521536	Intron	novel		0.37
LUSC	chr17	58521760	Silent	novel	P297P	0.32
OV	chr17	58520886	Intron	novel		0.36
OV	chr17	58520835	Missense_Mutation	novel	T429A	0.07
OV	chr17	58526957	Missense_Mutation	NA	T28P	0.25
OV	chr17	58529237	5'UTR	novel		0.14
OV	chr17	58521200	Intron	novel		0.15
OV	chr17	58520771	Missense_Mutation	novel	E450V	0.04
PAAD	chr17	58521132	Frame_Shift_Ins	novel	*K382Mfs36**	0.16
PAAD	chr17	58520935	Intron	novel		0.09
PAAD	chr17	58520817	Missense_Mutation	rs369282254	D435N	0.04
PAAD	chr17	58521196	Intron	novel		0.19
PAAD	chr17	58521996	Silent	rs144640338	C256C	0.18
PCPG	chr17	58520340	3'UTR	novel		0.2
PRAD	chr17	58521281	Nonsense_Mutation	NA	R363*	0.13
PRAD	chr17	58525716	Missense_Mutation	NA	R173G	0.07	MMR_HSR1
READ	chr17	58520889	Intron	rs375706047		0.2
READ	chr17	58521287	Missense_Mutation	rs200367887	R361W	0.37
READ	chr17	58522046	Missense_Mutation	rs754556138	E240K	0.6
READ	chr17	58520832	Missense_Mutation	rs147468433	R430W	0.45
READ	chr17	58522051	Missense_Mutation	novel	R238Q	0.4
READ	chr17	58526760	Missense_Mutation	NA	F93L	0.29
READ	chr17	58526375	Intron	novel		0.36
SARC	chr17	58526747	Missense_Mutation	novel	P98T	0.1
SKCM	chr17	58521616	Missense_Mutation	NA	K316Q	0.39
SKCM	chr17	58522020	Silent	NA	I248I	0.29
SKCM	chr17	58521754	Silent	NA	V299V	0.26
SKCM	chr17	58521439	Intron	novel		0.56
SKCM	chr17	58521790	Silent	NA	I287I	0.36
SKCM	chr17	58526981	Splice_Region	novel		0.46
SKCM	chr17	58521920	Intron	novel		0.42
SKCM	chr17	58521921	Intron	novel		0.43
SKCM	chr17	58526916	Silent	NA	F41F	0.42
SKCM	chr17	58520991	Splice_Region	novel		0.38
SKCM	chr17	58526746	Missense_Mutation	NA	P98L	0.35
SKCM	chr17	58520812	Silent	novel	F436F	0.81
SKCM	chr17	58521342	Silent	NA	I342I	0.21
STAD	chr17	58521846	Missense_Mutation	NA	P269S	0.27
STAD	chr17	58521272	Missense_Mutation	NA	P366S	0.44
STAD	chr17	58520868	Intron	novel		0.21
STAD	chr17	58520797	Silent	NA	V441V	0.3
STAD	chr17	58521048	Silent	NA	A409A	0.18
STAD	chr17	58526928	Silent	NA	F37F	0.24
STAD	chr17	58526972	Missense_Mutation	rs747126892	R23C	0.41
STAD	chr17	58521848	Missense_Mutation	novel	R268L	0.07
STAD	chr17	58521260	Missense_Mutation	NA	V370M	0.15
STAD	chr17	58521182	Intron	novel		0.29
UCEC	chr17	58520837	Missense_Mutation	rs746376040	L428R	0.32
UCEC	chr17	58521493	Intron	novel		0.17
UCEC	chr17	58521109	Missense_Mutation	NA	R389H	0.36
UCEC	chr17	58520322	3'UTR	novel		0.33
UCEC	chr17	58526364	Intron	rs774348822		0.71
UCEC	chr17	58521492	Intron	novel		0.4
UCEC	chr17	58520770	Missense_Mutation	novel	E450D	0.5
UCEC	chr17	58526264	Missense_Mutation	novel	R136Q	0.41
UCEC	chr17	58525728	Silent	novel	L169L	0.39
UCEC	chr17	58526972	Missense_Mutation	rs747126892	R23C	0.33
UCEC	chr17	58527267	Intron	novel		0.64
UCEC	chr17	58521415	Intron	novel		0.38
UCEC	chr17	58526663	Intron	novel		0.09
UCEC	chr17	58527219	Intron	novel		0.52
UCEC	chr17	58520894	Intron	novel		0.25
UCEC	chr17	58521792	Missense_Mutation	rs371918956	I287V	0.28
UCEC	chr17	58522101	Nonsense_Mutation	novel	C221*	0.05
UCEC	chr17	58521260	Missense_Mutation	NA	V370M	0.28
UCEC	chr17	58521367	Intron	novel		0.24
UCEC	chr17	58521611	Silent	rs757729640	I317I	0.29
UCEC	chr17	58526843	Missense_Mutation	novel	P66S	0.46
UCEC	chr17	58521017	Missense_Mutation	novel	V420M	0.23
UCEC	chr17	58526666	Intron	novel		0.23
UCEC	chr17	58520889	Intron	rs375706047		0.36
UCEC	chr17	58521260	Missense_Mutation	NA	V370M	0.65
UCEC	chr17	58521643	Missense_Mutation	rs770721575	R307W	0.43
UCEC	chr17	58521933	Intron	NA		0.33
UCEC	chr17	58521875	Intron	novel		0.09
UCEC	chr17	58521825	Missense_Mutation	novel	K276E	0.06
UCEC	chr17	58520322	3'UTR	novel		0.31
UCEC	chr17	58520970	Intron	novel		0.35
UCEC	chr17	58526229	Missense_Mutation	novel	M148V	0.18
UCEC	chr17	58526355	Intron	rs766489624		0.38
UCEC	chr17	58520361	3'UTR	novel		0.11
UCEC	chr17	58526414	Intron	novel		0.41
UCEC	chr17	58521759	Missense_Mutation	novel	E298K	0.17
UCEC	chr17	58525715	Missense_Mutation	rs772182274	R173Q	0.2	MMR_HSR1
UCEC	chr17	58526928	Silent	NA	F37F	0.12
UCEC	chr17	58521664	Intron	novel		0.34
UCEC	chr17	58526265	Nonsense_Mutation	novel	R136*	0.43
UCEC	chr17	58525133	Missense_Mutation	rs746324621	R203W	0.41	MMR_HSR1
UCEC	chr17	58520344	3'UTR	novel		0.16
UCEC	chr17	58521635	Silent	novel	E309E	0.24
UCEC	chr17	58521780	Missense_Mutation	novel	A291T	0.36
UCEC	chr17	58525751	Missense_Mutation	novel	V161A	0.21	MMR_HSR1
UCEC	chr17	58521334	Missense_Mutation	NA	A345V	0.09
UCEC	chr17	58525710	Missense_Mutation	NA	L175I	0.44	MMR_HSR1
UCEC	chr17	58522047	Silent	rs148226154	D239D	0.42
UCEC	chr17	58526972	Missense_Mutation	rs747126892	R23C	0.27
UCEC	chr17	58529148	Silent	novel	G9G	0.15
UCEC	chr17	58521869	Intron	novel		0.4
UCEC	chr17	58527229	Intron	novel		0.33
UCEC	chr17	58521443	Intron	novel		0.26
UCS	chr17	58521596	Missense_Mutation	novel	D322E	0.31
UCS	chr17	58526928	Silent	NA	F37F	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0417	0.18166
KIRP	AMP	0.6632	0.14801
PAAD	DEL	0.2174	1.3088e-08
READ	AMP	0.1758	0.15915
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0091	Kaplan-Meier Survival Analysis
STAD	0.00055	Kaplan-Meier Survival Analysis
KIRP	0.00085	Kaplan-Meier Survival Analysis
COAD	0.0053	Kaplan-Meier Survival Analysis
PAAD	0.042	Kaplan-Meier Survival Analysis
PCPG	0.023	Kaplan-Meier Survival Analysis
BLCA	0.0026	Kaplan-Meier Survival Analysis
LIHC	0.0083	Kaplan-Meier Survival Analysis
LGG	0.034	Kaplan-Meier Survival Analysis
LUAD	0.0032	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742