EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108406 (Gene tree)
Gene ID: 79665
Gene Symbol: DHX40
Alias: ARG147|PAD|FLJ22060|DDX40
Full Name: DEAH-box helicase 40
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 42,828 bases
Position: chr17:59,565,525-59,608,352
Accession: 18018
RBP type: canonical RBP
Summary: This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Oct 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000462686	DEAD	PF00270.29	3.1e-09	1	1
ENSP00000251241	DEAD	PF00270.29	2e-08	1	1
ENSP00000463025	DEAD	PF00270.29	1.6e-05	1	1
ENSP00000388749	HA2	PF04408.23	2e-14	1	1
ENSP00000251241	HA2	PF04408.23	2.5e-14	1	1
ENSP00000437958	HA2	PF04408.23	2.9e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000580030	DHX40-207	855	-	ENSP00000462686	268 (aa)	-	J3KSW6
ENST00000578204	DHX40-206	747	-	-	- (aa)	-	-
ENST00000538926	DHX40-203	750	-	ENSP00000437958	250 (aa)	-	F5H625
ENST00000577549	DHX40-204	2654	-	-	- (aa)	-	-
ENST00000580218	DHX40-208	814	-	ENSP00000462702	101 (aa)	-	J3KSX9
ENST00000251241	DHX40-201	3660	XM_006722083	ENSP00000251241	779 (aa)	XP_006722146	Q8IX18
ENST00000577596	DHX40-205	539	-	ENSP00000462246	71 (aa)	-	J3KS08
ENST00000583439	DHX40-209	541	-	-	- (aa)	-	-
ENST00000425628	DHX40-202	2255	-	ENSP00000388749	702 (aa)	-	Q8IX18
ENST00000584385	DHX40-210	580	-	ENSP00000463025	173 (aa)	-	J3KTK0

Gene Model

Click here to download ENSG00000108406's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000108406	Blood Pressure	2.1039880E-014	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108406's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000108406	DHX40	88	44.915	ENSG00000005100	DHX33	98	33.281
ENSG00000108406	DHX40	97	40.892	ENSG00000150990	DHX37	73	39.568
ENSG00000108406	DHX40	93	40.580	ENSG00000101452	DHX35	98	36.364
ENSG00000108406	DHX40	88	53.617	ENSG00000067596	DHX8	52	43.223
ENSG00000108406	DHX40	88	51.271	ENSG00000140829	DHX38	74	40.594
ENSG00000108406	DHX40	79	42.143	ENSG00000174953	DHX36	98	31.481
ENSG00000108406	DHX40	90	48.963	ENSG00000204560	DHX16	93	38.652
ENSG00000108406	DHX40	99	39.362	ENSG00000109606	DHX15	78	41.564
ENSG00000108406	DHX40	87	35.391	ENSG00000144045	DQX1	90	38.182

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108406	DHX40	99	64.493	ENSAPOG00000018707	dhx40	98	66.390	Acanthochromis_polyacanthus
ENSG00000108406	DHX40	100	98.588	ENSAMEG00000011567	DHX40	100	98.588	Ailuropoda_melanoleuca
ENSG00000108406	DHX40	99	63.406	ENSACIG00000020220	dhx40	98	65.698	Amphilophus_citrinellus
ENSG00000108406	DHX40	99	64.493	ENSAOCG00000000250	dhx40	98	66.252	Amphiprion_ocellaris
ENSG00000108406	DHX40	99	64.130	ENSAPEG00000022898	dhx40	97	66.390	Amphiprion_percula
ENSG00000108406	DHX40	99	64.130	ENSATEG00000023287	dhx40	98	65.975	Anabas_testudineus
ENSG00000108406	DHX40	99	70.652	ENSAPLG00000013368	DHX40	100	72.700	Anas_platyrhynchos
ENSG00000108406	DHX40	99	68.841	ENSACAG00000012418	DHX40	99	67.667	Anolis_carolinensis
ENSG00000108406	DHX40	100	99.615	ENSANAG00000019888	DHX40	100	99.686	Aotus_nancymaae
ENSG00000108406	DHX40	99	63.043	ENSACLG00000024213	dhx40	97	66.111	Astatotilapia_calliptera
ENSG00000108406	DHX40	99	63.043	ENSAMXG00000002031	dhx40	95	65.109	Astyanax_mexicanus
ENSG00000108406	DHX40	100	98.588	ENSBTAG00000017868	DHX40	100	98.588	Bos_taurus
ENSG00000108406	DHX40	100	99.358	ENSCJAG00000001554	DHX40	100	99.372	Callithrix_jacchus
ENSG00000108406	DHX40	100	99.215	ENSCAFG00000017625	DHX40	100	97.951	Canis_familiaris
ENSG00000108406	DHX40	100	99.372	ENSCAFG00020026016	DHX40	91	98.845	Canis_lupus_dingo
ENSG00000108406	DHX40	100	98.460	ENSCHIG00000016173	DHX40	100	98.460	Capra_hircus
ENSG00000108406	DHX40	100	98.588	ENSTSYG00000034797	DHX40	100	99.058	Carlito_syrichta
ENSG00000108406	DHX40	99	86.957	ENSCAPG00000016034	DHX40	99	86.781	Cavia_aperea
ENSG00000108406	DHX40	100	96.021	ENSCPOG00000003432	DHX40	100	96.021	Cavia_porcellus
ENSG00000108406	DHX40	97	94.898	ENSCCAG00000028712	DHX40	100	100.000	Cebus_capucinus
ENSG00000108406	DHX40	100	96.923	ENSCATG00000030038	DHX40	100	95.147	Cercocebus_atys
ENSG00000108406	DHX40	100	98.845	ENSCLAG00000012016	DHX40	100	98.845	Chinchilla_lanigera
ENSG00000108406	DHX40	99	100.000	ENSCSAG00000005860	DHX40	100	95.156	Chlorocebus_sabaeus
ENSG00000108406	DHX40	95	98.744	ENSCHOG00000004423	DHX40	100	98.381	Choloepus_hoffmanni
ENSG00000108406	DHX40	99	73.913	ENSCPBG00000006085	DHX40	97	74.623	Chrysemys_picta_bellii
ENSG00000108406	DHX40	100	99.743	ENSCANG00000038492	DHX40	100	99.843	Colobus_angolensis_palliatus
ENSG00000108406	DHX40	100	98.430	ENSCGRG00001000389	Dhx40	100	97.946	Cricetulus_griseus_chok1gshd
ENSG00000108406	DHX40	100	98.430	ENSCGRG00000009491	Dhx40	100	97.946	Cricetulus_griseus_crigri
ENSG00000108406	DHX40	99	62.681	ENSCSEG00000002696	dhx40	98	65.881	Cynoglossus_semilaevis
ENSG00000108406	DHX40	99	62.681	ENSCVAG00000018991	dhx40	97	66.944	Cyprinodon_variegatus
ENSG00000108406	DHX40	99	63.768	ENSDARG00000041586	dhx40	99	66.529	Danio_rerio
ENSG00000108406	DHX40	100	98.331	ENSDNOG00000025497	DHX40	100	98.331	Dasypus_novemcinctus
ENSG00000108406	DHX40	100	94.865	ENSDORG00000006521	Dhx40	100	94.865	Dipodomys_ordii
ENSG00000108406	DHX40	92	94.624	ENSETEG00000018771	DHX40	87	91.111	Echinops_telfairi
ENSG00000108406	DHX40	100	98.588	ENSEASG00005002476	DHX40	100	98.588	Equus_asinus_asinus
ENSG00000108406	DHX40	100	98.588	ENSECAG00000018606	DHX40	100	98.588	Equus_caballus
ENSG00000108406	DHX40	100	93.838	ENSEEUG00000002531	DHX40	100	93.838	Erinaceus_europaeus
ENSG00000108406	DHX40	99	63.636	ENSELUG00000008644	dhx40	97	65.145	Esox_lucius
ENSG00000108406	DHX40	100	98.973	ENSFCAG00000001409	DHX40	100	98.973	Felis_catus
ENSG00000108406	DHX40	99	67.391	ENSFALG00000005587	DHX40	99	69.767	Ficedula_albicollis
ENSG00000108406	DHX40	100	98.845	ENSFDAG00000017214	DHX40	100	98.845	Fukomys_damarensis
ENSG00000108406	DHX40	99	62.681	ENSFHEG00000001190	dhx40	99	65.205	Fundulus_heteroclitus
ENSG00000108406	DHX40	99	60.507	ENSGMOG00000001188	dhx40	99	63.077	Gadus_morhua
ENSG00000108406	DHX40	99	68.841	ENSGALG00000005126	DHX40	100	71.203	Gallus_gallus
ENSG00000108406	DHX40	99	66.540	ENSGAFG00000014480	dhx40	98	66.390	Gambusia_affinis
ENSG00000108406	DHX40	99	63.406	ENSGACG00000006300	dhx40	99	65.145	Gasterosteus_aculeatus
ENSG00000108406	DHX40	99	73.188	ENSGAGG00000024012	DHX40	97	73.865	Gopherus_agassizii
ENSG00000108406	DHX40	54	100.000	ENSGGOG00000042982	-	100	91.169	Gorilla_gorilla
ENSG00000108406	DHX40	99	63.406	ENSHBUG00000022398	dhx40	97	66.250	Haplochromis_burtoni
ENSG00000108406	DHX40	100	98.588	ENSHGLG00000006600	DHX40	100	98.588	Heterocephalus_glaber_female
ENSG00000108406	DHX40	94	91.270	ENSHGLG00000006411	-	96	79.386	Heterocephalus_glaber_female
ENSG00000108406	DHX40	94	91.270	ENSHGLG00100009091	-	96	79.532	Heterocephalus_glaber_male
ENSG00000108406	DHX40	100	96.919	ENSHGLG00100009935	-	100	96.919	Heterocephalus_glaber_male
ENSG00000108406	DHX40	99	63.768	ENSHCOG00000012913	dhx40	96	65.049	Hippocampus_comes
ENSG00000108406	DHX40	99	61.957	ENSIPUG00000015673	dhx40	97	65.411	Ictalurus_punctatus
ENSG00000108406	DHX40	100	93.196	ENSSTOG00000016219	DHX40	100	94.012	Ictidomys_tridecemlineatus
ENSG00000108406	DHX40	100	94.352	ENSJJAG00000010433	Dhx40	100	94.352	Jaculus_jaculus
ENSG00000108406	DHX40	99	62.681	ENSKMAG00000003505	dhx40	98	65.698	Kryptolebias_marmoratus
ENSG00000108406	DHX40	99	62.681	ENSLBEG00000018707	dhx40	98	67.083	Labrus_bergylta
ENSG00000108406	DHX40	99	66.429	ENSLACG00000008892	DHX40	98	68.336	Latimeria_chalumnae
ENSG00000108406	DHX40	99	63.406	ENSLOCG00000003916	dhx40	99	63.398	Lepisosteus_oculatus
ENSG00000108406	DHX40	100	99.372	ENSLAFG00000000087	DHX40	100	98.716	Loxodonta_africana
ENSG00000108406	DHX40	100	99.487	ENSMFAG00000041526	DHX40	100	99.686	Macaca_fascicularis
ENSG00000108406	DHX40	100	96.923	ENSMNEG00000043921	DHX40	100	94.223	Macaca_nemestrina
ENSG00000108406	DHX40	100	99.487	ENSMLEG00000043033	DHX40	100	99.686	Mandrillus_leucophaeus
ENSG00000108406	DHX40	99	62.681	ENSMAMG00000001985	dhx40	98	65.837	Mastacembelus_armatus
ENSG00000108406	DHX40	99	63.043	ENSMZEG00005013826	dhx40	97	66.111	Maylandia_zebra
ENSG00000108406	DHX40	99	68.100	ENSMGAG00000007238	DHX40	100	71.118	Meleagris_gallopavo
ENSG00000108406	DHX40	100	91.667	ENSMAUG00000014047	Dhx40	100	88.062	Mesocricetus_auratus
ENSG00000108406	DHX40	100	99.101	ENSMICG00000027647	DHX40	100	99.101	Microcebus_murinus
ENSG00000108406	DHX40	100	97.433	ENSMOCG00000022697	Dhx40	100	97.433	Microtus_ochrogaster
ENSG00000108406	DHX40	99	61.957	ENSMMOG00000005353	dhx40	97	64.924	Mola_mola
ENSG00000108406	DHX40	99	76.449	ENSMODG00000014468	DHX40	99	76.394	Monodelphis_domestica
ENSG00000108406	DHX40	99	63.043	ENSMALG00000012529	dhx40	98	66.113	Monopterus_albus
ENSG00000108406	DHX40	100	97.561	MGP_CAROLIEiJ_G0016920	Dhx40	100	97.561	Mus_caroli
ENSG00000108406	DHX40	100	97.561	ENSMUSG00000018425	Dhx40	100	97.561	Mus_musculus
ENSG00000108406	DHX40	100	97.818	MGP_PahariEiJ_G0018050	Dhx40	100	97.818	Mus_pahari
ENSG00000108406	DHX40	100	97.561	MGP_SPRETEiJ_G0017766	Dhx40	100	97.561	Mus_spretus
ENSG00000108406	DHX40	100	98.845	ENSMPUG00000015213	DHX40	100	98.845	Mustela_putorius_furo
ENSG00000108406	DHX40	100	96.410	ENSMLUG00000003644	DHX40	100	96.410	Myotis_lucifugus
ENSG00000108406	DHX40	100	97.818	ENSNGAG00000014507	Dhx40	100	97.818	Nannospalax_galili
ENSG00000108406	DHX40	99	63.768	ENSNBRG00000018144	dhx40	98	65.698	Neolamprologus_brichardi
ENSG00000108406	DHX40	80	85.000	ENSMEUG00000002887	-	88	85.000	Notamacropus_eugenii
ENSG00000108406	DHX40	100	98.203	ENSODEG00000013635	DHX40	100	98.203	Octodon_degus
ENSG00000108406	DHX40	99	64.130	ENSONIG00000005195	dhx40	100	66.205	Oreochromis_niloticus
ENSG00000108406	DHX40	95	76.747	ENSOANG00000008516	DHX40	99	76.747	Ornithorhynchus_anatinus
ENSG00000108406	DHX40	99	62.681	ENSORLG00000014185	dhx40	99	65.746	Oryzias_latipes
ENSG00000108406	DHX40	99	62.681	ENSORLG00015016235	dhx40	99	65.746	Oryzias_latipes_hsok
ENSG00000108406	DHX40	99	63.049	ENSOMEG00000006570	dhx40	99	66.252	Oryzias_melastigma
ENSG00000108406	DHX40	100	98.845	ENSOGAG00000007790	DHX40	100	98.845	Otolemur_garnettii
ENSG00000108406	DHX40	100	98.460	ENSOARG00000012632	DHX40	100	98.460	Ovis_aries
ENSG00000108406	DHX40	100	100.000	ENSPPAG00000032782	DHX40	100	100.000	Pan_paniscus
ENSG00000108406	DHX40	100	98.973	ENSPPRG00000010073	DHX40	100	98.973	Panthera_pardus
ENSG00000108406	DHX40	100	98.588	ENSPTIG00000006557	DHX40	100	99.215	Panthera_tigris_altaica
ENSG00000108406	DHX40	100	99.487	ENSPANG00000022266	DHX40	100	99.686	Papio_anubis
ENSG00000108406	DHX40	99	59.420	ENSPKIG00000013016	dhx40	97	64.404	Paramormyrops_kingsleyae
ENSG00000108406	DHX40	99	72.826	ENSPSIG00000010463	DHX40	91	74.373	Pelodiscus_sinensis
ENSG00000108406	DHX40	99	64.130	ENSPMGG00000015257	dhx40	97	65.877	Periophthalmus_magnuspinnatus
ENSG00000108406	DHX40	100	97.946	ENSPEMG00000013338	Dhx40	100	97.946	Peromyscus_maniculatus_bairdii
ENSG00000108406	DHX40	99	76.812	ENSPCIG00000021874	DHX40	95	79.201	Phascolarctos_cinereus
ENSG00000108406	DHX40	99	63.043	ENSPFOG00000006579	dhx40	98	65.975	Poecilia_formosa
ENSG00000108406	DHX40	99	63.043	ENSPLAG00000007062	dhx40	98	65.975	Poecilia_latipinna
ENSG00000108406	DHX40	99	63.043	ENSPMEG00000008446	dhx40	98	66.113	Poecilia_mexicana
ENSG00000108406	DHX40	99	63.043	ENSPREG00000005584	dhx40	98	66.252	Poecilia_reticulata
ENSG00000108406	DHX40	99	99.598	ENSPPYG00000008812	DHX40	100	96.149	Pongo_abelii
ENSG00000108406	DHX40	92	91.398	ENSPCAG00000006468	DHX40	83	98.947	Procavia_capensis
ENSG00000108406	DHX40	99	90.217	ENSPCOG00000008219	DHX40	100	94.595	Propithecus_coquereli
ENSG00000108406	DHX40	99	63.043	ENSPNYG00000013343	dhx40	97	66.111	Pundamilia_nyererei
ENSG00000108406	DHX40	99	64.130	ENSPNAG00000024815	dhx40	97	61.958	Pygocentrus_nattereri
ENSG00000108406	DHX40	100	97.561	ENSRNOG00000004549	Dhx40	100	97.561	Rattus_norvegicus
ENSG00000108406	DHX40	100	99.358	ENSSBOG00000024911	DHX40	100	99.686	Saimiri_boliviensis_boliviensis
ENSG00000108406	DHX40	99	76.812	ENSSHAG00000016859	DHX40	95	78.788	Sarcophilus_harrisii
ENSG00000108406	DHX40	99	63.406	ENSSFOG00015003020	dhx40	97	66.019	Scleropages_formosus
ENSG00000108406	DHX40	99	63.768	ENSSMAG00000001178	dhx40	98	65.928	Scophthalmus_maximus
ENSG00000108406	DHX40	99	62.681	ENSSDUG00000012511	dhx40	98	65.975	Seriola_dumerili
ENSG00000108406	DHX40	99	62.681	ENSSLDG00000010146	dhx40	98	66.252	Seriola_lalandi_dorsalis
ENSG00000108406	DHX40	97	93.878	ENSSARG00000009800	DHX40	87	98.450	Sorex_araneus
ENSG00000108406	DHX40	99	72.464	ENSSPUG00000016309	DHX40	96	74.791	Sphenodon_punctatus
ENSG00000108406	DHX40	99	62.319	ENSSPAG00000015901	dhx40	99	65.348	Stegastes_partitus
ENSG00000108406	DHX40	100	98.973	ENSSSCG00000017665	DHX40	100	98.973	Sus_scrofa
ENSG00000108406	DHX40	99	68.841	ENSTGUG00000007512	DHX40	100	70.685	Taeniopygia_guttata
ENSG00000108406	DHX40	99	59.058	ENSTRUG00000010369	dhx40	97	62.639	Takifugu_rubripes
ENSG00000108406	DHX40	99	59.783	ENSTNIG00000004503	dhx40	100	61.806	Tetraodon_nigroviridis
ENSG00000108406	DHX40	100	97.561	ENSTBEG00000014980	DHX40	100	97.561	Tupaia_belangeri
ENSG00000108406	DHX40	99	95.385	ENSTTRG00000017203	DHX40	99	93.943	Tursiops_truncatus
ENSG00000108406	DHX40	100	98.845	ENSUAMG00000009734	DHX40	100	99.412	Ursus_americanus
ENSG00000108406	DHX40	100	98.460	ENSUMAG00000022721	DHX40	100	98.460	Ursus_maritimus
ENSG00000108406	DHX40	96	98.663	ENSVPAG00000009355	DHX40	100	98.663	Vicugna_pacos
ENSG00000108406	DHX40	100	99.372	ENSVVUG00000013502	DHX40	91	98.845	Vulpes_vulpes
ENSG00000108406	DHX40	99	63.406	ENSXETG00000010939	dhx40	99	66.205	Xenopus_tropicalis
ENSG00000108406	DHX40	99	63.406	ENSXCOG00000001822	dhx40	96	66.432	Xiphophorus_couchianus
ENSG00000108406	DHX40	99	63.406	ENSXMAG00000012466	dhx40	98	66.390	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0034459	ATP-dependent 3'-5' RNA helicase activity	21873635.	IBA	Function