EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108506 (Gene tree)
Gene ID: 57508
Gene Symbol: INTS2
Alias: INT2|KIAA1287
Full Name: integrator complex subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 62,664 bases
Position: chr17:61,865,367-61,928,030
Accession: 29241
RBP type: canonical RBP
Summary: INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000251334	INTS2	PF14750.6	0	1	1
ENSP00000496407	INTS2	PF14750.6	0	1	1
ENSP00000414237	INTS2	PF14750.6	0	1	1
ENSP00000482710	INTS2	PF14750.6	0	1	1
ENSP00000494174	INTS2	PF14750.6	7.7e-135	1	1
ENSP00000461996	INTS2	PF14750.6	4.3e-19	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000617492	INTS2-207	5805	-	ENSP00000482710	1204 (aa)	-	Q9H0H0
ENST00000646954	INTS2-209	2396	-	ENSP00000494174	332 (aa)	-	A0A2R8Y4Z6
ENST00000584967	INTS2-206	663	-	-	- (aa)	-	-
ENST00000583822	INTS2-205	1036	-	-	- (aa)	-	-
ENST00000583076	INTS2-204	411	-	ENSP00000461996	79 (aa)	-	J3KRH0
ENST00000444766	INTS2-202	5878	-	ENSP00000414237	1204 (aa)	-	Q9H0H0
ENST00000646745	INTS2-208	6226	-	ENSP00000495976	199 (aa)	-	A0A2R8Y7F8
ENST00000647009	INTS2-210	5837	XM_011525058	ENSP00000496407	1196 (aa)	XP_011523360	J3KMZ7
ENST00000251334	INTS2-201	4255	-	ENSP00000251334	1196 (aa)	-	J3KMZ7
ENST00000578805	INTS2-203	535	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000108506's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000108506	rs56794817	17	61924617	A	Educational attainment (MTAG)	30038396	[0.0089-0.0159] unit increase	0.0124	EFO_0004784
ENSG00000108506	rs2014444	17	61890579	T	Highest math class taken (MTAG)	30038396	[0.0071-0.0141] unit decrease	0.0106	EFO_0004875
ENSG00000108506	rs56794817	17	61924617	A	Educational attainment (years of education)	30038396	[0.0085-0.0159] unit increase	0.0122	EFO_0004784
ENSG00000108506	rs75545207	17	61902151	A	Educational attainment (years of education)	30038396	[0.0085-0.0163] unit increase	0.0124	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108506's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108506	INTS2	100	91.139	ENSAPOG00000008035	ints2	100	77.833	Acanthochromis_polyacanthus
ENSG00000108506	INTS2	100	98.246	ENSAMEG00000008767	INTS2	99	98.250	Ailuropoda_melanoleuca
ENSG00000108506	INTS2	100	89.873	ENSACIG00000004348	ints2	100	77.924	Amphilophus_citrinellus
ENSG00000108506	INTS2	100	91.139	ENSAOCG00000005547	ints2	100	77.504	Amphiprion_ocellaris
ENSG00000108506	INTS2	100	91.139	ENSAPEG00000015071	ints2	96	90.345	Amphiprion_percula
ENSG00000108506	INTS2	100	91.139	ENSATEG00000003724	ints2	100	77.107	Anabas_testudineus
ENSG00000108506	INTS2	100	92.405	ENSAPLG00000009449	INTS2	100	90.902	Anas_platyrhynchos
ENSG00000108506	INTS2	100	91.139	ENSACAG00000013143	INTS2	98	92.734	Anolis_carolinensis
ENSG00000108506	INTS2	100	99.332	ENSANAG00000027163	INTS2	100	99.332	Aotus_nancymaae
ENSG00000108506	INTS2	100	87.342	ENSACLG00000026142	ints2	100	76.669	Astatotilapia_calliptera
ENSG00000108506	INTS2	100	98.734	ENSBTAG00000012070	INTS2	99	97.431	Bos_taurus
ENSG00000108506	INTS2	100	99.248	ENSCJAG00000001324	INTS2	99	99.250	Callithrix_jacchus
ENSG00000108506	INTS2	100	98.079	ENSCAFG00000017724	INTS2	100	97.759	Canis_familiaris
ENSG00000108506	INTS2	100	98.162	ENSCAFG00020001542	INTS2	100	97.997	Canis_lupus_dingo
ENSG00000108506	INTS2	100	98.734	ENSCHIG00000025276	INTS2	100	97.510	Capra_hircus
ENSG00000108506	INTS2	100	98.734	ENSTSYG00000011050	INTS2	99	98.500	Carlito_syrichta
ENSG00000108506	INTS2	93	100.000	ENSCAPG00000013390	INTS2	99	100.000	Cavia_aperea
ENSG00000108506	INTS2	100	98.734	ENSCPOG00000011664	INTS2	100	97.579	Cavia_porcellus
ENSG00000108506	INTS2	100	99.332	ENSCCAG00000035119	INTS2	100	99.249	Cebus_capucinus
ENSG00000108506	INTS2	100	99.415	ENSCATG00000005965	INTS2	100	99.415	Cercocebus_atys
ENSG00000108506	INTS2	100	98.734	ENSCLAG00000013460	INTS2	100	97.245	Chinchilla_lanigera
ENSG00000108506	INTS2	100	99.331	ENSCSAG00000005911	INTS2	100	99.331	Chlorocebus_sabaeus
ENSG00000108506	INTS2	100	98.734	ENSCHOG00000012125	INTS2	93	99.588	Choloepus_hoffmanni
ENSG00000108506	INTS2	100	92.405	ENSCPBG00000009362	INTS2	100	91.068	Chrysemys_picta_bellii
ENSG00000108506	INTS2	93	45.631	ENSCING00000008614	-	99	42.467	Ciona_intestinalis
ENSG00000108506	INTS2	94	44.795	ENSCSAVG00000011717	-	99	41.578	Ciona_savignyi
ENSG00000108506	INTS2	100	98.734	ENSCANG00000040791	INTS2	100	96.909	Colobus_angolensis_palliatus
ENSG00000108506	INTS2	100	98.734	ENSCGRG00001004999	Ints2	100	96.912	Cricetulus_griseus_chok1gshd
ENSG00000108506	INTS2	100	98.734	ENSCGRG00000001448	-	100	96.912	Cricetulus_griseus_crigri
ENSG00000108506	INTS2	100	89.873	ENSCSEG00000011730	ints2	99	76.675	Cynoglossus_semilaevis
ENSG00000108506	INTS2	100	88.608	ENSCVAG00000014735	ints2	100	77.018	Cyprinodon_variegatus
ENSG00000108506	INTS2	100	88.608	ENSDARG00000069085	ints2	100	78.418	Danio_rerio
ENSG00000108506	INTS2	100	97.577	ENSDNOG00000008076	INTS2	100	97.577	Dasypus_novemcinctus
ENSG00000108506	INTS2	100	97.468	ENSDORG00000009302	Ints2	100	94.574	Dipodomys_ordii
ENSG00000108506	INTS2	97	41.176	FBgn0030858	IntS2	95	38.536	Drosophila_melanogaster
ENSG00000108506	INTS2	58	98.551	ENSETEG00000004817	-	60	98.551	Echinops_telfairi
ENSG00000108506	INTS2	100	62.025	ENSEBUG00000014395	ints2	93	56.638	Eptatretus_burgeri
ENSG00000108506	INTS2	100	98.734	ENSECAG00000020839	INTS2	97	98.217	Equus_caballus
ENSG00000108506	INTS2	100	97.468	ENSEEUG00000011147	-	59	100.000	Erinaceus_europaeus
ENSG00000108506	INTS2	100	89.873	ENSELUG00000023402	ints2	100	78.683	Esox_lucius
ENSG00000108506	INTS2	100	98.413	ENSFCAG00000028418	INTS2	100	98.413	Felis_catus
ENSG00000108506	INTS2	100	92.405	ENSFALG00000005505	INTS2	100	90.000	Ficedula_albicollis
ENSG00000108506	INTS2	100	98.734	ENSFDAG00000014605	INTS2	99	97.410	Fukomys_damarensis
ENSG00000108506	INTS2	100	89.873	ENSFHEG00000015234	ints2	100	77.100	Fundulus_heteroclitus
ENSG00000108506	INTS2	100	89.873	ENSGMOG00000012241	ints2	99	73.432	Gadus_morhua
ENSG00000108506	INTS2	100	92.405	ENSGALG00000005269	INTS2	100	90.568	Gallus_gallus
ENSG00000108506	INTS2	100	89.873	ENSGAFG00000015576	ints2	100	77.833	Gambusia_affinis
ENSG00000108506	INTS2	100	89.873	ENSGACG00000020212	ints2	100	77.070	Gasterosteus_aculeatus
ENSG00000108506	INTS2	100	92.405	ENSGAGG00000003837	INTS2	100	90.902	Gopherus_agassizii
ENSG00000108506	INTS2	100	100.000	ENSGGOG00000004385	INTS2	99	99.247	Gorilla_gorilla
ENSG00000108506	INTS2	100	87.342	ENSHBUG00000018293	ints2	94	87.586	Haplochromis_burtoni
ENSG00000108506	INTS2	100	98.734	ENSHGLG00000009029	INTS2	99	97.410	Heterocephalus_glaber_female
ENSG00000108506	INTS2	100	98.734	ENSHGLG00100015189	INTS2	100	97.410	Heterocephalus_glaber_male
ENSG00000108506	INTS2	100	88.608	ENSHCOG00000012559	ints2	100	76.374	Hippocampus_comes
ENSG00000108506	INTS2	100	83.544	ENSIPUG00000019153	INTS2	99	76.203	Ictalurus_punctatus
ENSG00000108506	INTS2	100	98.747	ENSSTOG00000011102	INTS2	100	98.748	Ictidomys_tridecemlineatus
ENSG00000108506	INTS2	100	97.468	ENSJJAG00000003384	Ints2	100	96.912	Jaculus_jaculus
ENSG00000108506	INTS2	100	87.342	ENSKMAG00000001184	ints2	100	77.100	Kryptolebias_marmoratus
ENSG00000108506	INTS2	100	89.873	ENSLBEG00000013486	ints2	99	76.853	Labrus_bergylta
ENSG00000108506	INTS2	100	89.873	ENSLACG00000013445	INTS2	100	81.660	Latimeria_chalumnae
ENSG00000108506	INTS2	100	87.342	ENSLOCG00000003709	ints2	96	82.487	Lepisosteus_oculatus
ENSG00000108506	INTS2	100	98.734	ENSLAFG00000021978	INTS2	100	95.246	Loxodonta_africana
ENSG00000108506	INTS2	100	99.331	ENSMFAG00000017924	INTS2	100	99.332	Macaca_fascicularis
ENSG00000108506	INTS2	100	99.415	ENSMMUG00000007242	INTS2	100	99.415	Macaca_mulatta
ENSG00000108506	INTS2	100	98.734	ENSMNEG00000035838	INTS2	99	95.591	Macaca_nemestrina
ENSG00000108506	INTS2	100	99.498	ENSMLEG00000029051	INTS2	100	99.499	Mandrillus_leucophaeus
ENSG00000108506	INTS2	100	89.873	ENSMAMG00000004802	ints2	100	77.677	Mastacembelus_armatus
ENSG00000108506	INTS2	100	87.342	ENSMZEG00005023345	ints2	100	76.669	Maylandia_zebra
ENSG00000108506	INTS2	100	92.405	ENSMGAG00000007537	INTS2	100	89.566	Meleagris_gallopavo
ENSG00000108506	INTS2	100	98.734	ENSMAUG00000016751	Ints2	100	96.658	Mesocricetus_auratus
ENSG00000108506	INTS2	100	98.734	ENSMICG00000016853	INTS2	100	98.580	Microcebus_murinus
ENSG00000108506	INTS2	100	97.468	ENSMOCG00000022017	Ints2	100	96.244	Microtus_ochrogaster
ENSG00000108506	INTS2	100	88.608	ENSMMOG00000005826	ints2	100	77.209	Mola_mola
ENSG00000108506	INTS2	100	96.203	ENSMODG00000014273	INTS2	100	92.512	Monodelphis_domestica
ENSG00000108506	INTS2	100	87.342	ENSMALG00000002108	ints2	100	77.276	Monopterus_albus
ENSG00000108506	INTS2	99	95.983	MGP_CAROLIEiJ_G0016912	Ints2	98	97.810	Mus_caroli
ENSG00000108506	INTS2	99	96.067	ENSMUSG00000018068	Ints2	98	97.810	Mus_musculus
ENSG00000108506	INTS2	100	97.468	MGP_PahariEiJ_G0018042	Ints2	100	97.857	Mus_pahari
ENSG00000108506	INTS2	99	95.983	MGP_SPRETEiJ_G0017757	Ints2	98	97.080	Mus_spretus
ENSG00000108506	INTS2	88	97.727	ENSMPUG00000015171	INTS2	100	97.727	Mustela_putorius_furo
ENSG00000108506	INTS2	100	98.734	ENSMLUG00000003877	INTS2	99	96.241	Myotis_lucifugus
ENSG00000108506	INTS2	100	98.734	ENSNGAG00000017259	Ints2	99	97.243	Nannospalax_galili
ENSG00000108506	INTS2	100	88.608	ENSNBRG00000018077	ints2	94	88.276	Neolamprologus_brichardi
ENSG00000108506	INTS2	100	99.582	ENSNLEG00000000462	INTS2	100	99.582	Nomascus_leucogenys
ENSG00000108506	INTS2	87	95.652	ENSMEUG00000006657	-	73	95.556	Notamacropus_eugenii
ENSG00000108506	INTS2	100	97.468	ENSOPRG00000005282	INTS2	87	95.614	Ochotona_princeps
ENSG00000108506	INTS2	100	97.468	ENSODEG00000013812	INTS2	100	94.746	Octodon_degus
ENSG00000108506	INTS2	100	88.608	ENSONIG00000017550	ints2	99	77.449	Oreochromis_niloticus
ENSG00000108506	INTS2	100	97.468	ENSOANG00000002229	INTS2	99	94.167	Ornithorhynchus_anatinus
ENSG00000108506	INTS2	100	98.164	ENSOCUG00000006693	INTS2	99	98.164	Oryctolagus_cuniculus
ENSG00000108506	INTS2	100	87.342	ENSORLG00000012396	ints2	99	77.075	Oryzias_latipes
ENSG00000108506	INTS2	100	87.342	ENSORLG00020014962	ints2	99	77.075	Oryzias_latipes_hni
ENSG00000108506	INTS2	100	87.342	ENSORLG00015021803	ints2	99	76.910	Oryzias_latipes_hsok
ENSG00000108506	INTS2	100	86.076	ENSOMEG00000017250	ints2	99	74.733	Oryzias_melastigma
ENSG00000108506	INTS2	100	98.734	ENSOGAG00000007486	INTS2	100	91.840	Otolemur_garnettii
ENSG00000108506	INTS2	100	98.734	ENSOARG00000015532	INTS2	96	97.344	Ovis_aries
ENSG00000108506	INTS2	100	100.000	ENSPPAG00000043030	INTS2	100	97.902	Pan_paniscus
ENSG00000108506	INTS2	100	98.413	ENSPPRG00000006723	INTS2	100	98.413	Panthera_pardus
ENSG00000108506	INTS2	100	98.413	ENSPTIG00000005455	INTS2	100	98.413	Panthera_tigris_altaica
ENSG00000108506	INTS2	100	100.000	ENSPTRG00000009496	INTS2	100	99.833	Pan_troglodytes
ENSG00000108506	INTS2	100	99.419	ENSPANG00000022170	INTS2	100	99.419	Papio_anubis
ENSG00000108506	INTS2	100	88.608	ENSPKIG00000020268	ints2	99	76.777	Paramormyrops_kingsleyae
ENSG00000108506	INTS2	88	89.792	ENSPSIG00000018160	INTS2	100	89.792	Pelodiscus_sinensis
ENSG00000108506	INTS2	100	88.608	ENSPMGG00000014520	ints2	99	76.403	Periophthalmus_magnuspinnatus
ENSG00000108506	INTS2	100	98.734	ENSPEMG00000000802	Ints2	100	96.828	Peromyscus_maniculatus_bairdii
ENSG00000108506	INTS2	100	96.203	ENSPCIG00000027084	INTS2	97	92.193	Phascolarctos_cinereus
ENSG00000108506	INTS2	100	88.608	ENSPFOG00000013081	ints2	100	77.374	Poecilia_formosa
ENSG00000108506	INTS2	100	88.608	ENSPLAG00000007992	ints2	100	77.374	Poecilia_latipinna
ENSG00000108506	INTS2	100	88.608	ENSPMEG00000003473	ints2	100	77.374	Poecilia_mexicana
ENSG00000108506	INTS2	100	88.608	ENSPREG00000009357	ints2	100	77.157	Poecilia_reticulata
ENSG00000108506	INTS2	100	98.734	ENSPPYG00000008803	INTS2	99	99.796	Pongo_abelii
ENSG00000108506	INTS2	77	96.928	ENSPCAG00000005692	INTS2	84	96.928	Procavia_capensis
ENSG00000108506	INTS2	100	98.734	ENSPCOG00000015040	INTS2	100	94.987	Propithecus_coquereli
ENSG00000108506	INTS2	100	98.734	ENSPVAG00000007071	INTS2	94	95.767	Pteropus_vampyrus
ENSG00000108506	INTS2	100	87.342	ENSPNYG00000022152	ints2	94	87.586	Pundamilia_nyererei
ENSG00000108506	INTS2	100	88.608	ENSPNAG00000011813	ints2	100	73.757	Pygocentrus_nattereri
ENSG00000108506	INTS2	100	96.203	ENSRNOG00000003576	Ints2	99	97.703	Rattus_norvegicus
ENSG00000108506	INTS2	88	91.611	ENSRBIG00000037281	INTS2	100	91.706	Rhinopithecus_bieti
ENSG00000108506	INTS2	100	99.498	ENSRROG00000026994	INTS2	100	99.499	Rhinopithecus_roxellana
ENSG00000108506	INTS2	100	98.734	ENSSBOG00000033684	INTS2	100	96.241	Saimiri_boliviensis_boliviensis
ENSG00000108506	INTS2	100	96.203	ENSSHAG00000014610	INTS2	99	92.123	Sarcophilus_harrisii
ENSG00000108506	INTS2	100	88.608	ENSSFOG00015014282	ints2	99	79.091	Scleropages_formosus
ENSG00000108506	INTS2	100	87.342	ENSSMAG00000000829	ints2	100	77.056	Scophthalmus_maximus
ENSG00000108506	INTS2	100	88.608	ENSSDUG00000018651	ints2	100	77.176	Seriola_dumerili
ENSG00000108506	INTS2	100	88.608	ENSSLDG00000021035	ints2	100	77.176	Seriola_lalandi_dorsalis
ENSG00000108506	INTS2	100	96.203	ENSSARG00000011786	INTS2	99	82.107	Sorex_araneus
ENSG00000108506	INTS2	100	91.139	ENSSPUG00000016601	INTS2	100	89.566	Sphenodon_punctatus
ENSG00000108506	INTS2	100	89.873	ENSSPAG00000005670	ints2	100	77.531	Stegastes_partitus
ENSG00000108506	INTS2	100	98.734	ENSSSCG00000017673	INTS2	100	97.661	Sus_scrofa
ENSG00000108506	INTS2	100	92.405	ENSTGUG00000007739	-	100	89.733	Taeniopygia_guttata
ENSG00000108506	INTS2	66	85.822	ENSTGUG00000015932	-	100	85.822	Taeniopygia_guttata
ENSG00000108506	INTS2	100	88.608	ENSTRUG00000009276	ints2	100	75.885	Takifugu_rubripes
ENSG00000108506	INTS2	100	89.873	ENSTNIG00000011640	ints2	100	77.076	Tetraodon_nigroviridis
ENSG00000108506	INTS2	100	98.734	ENSTBEG00000017598	INTS2	81	92.453	Tupaia_belangeri
ENSG00000108506	INTS2	100	98.734	ENSTTRG00000004559	INTS2	87	99.315	Tursiops_truncatus
ENSG00000108506	INTS2	100	97.468	ENSUAMG00000022956	INTS2	99	97.479	Ursus_americanus
ENSG00000108506	INTS2	100	98.246	ENSUMAG00000022361	INTS2	100	98.247	Ursus_maritimus
ENSG00000108506	INTS2	100	98.734	ENSVPAG00000005059	INTS2	99	97.748	Vicugna_pacos
ENSG00000108506	INTS2	100	98.162	ENSVVUG00000018181	INTS2	99	98.162	Vulpes_vulpes
ENSG00000108506	INTS2	100	86.076	ENSXETG00000010721	ints2	99	82.931	Xenopus_tropicalis
ENSG00000108506	INTS2	100	88.608	ENSXCOG00000004833	ints2	100	77.585	Xiphophorus_couchianus
ENSG00000108506	INTS2	100	88.608	ENSXMAG00000000085	ints2	99	79.583	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	16239144.	IPI	Function
GO:0005634	nucleus	23904267.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	23904267.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016180	snRNA processing	16239144.	IDA	Process
GO:0031965	nuclear membrane	-	IEA	Component
GO:0032039	integrator complex	21873635.	IBA	Component
GO:0032039	integrator complex	16239144.	IDA	Component
GO:0034472	snRNA 3'-end processing	21873635.	IBA	Process
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process