EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108654 (Gene tree)
Gene ID: 1655
Gene Symbol: DDX5
Alias: p68|HLR1|G17P1
Full Name: DEAD-box helicase 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 9,944 bases
Position: chr17:64,498,256-64,508,199
Accession: 2746
RBP type: canonical RBP
Summary: This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000462885	P68HR	PF08061.11	4e-35	1	2
ENSP00000462885	P68HR	PF08061.11	4e-35	2	2
ENSP00000403085	P68HR	PF08061.11	2.1e-33	1	2
ENSP00000403085	P68HR	PF08061.11	2.1e-33	2	2
ENSP00000225792	P68HR	PF08061.11	3.3e-33	1	2
ENSP00000225792	P68HR	PF08061.11	3.3e-33	2	2
ENSP00000462885	DEAD	PF00270.29	6.4e-47	1	1
ENSP00000225792	DEAD	PF00270.29	6.4e-47	1	1
ENSP00000462222	DEAD	PF00270.29	4.4e-33	1	1
ENSP00000403085	DEAD	PF00270.29	1.6e-32	1	1
ENSP00000464337	DEAD	PF00270.29	7e-20	1	1
ENSP00000464659	DEAD	PF00270.29	1e-19	1	1
ENSP00000464304	DEAD	PF00270.29	2.4e-09	1	1
ENSP00000464064	DEAD	PF00270.29	6.4e-09	1	1
ENSP00000463541	DEAD	PF00270.29	2e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27338022	RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis.	Hepatology	2016 Oct	Zhang H	doi: 10.1002/hep.28698
30042133	Coordinate regulation of alternative pre-mRNA splicing events by the human RNA chaperone proteins hnRNPA1 and DDX5.	Genes Dev	2018 Aug 1	Lee YJ	doi: 10.1101/gad.316034.118
11823473	The ATPase, RNA unwinding, and RNA binding activities of recombinant p68 RNA helicase.	J Biol Chem	2002 Apr 12	Huang Y	-
14733953	Phosphorylation of p68 RNA helicase regulates RNA binding by the C-terminal domain of the protein.	Biochem Biophys Res Commun	2004 Feb 6	Yang L	-
21249130	Gadd45a is an RNA binding protein and is localized in nuclear speckles.	PLoS One	2011 Jan 7	Sytnikova YA	doi: 10.1371/journal.pone.0014500.
23536431	Dysfunction of protein homeostasis in myotonic dystrophies.	Histol Histopathol	2013 Sep	Meola G	doi: 10.14670/HH-28.1089
8041617	Detection of dsRNA-binding domains in RNA helicase A and Drosophila maleless: implications for monomeric RNA helicases.	Nucleic Acids Res	1994 Jul 11	Gibson TJ	-
20966046	Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA.	Genes Dev	2010 Nov 15	Yao H	doi: 10.1101/gad.1967810
29374155	Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis.	Nat Commun	2018 Jan 26	Moon BS	doi: 10.1038/s41467-017-02720-9.
11250900	A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.	EMBO J	2001 Mar 15	Watanabe M	-
22892953	Myotonic dystrophy: is a narrow focus obscuring the rest of the field?	Curr Opin Neurol	2012 Oct	Mahadevan MS	doi: 10.1097/WCO.0b013e328357b0d9.
21846828	Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.	MBio	2011 Aug 16	Bortz E	doi: 10.1128/mBio.00151-11
23791529	DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway.	Cell Rep	2013 Jun 27	Wan G	doi: 10.1016/j.celrep.2013.05.038
28388421	DEAD-Box RNA Binding Protein DDX5: Not a Black-Box during Reprogramming.	Cell Stem Cell	2017 Apr 6	Nefzger CM	doi: 10.1016/j.stem.2017.03.006.
30281815	DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1.	Hepatology	2019 Mar	Zhang H	doi: 10.1002/hep.30300
24965446	Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.	J Virol	2014 Sep	Jefferson M	doi: 10.1128/JVI.00984-14
16935882	DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.	Nucleic Acids Res	2006	Fuller-Pace FV	-
21277973	(-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68.	Free Radic Biol Med	2011 May 15	Tanaka T	doi: 10.1016/j.freeradbiomed.2011.01.024
15657085	Satellite DNA binding and cellular localisation of RNA helicase P68.	J Cell Sci	2005 Feb 1	Enukashvily N	-
19673543	Analysis of Ewing sarcoma (EWS)-binding proteins: interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexes.	J Proteome Res	2009 Oct	Pahlich S	doi: 10.1021/pr900235t.
25649741	A Novel Anti-Cancer Agent, 1-(3,5-Dimethoxyphenyl)-4-[(6-Fluoro-2-Methoxyquinoxalin-3-yl)Aminocarbonyl] Piperazine (RX-5902), Interferes With β-Catenin Function Through Y593 Phospho-p68 RNA Helicase.	J Cell Biochem	2015 Aug	Kost GC	doi: 10.1002/jcb.25113.
24035833	The DEAD-box RNA helicase DDX5 acts as a positive regulator of Japanese encephalitis virus replication by binding to viral 3' UTR.	Antiviral Res	2013 Nov	Li C	doi: 10.1016/j.antiviral.2013.09.002
26675721	DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.	Nature	2015 Dec 24	Huang W	doi: 10.1038/nature16193
26496121	Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes.	PLoS Genet	2015 Oct 23	Wongtrakoongate P	doi: 10.1371/journal.pgen.1005615
15464984	Functional interaction between Smad, CREB binding protein, and p68 RNA helicase.	Biochem Biophys Res Commun	2004 Nov 5	Warner DR	-
22156369	New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats.	Nucleic Acids Res	2012 Apr	Laurent FX	doi: 10.1093/nar/gkr1228
7525583	Regulation of p68 RNA helicase by calmodulin and protein kinase C.	J Biol Chem	1994 Nov 25	Buelt MK	-
7677776	Male germ cell extracts contain proteins binding to the conserved 3'-end of mouse p68 RNA helicase mRNA.	Biochem Biophys Res Commun	1995 Sep 14	Sandhu H	-
11279182	A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase.	J Biol Chem	2001 May 18	Akileswaran L	-
23022728	Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness.	Nat Struct Mol Biol	2012 Nov	Dardenne E	doi: 10.1038/nsmb.2390
18630756	Nuclear RNA export and its importance in abiotic stress responses of plants.	Curr Top Microbiol Immunol	2008	Chinnusamy V	-
17011493	The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.	Dev Cell	2006 Oct	Caretti G	-
29729328	Structural characterization of β-catenin and RX-5902 binding to phospho-p68 RNA helicase by molecular dynamics simulation.	Prog Biophys Mol Biol	2018 Dec	Ali W	doi: 10.1016/j.pbiomolbio.2018.04.011

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000585111	DDX5-232	1051	-	ENSP00000463168	44 (aa)	-	J3QKN9
ENST00000581806	DDX5-220	576	-	ENSP00000464064	52 (aa)	-	J3QR62
ENST00000583894	DDX5-227	712	-	-	- (aa)	-	-
ENST00000577922	DDX5-205	996	-	ENSP00000464337	212 (aa)	-	J3QRQ7
ENST00000577787	DDX5-204	838	-	ENSP00000462222	166 (aa)	-	J3KRZ1
ENST00000580026	DDX5-214	1171	-	-	- (aa)	-	-
ENST00000583212	DDX5-223	543	-	ENSP00000463903	10 (aa)	-	A0A0G2JLI4
ENST00000583239	DDX5-224	543	-	ENSP00000463101	181 (aa)	-	J3KTQ4
ENST00000581551	DDX5-217	573	-	-	- (aa)	-	-
ENST00000578491	DDX5-208	463	-	-	- (aa)	-	-
ENST00000583699	DDX5-226	750	-	-	- (aa)	-	-
ENST00000581230	DDX5-215	3558	-	-	- (aa)	-	-
ENST00000579091	DDX5-211	531	-	ENSP00000464587	31 (aa)	-	J3QS97
ENST00000581237	DDX5-216	592	-	-	- (aa)	-	-
ENST00000225792	DDX5-201	2554	-	ENSP00000225792	614 (aa)	-	P17844
ENST00000578804	DDX5-210	2021	-	ENSP00000462885	614 (aa)	-	J3KTA4
ENST00000585223	DDX5-233	699	-	-	- (aa)	-	-
ENST00000584500	DDX5-229	531	-	-	- (aa)	-	-
ENST00000581697	DDX5-219	580	-	ENSP00000464304	65 (aa)	-	J3QRN5
ENST00000630471	DDX5-235	473	-	ENSP00000485764	99 (aa)	-	J3QR02
ENST00000582326	DDX5-221	585	-	-	- (aa)	-	-
ENST00000581693	DDX5-218	2156	-	ENSP00000464566	38 (aa)	-	J3QS79
ENST00000583562	DDX5-225	465	-	-	- (aa)	-	-
ENST00000578190	DDX5-206	582	-	ENSP00000463541	46 (aa)	-	J3QLG9
ENST00000584279	DDX5-228	676	-	ENSP00000462206	120 (aa)	-	J3KRX8
ENST00000584549	DDX5-230	807	-	-	- (aa)	-	-
ENST00000585060	DDX5-231	572	-	ENSP00000465791	16 (aa)	-	K7EKV0
ENST00000583201	DDX5-222	556	-	-	- (aa)	-	-
ENST00000450599	DDX5-202	2077	-	ENSP00000403085	535 (aa)	-	P17844
ENST00000579996	DDX5-213	820	-	ENSP00000464659	153 (aa)	-	J3QSF1
ENST00000579461	DDX5-212	814	-	-	- (aa)	-	-
ENST00000540698	DDX5-203	2225	-	ENSP00000440276	96 (aa)	-	X6RLV5
ENST00000578400	DDX5-207	575	-	ENSP00000463975	99 (aa)	-	J3QR02
ENST00000578758	DDX5-209	667	-	-	- (aa)	-	-
ENST00000585317	DDX5-234	923	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000108654's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG
hsa05205	Proteoglycans in cancer	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000108654	rs1991401	17	64506317	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000108654	rs77672322	17	64501846	T	Lung function (FVC)	30804560	[0.03-0.06] unit decrease	0.0451	EFO_0004312

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108654's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000108654	DDX5	93	53.488	ENSG00000183258	DDX41	80	38.298
ENSG00000108654	DDX5	52	30.034	ENSG00000157349	DDX19B	75	30.345
ENSG00000108654	DDX5	100	58.065	ENSG00000198231	DDX42	77	38.061
ENSG00000108654	DDX5	98	53.374	ENSG00000184735	DDX53	69	43.018
ENSG00000108654	DDX5	83	50.000	ENSG00000278053	DDX52	66	30.713
ENSG00000108654	DDX5	93	48.837	ENSG00000123064	DDX54	86	37.363
ENSG00000108654	DDX5	98	53.012	ENSG00000067048	DDX3Y	74	39.880
ENSG00000108654	DDX5	100	89.759	ENSG00000100201	DDX17	71	90.000
ENSG00000108654	DDX5	92	39.583	ENSG00000124228	DDX27	88	32.653
ENSG00000108654	DDX5	74	55.882	ENSG00000178105	DDX10	50	35.043
ENSG00000108654	DDX5	83	47.368	ENSG00000136271	DDX56	96	30.055
ENSG00000108654	DDX5	51	30.345	ENSG00000168872	DDX19A	70	30.345
ENSG00000108654	DDX5	68	40.496	ENSG00000089737	DDX24	66	30.721
ENSG00000108654	DDX5	100	56.522	ENSG00000080007	DDX43	68	43.430
ENSG00000108654	DDX5	74	39.370	ENSG00000105671	DDX49	74	34.435
ENSG00000108654	DDX5	94	35.976	ENSG00000125485	DDX31	57	30.178
ENSG00000108654	DDX5	97	32.680	ENSG00000109832	DDX25	93	31.768
ENSG00000108654	DDX5	93	32.867	ENSG00000156976	EIF4A2	92	33.714
ENSG00000108654	DDX5	100	47.826	ENSG00000174243	DDX23	55	38.554
ENSG00000108654	DDX5	93	46.512	ENSG00000152670	DDX4	68	39.698
ENSG00000108654	DDX5	83	52.632	ENSG00000213782	DDX47	73	39.233
ENSG00000108654	DDX5	88	33.333	ENSG00000111364	DDX55	88	32.941
ENSG00000108654	DDX5	94	34.694	ENSG00000110367	DDX6	68	30.678
ENSG00000108654	DDX5	98	32.000	ENSG00000141543	EIF4A3	82	34.857
ENSG00000108654	DDX5	93	46.512	ENSG00000118197	DDX59	100	36.842
ENSG00000108654	DDX5	93	54.430	ENSG00000215301	DDX3X	98	40.756
ENSG00000108654	DDX5	93	32.867	ENSG00000161960	EIF4A1	99	32.184
ENSG00000108654	DDX5	70	30.081	ENSG00000198563	DDX39B	77	30.029
ENSG00000108654	DDX5	92	41.667	ENSG00000088205	DDX18	93	31.140

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108654	DDX5	100	92.771	ENSAPOG00000018223	DDX5	100	73.981	Acanthochromis_polyacanthus
ENSG00000108654	DDX5	100	92.771	ENSAPOG00000002749	ddx5	100	74.363	Acanthochromis_polyacanthus
ENSG00000108654	DDX5	100	89.759	ENSAPOG00000002796	-	96	77.521	Acanthochromis_polyacanthus
ENSG00000108654	DDX5	100	100.000	ENSAMEG00000002685	DDX5	92	100.000	Ailuropoda_melanoleuca
ENSG00000108654	DDX5	100	89.759	ENSACIG00000001068	-	97	77.521	Amphilophus_citrinellus
ENSG00000108654	DDX5	100	88.554	ENSACIG00000007438	-	91	79.853	Amphilophus_citrinellus
ENSG00000108654	DDX5	100	92.169	ENSACIG00000022414	ddx5	95	85.683	Amphilophus_citrinellus
ENSG00000108654	DDX5	100	92.771	ENSACIG00000006502	DDX5	100	71.003	Amphilophus_citrinellus
ENSG00000108654	DDX5	100	92.771	ENSAOCG00000010337	DDX5	100	73.668	Amphiprion_ocellaris
ENSG00000108654	DDX5	100	89.759	ENSAOCG00000003224	-	72	82.553	Amphiprion_ocellaris
ENSG00000108654	DDX5	100	92.771	ENSAOCG00000022960	ddx5	99	76.642	Amphiprion_ocellaris
ENSG00000108654	DDX5	100	92.771	ENSAPEG00000002878	DDX5	100	73.668	Amphiprion_percula
ENSG00000108654	DDX5	100	89.759	ENSAPEG00000012868	-	72	82.553	Amphiprion_percula
ENSG00000108654	DDX5	100	92.771	ENSAPEG00000014685	ddx5	100	74.322	Amphiprion_percula
ENSG00000108654	DDX5	100	90.361	ENSATEG00000008746	-	94	82.957	Anabas_testudineus
ENSG00000108654	DDX5	100	92.771	ENSATEG00000010482	ddx5	100	72.785	Anabas_testudineus
ENSG00000108654	DDX5	100	92.771	ENSATEG00000005840	DDX5	100	73.824	Anabas_testudineus
ENSG00000108654	DDX5	100	96.923	ENSAPLG00000009071	DDX5	99	89.185	Anas_platyrhynchos
ENSG00000108654	DDX5	100	96.386	ENSACAG00000000843	-	100	86.829	Anolis_carolinensis
ENSG00000108654	DDX5	100	89.231	ENSACAG00000025568	-	99	77.941	Anolis_carolinensis
ENSG00000108654	DDX5	100	89.759	ENSACAG00000008158	-	87	76.892	Anolis_carolinensis
ENSG00000108654	DDX5	100	100.000	ENSANAG00000007624	DDX5	100	100.000	Aotus_nancymaae
ENSG00000108654	DDX5	100	92.771	ENSACLG00000018254	ddx5	100	72.828	Astatotilapia_calliptera
ENSG00000108654	DDX5	100	93.373	ENSACLG00000003098	DDX5	95	76.898	Astatotilapia_calliptera
ENSG00000108654	DDX5	100	92.169	ENSAMXG00000004466	ddx5	99	75.935	Astyanax_mexicanus
ENSG00000108654	DDX5	100	92.771	ENSAMXG00000015550	DDX5	92	84.521	Astyanax_mexicanus
ENSG00000108654	DDX5	99	89.404	ENSAMXG00000042015	-	96	86.645	Astyanax_mexicanus
ENSG00000108654	DDX5	100	100.000	ENSBTAG00000018423	DDX5	100	100.000	Bos_taurus
ENSG00000108654	DDX5	100	100.000	ENSCJAG00000019310	DDX5	100	100.000	Callithrix_jacchus
ENSG00000108654	DDX5	100	100.000	ENSCAFG00000011713	DDX5	92	100.000	Canis_familiaris
ENSG00000108654	DDX5	100	100.000	ENSCAFG00020026563	DDX5	100	100.000	Canis_lupus_dingo
ENSG00000108654	DDX5	100	100.000	ENSCHIG00000011800	DDX5	100	100.000	Capra_hircus
ENSG00000108654	DDX5	100	100.000	ENSTSYG00000012149	DDX5	100	99.779	Carlito_syrichta
ENSG00000108654	DDX5	96	98.113	ENSCAPG00000007398	DDX5	98	81.867	Cavia_aperea
ENSG00000108654	DDX5	100	100.000	ENSCPOG00000007133	DDX5	100	99.674	Cavia_porcellus
ENSG00000108654	DDX5	100	100.000	ENSCCAG00000037932	DDX5	100	100.000	Cebus_capucinus
ENSG00000108654	DDX5	100	100.000	ENSCATG00000040784	DDX5	100	100.000	Cercocebus_atys
ENSG00000108654	DDX5	100	100.000	ENSCLAG00000006874	DDX5	100	99.674	Chinchilla_lanigera
ENSG00000108654	DDX5	100	100.000	ENSCSAG00000004022	DDX5	100	100.000	Chlorocebus_sabaeus
ENSG00000108654	DDX5	100	100.000	ENSCHOG00000008207	DDX5	100	93.656	Choloepus_hoffmanni
ENSG00000108654	DDX5	100	96.386	ENSCPBG00000009227	DDX5	99	88.411	Chrysemys_picta_bellii
ENSG00000108654	DDX5	100	89.759	ENSCPBG00000023015	-	95	82.308	Chrysemys_picta_bellii
ENSG00000108654	DDX5	100	100.000	ENSCANG00000038487	DDX5	100	100.000	Colobus_angolensis_palliatus
ENSG00000108654	DDX5	100	100.000	ENSCGRG00001014644	Ddx5	100	99.187	Cricetulus_griseus_chok1gshd
ENSG00000108654	DDX5	100	100.000	ENSCGRG00000013097	Ddx5	100	99.187	Cricetulus_griseus_crigri
ENSG00000108654	DDX5	100	92.169	ENSCSEG00000007987	DDX5	100	73.469	Cynoglossus_semilaevis
ENSG00000108654	DDX5	100	92.771	ENSCSEG00000014167	ddx5	82	82.937	Cynoglossus_semilaevis
ENSG00000108654	DDX5	100	92.169	ENSCVAG00000018093	ddx5	97	85.447	Cyprinodon_variegatus
ENSG00000108654	DDX5	100	84.615	ENSCVAG00000015378	-	93	81.455	Cyprinodon_variegatus
ENSG00000108654	DDX5	100	90.964	ENSDARG00000038068	ddx5	97	86.042	Danio_rerio
ENSG00000108654	DDX5	100	100.000	ENSDNOG00000004247	-	93	99.330	Dasypus_novemcinctus
ENSG00000108654	DDX5	100	100.000	ENSDNOG00000039281	-	100	99.186	Dasypus_novemcinctus
ENSG00000108654	DDX5	100	100.000	ENSDORG00000004866	Ddx5	100	99.674	Dipodomys_ordii
ENSG00000108654	DDX5	100	100.000	ENSETEG00000019950	DDX5	100	98.862	Echinops_telfairi
ENSG00000108654	DDX5	99	86.755	ENSEBUG00000011578	ddx5	68	75.688	Eptatretus_burgeri
ENSG00000108654	DDX5	99	91.391	ENSEBUG00000004340	ddx5	85	76.613	Eptatretus_burgeri
ENSG00000108654	DDX5	100	100.000	ENSEASG00005014694	DDX5	99	98.858	Equus_asinus_asinus
ENSG00000108654	DDX5	100	100.000	ENSECAG00000011132	DDX5	100	99.837	Equus_caballus
ENSG00000108654	DDX5	64	98.551	ENSEEUG00000008206	-	56	98.551	Erinaceus_europaeus
ENSG00000108654	DDX5	100	86.747	ENSEEUG00000002487	-	64	80.384	Erinaceus_europaeus
ENSG00000108654	DDX5	100	89.759	ENSELUG00000001184	-	72	82.128	Esox_lucius
ENSG00000108654	DDX5	100	89.759	ENSELUG00000024602	-	92	68.552	Esox_lucius
ENSG00000108654	DDX5	100	91.566	ENSELUG00000009107	ddx5	100	73.642	Esox_lucius
ENSG00000108654	DDX5	100	90.361	ENSELUG00000007424	DDX5	96	77.431	Esox_lucius
ENSG00000108654	DDX5	100	100.000	ENSFCAG00000003512	DDX5	100	100.000	Felis_catus
ENSG00000108654	DDX5	100	96.923	ENSFALG00000002317	DDX5	99	89.123	Ficedula_albicollis
ENSG00000108654	DDX5	100	100.000	ENSFDAG00000019420	-	100	99.500	Fukomys_damarensis
ENSG00000108654	DDX5	100	89.231	ENSFDAG00000017549	-	100	75.812	Fukomys_damarensis
ENSG00000108654	DDX5	100	92.169	ENSFHEG00000011093	ddx5	97	85.300	Fundulus_heteroclitus
ENSG00000108654	DDX5	100	84.615	ENSFHEG00000015667	-	86	63.845	Fundulus_heteroclitus
ENSG00000108654	DDX5	100	92.169	ENSFHEG00000005567	DDX5	90	83.942	Fundulus_heteroclitus
ENSG00000108654	DDX5	100	92.169	ENSGMOG00000010758	ddx5	100	72.397	Gadus_morhua
ENSG00000108654	DDX5	100	84.615	ENSGMOG00000010007	-	100	72.727	Gadus_morhua
ENSG00000108654	DDX5	100	96.923	ENSGALG00000003532	DDX5	100	88.943	Gallus_gallus
ENSG00000108654	DDX5	100	89.157	ENSGAFG00000013389	-	92	69.294	Gambusia_affinis
ENSG00000108654	DDX5	100	92.169	ENSGAFG00000010491	-	88	65.674	Gambusia_affinis
ENSG00000108654	DDX5	100	91.566	ENSGAFG00000017380	ddx5	90	85.086	Gambusia_affinis
ENSG00000108654	DDX5	100	92.169	ENSGACG00000007026	ddx5	90	78.345	Gasterosteus_aculeatus
ENSG00000108654	DDX5	100	80.000	ENSGACG00000019254	DDX5	95	67.541	Gasterosteus_aculeatus
ENSG00000108654	DDX5	100	96.386	ENSGAGG00000020790	DDX5	99	88.411	Gopherus_agassizii
ENSG00000108654	DDX5	100	89.759	ENSGAGG00000021204	-	86	73.050	Gopherus_agassizii
ENSG00000108654	DDX5	100	100.000	ENSGGOG00000015418	DDX5	100	100.000	Gorilla_gorilla
ENSG00000108654	DDX5	100	93.373	ENSHBUG00000002856	DDX5	95	76.898	Haplochromis_burtoni
ENSG00000108654	DDX5	100	92.771	ENSHBUG00000022017	ddx5	100	72.943	Haplochromis_burtoni
ENSG00000108654	DDX5	100	100.000	ENSHGLG00000001771	DDX5	100	99.512	Heterocephalus_glaber_female
ENSG00000108654	DDX5	100	100.000	ENSHGLG00100001046	DDX5	100	99.512	Heterocephalus_glaber_male
ENSG00000108654	DDX5	100	88.554	ENSHCOG00000017168	-	72	78.814	Hippocampus_comes
ENSG00000108654	DDX5	100	93.373	ENSHCOG00000019168	DDX5	100	73.011	Hippocampus_comes
ENSG00000108654	DDX5	100	90.361	ENSHCOG00000006456	-	70	82.340	Hippocampus_comes
ENSG00000108654	DDX5	100	92.771	ENSHCOG00000008800	ddx5	95	76.650	Hippocampus_comes
ENSG00000108654	DDX5	100	92.771	ENSIPUG00000014448	ddx5	100	75.000	Ictalurus_punctatus
ENSG00000108654	DDX5	100	90.964	ENSIPUG00000007815	ddx5	97	74.507	Ictalurus_punctatus
ENSG00000108654	DDX5	100	100.000	ENSSTOG00000012526	DDX5	100	100.000	Ictidomys_tridecemlineatus
ENSG00000108654	DDX5	100	100.000	ENSJJAG00000017587	Ddx5	100	99.511	Jaculus_jaculus
ENSG00000108654	DDX5	100	91.566	ENSKMAG00000012930	ddx5	96	75.251	Kryptolebias_marmoratus
ENSG00000108654	DDX5	100	89.157	ENSKMAG00000021636	-	92	68.914	Kryptolebias_marmoratus
ENSG00000108654	DDX5	100	92.169	ENSKMAG00000011257	DDX5	95	79.909	Kryptolebias_marmoratus
ENSG00000108654	DDX5	100	89.759	ENSLBEG00000026649	-	92	77.206	Labrus_bergylta
ENSG00000108654	DDX5	100	92.771	ENSLBEG00000022905	ddx5	100	72.607	Labrus_bergylta
ENSG00000108654	DDX5	100	91.566	ENSLBEG00000010767	DDX5	100	73.668	Labrus_bergylta
ENSG00000108654	DDX5	100	89.759	ENSLACG00000006598	-	98	64.787	Latimeria_chalumnae
ENSG00000108654	DDX5	100	95.385	ENSLACG00000015051	DDX5	100	83.268	Latimeria_chalumnae
ENSG00000108654	DDX5	100	92.169	ENSLOCG00000013534	ddx5	99	77.107	Lepisosteus_oculatus
ENSG00000108654	DDX5	100	100.000	ENSLAFG00000004461	DDX5	95	98.864	Loxodonta_africana
ENSG00000108654	DDX5	100	89.759	ENSLAFG00000009820	-	97	81.263	Loxodonta_africana
ENSG00000108654	DDX5	100	100.000	ENSMFAG00000026858	DDX5	100	100.000	Macaca_fascicularis
ENSG00000108654	DDX5	100	100.000	ENSMMUG00000009463	DDX5	100	100.000	Macaca_mulatta
ENSG00000108654	DDX5	100	100.000	ENSMNEG00000039559	DDX5	100	98.936	Macaca_nemestrina
ENSG00000108654	DDX5	100	100.000	ENSMLEG00000041700	DDX5	100	100.000	Mandrillus_leucophaeus
ENSG00000108654	DDX5	100	92.771	ENSMAMG00000016568	DDX5	100	73.668	Mastacembelus_armatus
ENSG00000108654	DDX5	100	92.771	ENSMAMG00000008781	ddx5	100	74.121	Mastacembelus_armatus
ENSG00000108654	DDX5	100	89.759	ENSMAMG00000007912	-	88	72.549	Mastacembelus_armatus
ENSG00000108654	DDX5	100	93.373	ENSMZEG00005001247	DDX5	95	76.898	Maylandia_zebra
ENSG00000108654	DDX5	100	92.771	ENSMZEG00005004609	ddx5	100	72.943	Maylandia_zebra
ENSG00000108654	DDX5	100	89.759	ENSMZEG00005005770	-	75	86.901	Maylandia_zebra
ENSG00000108654	DDX5	100	96.923	ENSMGAG00000007667	DDX5	99	89.500	Meleagris_gallopavo
ENSG00000108654	DDX5	100	100.000	ENSMAUG00000008696	Ddx5	100	99.187	Mesocricetus_auratus
ENSG00000108654	DDX5	100	100.000	ENSMICG00000009267	DDX5	100	99.778	Microcebus_murinus
ENSG00000108654	DDX5	100	100.000	ENSMOCG00000012124	Ddx5	100	99.187	Microtus_ochrogaster
ENSG00000108654	DDX5	100	92.771	ENSMMOG00000015736	DDX5	95	77.409	Mola_mola
ENSG00000108654	DDX5	100	92.771	ENSMMOG00000009479	ddx5	99	85.093	Mola_mola
ENSG00000108654	DDX5	100	100.000	ENSMODG00000003743	DDX5	90	98.697	Monodelphis_domestica
ENSG00000108654	DDX5	100	90.361	ENSMALG00000001286	-	83	70.435	Monopterus_albus
ENSG00000108654	DDX5	100	89.231	ENSMALG00000002954	ddx5	95	83.514	Monopterus_albus
ENSG00000108654	DDX5	100	92.771	ENSMALG00000022550	DDX5	90	83.610	Monopterus_albus
ENSG00000108654	DDX5	100	100.000	ENSMUSG00000020719	Ddx5	100	99.024	Mus_musculus
ENSG00000108654	DDX5	100	100.000	MGP_SPRETEiJ_G0018173	Ddx5	100	99.024	Mus_spretus
ENSG00000108654	DDX5	100	100.000	ENSMPUG00000014596	-	97	89.785	Mustela_putorius_furo
ENSG00000108654	DDX5	100	100.000	ENSMPUG00000009262	-	92	99.837	Mustela_putorius_furo
ENSG00000108654	DDX5	100	100.000	ENSMLUG00000009496	DDX5	92	99.837	Myotis_lucifugus
ENSG00000108654	DDX5	100	100.000	ENSNGAG00000016241	Ddx5	100	99.350	Nannospalax_galili
ENSG00000108654	DDX5	100	82.609	ENSNBRG00000002979	DDX5	94	61.897	Neolamprologus_brichardi
ENSG00000108654	DDX5	100	92.771	ENSNBRG00000001026	ddx5	95	72.890	Neolamprologus_brichardi
ENSG00000108654	DDX5	100	100.000	ENSNLEG00000014929	DDX5	100	100.000	Nomascus_leucogenys
ENSG00000108654	DDX5	100	100.000	ENSMEUG00000003843	DDX5	88	98.272	Notamacropus_eugenii
ENSG00000108654	DDX5	100	100.000	ENSOPRG00000008204	DDX5	100	93.496	Ochotona_princeps
ENSG00000108654	DDX5	100	87.097	ENSODEG00000006088	-	90	81.378	Octodon_degus
ENSG00000108654	DDX5	100	93.373	ENSONIG00000018269	DDX5	95	76.733	Oreochromis_niloticus
ENSG00000108654	DDX5	100	89.759	ENSONIG00000008402	-	92	80.741	Oreochromis_niloticus
ENSG00000108654	DDX5	100	92.771	ENSONIG00000008283	ddx5	100	71.924	Oreochromis_niloticus
ENSG00000108654	DDX5	100	100.000	ENSOANG00000010957	-	96	95.706	Ornithorhynchus_anatinus
ENSG00000108654	DDX5	100	89.157	ENSOANG00000010568	-	97	80.585	Ornithorhynchus_anatinus
ENSG00000108654	DDX5	100	100.000	ENSOANG00000008043	-	100	98.371	Ornithorhynchus_anatinus
ENSG00000108654	DDX5	100	100.000	ENSOCUG00000026305	DDX5	99	97.213	Oryctolagus_cuniculus
ENSG00000108654	DDX5	100	92.169	ENSORLG00000015098	ddx5	91	83.268	Oryzias_latipes
ENSG00000108654	DDX5	100	89.157	ENSORLG00000014497	-	97	75.630	Oryzias_latipes
ENSG00000108654	DDX5	100	92.771	ENSORLG00000000866	DDX5	90	83.252	Oryzias_latipes
ENSG00000108654	DDX5	100	89.157	ENSORLG00020007089	-	75	79.832	Oryzias_latipes_hni
ENSG00000108654	DDX5	100	92.771	ENSORLG00020000846	DDX5	94	84.298	Oryzias_latipes_hni
ENSG00000108654	DDX5	100	92.169	ENSORLG00020005294	ddx5	95	74.709	Oryzias_latipes_hni
ENSG00000108654	DDX5	100	92.771	ENSORLG00015017400	DDX5	94	84.362	Oryzias_latipes_hsok
ENSG00000108654	DDX5	100	92.169	ENSORLG00015017383	ddx5	95	74.709	Oryzias_latipes_hsok
ENSG00000108654	DDX5	100	89.759	ENSOMEG00000006411	-	75	87.540	Oryzias_melastigma
ENSG00000108654	DDX5	100	92.771	ENSOMEG00000008956	DDX5	100	73.113	Oryzias_melastigma
ENSG00000108654	DDX5	100	92.771	ENSOMEG00000008354	ddx5	92	84.223	Oryzias_melastigma
ENSG00000108654	DDX5	100	100.000	ENSOARG00000015045	DDX5	92	100.000	Ovis_aries
ENSG00000108654	DDX5	100	100.000	ENSPPAG00000042005	DDX5	100	100.000	Pan_paniscus
ENSG00000108654	DDX5	100	100.000	ENSPPRG00000017727	-	100	98.046	Panthera_pardus
ENSG00000108654	DDX5	100	100.000	ENSPPRG00000013254	-	100	100.000	Panthera_pardus
ENSG00000108654	DDX5	100	100.000	ENSPTIG00000010353	DDX5	100	100.000	Panthera_tigris_altaica
ENSG00000108654	DDX5	100	100.000	ENSPTRG00000009543	DDX5	100	100.000	Pan_troglodytes
ENSG00000108654	DDX5	100	100.000	ENSPANG00000020701	DDX5	100	100.000	Papio_anubis
ENSG00000108654	DDX5	100	91.566	ENSPKIG00000007686	ddx5	100	74.003	Paramormyrops_kingsleyae
ENSG00000108654	DDX5	100	92.169	ENSPKIG00000006762	DDX5	91	87.192	Paramormyrops_kingsleyae
ENSG00000108654	DDX5	100	89.759	ENSPSIG00000004118	-	68	86.792	Pelodiscus_sinensis
ENSG00000108654	DDX5	100	96.386	ENSPSIG00000010830	DDX5	99	89.073	Pelodiscus_sinensis
ENSG00000108654	DDX5	99	92.121	ENSPMGG00000009902	ddx5	95	76.138	Periophthalmus_magnuspinnatus
ENSG00000108654	DDX5	93	89.744	ENSPMGG00000002172	DDX5	75	68.615	Periophthalmus_magnuspinnatus
ENSG00000108654	DDX5	100	100.000	ENSPEMG00000016502	Ddx5	100	99.187	Peromyscus_maniculatus_bairdii
ENSG00000108654	DDX5	100	100.000	ENSPCIG00000014428	DDX5	100	98.534	Phascolarctos_cinereus
ENSG00000108654	DDX5	100	92.169	ENSPFOG00000004109	ddx5	100	72.628	Poecilia_formosa
ENSG00000108654	DDX5	100	92.169	ENSPFOG00000011690	DDX5	91	83.942	Poecilia_formosa
ENSG00000108654	DDX5	100	89.157	ENSPFOG00000011861	-	98	80.244	Poecilia_formosa
ENSG00000108654	DDX5	100	92.169	ENSPLAG00000014263	ddx5	100	73.469	Poecilia_latipinna
ENSG00000108654	DDX5	100	92.169	ENSPLAG00000013054	DDX5	100	72.656	Poecilia_latipinna
ENSG00000108654	DDX5	100	89.157	ENSPLAG00000006320	-	92	69.522	Poecilia_latipinna
ENSG00000108654	DDX5	100	89.157	ENSPMEG00000009339	-	92	69.522	Poecilia_mexicana
ENSG00000108654	DDX5	100	92.169	ENSPMEG00000018534	ddx5	93	76.717	Poecilia_mexicana
ENSG00000108654	DDX5	100	92.169	ENSPMEG00000011703	DDX5	100	72.500	Poecilia_mexicana
ENSG00000108654	DDX5	100	92.169	ENSPREG00000015413	ddx5	98	81.391	Poecilia_reticulata
ENSG00000108654	DDX5	100	92.771	ENSPREG00000018914	DDX5	100	72.613	Poecilia_reticulata
ENSG00000108654	DDX5	100	100.000	ENSPPYG00000008547	DDX5	100	100.000	Pongo_abelii
ENSG00000108654	DDX5	100	100.000	ENSPCAG00000007111	DDX5	76	95.238	Procavia_capensis
ENSG00000108654	DDX5	100	100.000	ENSPCOG00000023732	DDX5	100	100.000	Propithecus_coquereli
ENSG00000108654	DDX5	100	100.000	ENSPVAG00000001932	DDX5	100	99.511	Pteropus_vampyrus
ENSG00000108654	DDX5	100	92.771	ENSPNYG00000020909	ddx5	100	72.943	Pundamilia_nyererei
ENSG00000108654	DDX5	100	93.373	ENSPNYG00000017510	DDX5	95	76.733	Pundamilia_nyererei
ENSG00000108654	DDX5	100	92.771	ENSPNAG00000029431	DDX5	92	85.012	Pygocentrus_nattereri
ENSG00000108654	DDX5	100	92.771	ENSPNAG00000000825	ddx5	95	78.020	Pygocentrus_nattereri
ENSG00000108654	DDX5	100	100.000	ENSRNOG00000030680	Ddx5	100	99.187	Rattus_norvegicus
ENSG00000108654	DDX5	100	100.000	ENSRBIG00000038867	DDX5	100	100.000	Rhinopithecus_bieti
ENSG00000108654	DDX5	100	100.000	ENSRROG00000000127	DDX5	100	100.000	Rhinopithecus_roxellana
ENSG00000108654	DDX5	100	100.000	ENSSBOG00000018926	DDX5	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000108654	DDX5	100	100.000	ENSSHAG00000012772	DDX5	90	98.534	Sarcophilus_harrisii
ENSG00000108654	DDX5	100	92.771	ENSSFOG00015003802	ddx5	94	78.224	Scleropages_formosus
ENSG00000108654	DDX5	100	92.771	ENSSFOG00015004961	DDX5	100	75.283	Scleropages_formosus
ENSG00000108654	DDX5	100	89.157	ENSSFOG00015013052	-	93	82.447	Scleropages_formosus
ENSG00000108654	DDX5	100	92.771	ENSSMAG00000017903	DDX5	100	73.175	Scophthalmus_maximus
ENSG00000108654	DDX5	100	92.169	ENSSMAG00000003994	ddx5	97	84.124	Scophthalmus_maximus
ENSG00000108654	DDX5	100	92.771	ENSSDUG00000019456	DDX5	100	74.138	Seriola_dumerili
ENSG00000108654	DDX5	100	88.554	ENSSDUG00000020428	-	73	80.335	Seriola_dumerili
ENSG00000108654	DDX5	100	89.759	ENSSDUG00000016136	-	96	87.220	Seriola_dumerili
ENSG00000108654	DDX5	100	92.169	ENSSDUG00000017954	ddx5	94	80.292	Seriola_dumerili
ENSG00000108654	DDX5	100	88.554	ENSSLDG00000008526	-	89	79.012	Seriola_lalandi_dorsalis
ENSG00000108654	DDX5	100	92.771	ENSSLDG00000003614	DDX5	100	74.138	Seriola_lalandi_dorsalis
ENSG00000108654	DDX5	100	92.169	ENSSLDG00000024131	ddx5	100	73.726	Seriola_lalandi_dorsalis
ENSG00000108654	DDX5	100	89.759	ENSSLDG00000024923	-	91	77.094	Seriola_lalandi_dorsalis
ENSG00000108654	DDX5	100	87.349	ENSSARG00000004642	-	80	82.171	Sorex_araneus
ENSG00000108654	DDX5	95	81.395	ENSSARG00000007813	DDX5	61	99.281	Sorex_araneus
ENSG00000108654	DDX5	100	96.923	ENSSPUG00000004544	-	98	96.818	Sphenodon_punctatus
ENSG00000108654	DDX5	100	88.554	ENSSPUG00000011141	-	92	67.869	Sphenodon_punctatus
ENSG00000108654	DDX5	100	96.923	ENSSPUG00000004555	-	100	87.728	Sphenodon_punctatus
ENSG00000108654	DDX5	100	92.771	ENSSPAG00000004363	ddx5	100	73.684	Stegastes_partitus
ENSG00000108654	DDX5	100	92.771	ENSSPAG00000014946	DDX5	100	73.981	Stegastes_partitus
ENSG00000108654	DDX5	100	100.000	ENSSSCG00000032092	DDX5	100	99.804	Sus_scrofa
ENSG00000108654	DDX5	100	96.923	ENSTGUG00000004622	DDX5	99	89.465	Taeniopygia_guttata
ENSG00000108654	DDX5	100	89.759	ENSTGUG00000015887	-	99	84.179	Taeniopygia_guttata
ENSG00000108654	DDX5	100	93.373	ENSTRUG00000002356	DDX5	100	73.543	Takifugu_rubripes
ENSG00000108654	DDX5	100	92.169	ENSTRUG00000009308	ddx5	100	72.596	Takifugu_rubripes
ENSG00000108654	DDX5	100	89.759	ENSTRUG00000009294	-	95	81.297	Takifugu_rubripes
ENSG00000108654	DDX5	100	89.759	ENSTNIG00000017510	DDX5	100	70.681	Tetraodon_nigroviridis
ENSG00000108654	DDX5	100	89.759	ENSTNIG00000006247	-	92	78.542	Tetraodon_nigroviridis
ENSG00000108654	DDX5	100	100.000	ENSTBEG00000009490	DDX5	100	99.792	Tupaia_belangeri
ENSG00000108654	DDX5	100	89.157	ENSTBEG00000012479	-	69	69.643	Tupaia_belangeri
ENSG00000108654	DDX5	100	100.000	ENSTTRG00000008793	DDX5	100	99.837	Tursiops_truncatus
ENSG00000108654	DDX5	100	100.000	ENSUAMG00000023388	DDX5	100	100.000	Ursus_americanus
ENSG00000108654	DDX5	100	89.759	ENSUMAG00000014651	-	93	81.841	Ursus_maritimus
ENSG00000108654	DDX5	100	100.000	ENSUMAG00000017787	DDX5	100	100.000	Ursus_maritimus
ENSG00000108654	DDX5	100	100.000	ENSVPAG00000010759	DDX5	100	98.860	Vicugna_pacos
ENSG00000108654	DDX5	100	100.000	ENSVVUG00000006263	DDX5	100	99.349	Vulpes_vulpes
ENSG00000108654	DDX5	100	93.373	ENSXETG00000012580	ddx5	100	79.006	Xenopus_tropicalis
ENSG00000108654	DDX5	100	91.566	ENSXCOG00000015774	ddx5	90	86.010	Xiphophorus_couchianus
ENSG00000108654	DDX5	100	92.771	ENSXCOG00000012265	DDX5	100	72.457	Xiphophorus_couchianus
ENSG00000108654	DDX5	100	89.157	ENSXCOG00000012232	-	92	76.688	Xiphophorus_couchianus
ENSG00000108654	DDX5	100	91.566	ENSXMAG00000008305	ddx5	97	85.903	Xiphophorus_maculatus
ENSG00000108654	DDX5	100	92.771	ENSXMAG00000006131	DDX5	100	72.613	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	15298701.	IDA	Process
GO:0000380	alternative mRNA splicing, via spliceosome	24275493.24910439.	IMP	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21343338.	IDA	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	23022728.	IMP	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000956	nuclear-transcribed mRNA catabolic process	23788676.	IDA	Process
GO:0001837	epithelial to mesenchymal transition	24910439.	IMP	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003724	RNA helicase activity	21343338.	IMP	Function
GO:0003724	RNA helicase activity	1996094.	NAS	Function
GO:0003730	mRNA 3'-UTR binding	23788676.	IDA	Function
GO:0004004	ATP-dependent RNA helicase activity	-	IEA	Function
GO:0005515	protein binding	10837141.12527917.15113910.15298701.15660129.15846844.17011493.17932509.17960593.18279852.18457437.18548003.19626115.20676135.20818423.21343338.21911577.21994455.22222205.22266867.22365833.22640416.23143267.23741449.23788676.24219989.24581491.24910439.24965446.26420826.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005634	nucleus	24910439.	IDA	Component
GO:0005634	nucleus	2451786.	NAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	10837141.	IDA	Component
GO:0006357	regulation of transcription by RNA polymerase II	24275493.	IMP	Process
GO:0009299	mRNA transcription	23143267.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019899	enzyme binding	-	IEA	Function
GO:0030509	BMP signaling pathway	18548003.	IMP	Process
GO:0030520	intracellular estrogen receptor signaling pathway	24275493.	IMP	Process
GO:0030521	androgen receptor signaling pathway	24275493.	IMP	Process
GO:0035500	MH2 domain binding	18548003.	IPI	Function
GO:0036002	pre-mRNA binding	21343338.	IDA	Function
GO:0043021	ribonucleoprotein complex binding	23788676.	IDA	Function
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	15660129.	IMP	Process
GO:0045069	regulation of viral genome replication	-	IEA	Process
GO:0045445	myoblast differentiation	-	ISS	Process
GO:0045667	regulation of osteoblast differentiation	-	ISS	Process
GO:0046332	SMAD binding	18548003.	IPI	Function
GO:0048306	calcium-dependent protein binding	-	IEA	Function
GO:0048511	rhythmic process	-	IEA	Process
GO:0050681	androgen receptor binding	18829551.	IDA	Function
GO:0060765	regulation of androgen receptor signaling pathway	18829551.	IMP	Process
GO:0061614	pri-miRNA transcription by RNA polymerase II	-	ISS	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0070412	R-SMAD binding	18548003.	IPI	Function
GO:0070878	primary miRNA binding	18548003.	IDA	Function
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	15660129.	IMP	Process
GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	18548003.	IMP	Process
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	18548003.	IMP	Process
GO:1990841	promoter-specific chromatin binding	-	ISS	Function
GO:1990904	ribonucleoprotein complex	18809582.	IDA	Component
GO:2001014	regulation of skeletal muscle cell differentiation	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25745998	The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis.	Oncogene	2015 Nov 19	Sarkar M	doi: 10.1038/onc.2015.42
23022728	Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness.	Nat Struct Mol Biol	2012 Nov	Dardenne E	doi: 10.1038/nsmb.2390
22750847	DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells.	Cancer Discov	2012 Sep	Mazurek A	doi: 10.1158/2159-8290.CD-12-0116
28244855	Knockdown of DDX5 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer.	Oncol Res	2017 Jul 5	Ma Z	doi: 10.3727/096504016X14817158982636
28216662	DDX5 promotes gastric cancer cell proliferation in vitro and in vivo through mTOR signaling pathway.	Sci Rep	2017 Feb 20	Du C	doi: 10.1038/srep42876.
19718048	The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer.	Oncogene	2009 Nov 19	Wortham NC	doi: 10.1038/onc.2009.261
18239468	DEAD-box RNA helicase p68 is not required for nuclear translocation of beta-catenin in colon cancer cells.	Cell Cycle	2008 Mar 15	Stucke VM	-
26212035	DDX5 promotes proliferation and tumorigenesis of non-small-cell lung cancer cells by activating β-catenin signaling pathway.	Cancer Sci	2015 Oct	Wang Z	doi: 10.1111/cas.12755
24626184	The RNA helicase/transcriptional co-regulator, p68 (DDX5), stimulates expression of oncogenic protein kinase, Polo-like kinase-1 (PLK1), and is associated with elevated PLK1 levels in human breast cancers.	Cell Cycle	2014	Iyer RS	doi: 10.4161/cc.28415
17699760	Involvement of RNA helicases p68 and p72 in colon cancer.	Cancer Res	2007 Aug 15	Shin S	-
18794152	A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer.	Cancer Res	2008 Sep 15	Han B	doi: 10.1158/0008-5472.CAN-08-2014.
22086602	RNA helicase DDX5 regulates microRNA expression and contributes to cytoskeletal reorganization in basal breast cancer cells.	Mol Cell Proteomics	2012 Feb	Wang D	doi: 10.1074/mcp.M111.011932
26314252	The expression of RNA helicase DDX5 is transcriptionally upregulated by calcitriol through a vitamin D response element in the proximal promoter in SiHa cervical cells.	Mol Cell Biochem	2015 Dec	Gonz??lez-Duarte RJ	doi: 10.1007/s11010-015-2538-4
23349811	p68/DdX5 supports β-catenin & RNAP II during androgen receptor mediated transcription in prostate cancer.	PLoS One	2013	Clark EL	doi: 10.1371/journal.pone.0054150

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr17	64500127	Frame_Shift_Ins	novel	*S547Rfs55**	0.07
ACC	chr17	64506313	5'UTR	novel		0.33
BLCA	chr17	64503235	Missense_Mutation	novel	D255N	0.22
BLCA	chr17	64503821	Silent	novel	E163E	0.33
BLCA	chr17	64499860	3'UTR	novel		0.21
BLCA	chr17	64502276	Intron	novel		0.13
BLCA	chr17	64500125	Missense_Mutation	NA	N548S	0.5
BLCA	chr17	64503095	Missense_Mutation	novel	D272N	0.08
BLCA	chr17	64503550	Missense_Mutation	novel	R177W	0.06
BLCA	chr17	64504298	Splice_Site	novel	X71_splice	0.17
BLCA	chr17	64500045	Nonsense_Mutation	NA	Q575*	0.4
BLCA	chr17	64500064	Silent	novel	Q568Q	0.33
BLCA	chr17	64503279	Missense_Mutation	novel	R240T	0.33
BLCA	chr17	64503835	Nonsense_Mutation	NA	Q159*	0.19
BLCA	chr17	64506097	Missense_Mutation	NA	R8Q	0.31
BLCA	chr17	64502177	Missense_Mutation	novel	D381H	0.15
BLCA	chr17	64503508	Missense_Mutation	NA	C191G	0.26
BRCA	chr17	64503981	Splice_Site	NA	X147_splice	0.05
BRCA	chr17	64504760	Nonsense_Mutation	novel	K43*	0.09	P68HR
BRCA	chr17	64500148	Frame_Shift_Del	rs782756724	Y540*	0.27
BRCA	chr17	64506149	5'UTR	novel		0.05
BRCA	chr17	64503220	Missense_Mutation	novel	P260T	0.04
BRCA	chr17	64503231	Frame_Shift_Ins	novel	*M256Nfs4**	0.07
BRCA	chr17	64504315	Missense_Mutation	novel	E72K	0.08
BRCA	chr17	64500602	Missense_Mutation	novel	A463D	0.05
BRCA	chr17	64503190	Splice_Region	NA	R270R	0.13
BRCA	chr17	64502518	Nonsense_Mutation	NA	E339*	0.16
BRCA	chr17	64506202	5'UTR	novel		0.48
BRCA	chr17	64506219	5'UTR	novel		0.25
BRCA	chr17	64500611	Missense_Mutation	NA	L460R	0.33
BRCA	chr17	64502542	Missense_Mutation	NA	R331C	0.03
BRCA	chr17	64504281	Missense_Mutation	novel	T83R	0.07
BRCA	chr17	64504690	Missense_Mutation	novel	A66G	0.21
CESC	chr17	64504697	Missense_Mutation	NA	D64N	0.16
CESC	chr17	64499835	3'UTR	novel		0.23
CESC	chr17	64506202	5'UTR	novel		0.1
CESC	chr17	64502031	Missense_Mutation	NA	D399Y	0.2
CESC	chr17	64500308	Missense_Mutation	novel	G487E	0.5
CESC	chr17	64500291	Missense_Mutation	rs782455211	R493C	0.69
CESC	chr17	64500195	Missense_Mutation	NA	D525H	0.45
COAD	chr17	64500632	Missense_Mutation	NA	V453A	0.33
COAD	chr17	64504259	Silent	novel	P90P	0.08
COAD	chr17	64499991	Missense_Mutation	NA	Y593H	0.09
COAD	chr17	64499895	3'UTR	novel		0.27
COAD	chr17	64500264	Frame_Shift_Del	NA	*R502Gfs87**	0.21
COAD	chr17	64499915	3'UTR	novel		0.24
COAD	chr17	64506196	5'UTR	novel		0.31
COAD	chr17	64502418	Intron	NA		0.23
COAD	chr17	64503431	Missense_Mutation	novel	R216S	0.13
COAD	chr17	64503815	Silent	rs79187435	G165G	0.2
COAD	chr17	64500036	Missense_Mutation	rs782608247	G578R	0.25
COAD	chr17	64500054	Frame_Shift_Ins	novel	*D572Nfs6**	0.04
COAD	chr17	64500720	Frame_Shift_Ins	novel	*D424Ifs31**	0.03
ESCA	chr17	64499936	Missense_Mutation	novel	G611V	0.54
ESCA	chr17	64500311	Missense_Mutation	novel	R486T	0.42
ESCA	chr17	64502993	Nonsense_Mutation	novel	E306*	0.53
GBM	chr17	64506099	Missense_Mutation	novel	D7E	0.41
GBM	chr17	64504259	Silent	novel	P90P	0.37
GBM	chr17	64499958	Missense_Mutation	novel	I604L	0.05
GBM	chr17	64503981	Splice_Site	NA	X147_splice	0.38
HNSC	chr17	64503193	Missense_Mutation	NA	I269V	0.26
HNSC	chr17	64503188	Splice_Region	novel	R270R	0.51
KIRC	chr17	64503981	Splice_Site	NA	X147_splice	0.03
KIRC	chr17	64502470	Missense_Mutation	novel	D355H	0.12
KIRC	chr17	64503981	Splice_Site	NA	X147_splice	0.26
KIRC	chr17	64499925	Nonstop_Mutation	NA	615Qext24	0.1
KIRP	chr17	64500615	Missense_Mutation	rs782549207	V459L	0.26
KIRP	chr17	64503805	Missense_Mutation	rs781979552	I169V	0.38
KIRP	chr17	64506267	5'UTR	novel		0.5
KIRP	chr17	64500173	Missense_Mutation	novel	N532S	0.28
KIRP	chr17	64500632	Missense_Mutation	novel	V453E	0.53
KIRP	chr17	64503981	Splice_Site	NA	X147_splice	0.28
KIRP	chr17	64500734	Missense_Mutation	NA	P419R	0.25
KIRP	chr17	64504052	Silent	NA	G124G	0.59
KIRP	chr17	64499886	3'UTR	novel		0.6
LAML	chr17	64502406	Intron	novel		0.26
LGG	chr17	64503981	Splice_Site	NA	X147_splice	0.37
LGG	chr17	64503981	Splice_Site	NA	X147_splice	0.04
LGG	chr17	64502184	Missense_Mutation	NA	Q378H	0.18
LIHC	chr17	64500143	Missense_Mutation	rs200823006	N542S	0.31
LIHC	chr17	64500643	Silent	novel	N449N	0.28
LIHC	chr17	64502192	Missense_Mutation	NA	S376G	0.12
LUAD	chr17	64500177	Missense_Mutation	NA	Q531E	0.2
LUAD	chr17	64503068	Missense_Mutation	novel	T281S	0.14
LUSC	chr17	64500768	Missense_Mutation	novel	E408K	0.47
LUSC	chr17	64503989	Silent	novel	T145T	0.34
LUSC	chr17	64504830	Silent	novel	P19P	0.36
LUSC	chr17	64504241	Missense_Mutation	NA	F96L	0.24
OV	chr17	64500196	Frame_Shift_Del	novel	*D515Efs65**	0.81
OV	chr17	64500170	Missense_Mutation	NA	G533A	0.2
OV	chr17	64504789	Missense_Mutation	novel	K33M	0.05	P68HR
OV	chr17	64502055	Nonsense_Mutation	novel	*K391Vfs7**	0.05
OV	chr17	64503011	Missense_Mutation	NA	I300V	0.25
OV	chr17	64503981	Splice_Site	NA	X147_splice	0.75
PAAD	chr17	64500280	Missense_Mutation	novel	R496S	0.21
PAAD	chr17	64502999	Missense_Mutation	novel	A304S	0.19
PRAD	chr17	64503981	Splice_Site	NA	X147_splice	0.26
PRAD	chr17	64500292	Silent	rs782678991	D492D	0.39
READ	chr17	64502401	Intron	novel		0.46
READ	chr17	64500137	Missense_Mutation	NA	S544N	0.4
SARC	chr17	64503981	Splice_Site	NA	X147_splice	0.33
SARC	chr17	64503981	Splice_Site	NA	X147_splice	0.17
SKCM	chr17	64499981	Missense_Mutation	NA	P596L	0.11
SKCM	chr17	64500324	Missense_Mutation	NA	R482C	0.46
SKCM	chr17	64499890	3'UTR	rs201728992		0.25
SKCM	chr17	64503854	Silent	rs782816392	A152A	0.15
SKCM	chr17	64503855	Missense_Mutation	novel	A152V	0.14
SKCM	chr17	64504700	Missense_Mutation	rs533155437	P63S	0.31
SKCM	chr17	64503028	Missense_Mutation	NA	L294R	0.4
SKCM	chr17	64499835	3'UTR	novel		0.45
SKCM	chr17	64500716	Frame_Shift_Ins	novel	*Y425Lfs24**	0.13
SKCM	chr17	64503083	Silent	novel	L276L	0.34
SKCM	chr17	64502052	Missense_Mutation	novel	A392T	0.56
SKCM	chr17	64503271	Missense_Mutation	NA	T243A	0.2
SKCM	chr17	64500207	Silent	novel	L521L	0.1
SKCM	chr17	64500208	Silent	NA	S520S	0.1
SKCM	chr17	64500609	Missense_Mutation	NA	R461C	0.21
SKCM	chr17	64503994	Missense_Mutation	NA	K144E	0.31
STAD	chr17	64500180	Frame_Shift_Del	NA	*T530Lfs59**	0.26
STAD	chr17	64499959	Missense_Mutation	NA	M603I	0.26
STAD	chr17	64500278	Missense_Mutation	NA	Y497C	0.19
STAD	chr17	64504238	Nonsense_Mutation	NA	Y97*	0.12
THYM	chr17	64500035	Missense_Mutation	novel	G578E	0.34
UCEC	chr17	64499880	3'UTR	novel		0.37
UCEC	chr17	64499882	3'UTR	novel		0.1
UCEC	chr17	64503562	Missense_Mutation	rs782126204	L173M	0.34
UCEC	chr17	64503865	Silent	novel	L149L	0.36
UCEC	chr17	64500626	Missense_Mutation	NA	D455G	0.37
UCEC	chr17	64504839	Silent	novel	F16F	0.26
UCEC	chr17	64506174	5'UTR	novel		0.78
UCEC	chr17	64503986	Silent	rs781994725	L146L	0.36
UCEC	chr17	64499937	Nonsense_Mutation	novel	G611*	0.28
UCEC	chr17	64500185	Missense_Mutation	novel	A528V	0.32
UCEC	chr17	64502996	Missense_Mutation	rs782575221	L305F	0.22
UCEC	chr17	64504313	Silent	novel	E72E	0.04
UCEC	chr17	64502943	Silent	rs370378223	D322D	0.56
UCEC	chr17	64499737	3'UTR	novel		0.33
UCEC	chr17	64500708	Nonsense_Mutation	novel	R428*	0.37
UCEC	chr17	64503253	Nonsense_Mutation	novel	E249*	0.26
UCEC	chr17	64499794	3'UTR	novel		0.24
UCEC	chr17	64500291	Missense_Mutation	NA	R493S	0.25
UCEC	chr17	64499650	3'UTR	novel		0.5
UCEC	chr17	64503289	Frame_Shift_Del	novel	*T237Pfs3**	0.39
UCEC	chr17	64502939	Nonsense_Mutation	novel	E324*	0.5
UCEC	chr17	64503495	Missense_Mutation	rs782356381	R195H	0.35
UCEC	chr17	64500150	Missense_Mutation	NA	Y540H	0.22
UCEC	chr17	64499670	3'UTR	novel		0.21
UCEC	chr17	64499882	3'UTR	rs372481282		0.32
UCEC	chr17	64500609	Frame_Shift_Del	NA	*L456Vfs29**	0.64
UCEC	chr17	64500151	Missense_Mutation	novel	N539K	0.15
UCEC	chr17	64503078	Missense_Mutation	NA	M277I	0.06
UCEC	chr17	64502223	Splice_Region	novel	G365G	0.56
UCEC	chr17	64500191	Missense_Mutation	rs782040676	F526C	0.42
UCEC	chr17	64500197	Missense_Mutation	novel	R524I	0.04
UCEC	chr17	64500627	Missense_Mutation	rs369801003	D455N	0.3
UCEC	chr17	64500247	Silent	rs782704842	T507T	0.43
UCEC	chr17	64499846	3'UTR	novel		0.16
UCEC	chr17	64500288	Missense_Mutation	rs781795667	R494W	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3946	0.00012456
KIRP	AMP	0.6667	0.14801
LGG	AMP	0.0585	1.52e-05
READ	AMP	0.1879	0.15915
SARC	AMP	0.214	0.032181
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0061	Kaplan-Meier Survival Analysis
SARC	0.018	Kaplan-Meier Survival Analysis
MESO	0.04	Kaplan-Meier Survival Analysis
SKCM	0.00015	Kaplan-Meier Survival Analysis
COAD	0.0062	Kaplan-Meier Survival Analysis
PAAD	0.0019	Kaplan-Meier Survival Analysis
PCPG	0.039	Kaplan-Meier Survival Analysis
BLCA	0.0028	Kaplan-Meier Survival Analysis
READ	0.019	Kaplan-Meier Survival Analysis
LGG	0.00089	Kaplan-Meier Survival Analysis
LUAD	0.021	Kaplan-Meier Survival Analysis
UVM	0.037	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742