EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108671 (Gene tree)
Gene ID: 5717
Gene Symbol: PSMD11
Alias: S9|p44.5|MGC3844|Rpn6
Full Name: proteasome 26S subunit, non-ATPase 11
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 39,059 bases
Position: chr17:32,444,261-32,483,319
Accession: 9556
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000580904	PSMD11-209	540	-	ENSP00000463728	5 (aa)	-	UPI000268B0D9
ENST00000457654	PSMD11-202	2159	-	ENSP00000393185	422 (aa)	-	O00231
ENST00000469475	PSMD11-203	473	-	-	- (aa)	-	-
ENST00000261712	PSMD11-201	4098	-	ENSP00000261712	422 (aa)	-	O00231
ENST00000649012	PSMD11-212	3317	-	ENSP00000497128	422 (aa)	-	UPI0000132791
ENST00000481992	PSMD11-204	492	-	-	- (aa)	-	-
ENST00000579451	PSMD11-208	582	-	ENSP00000464434	187 (aa)	-	J3QRY4
ENST00000578397	PSMD11-207	1178	-	-	- (aa)	-	-
ENST00000493026	PSMD11-205	2387	-	-	- (aa)	-	-
ENST00000578213	PSMD11-206	480	-	ENSP00000462683	45 (aa)	-	J3KSW3
ENST00000585265	PSMD11-211	670	-	-	- (aa)	-	-
ENST00000584340	PSMD11-210	559	-	ENSP00000464475	90 (aa)	-	J3QS13

Gene Model

Click here to download ENSG00000108671's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000108671	rs9899540	17	32450906	A	Systolic blood pressure	30224653	[0.14-0.26] mmHg increase	0.2011	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108671's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108671	PSMD11	97	85.057	FBgn0028689	Rpn6	100	67.925	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	17323924.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0005198	structural molecule activity	21873635.	IBA	Function
GO:0005515	protein binding	23455924.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0006511	ubiquitin-dependent protein catabolic process	22972301.	IMP	Process
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008541	proteasome regulatory particle, lid subcomplex	21873635.	IBA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0022624	proteasome accessory complex	22972301.	IDA	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043248	proteasome assembly	21873635.	IBA	Process
GO:0043248	proteasome assembly	22972301.	IMP	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0048863	stem cell differentiation	22972301.	IMP	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component