EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108774 (Gene tree)
Gene ID: 5878
Gene Symbol: RAB5C
Alias: RAB5CL|RABL
Full Name: RAB5C, member RAS oncogene family
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 30,069 bases
Position: chr17:42,124,976-42,155,044
Accession: 9785
RBP type: canonical RBP
Summary: Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000345689	MMR_HSR1	PF01926.23	0.00049	1	1
ENSP00000377440	MMR_HSR1	PF01926.23	0.00049	1	1
ENSP00000449612	MMR_HSR1	PF01926.23	0.00064	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000551338	RAB5C-208	560	-	ENSP00000467144	150 (aa)	-	K7ENY4
ENST00000552162	RAB5C-209	551	-	ENSP00000449612	124 (aa)	-	F8VVK3
ENST00000546881	RAB5C-203	608	-	-	- (aa)	-	-
ENST00000547517	RAB5C-204	1167	-	ENSP00000447053	249 (aa)	-	P51148
ENST00000550504	RAB5C-207	583	-	ENSP00000449777	91 (aa)	-	F8VWU4
ENST00000550406	RAB5C-206	500	-	ENSP00000448314	74 (aa)	-	F8VSF8
ENST00000393860	RAB5C-202	1912	-	ENSP00000377440	216 (aa)	-	P51148
ENST00000346213	RAB5C-201	1671	XM_011525090	ENSP00000345689	216 (aa)	XP_011523392	P51148
ENST00000550013	RAB5C-205	555	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000108774's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04014	Ras signaling pathway	KEGG
hsa04144	Endocytosis	KEGG
hsa04145	Phagosome	KEGG
hsa04962	Vasopressin-regulated water reabsorption	KEGG
hsa05146	Amoebiasis	KEGG
hsa05152	Tuberculosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000108774	Fibrinogen	2E-9	28107422
ENSG00000108774	Fibrinogen	6E-9	26561523
ENSG00000108774	Fibrinogen	5E-9	28107422

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000108774	rs7224737	17	42137346	A	Fibrinogen levels	26561523	NR unit increase	0.0061	EFO_0004623
ENSG00000108774	rs11079035	17	42136994	A	Vitiligo	27723757	[1.14-1.29]	1.209	EFO_0004208
ENSG00000108774	rs7224737	17	42137346	?	Fibrinogen levels	28107422	unit increase	0.0073	EFO_0004623
ENSG00000108774	rs7224737	17	42137346	?	Fibrinogen levels	28107422	unit increase	0.0068	EFO_0004623
ENSG00000108774	rs13380830	17	42145640	?	Autoimmune traits	30595370			EFO_0005140
ENSG00000108774	rs12325861	17	42137394	?	Hypothyroidism	30595370			EFO_0004705
ENSG00000108774	rs78862468	17	42135088	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000108774	rs11079035	17	42136994	?	White blood cell count	30595370			EFO_0004308
ENSG00000108774	rs1869365	17	42141847	?	vWF and FVIII levels	30586737			EFO_0004630\|EFO_0004629

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108774's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108774	RAB5C	100	95.968	ENSAPOG00000016864	rab5c	98	91.163	Acanthochromis_polyacanthus
ENSG00000108774	RAB5C	100	100.000	ENSAMEG00000006003	RAB5C	100	99.074	Ailuropoda_melanoleuca
ENSG00000108774	RAB5C	100	95.161	ENSACIG00000010896	rab5c	98	90.278	Amphilophus_citrinellus
ENSG00000108774	RAB5C	100	95.968	ENSAOCG00000016614	rab5c	98	91.204	Amphiprion_ocellaris
ENSG00000108774	RAB5C	96	95.798	ENSAPEG00000017868	-	97	90.995	Amphiprion_percula
ENSG00000108774	RAB5C	100	95.968	ENSATEG00000001937	rab5c	100	90.826	Anabas_testudineus
ENSG00000108774	RAB5C	100	99.194	ENSANAG00000025390	RAB5C	100	99.020	Aotus_nancymaae
ENSG00000108774	RAB5C	95	95.763	ENSACLG00000008615	-	99	88.584	Astatotilapia_calliptera
ENSG00000108774	RAB5C	100	94.355	ENSACLG00000002706	rab5c	98	90.278	Astatotilapia_calliptera
ENSG00000108774	RAB5C	100	96.000	ENSAMXG00000043717	rab5c	99	90.826	Astyanax_mexicanus
ENSG00000108774	RAB5C	95	97.458	ENSAMXG00000037267	-	99	90.952	Astyanax_mexicanus
ENSG00000108774	RAB5C	100	100.000	ENSBTAG00000006982	RAB5C	100	99.074	Bos_taurus
ENSG00000108774	RAB5C	100	86.957	WBGene00004268	rab-5	99	75.814	Caenorhabditis_elegans
ENSG00000108774	RAB5C	100	100.000	ENSCAFG00000015629	RAB5C	100	98.611	Canis_familiaris
ENSG00000108774	RAB5C	100	100.000	ENSCAFG00020013537	RAB5C	100	98.611	Canis_lupus_dingo
ENSG00000108774	RAB5C	100	100.000	ENSCHIG00000012960	RAB5C	100	99.074	Capra_hircus
ENSG00000108774	RAB5C	100	100.000	ENSTSYG00000030531	RAB5C	100	99.537	Carlito_syrichta
ENSG00000108774	RAB5C	100	99.194	ENSCCAG00000025940	RAB5C	100	98.611	Cebus_capucinus
ENSG00000108774	RAB5C	100	100.000	ENSCATG00000040873	RAB5C	100	100.000	Cercocebus_atys
ENSG00000108774	RAB5C	100	99.194	ENSCLAG00000016650	RAB5C	100	97.222	Chinchilla_lanigera
ENSG00000108774	RAB5C	100	99.194	ENSCHOG00000009886	RAB5C	100	99.438	Choloepus_hoffmanni
ENSG00000108774	RAB5C	100	89.516	ENSCING00000003340	-	99	76.168	Ciona_intestinalis
ENSG00000108774	RAB5C	100	87.097	ENSCSAVG00000000613	-	99	83.333	Ciona_savignyi
ENSG00000108774	RAB5C	100	100.000	ENSCGRG00001014226	Rab5c	100	99.074	Cricetulus_griseus_chok1gshd
ENSG00000108774	RAB5C	100	100.000	ENSCGRG00000007534	Rab5c	100	99.074	Cricetulus_griseus_crigri
ENSG00000108774	RAB5C	100	95.161	ENSCSEG00000017024	rab5c	98	90.741	Cynoglossus_semilaevis
ENSG00000108774	RAB5C	100	95.604	ENSCVAG00000009550	rab5c	98	90.741	Cyprinodon_variegatus
ENSG00000108774	RAB5C	100	99.194	ENSDNOG00000038853	RAB5C	100	98.611	Dasypus_novemcinctus
ENSG00000108774	RAB5C	100	99.194	ENSDORG00000006819	Rab5c	100	98.611	Dipodomys_ordii
ENSG00000108774	RAB5C	99	85.556	FBgn0014010	Rab5	99	72.197	Drosophila_melanogaster
ENSG00000108774	RAB5C	100	90.110	ENSEBUG00000014794	rab5c	100	79.535	Eptatretus_burgeri
ENSG00000108774	RAB5C	100	100.000	ENSEASG00005009281	RAB5C	100	99.074	Equus_asinus_asinus
ENSG00000108774	RAB5C	100	100.000	ENSECAG00000025054	RAB5C	100	99.537	Equus_caballus
ENSG00000108774	RAB5C	100	100.000	ENSEEUG00000002790	RAB5C	100	99.074	Erinaceus_europaeus
ENSG00000108774	RAB5C	100	95.968	ENSELUG00000010439	-	98	88.426	Esox_lucius
ENSG00000108774	RAB5C	100	95.968	ENSELUG00000018516	rab5c	99	89.815	Esox_lucius
ENSG00000108774	RAB5C	100	100.000	ENSFCAG00000002148	RAB5C	100	99.074	Felis_catus
ENSG00000108774	RAB5C	100	100.000	ENSFDAG00000021541	RAB5C	100	95.370	Fukomys_damarensis
ENSG00000108774	RAB5C	100	96.000	ENSFHEG00000015268	-	99	90.783	Fundulus_heteroclitus
ENSG00000108774	RAB5C	100	95.604	ENSFHEG00000012117	rab5c	98	90.741	Fundulus_heteroclitus
ENSG00000108774	RAB5C	100	95.968	ENSGMOG00000015096	rab5c	98	90.278	Gadus_morhua
ENSG00000108774	RAB5C	95	88.983	ENSGMOG00000001876	-	99	87.209	Gadus_morhua
ENSG00000108774	RAB5C	100	95.604	ENSGAFG00000000884	rab5c	98	91.204	Gambusia_affinis
ENSG00000108774	RAB5C	100	95.200	ENSGAFG00000003642	-	99	88.182	Gambusia_affinis
ENSG00000108774	RAB5C	100	95.161	ENSGACG00000008659	rab5c	99	86.175	Gasterosteus_aculeatus
ENSG00000108774	RAB5C	100	100.000	ENSGGOG00000005472	RAB5C	100	100.000	Gorilla_gorilla
ENSG00000108774	RAB5C	100	94.355	ENSHBUG00000002014	rab5c	98	90.278	Haplochromis_burtoni
ENSG00000108774	RAB5C	95	95.763	ENSHBUG00000006823	-	99	88.584	Haplochromis_burtoni
ENSG00000108774	RAB5C	100	99.194	ENSHGLG00000012067	RAB5C	100	94.907	Heterocephalus_glaber_female
ENSG00000108774	RAB5C	95	90.756	ENSHCOG00000020238	-	100	80.455	Hippocampus_comes
ENSG00000108774	RAB5C	100	95.200	ENSHCOG00000004662	rab5c	97	90.783	Hippocampus_comes
ENSG00000108774	RAB5C	95	91.525	ENSIPUG00000020082	rab5c	98	88.532	Ictalurus_punctatus
ENSG00000108774	RAB5C	100	100.000	ENSSTOG00000006620	RAB5C	100	97.685	Ictidomys_tridecemlineatus
ENSG00000108774	RAB5C	100	100.000	ENSJJAG00000021181	Rab5c	100	99.074	Jaculus_jaculus
ENSG00000108774	RAB5C	100	95.604	ENSKMAG00000020038	rab5c	98	90.741	Kryptolebias_marmoratus
ENSG00000108774	RAB5C	100	93.600	ENSKMAG00000017417	-	99	88.018	Kryptolebias_marmoratus
ENSG00000108774	RAB5C	100	94.400	ENSLBEG00000010408	-	99	87.615	Labrus_bergylta
ENSG00000108774	RAB5C	100	95.968	ENSLBEG00000004128	rab5c	98	91.667	Labrus_bergylta
ENSG00000108774	RAB5C	100	97.581	ENSLOCG00000012566	rab5c	100	93.925	Lepisosteus_oculatus
ENSG00000108774	RAB5C	100	100.000	ENSMFAG00000039627	RAB5C	100	100.000	Macaca_fascicularis
ENSG00000108774	RAB5C	100	100.000	ENSMNEG00000000355	RAB5C	100	100.000	Macaca_nemestrina
ENSG00000108774	RAB5C	100	94.400	ENSMAMG00000016207	-	99	88.018	Mastacembelus_armatus
ENSG00000108774	RAB5C	100	94.355	ENSMAMG00000022322	rab5c	98	90.278	Mastacembelus_armatus
ENSG00000108774	RAB5C	95	95.763	ENSMZEG00005021090	-	99	88.584	Maylandia_zebra
ENSG00000108774	RAB5C	100	94.355	ENSMZEG00005022735	rab5c	98	90.278	Maylandia_zebra
ENSG00000108774	RAB5C	100	100.000	ENSMAUG00000015005	Rab5c	100	99.074	Mesocricetus_auratus
ENSG00000108774	RAB5C	100	100.000	ENSMICG00000041608	RAB5C	100	99.074	Microcebus_murinus
ENSG00000108774	RAB5C	100	100.000	ENSMOCG00000018531	-	100	98.148	Microtus_ochrogaster
ENSG00000108774	RAB5C	100	95.161	ENSMMOG00000020621	rab5c	99	89.450	Mola_mola
ENSG00000108774	RAB5C	100	91.129	ENSMALG00000006052	rab5c	98	84.091	Monopterus_albus
ENSG00000108774	RAB5C	100	92.000	ENSMALG00000022348	-	99	87.156	Monopterus_albus
ENSG00000108774	RAB5C	100	100.000	MGP_CAROLIEiJ_G0017184	Rab5c	100	98.611	Mus_caroli
ENSG00000108774	RAB5C	100	100.000	ENSMUSG00000019173	Rab5c	100	98.611	Mus_musculus
ENSG00000108774	RAB5C	100	100.000	MGP_PahariEiJ_G0018314	Rab5c	100	98.611	Mus_pahari
ENSG00000108774	RAB5C	100	100.000	MGP_SPRETEiJ_G0018027	Rab5c	100	98.611	Mus_spretus
ENSG00000108774	RAB5C	100	100.000	ENSMPUG00000010554	RAB5C	100	99.074	Mustela_putorius_furo
ENSG00000108774	RAB5C	100	98.387	ENSNGAG00000010286	Rab5c	100	98.148	Nannospalax_galili
ENSG00000108774	RAB5C	95	95.763	ENSNBRG00000016922	-	99	88.584	Neolamprologus_brichardi
ENSG00000108774	RAB5C	100	95.161	ENSNBRG00000018165	rab5c	98	91.204	Neolamprologus_brichardi
ENSG00000108774	RAB5C	100	100.000	ENSOPRG00000008255	RAB5C	100	92.697	Ochotona_princeps
ENSG00000108774	RAB5C	100	98.387	ENSODEG00000017920	RAB5C	100	96.296	Octodon_degus
ENSG00000108774	RAB5C	100	95.161	ENSONIG00000001113	rab5c	98	91.204	Oreochromis_niloticus
ENSG00000108774	RAB5C	100	95.604	ENSORLG00000003882	rab5c	100	89.450	Oryzias_latipes
ENSG00000108774	RAB5C	100	95.604	ENSORLG00020008388	rab5c	100	88.991	Oryzias_latipes_hni
ENSG00000108774	RAB5C	100	95.604	ENSORLG00015021900	rab5c	100	89.450	Oryzias_latipes_hsok
ENSG00000108774	RAB5C	100	95.604	ENSOMEG00000023078	rab5c	100	89.450	Oryzias_melastigma
ENSG00000108774	RAB5C	100	99.194	ENSOGAG00000009456	RAB5C	100	99.074	Otolemur_garnettii
ENSG00000108774	RAB5C	100	100.000	ENSOARG00000018768	RAB5C	100	99.074	Ovis_aries
ENSG00000108774	RAB5C	100	100.000	ENSPPAG00000037206	RAB5C	100	100.000	Pan_paniscus
ENSG00000108774	RAB5C	100	100.000	ENSPPRG00000005745	RAB5C	100	99.074	Panthera_pardus
ENSG00000108774	RAB5C	100	100.000	ENSPTIG00000008177	RAB5C	100	99.074	Panthera_tigris_altaica
ENSG00000108774	RAB5C	100	100.000	ENSPTRG00000009194	RAB5C	100	100.000	Pan_troglodytes
ENSG00000108774	RAB5C	100	96.774	ENSPKIG00000001237	-	99	89.767	Paramormyrops_kingsleyae
ENSG00000108774	RAB5C	100	95.968	ENSPKIG00000020112	-	99	87.500	Paramormyrops_kingsleyae
ENSG00000108774	RAB5C	100	91.129	ENSPMGG00000010792	rab5c	97	89.573	Periophthalmus_magnuspinnatus
ENSG00000108774	RAB5C	100	100.000	ENSPEMG00000017971	Rab5c	100	98.148	Peromyscus_maniculatus_bairdii
ENSG00000108774	RAB5C	100	86.822	ENSPMAG00000000008	rab5c	100	78.829	Petromyzon_marinus
ENSG00000108774	RAB5C	100	89.011	ENSPMAG00000007867	rab5c	100	78.605	Petromyzon_marinus
ENSG00000108774	RAB5C	100	91.209	ENSPMAG00000001399	rab5c	100	79.535	Petromyzon_marinus
ENSG00000108774	RAB5C	100	99.194	ENSPCIG00000020225	-	100	97.685	Phascolarctos_cinereus
ENSG00000108774	RAB5C	100	94.565	ENSPLAG00000016333	-	99	89.862	Poecilia_latipinna
ENSG00000108774	RAB5C	100	95.604	ENSPLAG00000004790	rab5c	98	91.204	Poecilia_latipinna
ENSG00000108774	RAB5C	100	95.200	ENSPMEG00000012614	-	99	88.182	Poecilia_mexicana
ENSG00000108774	RAB5C	100	95.604	ENSPMEG00000011336	rab5c	98	91.204	Poecilia_mexicana
ENSG00000108774	RAB5C	100	95.200	ENSPREG00000022167	-	89	93.989	Poecilia_reticulata
ENSG00000108774	RAB5C	100	95.604	ENSPREG00000010146	rab5c	98	91.204	Poecilia_reticulata
ENSG00000108774	RAB5C	100	100.000	ENSPPYG00000008398	RAB5C	100	100.000	Pongo_abelii
ENSG00000108774	RAB5C	100	99.194	ENSPCAG00000016412	RAB5C	100	98.148	Procavia_capensis
ENSG00000108774	RAB5C	100	99.194	ENSPCOG00000026327	RAB5C	100	98.148	Propithecus_coquereli
ENSG00000108774	RAB5C	100	100.000	ENSPVAG00000003867	RAB5C	100	99.537	Pteropus_vampyrus
ENSG00000108774	RAB5C	95	95.763	ENSPNYG00000015851	-	99	88.584	Pundamilia_nyererei
ENSG00000108774	RAB5C	100	94.355	ENSPNYG00000010615	rab5c	98	90.278	Pundamilia_nyererei
ENSG00000108774	RAB5C	100	96.000	ENSPNAG00000028138	rab5c	99	91.284	Pygocentrus_nattereri
ENSG00000108774	RAB5C	95	96.610	ENSPNAG00000002218	-	99	89.151	Pygocentrus_nattereri
ENSG00000108774	RAB5C	100	100.000	ENSRNOG00000018568	Rab5c	100	99.074	Rattus_norvegicus
ENSG00000108774	RAB5C	100	100.000	ENSRBIG00000031376	RAB5C	100	100.000	Rhinopithecus_bieti
ENSG00000108774	RAB5C	100	100.000	ENSRROG00000032895	RAB5C	100	100.000	Rhinopithecus_roxellana
ENSG00000108774	RAB5C	100	99.194	ENSSBOG00000032552	-	100	98.611	Saimiri_boliviensis_boliviensis
ENSG00000108774	RAB5C	100	100.000	ENSSHAG00000005267	-	100	98.148	Sarcophilus_harrisii
ENSG00000108774	RAB5C	100	95.604	ENSSFOG00015009988	-	99	87.097	Scleropages_formosus
ENSG00000108774	RAB5C	100	95.161	ENSSMAG00000007323	rab5c	98	89.815	Scophthalmus_maximus
ENSG00000108774	RAB5C	100	95.968	ENSSDUG00000023008	rab5c	98	91.204	Seriola_dumerili
ENSG00000108774	RAB5C	100	95.968	ENSSLDG00000017771	rab5c	98	90.741	Seriola_lalandi_dorsalis
ENSG00000108774	RAB5C	100	100.000	ENSSPUG00000012950	-	100	95.833	Sphenodon_punctatus
ENSG00000108774	RAB5C	100	95.968	ENSSPAG00000006436	rab5c	98	92.130	Stegastes_partitus
ENSG00000108774	RAB5C	100	100.000	ENSSSCG00000032467	RAB5C	100	99.074	Sus_scrofa
ENSG00000108774	RAB5C	100	94.355	ENSTRUG00000015590	rab5c	98	90.278	Takifugu_rubripes
ENSG00000108774	RAB5C	94	96.581	ENSTNIG00000011711	rab5c	99	88.182	Tetraodon_nigroviridis
ENSG00000108774	RAB5C	100	100.000	ENSTBEG00000007092	RAB5C	100	99.537	Tupaia_belangeri
ENSG00000108774	RAB5C	100	100.000	ENSTTRG00000006673	RAB5C	100	98.148	Tursiops_truncatus
ENSG00000108774	RAB5C	100	100.000	ENSUAMG00000024343	RAB5C	100	99.074	Ursus_americanus
ENSG00000108774	RAB5C	100	100.000	ENSUMAG00000023270	RAB5C	100	99.074	Ursus_maritimus
ENSG00000108774	RAB5C	100	96.000	ENSXCOG00000006300	-	99	88.235	Xiphophorus_couchianus
ENSG00000108774	RAB5C	100	95.604	ENSXCOG00000016788	rab5c	98	91.204	Xiphophorus_couchianus
ENSG00000108774	RAB5C	100	96.000	ENSXMAG00000022179	-	99	90.323	Xiphophorus_maculatus
ENSG00000108774	RAB5C	100	95.604	ENSXMAG00000003266	rab5c	98	91.204	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	17562788.	IDA	Function
GO:0005515	protein binding	17562788.21750715.25416956.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005765	lysosomal membrane	17897319.	HDA	Component
GO:0005768	endosome	21873635.	IBA	Component
GO:0005768	endosome	-	IDA	Component
GO:0005769	early endosome	21873635.	IBA	Component
GO:0005811	lipid droplet	14741744.	IDA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0019003	GDP binding	20937701.	IDA	Function
GO:0030100	regulation of endocytosis	21873635.	IBA	Process
GO:0030139	endocytic vesicle	21873635.	IBA	Component
GO:0031901	early endosome membrane	-	TAS	Component
GO:0032482	Rab protein signal transduction	21873635.	IBA	Process
GO:0035577	azurophil granule membrane	-	TAS	Component
GO:0042470	melanosome	-	IEA	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0048227	plasma membrane to endosome transport	17562788.	IMP	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0098993	anchored component of synaptic vesicle membrane	-	IEA	Component