EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000108829 (Gene tree)
Gene ID
55379
Gene Symbol
LRRC59
Alias
PRO1855|FLJ21675
Full Name
leucine rich repeat containing 59
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
22,495 bases
Position
chr17:50,375,059-50,397,553
Accession
28817
RBP type
non-canonical RBP
Summary
(Leucine Rich Repeat Containing 59) is a Protein Coding gene.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
12076772Two families of RNA binding proteins from Trypanosoma brucei associate in a direct protein-protein interaction.Mol Biochem Parasitol2002 JunPitula JS-
11779210Two novel RNA binding proteins from Trypanosoma brucei are associated with 5S rRNA.Biochem Biophys Res Commun2002 Jan 11Pitula J-
17715362Two trypanosome-specific proteins are essential factors for 5S rRNA abundance and ribosomal assembly in Trypanosoma brucei.Eukaryot Cell2007 OctHellman KM-
22859981A novel association between two trypanosome-specific factors and the conserved L5-5S rRNA complex.PLoS One2012Ciganda Mdoi: 10.1371/journal.pone.0041398
22253864Characterization of a novel association between two trypanosome-specific proteins and 5S rRNA.PLoS One2012Ciganda Mdoi: 10.1371/journal.pone.0030029
27760165The Role of the Trypanosoma cruzi TcNRBD1 Protein in Translation.PLoS One2016 Oct 19Oliveira Cdoi: 10.1371/journal.pone.0164650
28542332Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP).PLoS One2017 May 18Kamina ADdoi: 10.1371/journal.pone.0177890
29062898Essential Assembly Factor Rpf2 Forms Novel Interactions within the 5S RNP in Trypanosoma brucei.mSphere2017 Oct 18Kamina ADdoi: 10.1128/mSphere.00394-17
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000576448LRRC59-2031531-ENSP0000045930562 (aa)-I3L223
ENST00000225972LRRC59-2012910-ENSP00000225972307 (aa)-Q96AG4
ENST00000503118LRRC59-202438-ENSP0000045961657 (aa)-I3L2E8
Gene Model
Click here to download ENSG00000108829's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000108829Platelet Function Tests3.5715381E-006-
ENSG00000108829Platelet Function Tests8.8944960E-006-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108829's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000108829LRRC5910095.440ENSMUSG00000020869Lrrc5910095.440Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005635nuclear envelope-IEAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005783endoplasmic reticulum-IDAComponent
GO:0005789endoplasmic reticulum membrane-IEAComponent
GO:0016020membrane19946888.HDAComponent
GO:0016021integral component of membrane-IEAComponent
GO:0042645mitochondrial nucleoid18063578.IDAComponent
GO:0045296cadherin binding25468996.HDAFunction

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1750388099Nonsense_MutationnovelQ155*0.41
BLCAchr1750385176Silentrs758251033L206L0.25
BLCAchr17503973735'UTRnovel0.6
BLCAchr1750392813Missense_MutationnovelL84V0.25
BRCAchr17503813933'UTRnovel0.3
BRCAchr1750392425Missense_MutationnovelE134D0.08
BRCAchr1750394928Splice_SitenovelX55_splice0.08
CESCchr1750392466Missense_MutationnovelD121H0.05
CESCchr17503974125'UTRnovel0.67
CESCchr17503814963'UTRnovel0.12
CESCchr1750388080Missense_Mutationrs139115894R161Q0.22
COADchr1750388111Missense_Mutationrs200977500V151M0.36
COADchr1750383051Silentrs149087944A287A0.21
COADchr1750388081Missense_Mutationrs143077743R161W0.25
COADchr17503829283'UTRnovel0.44
COADchr1750394977SilentnovelP39P0.18
COADchr1750388119Missense_MutationnovelM148T0.34
ESCAchr17503816303'UTRnovel0.17
GBMchr17503829303'UTRnovel0.15
GBMchr1750383034Missense_Mutationrs146642281R293H0.17
GBMchr1750385201Missense_MutationnovelR198L0.04
GBMchr1750385228Missense_MutationnovelK189T0.09
KIRCchr1750392891Missense_MutationNAF58I0.26
KIRPchr1750394961Missense_Mutationrs773759187D45H0.17
KIRPchr1750385256Nonsense_MutationnovelK180*0.29
LGGchr1750388093Missense_Mutationrs140038553R157W0.65
LUADchr1750397236Missense_Mutationrs760087086N28Y0.1
LUADchr1750388081Missense_Mutationrs143077743R161W0.24
LUADchr1750392742SilentnovelL107L0.25
LUADchr17503829103'UTRnovel0.31
LUADchr1750388082Missense_MutationnovelQ160H0.21
LUADchr1750385256Missense_MutationNAK180E0.13
LUSCchr1750385292Splice_SitenovelX168_splice0.41
LUSCchr17503973315'UTRnovel0.2
OVchr1750383112Missense_MutationnovelR267L0.45
OVchr1750392794Missense_MutationnovelL90Q0.31
OVchr1750383063Missense_MutationNAI283M0.27
PAADchr1750397248Missense_MutationnovelL24I0.17
READchr1750383109Missense_MutationnovelV268E0.28
READchr1750385165Missense_MutationNAK210R0.25
SARCchr1750392859SilentnovelD68D0.08
SARCchr1750385277Missense_MutationNAR173C0.27
SARCchr1750385132Missense_MutationnovelA221E0.13
SARCchr1750383027Missense_MutationnovelE295D0.31
SKCMchr1750383039SilentNAL291L0.2
STADchr1750394973Missense_MutationNAA41T0.13
STADchr1750385179SilentNAA205A0.19
STADchr1750392803Missense_MutationNAL87H0.08
STADchr1750397268Missense_MutationNAG17D0.09
STADchr1750385198Missense_Mutationrs751372015R199Q0.24
UCECchr1750385277Missense_MutationNAR173C0.43
UCECchr1750392754Missense_MutationnovelS103R0.33
UCECchr1750385119Splice_Regionrs746975375P225P0.36
UCECchr1750388082SilentnovelQ160Q0.16
UCECchr1750392886In_Frame_InsnovelC59delinsWPREATRLDTPHLSL0.08
UCECchr17503813163'UTRnovel0.3
UCECchr17503825503'UTRnovel0.59
UCECchr17503815243'UTRnovel0.41
UCECchr17503825503'UTRnovel0.52
UCECchr1750388063Missense_Mutationrs747583013R167C0.17
UCECchr1750394979Missense_MutationNAP39T0.05
UCECchr1750388109SilentnovelV151V0.41
UCECchr17503814023'UTRnovel0.28
UCECchr1750392890Missense_MutationnovelF58S0.11
UCECchr17503973555'UTRnovel0.15
UCECchr17503815153'UTRnovel0.31
UCECchr1750385162Missense_Mutationrs761436418R211Q0.48
UCECchr1750392439Missense_MutationnovelD130N0.16
UCECchr17503820703'UTRnovel0.09
UCECchr17503818773'UTRnovel0.39
UCECchr1750383080Missense_MutationnovelT278A0.42
UCECchr1750385232Missense_Mutationrs749579536R188W0.38
UCECchr1750392815Missense_Mutationrs368144838R83H0.26

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.02080.18166
KIRPAMP0.65970.14801
THCADEL0.0020.221
UVMDEL0.01250.22482

Survival Analysis
CancerP-value Q-value
THYM0.02

Kaplan-Meier Survival Analysis

SARC0.0018

Kaplan-Meier Survival Analysis

MESO0.00049

Kaplan-Meier Survival Analysis

ACC0.0001

Kaplan-Meier Survival Analysis

HNSC0.0001

Kaplan-Meier Survival Analysis

SKCM0.01

Kaplan-Meier Survival Analysis

KIRP0.00012

Kaplan-Meier Survival Analysis

COAD0.001

Kaplan-Meier Survival Analysis

PAAD0.0035

Kaplan-Meier Survival Analysis

BLCA0.0017

Kaplan-Meier Survival Analysis

KICH0.011

Kaplan-Meier Survival Analysis

UCEC0.015

Kaplan-Meier Survival Analysis

LIHC0.0026

Kaplan-Meier Survival Analysis

LGG0.00016

Kaplan-Meier Survival Analysis

LUAD0.0024

Kaplan-Meier Survival Analysis

UVM0.00012

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us