EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000109111 (Gene tree)
Gene ID
6830
Gene Symbol
SUPT6H
Alias
KIAA0162|SPT6H
Full Name
SPT6 homolog, histone chaperone and transcription elongation factor
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
40,594 bases
Position
chr17:28,662,091-28,702,684
Accession
11470
RBP type
canonical RBP
Summary
(SPT6 Homolog, Histone Chaperone And Transcription Elongation Factor) is a Protein Coding gene. Diseases associated with SUPT6H include Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb. Among its related pathways are Chromatin Regulation / Acetylation and Tat-mediated elongation of the HIV-1 transcript. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000319104S1PF00575.234.1e-0611
ENSP00000338143S1PF00575.234.1e-0611
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21676864Solution structure of tandem SH2 domains from Spt6 protein and their binding to the phosphorylated RNA polymerase II C-terminal domain.J Biol Chem2011 Aug 19Liu Jdoi: 10.1074/jbc.M111.252130
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000583972SUPT6H-2091969--- (aa)--
ENST00000585230SUPT6H-212567--- (aa)--
ENST00000577713SUPT6H-203505-ENSP0000046454550 (aa)-J3QS64
ENST00000581908SUPT6H-207679--- (aa)--
ENST00000577939SUPT6H-204583--- (aa)--
ENST00000580471SUPT6H-205578--- (aa)--
ENST00000584312SUPT6H-211483-ENSP0000046550853 (aa)-K7EK85
ENST00000581510SUPT6H-2061194--- (aa)--
ENST00000584285SUPT6H-210446--- (aa)--
ENST00000314616SUPT6H-2016523XM_017024979ENSP000003191041726 (aa)XP_016880468Q7KZ85
ENST00000347486SUPT6H-2025569XM_017024978ENSP000003381431726 (aa)XP_016880467Q7KZ85
ENST00000583340SUPT6H-208581--- (aa)--
Gene Model
Click here to download ENSG00000109111's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000109111rs177205941728676503APulse pressure30578418[0.31-0.52] mmHg decrease0.4155EFO_0005763
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109111's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000109111SUPT6H8980.169ENSAPOG00000019366supt6h9580.078Acanthochromis_polyacanthus
ENSG00000109111SUPT6H100100.000ENSAMEG00000004744SUPT6H10099.537Ailuropoda_melanoleuca
ENSG00000109111SUPT6H8880.971ENSACIG00000004887supt6h9680.906Amphilophus_citrinellus
ENSG00000109111SUPT6H9876.426ENSAOCG00000007013supt6h9777.900Amphiprion_ocellaris
ENSG00000109111SUPT6H9876.235ENSAPEG00000018434supt6h9777.656Amphiprion_percula
ENSG00000109111SUPT6H8978.252ENSATEG00000006950supt6h9377.850Anabas_testudineus
ENSG00000109111SUPT6H10092.729ENSAPLG00000001319SUPT6H10093.306Anas_platyrhynchos
ENSG00000109111SUPT6H100100.000ENSANAG00000029355SUPT6H10099.308Aotus_nancymaae
ENSG00000109111SUPT6H8980.814ENSACLG00000005753supt6h9980.138Astatotilapia_calliptera
ENSG00000109111SUPT6H9282.419ENSAMXG00000006025supt6h9480.645Astyanax_mexicanus
ENSG00000109111SUPT6H10098.957ENSBTAG00000009036SUPT6H10098.957Bos_taurus
ENSG00000109111SUPT6H7838.792WBGene00001259emb-58738.210Caenorhabditis_elegans
ENSG00000109111SUPT6H100100.000ENSCJAG00000012982SUPT6H9997.912Callithrix_jacchus
ENSG00000109111SUPT6H100100.000ENSCAFG00000018763SUPT6H10099.652Canis_familiaris
ENSG00000109111SUPT6H100100.000ENSCAFG00020011752SUPT6H10099.652Canis_lupus_dingo
ENSG00000109111SUPT6H10098.725ENSCHIG00000025101SUPT6H10098.725Capra_hircus
ENSG00000109111SUPT6H100100.000ENSTSYG00000004539SUPT6H10099.421Carlito_syrichta
ENSG00000109111SUPT6H9682.212ENSCAPG00000016785SUPT6H9987.170Cavia_aperea
ENSG00000109111SUPT6H100100.000ENSCPOG00000001442SUPT6H10099.247Cavia_porcellus
ENSG00000109111SUPT6H100100.000ENSCCAG00000031442SUPT6H10099.768Cebus_capucinus
ENSG00000109111SUPT6H100100.000ENSCATG00000041242SUPT6H10099.942Cercocebus_atys
ENSG00000109111SUPT6H10099.247ENSCLAG00000006422SUPT6H10099.247Chinchilla_lanigera
ENSG00000109111SUPT6H100100.000ENSCSAG00000007178SUPT6H9299.778Chlorocebus_sabaeus
ENSG00000109111SUPT6H10093.403ENSCPBG00000020288SUPT6H10093.692Chrysemys_picta_bellii
ENSG00000109111SUPT6H10099.768ENSCANG00000026929SUPT6H10099.768Colobus_angolensis_palliatus
ENSG00000109111SUPT6H10098.552ENSCGRG00000008708Supt610098.552Cricetulus_griseus_crigri
ENSG00000109111SUPT6H8978.562ENSCSEG00000018147supt6h9978.261Cynoglossus_semilaevis
ENSG00000109111SUPT6H8980.934ENSCVAG00000021195supt6h10080.739Cyprinodon_variegatus
ENSG00000109111SUPT6H9779.988ENSDARG00000006524supt6h10078.986Danio_rerio
ENSG00000109111SUPT6H10099.479ENSDNOG00000019476SUPT6H10099.479Dasypus_novemcinctus
ENSG00000109111SUPT6H9547.258FBgn0028982Spt68648.494Drosophila_melanogaster
ENSG00000109111SUPT6H10099.537ENSEASG00005009905SUPT6H10099.537Equus_asinus_asinus
ENSG00000109111SUPT6H10099.537ENSECAG00000020521SUPT6H10099.537Equus_caballus
ENSG00000109111SUPT6H72100.000ENSEEUG00000008265-61100.000Erinaceus_europaeus
ENSG00000109111SUPT6H9280.187ENSELUG00000022246SUPT6H9680.980Esox_lucius
ENSG00000109111SUPT6H8881.058ENSELUG00000005639supt6h9480.847Esox_lucius
ENSG00000109111SUPT6H100100.000ENSFCAG00000004014SUPT6H10099.710Felis_catus
ENSG00000109111SUPT6H10092.419ENSFALG00000006393SUPT6H10092.361Ficedula_albicollis
ENSG00000109111SUPT6H100100.000ENSFDAG00000016453SUPT6H10099.015Fukomys_damarensis
ENSG00000109111SUPT6H10075.394ENSFHEG00000004556supt6h10075.847Fundulus_heteroclitus
ENSG00000109111SUPT6H9775.236ENSGMOG00000007109supt6h10074.513Gadus_morhua
ENSG00000109111SUPT6H10092.593ENSGALG00000000146SUPT6H10093.291Gallus_gallus
ENSG00000109111SUPT6H9280.465ENSGAFG00000000803supt6h9980.189Gambusia_affinis
ENSG00000109111SUPT6H10076.359ENSGACG00000020513supt6h10079.116Gasterosteus_aculeatus
ENSG00000109111SUPT6H10093.345ENSGAGG00000016728SUPT6H10093.634Gopherus_agassizii
ENSG00000109111SUPT6H100100.000ENSGGOG00000016688SUPT6H10099.884Gorilla_gorilla
ENSG00000109111SUPT6H8981.076ENSHBUG00000021694supt6h9980.428Haplochromis_burtoni
ENSG00000109111SUPT6H100100.000ENSHGLG00000018764SUPT6H10099.305Heterocephalus_glaber_female
ENSG00000109111SUPT6H100100.000ENSHGLG00100018216SUPT6H10099.247Heterocephalus_glaber_male
ENSG00000109111SUPT6H9779.635ENSIPUG00000024533supt6h9881.207Ictalurus_punctatus
ENSG00000109111SUPT6H100100.000ENSSTOG00000000577SUPT6H10099.247Ictidomys_tridecemlineatus
ENSG00000109111SUPT6H10099.421ENSJJAG00000013309Supt610099.421Jaculus_jaculus
ENSG00000109111SUPT6H10075.196ENSKMAG00000019294supt6h10075.592Kryptolebias_marmoratus
ENSG00000109111SUPT6H9676.270ENSLBEG00000027907supt6h9676.886Labrus_bergylta
ENSG00000109111SUPT6H9785.952ENSLACG00000003186SUPT6H10084.971Latimeria_chalumnae
ENSG00000109111SUPT6H10099.305ENSLAFG00000017945SUPT6H10099.305Loxodonta_africana
ENSG00000109111SUPT6H100100.000ENSMFAG00000040784SUPT6H10099.942Macaca_fascicularis
ENSG00000109111SUPT6H100100.000ENSMMUG00000004708SUPT6H10099.942Macaca_mulatta
ENSG00000109111SUPT6H9899.941ENSMLEG00000030076SUPT6H100100.000Mandrillus_leucophaeus
ENSG00000109111SUPT6H9481.166ENSMAMG00000020232supt6h9977.898Mastacembelus_armatus
ENSG00000109111SUPT6H8980.814ENSMZEG00005024774supt6h9980.138Maylandia_zebra
ENSG00000109111SUPT6H10093.171ENSMGAG00000005881SUPT6H10093.345Meleagris_gallopavo
ENSG00000109111SUPT6H100100.000ENSMAUG00000012146Supt610098.494Mesocricetus_auratus
ENSG00000109111SUPT6H100100.000ENSMICG00000016884SUPT6H10098.788Microcebus_murinus
ENSG00000109111SUPT6H100100.000ENSMOCG00000021959Supt610098.667Microtus_ochrogaster
ENSG00000109111SUPT6H8880.774ENSMMOG00000010942supt6h9480.499Mola_mola
ENSG00000109111SUPT6H10096.761ENSMODG00000019291SUPT6H10096.761Monodelphis_domestica
ENSG00000109111SUPT6H9676.225ENSMALG00000000093supt6h9877.371Monopterus_albus
ENSG00000109111SUPT6H10098.262MGP_CAROLIEiJ_G0016796Supt610098.262Mus_caroli
ENSG00000109111SUPT6H10098.088ENSMUSG00000002052Supt610098.088Mus_musculus
ENSG00000109111SUPT6H10096.000MGP_PahariEiJ_G0017933Supt610094.902Mus_pahari
ENSG00000109111SUPT6H10098.088MGP_SPRETEiJ_G0017639Supt610098.088Mus_spretus
ENSG00000109111SUPT6H10099.652ENSMPUG00000014195SUPT6H10099.652Mustela_putorius_furo
ENSG00000109111SUPT6H10099.015ENSMLUG00000012423SUPT6H10099.015Myotis_lucifugus
ENSG00000109111SUPT6H100100.000ENSNGAG00000012801Supt610099.363Nannospalax_galili
ENSG00000109111SUPT6H8481.297ENSNBRG00000001035supt6h9680.396Neolamprologus_brichardi
ENSG00000109111SUPT6H10098.000ENSNLEG00000002730SUPT6H10099.696Nomascus_leucogenys
ENSG00000109111SUPT6H10098.000ENSMEUG00000009404SUPT6H9192.776Notamacropus_eugenii
ENSG00000109111SUPT6H10098.841ENSOPRG00000012549SUPT6H10098.841Ochotona_princeps
ENSG00000109111SUPT6H10098.783ENSODEG00000011930SUPT6H10098.783Octodon_degus
ENSG00000109111SUPT6H8981.032ENSONIG00000005512supt6h10078.039Oreochromis_niloticus
ENSG00000109111SUPT6H10099.017ENSOCUG00000000848SUPT6H10099.017Oryctolagus_cuniculus
ENSG00000109111SUPT6H9278.427ENSORLG00000003098supt6h10074.887Oryzias_latipes
ENSG00000109111SUPT6H9278.475ENSORLG00020016222supt6h9478.185Oryzias_latipes_hni
ENSG00000109111SUPT6H9278.475ENSORLG00015021046supt6h10074.929Oryzias_latipes_hsok
ENSG00000109111SUPT6H9277.989ENSOMEG00000010277supt6h9477.591Oryzias_melastigma
ENSG00000109111SUPT6H100100.000ENSOGAG00000012089SUPT6H10095.544Otolemur_garnettii
ENSG00000109111SUPT6H10097.574ENSOARG00000002727SUPT6H10097.574Ovis_aries
ENSG00000109111SUPT6H10099.768ENSPPAG00000036720SUPT6H10099.768Pan_paniscus
ENSG00000109111SUPT6H100100.000ENSPPRG00000024588SUPT6H10099.479Panthera_pardus
ENSG00000109111SUPT6H100100.000ENSPTIG00000014860SUPT6H10098.327Panthera_tigris_altaica
ENSG00000109111SUPT6H10099.768ENSPTRG00000008929SUPT6H10099.768Pan_troglodytes
ENSG00000109111SUPT6H100100.000ENSPANG00000023444SUPT6H10096.640Papio_anubis
ENSG00000109111SUPT6H9782.059ENSPKIG00000013468supt6h10080.857Paramormyrops_kingsleyae
ENSG00000109111SUPT6H10098.494ENSPEMG00000009972Supt610098.494Peromyscus_maniculatus_bairdii
ENSG00000109111SUPT6H10098.000ENSPCIG00000017943SUPT6H10097.050Phascolarctos_cinereus
ENSG00000109111SUPT6H10076.124ENSPFOG00000011171supt6h10076.225Poecilia_formosa
ENSG00000109111SUPT6H9178.414ENSPLAG00000005137supt6h9580.013Poecilia_latipinna
ENSG00000109111SUPT6H10076.067ENSPMEG00000013302supt6h10076.169Poecilia_mexicana
ENSG00000109111SUPT6H10075.688ENSPREG00000009725supt6h10075.887Poecilia_reticulata
ENSG00000109111SUPT6H100100.000ENSPPYG00000008105SUPT6H100100.000Pongo_abelii
ENSG00000109111SUPT6H10096.653ENSPCOG00000021329SUPT6H100100.000Propithecus_coquereli
ENSG00000109111SUPT6H8980.829ENSPNYG00000017271supt6h9980.189Pundamilia_nyererei
ENSG00000109111SUPT6H8883.496ENSPNAG00000015154supt6h9482.997Pygocentrus_nattereri
ENSG00000109111SUPT6H10098.378ENSRNOG00000012240Supt6h10098.378Rattus_norvegicus
ENSG00000109111SUPT6H100100.000ENSRBIG00000015392SUPT6H10099.884Rhinopithecus_bieti
ENSG00000109111SUPT6H100100.000ENSRROG00000035461SUPT6H10099.884Rhinopithecus_roxellana
ENSG00000109111SUPT6H100100.000ENSSBOG00000028535SUPT6H100100.000Saimiri_boliviensis_boliviensis
ENSG00000109111SUPT6H10098.000ENSSHAG00000014414SUPT6H10097.447Sarcophilus_harrisii
ENSG00000109111SUPT6H9581.224ENSSFOG00015005320supt6h9878.451Scleropages_formosus
ENSG00000109111SUPT6H8977.897ENSSMAG00000000771supt6h10075.577Scophthalmus_maximus
ENSG00000109111SUPT6H8581.119ENSSDUG00000016786supt6h9079.699Seriola_dumerili
ENSG00000109111SUPT6H8579.299ENSSLDG00000014842supt6h8977.931Seriola_lalandi_dorsalis
ENSG00000109111SUPT6H100100.000ENSSARG00000006988SUPT6H10096.642Sorex_araneus
ENSG00000109111SUPT6H10092.655ENSSPUG00000006119SUPT6H10092.828Sphenodon_punctatus
ENSG00000109111SUPT6H9478.808ENSSPAG00000016590supt6h9879.560Stegastes_partitus
ENSG00000109111SUPT6H9399.563ENSSSCG00000017773SUPT6H10099.563Sus_scrofa
ENSG00000109111SUPT6H10092.428ENSTGUG00000006101SUPT6H10091.965Taeniopygia_guttata
ENSG00000109111SUPT6H9775.668ENSTRUG00000014399supt6h10075.651Takifugu_rubripes
ENSG00000109111SUPT6H10075.385ENSTNIG00000016157supt6h10075.357Tetraodon_nigroviridis
ENSG00000109111SUPT6H10087.326ENSTBEG00000001874SUPT6H10087.326Tupaia_belangeri
ENSG00000109111SUPT6H100100.000ENSTTRG00000004092SUPT6H10098.727Tursiops_truncatus
ENSG00000109111SUPT6H100100.000ENSUAMG00000003188SUPT6H10099.656Ursus_americanus
ENSG00000109111SUPT6H100100.000ENSUMAG00000011783SUPT6H10099.363Ursus_maritimus
ENSG00000109111SUPT6H100100.000ENSVVUG00000017049SUPT6H10099.652Vulpes_vulpes
ENSG00000109111SUPT6H9782.381ENSXETG00000019265supt6h9782.852Xenopus_tropicalis
ENSG00000109111SUPT6H8980.220ENSXMAG00000014242supt6h9580.518Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001825blastocyst formation-IEAProcess
GO:0003677DNA binding-IEAFunction
GO:0003700DNA-binding transcription factor activity8786132.TASFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding10933715.16273093.17234882.19141475.21518874.IPIFunction
GO:0005634nucleus8786132.NASComponent
GO:0005654nucleoplasm-TASComponent
GO:0006338chromatin remodeling8786132.NASProcess
GO:0006355regulation of transcription, DNA-templated8786132.NASProcess
GO:0006366transcription by RNA polymerase II-TASProcess
GO:0006368transcription elongation from RNA polymerase II promoter21873635.IBAProcess
GO:0006368transcription elongation from RNA polymerase II promoter-TASProcess
GO:0006397mRNA processing-IEAProcess
GO:0008023transcription elongation factor complex21873635.IBAComponent
GO:0008380RNA splicing-IEAProcess
GO:0010793regulation of mRNA export from nucleus-ISSProcess
GO:0016032viral process-IEAProcess
GO:0031491nucleosome binding21873635.IBAFunction
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter21873635.IBAProcess
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter17234882.IMPProcess
GO:0034728nucleosome organization21873635.IBAProcess
GO:0035327transcriptionally active chromatin21873635.IBAComponent
GO:0042393histone binding21873635.IBAFunction
GO:0042393histone binding10933715.IDAFunction
GO:0042789mRNA transcription by RNA polymerase II21873635.IBAProcess
GO:0045191regulation of isotype switching-ISSProcess
GO:0050684regulation of mRNA processing21873635.IBAProcess
GO:0050684regulation of mRNA processing-ISSProcess
GO:0051028mRNA transport-IEAProcess
GO:0051147regulation of muscle cell differentiation-ISSProcess
GO:0061086negative regulation of histone H3-K27 methylation23503590.IMPProcess
GO:0070827chromatin maintenance21873635.IBAProcess

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