EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000109919 (Gene tree)
Gene ID: 23788
Gene Symbol: MTCH2
Alias: SLC25A50
Full Name: mitochondrial carrier 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 37,451 bases
Position: chr11:47,605,204-47,642,654
Accession: 17587
RBP type: non-canonical RBP
Summary: This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000539759	MTCH2-206	581	-	-	- (aa)	-	-
ENST00000534074	MTCH2-205	811	-	-	- (aa)	-	-
ENST00000302503	MTCH2-201	2587	XM_006718172	ENSP00000303222	303 (aa)	XP_006718235	Q9Y6C9
ENST00000533571	MTCH2-204	535	-	-	- (aa)	-	-
ENST00000530428	MTCH2-203	930	XM_011519960	ENSP00000432043	262 (aa)	XP_011518262	E9PIE4
ENST00000525649	MTCH2-202	599	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000109919's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000109919	Body Mass Index	1E-17	25673413
ENSG00000109919	Neuroticism	1E-7	27089181
ENSG00000109919	Body Mass Index	2E-12	20935630
ENSG00000109919	Body Mass Index	2E-10	25673413
ENSG00000109919	Body Mass Index	2E-11	25673413
ENSG00000109919	Body Mass Index	5E-17	25673413
ENSG00000109919	Body Mass Index	5E-9	19079261

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	28892062	[0.021-0.029] kg/m2 increase	0.025	EFO_0004340
ENSG00000109919	rs1064608	11	47618877	C	Cognitive performance	30038396	[0.013-0.025] unit decrease	0.0188	EFO_0008354
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	20935630	[0.02-0.10] kg/m2 increase	0.06	EFO_0004340
ENSG00000109919	rs10838738	11	47641497	G	Body mass index	19079261	[0.01-0.13] kg/m2 increase	0.07	EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index in physically active individuals	28448500	[0.014-0.03] kg/m2 increase	0.0224	EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	BMI (adjusted for smoking behaviour)	28443625	[0.012-0.028] kg/m2 increase	0.02	EFO_0004318\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	BMI (adjusted for smoking behaviour)	28443625	[0.016-0.029] kg/m2 increase	0.0223	EFO_0004318\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	BMI (adjusted for smoking behaviour)	28443625	[0.016-0.035] kg/m2 increase	0.0254	EFO_0004318\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	BMI in non-smokers	28443625	[0.014-0.028] kg/m2 increase	0.0212	EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	BMI in non-smokers	28443625	[0.014-0.035] kg/m2 increase	0.0245	EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	28448500	[0.017-0.031] kg/m2 increase	0.0241	EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	28448500	[0.019-0.041] kg/m2 increase	0.0297	EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	28448500	[0.019-0.033] kg/m2 increase	0.0258	EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	28448500	[0.013-0.032] kg/m2 increase	0.0225	EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	28448500	[0.017-0.037] kg/m2 increase	0.0269	EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	28448500	[0.013-0.03] kg/m2 increase	0.0216	EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index in physically active individuals	28448500	[0.016-0.033] kg/m2 increase	0.0243	EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index in physically active individuals	28448500	[0.016-0.039] kg/m2 increase	0.0276	EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	26426971	unit increase	0.024106821	EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	General cognitive ability	29844566	z-score decrease	6.132	EFO_0004337
ENSG00000109919	rs3817334	11	47629441	C	Body mass index	30108127	[NR] unit decrease	0.023	EFO_0004340
ENSG00000109919	rs3817334	11	47629441	T	Body mass index	26961502	[0.023-0.039] unit increase	0.031	EFO_0004340
ENSG00000109919	rs4752856	11	47626490	A	Worry	29942085	[0.0094-0.0191] unit decrease	0.01424	EFO_0005230

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109919's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005743	mitochondrial inner membrane	-	IEA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0043065	positive regulation of apoptotic process	21873635.	IBA	Process
GO:0070585	protein localization to mitochondrion	23744079.	IMP	Process