EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000110047 (Gene tree)
Gene ID: 10938
Gene Symbol: EHD1
Alias: H-PAST|HPAST1|FLJ42622|FLJ44618|PAST1
Full Name: EH domain containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 36,655 bases
Position: chr11:64,851,642-64,888,296
Accession: 3242
RBP type: canonical RBP
Summary: This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000404944	MMR_HSR1	PF01926.23	1.6e-08	1	1
ENSP00000320516	MMR_HSR1	PF01926.23	2.7e-08	1	1
ENSP00000352354	MMR_HSR1	PF01926.23	2.7e-08	1	1
ENSP00000479153	MMR_HSR1	PF01926.23	2.9e-08	1	1
ENSP00000396273	MMR_HSR1	PF01926.23	0.00012	1	1
ENSP00000391429	MMR_HSR1	PF01926.23	0.00029	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17868075	EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval.	Traffic	2007 Dec	Gokool S	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000411683	EHD1-203	557	-	ENSP00000403830	145 (aa)	-	C9JIJ3
ENST00000466015	EHD1-208	1290	-	-	- (aa)	-	-
ENST00000484846	EHD1-209	3469	-	-	- (aa)	-	-
ENST00000498472	EHD1-212	557	-	-	- (aa)	-	-
ENST00000421510	EHD1-204	1015	-	ENSP00000391429	306 (aa)	-	C9J2Z4
ENST00000621096	EHD1-213	3336	-	ENSP00000479153	548 (aa)	-	A0A024R571
ENST00000359393	EHD1-202	3618	XM_011544739	ENSP00000352354	534 (aa)	XP_011543041	Q9H4M9
ENST00000488711	EHD1-210	648	-	-	- (aa)	-	-
ENST00000489379	EHD1-211	588	-	-	- (aa)	-	-
ENST00000320631	EHD1-201	4551	-	ENSP00000320516	534 (aa)	-	Q9H4M9
ENST00000457202	EHD1-207	534	-	ENSP00000399022	148 (aa)	-	C9IZH1
ENST00000433803	EHD1-205	1191	-	ENSP00000404944	374 (aa)	-	C9JC03
ENST00000455148	EHD1-206	546	-	ENSP00000396273	162 (aa)	-	C9JDQ8

Gene Model

Click here to download ENSG00000110047's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000110047's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000110047	EHD1	100	93.827	ENSAPOG00000013440	ehd1a	98	88.269	Acanthochromis_polyacanthus
ENSG00000110047	EHD1	100	100.000	ENSAMEG00000017785	EHD1	98	98.527	Ailuropoda_melanoleuca
ENSG00000110047	EHD1	100	94.444	ENSACIG00000022182	ehd1a	98	87.885	Amphilophus_citrinellus
ENSG00000110047	EHD1	100	93.827	ENSAOCG00000016322	ehd1a	98	88.269	Amphiprion_ocellaris
ENSG00000110047	EHD1	100	93.827	ENSAPEG00000010363	ehd1a	98	88.269	Amphiprion_percula
ENSG00000110047	EHD1	100	95.062	ENSATEG00000013980	ehd1a	98	88.654	Anabas_testudineus
ENSG00000110047	EHD1	100	100.000	ENSANAG00000034810	EHD1	100	99.813	Aotus_nancymaae
ENSG00000110047	EHD1	100	94.444	ENSACLG00000016016	ehd1a	98	88.077	Astatotilapia_calliptera
ENSG00000110047	EHD1	100	95.062	ENSAMXG00000039344	ehd1a	99	86.142	Astyanax_mexicanus
ENSG00000110047	EHD1	100	90.123	ENSAMXG00000031892	-	100	83.333	Astyanax_mexicanus
ENSG00000110047	EHD1	100	100.000	ENSBTAG00000050712	EHD1	100	99.251	Bos_taurus
ENSG00000110047	EHD1	99	74.534	WBGene00004373	rme-1	97	67.222	Caenorhabditis_elegans
ENSG00000110047	EHD1	100	100.000	ENSCJAG00000002660	EHD1	100	99.625	Callithrix_jacchus
ENSG00000110047	EHD1	100	100.000	ENSCAFG00000014128	EHD1	94	98.427	Canis_familiaris
ENSG00000110047	EHD1	100	100.000	ENSCAFG00020014846	EHD1	100	99.625	Canis_lupus_dingo
ENSG00000110047	EHD1	100	100.000	ENSCHIG00000020707	-	100	99.251	Capra_hircus
ENSG00000110047	EHD1	100	100.000	ENSCPOG00000008157	EHD1	100	99.438	Cavia_porcellus
ENSG00000110047	EHD1	100	100.000	ENSCCAG00000004590	EHD1	100	99.818	Cebus_capucinus
ENSG00000110047	EHD1	100	100.000	ENSCATG00000010658	EHD1	100	99.818	Cercocebus_atys
ENSG00000110047	EHD1	100	100.000	ENSCLAG00000016412	EHD1	100	99.438	Chinchilla_lanigera
ENSG00000110047	EHD1	100	100.000	ENSCSAG00000007397	EHD1	100	100.000	Chlorocebus_sabaeus
ENSG00000110047	EHD1	100	98.765	ENSCPBG00000023692	EHD1	99	93.182	Chrysemys_picta_bellii
ENSG00000110047	EHD1	100	100.000	ENSCANG00000042123	EHD1	100	100.000	Colobus_angolensis_palliatus
ENSG00000110047	EHD1	100	100.000	ENSCGRG00001019701	Ehd1	100	99.438	Cricetulus_griseus_chok1gshd
ENSG00000110047	EHD1	100	100.000	ENSCGRG00000000662	Ehd1	100	98.016	Cricetulus_griseus_crigri
ENSG00000110047	EHD1	100	93.827	ENSCSEG00000006078	ehd1a	98	85.962	Cynoglossus_semilaevis
ENSG00000110047	EHD1	100	94.444	ENSCVAG00000012152	ehd1a	98	88.654	Cyprinodon_variegatus
ENSG00000110047	EHD1	100	94.444	ENSDARG00000098853	ehd1a	99	85.150	Danio_rerio
ENSG00000110047	EHD1	100	91.975	ENSDARG00000014793	ehd1b	100	86.679	Danio_rerio
ENSG00000110047	EHD1	100	100.000	ENSDNOG00000017834	EHD1	96	99.722	Dasypus_novemcinctus
ENSG00000110047	EHD1	100	100.000	ENSDORG00000030186	Ehd1	100	99.438	Dipodomys_ordii
ENSG00000110047	EHD1	99	77.640	FBgn0016693	Past1	99	68.785	Drosophila_melanogaster
ENSG00000110047	EHD1	93	86.093	ENSEBUG00000009968	EHD1	99	78.652	Eptatretus_burgeri
ENSG00000110047	EHD1	99	86.957	ENSEBUG00000010829	EHD1	91	80.831	Eptatretus_burgeri
ENSG00000110047	EHD1	100	100.000	ENSEASG00005018250	EHD1	100	99.064	Equus_asinus_asinus
ENSG00000110047	EHD1	100	100.000	ENSECAG00000011638	EHD1	100	99.064	Equus_caballus
ENSG00000110047	EHD1	100	93.210	ENSELUG00000007973	-	99	85.822	Esox_lucius
ENSG00000110047	EHD1	100	91.358	ENSELUG00000016093	ehd1b	99	86.553	Esox_lucius
ENSG00000110047	EHD1	100	100.000	ENSFCAG00000027734	EHD1	100	98.905	Felis_catus
ENSG00000110047	EHD1	100	100.000	ENSFDAG00000007697	EHD1	100	98.876	Fukomys_damarensis
ENSG00000110047	EHD1	100	94.444	ENSFHEG00000002690	ehd1a	98	88.654	Fundulus_heteroclitus
ENSG00000110047	EHD1	100	93.827	ENSGMOG00000012192	ehd1a	99	86.923	Gadus_morhua
ENSG00000110047	EHD1	100	94.444	ENSGAFG00000000730	ehd1a	98	88.846	Gambusia_affinis
ENSG00000110047	EHD1	100	94.444	ENSGACG00000017605	ehd1a	98	87.308	Gasterosteus_aculeatus
ENSG00000110047	EHD1	100	98.765	ENSGAGG00000001677	-	93	93.900	Gopherus_agassizii
ENSG00000110047	EHD1	100	94.444	ENSHBUG00000012087	ehd1a	98	88.077	Haplochromis_burtoni
ENSG00000110047	EHD1	100	100.000	ENSHGLG00000010254	EHD1	100	99.251	Heterocephalus_glaber_female
ENSG00000110047	EHD1	100	100.000	ENSHGLG00100014206	EHD1	100	99.251	Heterocephalus_glaber_male
ENSG00000110047	EHD1	100	95.062	ENSHCOG00000006825	ehd1a	98	87.885	Hippocampus_comes
ENSG00000110047	EHD1	100	91.358	ENSIPUG00000017390	EHD1	99	84.211	Ictalurus_punctatus
ENSG00000110047	EHD1	100	93.827	ENSIPUG00000002819	ehd1a	99	86.330	Ictalurus_punctatus
ENSG00000110047	EHD1	100	100.000	ENSSTOG00000009829	EHD1	100	99.813	Ictidomys_tridecemlineatus
ENSG00000110047	EHD1	100	100.000	ENSJJAG00000022299	Ehd1	100	99.251	Jaculus_jaculus
ENSG00000110047	EHD1	100	93.827	ENSKMAG00000004764	ehd1a	98	87.500	Kryptolebias_marmoratus
ENSG00000110047	EHD1	100	94.444	ENSLBEG00000004390	ehd1a	98	88.077	Labrus_bergylta
ENSG00000110047	EHD1	100	93.293	ENSLACG00000018148	EHD1	100	90.112	Latimeria_chalumnae
ENSG00000110047	EHD1	100	93.827	ENSLOCG00000000924	ehd1b	96	81.921	Lepisosteus_oculatus
ENSG00000110047	EHD1	100	98.148	ENSLAFG00000011643	EHD1	100	95.131	Loxodonta_africana
ENSG00000110047	EHD1	100	100.000	ENSMFAG00000032608	EHD1	100	100.000	Macaca_fascicularis
ENSG00000110047	EHD1	100	100.000	ENSMMUG00000003972	EHD1	100	100.000	Macaca_mulatta
ENSG00000110047	EHD1	100	100.000	ENSMNEG00000031673	EHD1	100	100.000	Macaca_nemestrina
ENSG00000110047	EHD1	100	100.000	ENSMLEG00000031992	EHD1	100	100.000	Mandrillus_leucophaeus
ENSG00000110047	EHD1	100	95.062	ENSMAMG00000021737	ehd1a	98	87.692	Mastacembelus_armatus
ENSG00000110047	EHD1	100	94.444	ENSMZEG00005004305	ehd1a	98	88.077	Maylandia_zebra
ENSG00000110047	EHD1	100	100.000	ENSMAUG00000013823	Ehd1	100	99.438	Mesocricetus_auratus
ENSG00000110047	EHD1	100	100.000	ENSMICG00000001239	EHD1	100	98.905	Microcebus_murinus
ENSG00000110047	EHD1	100	100.000	ENSMOCG00000015517	Ehd1	100	99.438	Microtus_ochrogaster
ENSG00000110047	EHD1	100	94.444	ENSMMOG00000003005	ehd1a	98	87.716	Mola_mola
ENSG00000110047	EHD1	100	95.062	ENSMALG00000012679	ehd1a	98	87.885	Monopterus_albus
ENSG00000110047	EHD1	100	100.000	MGP_CAROLIEiJ_G0022603	Ehd1	100	99.438	Mus_caroli
ENSG00000110047	EHD1	100	100.000	ENSMUSG00000024772	Ehd1	100	99.438	Mus_musculus
ENSG00000110047	EHD1	100	100.000	MGP_PahariEiJ_G0014097	Ehd1	100	99.251	Mus_pahari
ENSG00000110047	EHD1	100	100.000	MGP_SPRETEiJ_G0023514	Ehd1	100	99.438	Mus_spretus
ENSG00000110047	EHD1	100	100.000	ENSMPUG00000012497	EHD1	100	99.813	Mustela_putorius_furo
ENSG00000110047	EHD1	100	100.000	ENSNGAG00000020358	Ehd1	100	99.625	Nannospalax_galili
ENSG00000110047	EHD1	100	94.444	ENSNBRG00000002933	ehd1a	98	87.885	Neolamprologus_brichardi
ENSG00000110047	EHD1	100	100.000	ENSNLEG00000005375	EHD1	100	100.000	Nomascus_leucogenys
ENSG00000110047	EHD1	100	100.000	ENSOPRG00000011350	EHD1	100	98.876	Ochotona_princeps
ENSG00000110047	EHD1	100	100.000	ENSODEG00000014527	EHD1	100	99.251	Octodon_degus
ENSG00000110047	EHD1	100	100.000	ENSOCUG00000029532	EHD1	100	98.525	Oryctolagus_cuniculus
ENSG00000110047	EHD1	100	93.827	ENSORLG00000022561	ehd1a	98	87.692	Oryzias_latipes
ENSG00000110047	EHD1	100	93.827	ENSORLG00020018451	ehd1a	98	87.500	Oryzias_latipes_hni
ENSG00000110047	EHD1	100	93.827	ENSORLG00015017672	ehd1a	98	87.500	Oryzias_latipes_hsok
ENSG00000110047	EHD1	100	93.827	ENSOMEG00000019329	ehd1a	98	87.885	Oryzias_melastigma
ENSG00000110047	EHD1	100	100.000	ENSOGAG00000009351	EHD1	100	99.251	Otolemur_garnettii
ENSG00000110047	EHD1	100	100.000	ENSOARG00000010447	EHD1	99	98.975	Ovis_aries
ENSG00000110047	EHD1	100	100.000	ENSPPAG00000037178	EHD1	100	100.000	Pan_paniscus
ENSG00000110047	EHD1	100	99.324	ENSPPRG00000006031	EHD1	100	96.898	Panthera_pardus
ENSG00000110047	EHD1	100	100.000	ENSPTRG00000003851	EHD1	100	100.000	Pan_troglodytes
ENSG00000110047	EHD1	100	100.000	ENSPANG00000023358	EHD1	100	100.000	Papio_anubis
ENSG00000110047	EHD1	100	95.062	ENSPKIG00000020297	-	88	88.611	Paramormyrops_kingsleyae
ENSG00000110047	EHD1	100	93.210	ENSPKIG00000023165	-	99	86.260	Paramormyrops_kingsleyae
ENSG00000110047	EHD1	100	100.000	ENSPSIG00000005727	EHD1	100	95.318	Pelodiscus_sinensis
ENSG00000110047	EHD1	100	95.062	ENSPMGG00000017810	ehd1a	98	86.372	Periophthalmus_magnuspinnatus
ENSG00000110047	EHD1	100	100.000	ENSPEMG00000010917	Ehd1	100	99.625	Peromyscus_maniculatus_bairdii
ENSG00000110047	EHD1	100	99.383	ENSPCIG00000014850	EHD1	100	97.753	Phascolarctos_cinereus
ENSG00000110047	EHD1	100	75.309	ENSPCIG00000017053	-	96	71.795	Phascolarctos_cinereus
ENSG00000110047	EHD1	100	94.444	ENSPFOG00000010613	ehd1a	97	88.654	Poecilia_formosa
ENSG00000110047	EHD1	100	94.444	ENSPLAG00000023296	ehd1a	98	88.654	Poecilia_latipinna
ENSG00000110047	EHD1	100	94.444	ENSPMEG00000003397	ehd1a	98	88.654	Poecilia_mexicana
ENSG00000110047	EHD1	100	94.444	ENSPREG00000015893	ehd1a	98	88.462	Poecilia_reticulata
ENSG00000110047	EHD1	100	100.000	ENSPPYG00000003093	EHD1	100	100.000	Pongo_abelii
ENSG00000110047	EHD1	100	100.000	ENSPCOG00000010309	EHD1	100	99.257	Propithecus_coquereli
ENSG00000110047	EHD1	100	100.000	ENSPVAG00000007890	EHD1	100	98.502	Pteropus_vampyrus
ENSG00000110047	EHD1	100	94.444	ENSPNYG00000015448	ehd1a	98	88.077	Pundamilia_nyererei
ENSG00000110047	EHD1	100	94.444	ENSPNAG00000023091	ehd1a	99	85.955	Pygocentrus_nattereri
ENSG00000110047	EHD1	100	91.975	ENSPNAG00000007408	EHD1	99	86.252	Pygocentrus_nattereri
ENSG00000110047	EHD1	100	100.000	ENSRNOG00000043503	Ehd1	100	99.438	Rattus_norvegicus
ENSG00000110047	EHD1	100	100.000	ENSRBIG00000039111	EHD1	100	100.000	Rhinopithecus_bieti
ENSG00000110047	EHD1	100	100.000	ENSRROG00000026366	EHD1	100	100.000	Rhinopithecus_roxellana
ENSG00000110047	EHD1	100	100.000	ENSSBOG00000023399	EHD1	100	99.818	Saimiri_boliviensis_boliviensis
ENSG00000110047	EHD1	100	77.778	ENSSHAG00000007430	-	95	70.218	Sarcophilus_harrisii
ENSG00000110047	EHD1	100	94.444	ENSSFOG00015006481	-	99	87.571	Scleropages_formosus
ENSG00000110047	EHD1	100	92.593	ENSSFOG00015019587	EHD1	100	87.730	Scleropages_formosus
ENSG00000110047	EHD1	100	94.444	ENSSMAG00000018210	ehd1a	98	87.692	Scophthalmus_maximus
ENSG00000110047	EHD1	100	94.444	ENSSDUG00000016436	ehd1a	98	88.846	Seriola_dumerili
ENSG00000110047	EHD1	100	94.444	ENSSLDG00000015328	ehd1a	98	88.846	Seriola_lalandi_dorsalis
ENSG00000110047	EHD1	96	83.571	ENSSPAG00000010690	ehd1a	89	87.261	Stegastes_partitus
ENSG00000110047	EHD1	100	94.444	ENSSPAG00000008682	ehd1a	98	88.462	Stegastes_partitus
ENSG00000110047	EHD1	100	100.000	ENSSSCG00000013017	EHD1	99	98.684	Sus_scrofa
ENSG00000110047	EHD1	100	94.444	ENSTRUG00000025890	ehd1a	98	88.269	Takifugu_rubripes
ENSG00000110047	EHD1	100	94.444	ENSTNIG00000016792	ehd1a	97	87.500	Tetraodon_nigroviridis
ENSG00000110047	EHD1	100	98.649	ENSTBEG00000007057	EHD1	100	90.647	Tupaia_belangeri
ENSG00000110047	EHD1	100	100.000	ENSTTRG00000008887	EHD1	100	99.064	Tursiops_truncatus
ENSG00000110047	EHD1	100	100.000	ENSUAMG00000012071	EHD1	100	99.625	Ursus_americanus
ENSG00000110047	EHD1	100	97.419	ENSUMAG00000007890	EHD1	99	96.952	Ursus_maritimus
ENSG00000110047	EHD1	100	100.000	ENSVVUG00000027552	EHD1	86	99.083	Vulpes_vulpes
ENSG00000110047	EHD1	100	99.383	ENSXETG00000001638	ehd1	100	91.573	Xenopus_tropicalis
ENSG00000110047	EHD1	100	94.444	ENSXCOG00000001781	ehd1a	98	87.547	Xiphophorus_couchianus
ENSG00000110047	EHD1	100	94.444	ENSXMAG00000005301	ehd1a	98	88.654	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	12121420.15020713.17233914.19864458.22284051.23596323.26226295.27189942.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005811	lipid droplet	-	ISS	Component
GO:0005886	plasma membrane	-	ISS	Component
GO:0006886	intracellular protein transport	15020713.	IMP	Process
GO:0006897	endocytosis	20801876.	IMP	Process
GO:0007596	blood coagulation	-	TAS	Process
GO:0010008	endosome membrane	-	ISS	Component
GO:0010008	endosome membrane	-	TAS	Component
GO:0010886	positive regulation of cholesterol storage	-	ISS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0017137	Rab GTPase binding	19864458.	IPI	Function
GO:0020018	ciliary pocket membrane	25686250.	IDA	Component
GO:0031095	platelet dense tubular network membrane	-	ISS	Component
GO:0031175	neuron projection development	-	ISS	Process
GO:0031901	early endosome membrane	15020713.	IDA	Component
GO:0032456	endocytic recycling	17233914.	IGI	Process
GO:0032456	endocytic recycling	15020713.	IMP	Process
GO:0034383	low-density lipoprotein particle clearance	-	ISS	Process
GO:0042632	cholesterol homeostasis	-	ISS	Process
GO:0042802	identical protein binding	12121420.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051260	protein homooligomerization	17233914.	IPI	Process
GO:0055038	recycling endosome membrane	15020713.17233914.19864458.23596323.	IDA	Component
GO:0060271	cilium assembly	25686250.	IMP	Process
GO:0061512	protein localization to cilium	25686250.	IMP	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:1901741	positive regulation of myoblast fusion	-	ISS	Process
GO:1990090	cellular response to nerve growth factor stimulus	-	ISS	Process
GO:2001137	positive regulation of endocytic recycling	-	ISS	Process