EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000110063 (Gene tree)
Gene ID: 28960
Gene Symbol: DCPS
Alias: HSPC015|HINT-5|HSL1
Full Name: decapping enzyme, scavenger
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 42,003 bases
Position: chr11:126,303,752-126,345,754
Accession: 29812
RBP type: canonical RBP
Summary: This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000263579	DcpS	PF05652.12	1.1e-18	1	1
ENSP00000497684	DcpS_C	PF11969.8	7.5e-32	1	1
ENSP00000263579	DcpS_C	PF11969.8	1.8e-31	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
1398072	Multiple domains of the RNA polymerase I activator hUBF interact with the TATA-binding protein complex hSL1 to mediate transcription.	Genes Dev	1992 Oct	Jantzen HM	-
20709811	Pharmacological targeting of constitutively active truncated androgen receptor by nigericin and suppression of hormone-refractory prostate cancer cell growth.	Mol Pharmacol	2010 Nov	Mashima T	doi: 10.1124/mol.110.064790

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000263579	DCPS-201	1479	-	ENSP00000263579	337 (aa)	-	Q96C86
ENST00000648516	DCPS-204	1358	-	ENSP00000497684	244 (aa)	-	UPI00001FA66E
ENST00000529149	DCPS-202	2467	-	-	- (aa)	-	-
ENST00000530860	DCPS-203	661	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000110063's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000110063	rs73017399	11	126316417	C	Neutrophil percentage of white cells	27863252	[0.018-0.034] unit decrease	0.02595937	EFO_0007990
ENSG00000110063	rs2401	11	126341832	T	LDL cholesterol levels	28334899	[0.052-0.106] unit decrease	0.079	EFO_0004611
ENSG00000110063	rs604255	11	126327131	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000110063's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000110063	DCPS	86	64.929	ENSAPOG00000013927	dcps	78	60.825	Acanthochromis_polyacanthus
ENSG00000110063	DCPS	100	91.395	ENSAMEG00000000111	DCPS	100	91.395	Ailuropoda_melanoleuca
ENSG00000110063	DCPS	86	64.286	ENSACIG00000022830	dcps	91	60.825	Amphilophus_citrinellus
ENSG00000110063	DCPS	86	63.981	ENSAOCG00000011512	dcps	87	60.481	Amphiprion_ocellaris
ENSG00000110063	DCPS	86	64.455	ENSAPEG00000015231	dcps	87	60.825	Amphiprion_percula
ENSG00000110063	DCPS	96	57.143	ENSATEG00000017854	-	97	57.143	Anabas_testudineus
ENSG00000110063	DCPS	86	71.090	ENSAPLG00000002407	DCPS	99	67.424	Anas_platyrhynchos
ENSG00000110063	DCPS	86	67.453	ENSACAG00000000101	DCPS	99	68.182	Anolis_carolinensis
ENSG00000110063	DCPS	87	75.490	ENSANAG00000035483	-	100	75.490	Aotus_nancymaae
ENSG00000110063	DCPS	100	94.065	ENSANAG00000021856	-	91	94.065	Aotus_nancymaae
ENSG00000110063	DCPS	86	65.877	ENSACLG00000021703	dcps	91	59.740	Astatotilapia_calliptera
ENSG00000110063	DCPS	86	64.455	ENSAMXG00000037686	dcps	95	57.827	Astyanax_mexicanus
ENSG00000110063	DCPS	100	88.427	ENSBTAG00000002879	DCPS	100	88.427	Bos_taurus
ENSG00000110063	DCPS	85	45.192	WBGene00000940	dcs-1	97	46.316	Caenorhabditis_elegans
ENSG00000110063	DCPS	100	94.362	ENSCJAG00000008896	DCPS	100	94.362	Callithrix_jacchus
ENSG00000110063	DCPS	100	87.537	ENSCAFG00000010421	DCPS	92	87.537	Canis_familiaris
ENSG00000110063	DCPS	100	87.537	ENSCAFG00020010596	DCPS	100	87.537	Canis_lupus_dingo
ENSG00000110063	DCPS	100	87.240	ENSCHIG00000023271	DCPS	100	87.240	Capra_hircus
ENSG00000110063	DCPS	97	92.025	ENSTSYG00000006959	DCPS	100	91.691	Carlito_syrichta
ENSG00000110063	DCPS	89	87.727	ENSCAPG00000016263	DCPS	98	90.037	Cavia_aperea
ENSG00000110063	DCPS	99	86.905	ENSCPOG00000014358	DCPS	99	86.905	Cavia_porcellus
ENSG00000110063	DCPS	100	94.659	ENSCCAG00000030779	DCPS	95	94.659	Cebus_capucinus
ENSG00000110063	DCPS	98	96.677	ENSCATG00000006118	DCPS	98	96.677	Cercocebus_atys
ENSG00000110063	DCPS	99	89.286	ENSCLAG00000015708	DCPS	99	89.286	Chinchilla_lanigera
ENSG00000110063	DCPS	98	97.281	ENSCSAG00000002256	DCPS	98	97.281	Chlorocebus_sabaeus
ENSG00000110063	DCPS	63	86.364	ENSCHOG00000007561	-	63	86.364	Choloepus_hoffmanni
ENSG00000110063	DCPS	88	74.299	ENSCPBG00000011119	DCPS	95	68.919	Chrysemys_picta_bellii
ENSG00000110063	DCPS	90	43.506	ENSCING00000004583	-	99	43.506	Ciona_intestinalis
ENSG00000110063	DCPS	84	51.442	ENSCSAVG00000010841	-	87	49.485	Ciona_savignyi
ENSG00000110063	DCPS	98	96.677	ENSCANG00000031834	DCPS	98	96.677	Colobus_angolensis_palliatus
ENSG00000110063	DCPS	99	89.759	ENSCGRG00001022394	Dcps	98	89.759	Cricetulus_griseus_chok1gshd
ENSG00000110063	DCPS	99	89.759	ENSCGRG00000010900	Dcps	98	89.759	Cricetulus_griseus_crigri
ENSG00000110063	DCPS	87	55.399	ENSCSEG00000016894	-	95	47.892	Cynoglossus_semilaevis
ENSG00000110063	DCPS	96	55.319	ENSCSEG00000016877	dcps	97	55.319	Cynoglossus_semilaevis
ENSG00000110063	DCPS	86	67.143	ENSCVAG00000011377	dcps	84	64.844	Cyprinodon_variegatus
ENSG00000110063	DCPS	89	62.037	ENSDARG00000009862	dcps	88	58.904	Danio_rerio
ENSG00000110063	DCPS	100	86.053	ENSDNOG00000003974	DCPS	100	86.053	Dasypus_novemcinctus
ENSG00000110063	DCPS	99	90.774	ENSDORG00000000696	Dcps	99	90.774	Dipodomys_ordii
ENSG00000110063	DCPS	87	49.057	FBgn0037372	CG2091	79	42.193	Drosophila_melanogaster
ENSG00000110063	DCPS	87	53.774	ENSEBUG00000003242	dcps	98	51.751	Eptatretus_burgeri
ENSG00000110063	DCPS	100	90.801	ENSEASG00005022977	DCPS	100	90.801	Equus_asinus_asinus
ENSG00000110063	DCPS	100	91.395	ENSECAG00000012956	DCPS	100	91.395	Equus_caballus
ENSG00000110063	DCPS	100	87.537	ENSEEUG00000008046	DCPS	100	87.537	Erinaceus_europaeus
ENSG00000110063	DCPS	99	56.119	ENSELUG00000019902	dcps	99	56.119	Esox_lucius
ENSG00000110063	DCPS	100	90.801	ENSFCAG00000030687	DCPS	100	90.801	Felis_catus
ENSG00000110063	DCPS	86	71.905	ENSFALG00000005007	DCPS	96	68.846	Ficedula_albicollis
ENSG00000110063	DCPS	99	89.881	ENSFDAG00000020518	DCPS	99	89.881	Fukomys_damarensis
ENSG00000110063	DCPS	99	57.647	ENSFHEG00000021972	dcps	99	57.647	Fundulus_heteroclitus
ENSG00000110063	DCPS	90	58.940	ENSGMOG00000006034	dcps	95	58.940	Gadus_morhua
ENSG00000110063	DCPS	86	72.038	ENSGALG00000031143	DCPS	98	72.444	Gallus_gallus
ENSG00000110063	DCPS	96	57.143	ENSGAFG00000015532	dcps	97	57.143	Gambusia_affinis
ENSG00000110063	DCPS	87	65.566	ENSGACG00000018734	dcps	99	57.227	Gasterosteus_aculeatus
ENSG00000110063	DCPS	100	66.469	ENSGAGG00000006184	DCPS	97	66.469	Gopherus_agassizii
ENSG00000110063	DCPS	86	100.000	ENSGGOG00000005028	DCPS	76	100.000	Gorilla_gorilla
ENSG00000110063	DCPS	86	65.877	ENSHBUG00000012352	dcps	91	59.740	Haplochromis_burtoni
ENSG00000110063	DCPS	99	89.583	ENSHGLG00000005259	DCPS	99	89.583	Heterocephalus_glaber_female
ENSG00000110063	DCPS	99	89.053	ENSHGLG00100012366	DCPS	99	89.053	Heterocephalus_glaber_male
ENSG00000110063	DCPS	96	55.247	ENSHCOG00000004819	dcps	92	55.247	Hippocampus_comes
ENSG00000110063	DCPS	85	66.346	ENSIPUG00000020491	dcps	88	60.481	Ictalurus_punctatus
ENSG00000110063	DCPS	99	88.988	ENSSTOG00000009930	DCPS	99	88.988	Ictidomys_tridecemlineatus
ENSG00000110063	DCPS	99	86.607	ENSJJAG00000020913	Dcps	99	86.607	Jaculus_jaculus
ENSG00000110063	DCPS	87	67.453	ENSKMAG00000006439	dcps	89	59.223	Kryptolebias_marmoratus
ENSG00000110063	DCPS	86	67.143	ENSLBEG00000014244	dcps	92	62.094	Labrus_bergylta
ENSG00000110063	DCPS	68	72.455	ENSLACG00000002085	DCPS	96	72.455	Latimeria_chalumnae
ENSG00000110063	DCPS	100	90.801	ENSLAFG00000006052	DCPS	100	90.801	Loxodonta_africana
ENSG00000110063	DCPS	98	97.583	ENSMFAG00000018709	DCPS	98	97.583	Macaca_fascicularis
ENSG00000110063	DCPS	100	95.846	ENSMMUG00000007950	DCPS	100	95.846	Macaca_mulatta
ENSG00000110063	DCPS	98	97.583	ENSMNEG00000029735	DCPS	98	97.583	Macaca_nemestrina
ENSG00000110063	DCPS	98	97.281	ENSMLEG00000028091	DCPS	98	97.281	Mandrillus_leucophaeus
ENSG00000110063	DCPS	99	55.460	ENSMAMG00000000698	dcps	95	55.460	Mastacembelus_armatus
ENSG00000110063	DCPS	86	65.877	ENSMZEG00005005552	dcps	91	59.740	Maylandia_zebra
ENSG00000110063	DCPS	86	70.335	ENSMGAG00000000755	DCPS	99	70.335	Meleagris_gallopavo
ENSG00000110063	DCPS	97	89.877	ENSMAUG00000011332	Dcps	98	89.614	Mesocricetus_auratus
ENSG00000110063	DCPS	100	89.676	ENSMICG00000014834	DCPS	100	89.676	Microcebus_murinus
ENSG00000110063	DCPS	99	90.060	ENSMOCG00000006978	Dcps	98	90.060	Microtus_ochrogaster
ENSG00000110063	DCPS	86	65.403	ENSMMOG00000010000	dcps	86	60.137	Mola_mola
ENSG00000110063	DCPS	100	81.602	ENSMODG00000004617	DCPS	100	81.602	Monodelphis_domestica
ENSG00000110063	DCPS	99	56.305	ENSMALG00000012274	dcps	87	56.305	Monopterus_albus
ENSG00000110063	DCPS	97	89.571	MGP_CAROLIEiJ_G0031949	Dcps	99	89.286	Mus_caroli
ENSG00000110063	DCPS	97	90.184	ENSMUSG00000032040	Dcps	99	89.881	Mus_musculus
ENSG00000110063	DCPS	97	88.650	MGP_PahariEiJ_G0014814	Dcps	99	88.393	Mus_pahari
ENSG00000110063	DCPS	97	90.184	MGP_SPRETEiJ_G0033073	Dcps	99	89.881	Mus_spretus
ENSG00000110063	DCPS	100	87.611	ENSMPUG00000006653	DCPS	99	88.791	Mustela_putorius_furo
ENSG00000110063	DCPS	100	87.390	ENSMLUG00000017342	DCPS	100	87.390	Myotis_lucifugus
ENSG00000110063	DCPS	99	89.820	ENSNGAG00000011482	Dcps	100	89.820	Nannospalax_galili
ENSG00000110063	DCPS	86	65.403	ENSNBRG00000022078	dcps	91	59.740	Neolamprologus_brichardi
ENSG00000110063	DCPS	100	99.407	ENSNLEG00000033119	DCPS	100	99.407	Nomascus_leucogenys
ENSG00000110063	DCPS	91	85.294	ENSMEUG00000010896	DCPS	100	80.531	Notamacropus_eugenii
ENSG00000110063	DCPS	88	88.372	ENSOPRG00000013199	DCPS	99	89.963	Ochotona_princeps
ENSG00000110063	DCPS	99	88.988	ENSODEG00000003139	DCPS	97	88.988	Octodon_degus
ENSG00000110063	DCPS	99	56.176	ENSONIG00000015808	dcps	98	56.176	Oreochromis_niloticus
ENSG00000110063	DCPS	99	90.179	ENSOCUG00000029302	-	99	90.179	Oryctolagus_cuniculus
ENSG00000110063	DCPS	99	90.179	ENSOCUG00000012520	-	99	90.179	Oryctolagus_cuniculus
ENSG00000110063	DCPS	99	57.522	ENSORLG00000009177	dcps	99	57.522	Oryzias_latipes
ENSG00000110063	DCPS	99	57.101	ENSORLG00020020148	dcps	99	57.101	Oryzias_latipes_hni
ENSG00000110063	DCPS	99	56.083	ENSORLG00015015209	dcps	99	56.083	Oryzias_latipes_hsok
ENSG00000110063	DCPS	86	66.825	ENSOMEG00000017125	dcps	85	62.887	Oryzias_melastigma
ENSG00000110063	DCPS	99	89.021	ENSOGAG00000008937	DCPS	99	89.021	Otolemur_garnettii
ENSG00000110063	DCPS	100	85.294	ENSOARG00000012785	DCPS	100	85.294	Ovis_aries
ENSG00000110063	DCPS	100	99.703	ENSPPAG00000031830	DCPS	100	99.703	Pan_paniscus
ENSG00000110063	DCPS	100	90.801	ENSPPRG00000023157	DCPS	100	90.801	Panthera_pardus
ENSG00000110063	DCPS	100	91.395	ENSPTIG00000021939	DCPS	100	91.395	Panthera_tigris_altaica
ENSG00000110063	DCPS	100	99.703	ENSPTRG00000004459	DCPS	100	99.703	Pan_troglodytes
ENSG00000110063	DCPS	87	95.283	ENSPANG00000010632	DCPS	100	81.899	Papio_anubis
ENSG00000110063	DCPS	86	64.455	ENSPKIG00000005714	dcps	89	59.934	Paramormyrops_kingsleyae
ENSG00000110063	DCPS	86	73.460	ENSPSIG00000014678	DCPS	99	73.034	Pelodiscus_sinensis
ENSG00000110063	DCPS	86	63.810	ENSPMGG00000004946	dcps	84	60.137	Periophthalmus_magnuspinnatus
ENSG00000110063	DCPS	99	78.761	ENSPEMG00000009396	-	99	79.056	Peromyscus_maniculatus_bairdii
ENSG00000110063	DCPS	99	88.690	ENSPEMG00000016481	-	99	88.690	Peromyscus_maniculatus_bairdii
ENSG00000110063	DCPS	65	85.780	ENSPCIG00000010203	DCPS	76	78.210	Phascolarctos_cinereus
ENSG00000110063	DCPS	96	56.193	ENSPFOG00000004892	dcps	98	56.193	Poecilia_formosa
ENSG00000110063	DCPS	96	56.193	ENSPLAG00000004963	dcps	98	56.193	Poecilia_latipinna
ENSG00000110063	DCPS	96	56.535	ENSPMEG00000005609	dcps	97	56.535	Poecilia_mexicana
ENSG00000110063	DCPS	96	56.535	ENSPREG00000003444	dcps	97	56.535	Poecilia_reticulata
ENSG00000110063	DCPS	100	99.110	ENSPPYG00000004048	DCPS	100	99.110	Pongo_abelii
ENSG00000110063	DCPS	100	78.635	ENSPCAG00000010891	DCPS	100	78.635	Procavia_capensis
ENSG00000110063	DCPS	100	90.560	ENSPCOG00000004926	DCPS	100	90.560	Propithecus_coquereli
ENSG00000110063	DCPS	100	85.588	ENSPVAG00000000997	DCPS	100	85.588	Pteropus_vampyrus
ENSG00000110063	DCPS	86	65.877	ENSPNYG00000000048	dcps	91	59.740	Pundamilia_nyererei
ENSG00000110063	DCPS	87	66.981	ENSPNAG00000008535	dcps	91	60.656	Pygocentrus_nattereri
ENSG00000110063	DCPS	97	89.264	ENSRNOG00000009993	Dcps	99	88.988	Rattus_norvegicus
ENSG00000110063	DCPS	98	96.979	ENSRBIG00000044049	DCPS	98	96.979	Rhinopithecus_bieti
ENSG00000110063	DCPS	98	96.677	ENSRROG00000033864	DCPS	98	96.677	Rhinopithecus_roxellana
ENSG00000110063	DCPS	89	33.333	YLR270W	DCS1	88	30.599	Saccharomyces_cerevisiae
ENSG00000110063	DCPS	89	39.827	YOR173W	-	88	35.625	Saccharomyces_cerevisiae
ENSG00000110063	DCPS	89	94.907	ENSSBOG00000021447	-	99	95.941	Saimiri_boliviensis_boliviensis
ENSG00000110063	DCPS	100	73.591	ENSSBOG00000034164	-	100	73.591	Saimiri_boliviensis_boliviensis
ENSG00000110063	DCPS	91	86.275	ENSSHAG00000002250	DCPS	100	80.352	Sarcophilus_harrisii
ENSG00000110063	DCPS	100	54.360	ENSSFOG00015022277	dcps	97	54.360	Scleropages_formosus
ENSG00000110063	DCPS	99	57.015	ENSSMAG00000013606	dcps	97	57.015	Scophthalmus_maximus
ENSG00000110063	DCPS	99	57.478	ENSSDUG00000013850	dcps	99	57.478	Seriola_dumerili
ENSG00000110063	DCPS	99	57.478	ENSSLDG00000022373	dcps	99	57.478	Seriola_lalandi_dorsalis
ENSG00000110063	DCPS	74	87.149	ENSSARG00000000265	DCPS	100	87.149	Sorex_araneus
ENSG00000110063	DCPS	98	66.261	ENSSPUG00000000168	DCPS	98	66.261	Sphenodon_punctatus
ENSG00000110063	DCPS	87	67.453	ENSSPAG00000003336	dcps	94	64.828	Stegastes_partitus
ENSG00000110063	DCPS	100	89.911	ENSSSCG00000015231	DCPS	100	89.911	Sus_scrofa
ENSG00000110063	DCPS	86	72.512	ENSTGUG00000000833	-	97	69.615	Taeniopygia_guttata
ENSG00000110063	DCPS	66	73.913	ENSTGUG00000014634	-	98	73.913	Taeniopygia_guttata
ENSG00000110063	DCPS	86	63.507	ENSTRUG00000024323	dcps	87	59.524	Takifugu_rubripes
ENSG00000110063	DCPS	86	64.929	ENSTNIG00000005833	dcps	99	61.458	Tetraodon_nigroviridis
ENSG00000110063	DCPS	74	88.000	ENSTTRG00000001560	DCPS	74	88.000	Tursiops_truncatus
ENSG00000110063	DCPS	89	91.694	ENSUAMG00000005517	DCPS	99	91.694	Ursus_americanus
ENSG00000110063	DCPS	100	90.801	ENSUMAG00000002520	DCPS	100	90.801	Ursus_maritimus
ENSG00000110063	DCPS	78	86.207	ENSVPAG00000001086	DCPS	78	86.207	Vicugna_pacos
ENSG00000110063	DCPS	100	88.131	ENSVVUG00000020085	DCPS	87	88.131	Vulpes_vulpes
ENSG00000110063	DCPS	92	65.161	ENSXETG00000017917	dcps	95	65.161	Xenopus_tropicalis
ENSG00000110063	DCPS	86	66.351	ENSXMAG00000021614	dcps	97	57.447	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	12198172.15383679.22985415.	TAS	Process
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	21873635.	IBA	Process
GO:0000340	RNA 7-methylguanosine cap binding	21873635.	IBA	Function
GO:0000340	RNA 7-methylguanosine cap binding	12198172.15383679.18426921.18441014.22985415.	IDA	Function
GO:0000932	P-body	21873635.	IBA	Component
GO:0004532	exoribonuclease activity	-	TAS	Function
GO:0005515	protein binding	16140270.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	12871939.18441014.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	18441014.	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0036245	cellular response to menadione	16140270.	IDA	Process
GO:0043069	negative regulation of programmed cell death	16140270.	IDA	Process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:0045292	mRNA cis splicing, via spliceosome	18426921.	IDA	Process
GO:0050072	m7G(5')pppN diphosphatase activity	21873635.	IBA	Function
GO:0050072	m7G(5')pppN diphosphatase activity	12198172.15383679.18426921.18441014.18839960.22985415.	IDA	Function
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process