EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000110075 (Gene tree)
Gene ID: 55291
Gene Symbol: PPP6R3
Alias: SAPLa|DKFZp781E2374|DKFZp781O2362|DKFZp781E17107|SAP190|SAPL|PP6R3|FLJ11058|FLJ43065|KIAA1558|MGC125711|MGC125712|C11orf23|SAPS3
Full Name: protein phosphatase 6 regulatory subunit 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 154,617 bases
Position: chr11:68,460,718-68,615,334
Accession: 1173
RBP type: non-canonical RBP
Summary: Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000531244	PPP6R3-222	687	-	ENSP00000432837	186 (aa)	-	E9PNN8
ENST00000529172	PPP6R3-216	500	-	-	- (aa)	-	-
ENST00000528635	PPP6R3-215	538	-	ENSP00000436789	8 (aa)	-	A0A1D5RMU2
ENST00000524845	PPP6R3-205	2771	-	ENSP00000431415	844 (aa)	-	Q5H9R7
ENST00000524904	PPP6R3-206	4292	XM_006718612	ENSP00000433058	867 (aa)	XP_006718675	Q5H9R7
ENST00000525152	PPP6R3-208	582	-	-	- (aa)	-	-
ENST00000393800	PPP6R3-203	5093	XM_006718608	ENSP00000377389	873 (aa)	XP_006718671	Q5H9R7
ENST00000393801	PPP6R3-204	5069	XM_011545137	ENSP00000377390	879 (aa)	XP_011543439	Q5H9R7
ENST00000526574	PPP6R3-211	489	-	-	- (aa)	-	-
ENST00000530427	PPP6R3-220	560	-	-	- (aa)	-	-
ENST00000534534	PPP6R3-226	2968	-	ENSP00000434429	641 (aa)	-	E9PQP7
ENST00000527403	PPP6R3-214	4862	XM_017017974	ENSP00000433565	838 (aa)	XP_016873463	E9PKF6
ENST00000533127	PPP6R3-224	551	-	ENSP00000433768	39 (aa)	-	E9PJD8
ENST00000529907	PPP6R3-219	826	-	ENSP00000431738	140 (aa)	-	E9PK08
ENST00000526307	PPP6R3-210	4134	-	-	- (aa)	-	-
ENST00000525421	PPP6R3-209	830	-	ENSP00000434426	112 (aa)	-	H0YDW1
ENST00000525050	PPP6R3-207	513	-	-	- (aa)	-	-
ENST00000530734	PPP6R3-221	576	-	ENSP00000433853	51 (aa)	-	H0YDK9
ENST00000265637	PPP6R3-202	4783	XM_006718621	ENSP00000265637	827 (aa)	XP_006718684	H7BXH2
ENST00000534190	PPP6R3-225	1980	XM_024448603	ENSP00000436209	580 (aa)	XP_024304371	H0YEN2
ENST00000526593	PPP6R3-212	570	-	ENSP00000436601	109 (aa)	-	H0YEV0
ENST00000529710	PPP6R3-218	3228	-	ENSP00000437329	791 (aa)	-	Q5H9R7
ENST00000529344	PPP6R3-217	603	-	ENSP00000433551	75 (aa)	-	E9PKG4
ENST00000527069	PPP6R3-213	573	-	-	- (aa)	-	-
ENST00000531432	PPP6R3-223	589	-	-	- (aa)	-	-
ENST00000265636	PPP6R3-201	4794	XM_006718622	ENSP00000265636	793 (aa)	XP_006718685	Q5H9R7

Gene Model

Click here to download ENSG00000110075's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000110075	Platelet Function Tests	9.7357677E-006	-
ENSG00000110075	Platelet Function Tests	1.0689400E-005	-
ENSG00000110075	Platelet Function Tests	1.0007500E-005	-
ENSG00000110075	Child Development Disorders, Pervasive	2.9029000E-005	-
ENSG00000110075	Bone Density	1E-10	24945404
ENSG00000110075	Bone Density	2E-10	24945404

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000110075	rs7927592	11	68602492	A	Total body bone mineral density	29304378	unit decrease	0.0781	EFO_0003923
ENSG00000110075	rs7927592	11	68602492	A	Total body bone mineral density	29304378	unit decrease	0.0791	EFO_0003923
ENSG00000110075	rs12364620	11	68484655	T	Total body bone mineral density (age 0-15)	29304378	unit increase	0.0848	EFO_0003923
ENSG00000110075	rs3758643	11	68599725	T	Educational attainment (MTAG)	30038396	[0.0072-0.013] unit decrease	0.0101	EFO_0004784
ENSG00000110075	rs12284933	11	68552021	A	TB-LM or TBLH-BMD (pleiotropy)	28743860			EFO_0003923\|EFO_0004995
ENSG00000110075	rs6591341	11	68568010	T	Lean body mass	28743860	[NR] unit decrease	0.0741	EFO_0004995
ENSG00000110075	rs58332211	11	68543404	?	Heel bone mineral density	30048462	[0.027-0.036] unit decrease	0.0318014	EFO_0009270
ENSG00000110075	rs73518807	11	68515518	C	Educational attainment (years of education)	30038396	[0.0087-0.0169] unit decrease	0.0128	EFO_0004784
ENSG00000110075	rs2236708	11	68610577	A	Educational attainment (years of education)	30038396	[0.0059-0.0121] unit decrease	0.009	EFO_0004784
ENSG00000110075	rs12283755	11	68604190	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000110075	rs118074499	11	68533323	?	Hair color	30595370			EFO_0007822
ENSG00000110075	rs75356449	11	68574934	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000110075's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000110075	PPP6R3	100	82.051	ENSG00000105063	PPP6R1	100	64.331	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0005515	protein binding	18186651.21044950.21187329.24255178.28330616.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0019903	protein phosphatase binding	16716191.	IPI	Function
GO:0043666	regulation of phosphoprotein phosphatase activity	16716191.	IDA	Process
GO:0048208	COPII vesicle coating	-	TAS	Process