EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000110367 (Gene tree)
Gene ID: 1656
Gene Symbol: DDX6
Alias: RCK|HLR2
Full Name: DEAD-box helicase 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 43,501 bases
Position: chr11:118,747,763-118,791,263
Accession: 2747
RBP type: canonical RBP
Summary: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000433704	DEAD	PF00270.29	5.4e-42	1	1
ENSP00000442266	DEAD	PF00270.29	5.4e-42	1	1
ENSP00000478754	DEAD	PF00270.29	5.4e-42	1	1
ENSP00000483902	DEAD	PF00270.29	6.8e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23562722	Plasmodium falciparum DOZI, an RNA helicase interacts with eIF4E.	Gene	2013 Jun 10	Tarique M	doi: 10.1016/j.gene.2013.03.063
30273347	The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency.	PLoS One	2018 Oct 1	Kami D	doi: 10.1371/journal.pone.0203708
19285948	Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.	Mol Cell	2009 Mar 13	Tritschler F	doi: 10.1016/j.molcel.2009.02.014.
20075394	P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes.	Biol Reprod	2010 May	Flemr M	doi: 10.1095/biolreprod.109.082057
29987267	DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.	Int J Mol Sci	2018 Jul 9	Tajirika T	doi: 10.3390/ijms19072005.
31075158	Impact of a patient-derived hepatitis C viral RNA genome with a mutated microRNA binding site.	PLoS Pathog	2019 May 10	Mata M	doi: 10.1371/journal.ppat.1007467
23209657	Ataxin-2-like is a regulator of stress granules and processing bodies.	PLoS One	2012	Kaehler C	doi: 10.1371/journal.pone.0050134
23535175	Role of Rck-Pat1b binding in assembly of processing-bodies.	RNA Biol	2013 Apr	Ozgur S	doi: 10.4161/rna.24086
28456022	Cellular DEAD-box RNA helicase DDX6 modulates interaction of miR-122 with the 5' untranslated region of hepatitis C virus RNA.	Virology	2017 Jul	Biegel JM	doi: 10.1016/j.virol.2017.04.014

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000526070	DDX6-202	1936	-	ENSP00000433704	483 (aa)	-	P26196
ENST00000620157	DDX6-208	6152	XM_005271417	ENSP00000478754	483 (aa)	XP_005271474	P26196
ENST00000525082	DDX6-201	1232	-	-	- (aa)	-	-
ENST00000534980	DDX6-206	6097	XM_011542644	ENSP00000442266	483 (aa)	XP_011540946	P26196
ENST00000529162	DDX6-203	1795	-	-	- (aa)	-	-
ENST00000533239	DDX6-205	738	-	-	- (aa)	-	-
ENST00000531971	DDX6-204	4373	-	-	- (aa)	-	-
ENST00000617381	DDX6-207	2883	-	ENSP00000483902	187 (aa)	-	Q8IV96

Gene Model

Click here to download ENSG00000110367's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000110367	Hypersensitivity	9E-11	27182965
ENSG00000110367	Vitiligo	2E-9	22951725
ENSG00000110367	Body Height	4E-9	25429064

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000110367	rs10892286	11	118771376	?	Systemic lupus erythematosus	28714469	[1.08-1.2]	1.1363636	EFO_0002690
ENSG00000110367	rs61219050	11	118777915	A	Systemic sclerosis	24387989		1.1562	EFO_0000717
ENSG00000110367	rs2510897	11	118773873	A	Height	25429064	[0.017-0.041] unit decrease	0.029	EFO_0004339
ENSG00000110367	rs75411106	11	118768944	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000110367's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000110367	DDX6	78	31.759	ENSG00000118197	DDX59	61	31.759
ENSG00000110367	DDX6	77	30.971	ENSG00000100201	DDX17	52	30.971
ENSG00000110367	DDX6	76	38.441	ENSG00000156976	EIF4A2	91	38.441
ENSG00000110367	DDX6	76	30.933	ENSG00000278053	DDX52	63	30.933
ENSG00000110367	DDX6	82	36.591	ENSG00000123136	DDX39A	95	39.560
ENSG00000110367	DDX6	72	34.626	ENSG00000109832	DDX25	94	47.619
ENSG00000110367	DDX6	76	30.280	ENSG00000067048	DDX3Y	59	30.280
ENSG00000110367	DDX6	68	30.678	ENSG00000108654	DDX5	94	34.694
ENSG00000110367	DDX6	77	31.159	ENSG00000174243	DDX23	51	31.175
ENSG00000110367	DDX6	69	31.831	ENSG00000111364	DDX55	87	33.133
ENSG00000110367	DDX6	80	33.838	ENSG00000064703	DDX20	61	36.905
ENSG00000110367	DDX6	63	40.678	ENSG00000079785	DDX1	53	40.678
ENSG00000110367	DDX6	76	35.263	ENSG00000157349	DDX19B	97	34.890
ENSG00000110367	DDX6	79	35.659	ENSG00000198563	DDX39B	96	38.547
ENSG00000110367	DDX6	76	35.526	ENSG00000168872	DDX19A	93	35.294
ENSG00000110367	DDX6	70	34.097	ENSG00000178105	DDX10	51	33.811
ENSG00000110367	DDX6	78	32.987	ENSG00000213782	DDX47	84	32.987
ENSG00000110367	DDX6	76	38.710	ENSG00000161960	EIF4A1	99	38.272
ENSG00000110367	DDX6	71	32.022	ENSG00000183258	DDX41	57	32.022
ENSG00000110367	DDX6	73	30.833	ENSG00000124228	DDX27	85	30.932
ENSG00000110367	DDX6	71	33.056	ENSG00000152670	DDX4	62	33.056
ENSG00000110367	DDX6	72	30.769	ENSG00000198231	DDX42	50	30.769
ENSG00000110367	DDX6	70	32.081	ENSG00000184735	DDX53	55	32.081
ENSG00000110367	DDX6	74	30.854	ENSG00000123064	DDX54	99	32.212
ENSG00000110367	DDX6	73	33.241	ENSG00000080007	DDX43	55	33.241
ENSG00000110367	DDX6	75	32.703	ENSG00000105671	DDX49	75	33.151
ENSG00000110367	DDX6	78	37.831	ENSG00000141543	EIF4A3	91	37.831
ENSG00000110367	DDX6	74	31.915	ENSG00000136271	DDX56	95	35.196
ENSG00000110367	DDX6	76	30.789	ENSG00000215301	DDX3X	83	30.789

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000110367	DDX6	100	89.463	ENSAPOG00000007695	ddx6	100	89.463	Acanthochromis_polyacanthus
ENSG00000110367	DDX6	100	99.793	ENSAMEG00000006073	DDX6	100	99.793	Ailuropoda_melanoleuca
ENSG00000110367	DDX6	100	75.826	ENSACIG00000023989	ddx6	100	75.826	Amphilophus_citrinellus
ENSG00000110367	DDX6	100	89.463	ENSAOCG00000022849	ddx6	100	89.463	Amphiprion_ocellaris
ENSG00000110367	DDX6	100	89.463	ENSAPEG00000013047	ddx6	100	89.463	Amphiprion_percula
ENSG00000110367	DDX6	100	89.855	ENSATEG00000009693	ddx6	100	89.855	Anabas_testudineus
ENSG00000110367	DDX6	99	99.378	ENSAPLG00000007274	DDX6	99	99.378	Anas_platyrhynchos
ENSG00000110367	DDX6	99	96.687	ENSACAG00000017134	DDX6	99	96.687	Anolis_carolinensis
ENSG00000110367	DDX6	99	98.919	ENSANAG00000038280	-	100	94.444	Aotus_nancymaae
ENSG00000110367	DDX6	100	89.362	ENSANAG00000032103	-	90	89.362	Aotus_nancymaae
ENSG00000110367	DDX6	100	89.855	ENSACLG00000022164	ddx6	100	89.855	Astatotilapia_calliptera
ENSG00000110367	DDX6	99	89.441	ENSAMXG00000019553	ddx6	99	89.648	Astyanax_mexicanus
ENSG00000110367	DDX6	99	99.793	ENSBTAG00000009067	DDX6	99	99.793	Bos_taurus
ENSG00000110367	DDX6	100	99.793	ENSCJAG00000013591	DDX6	100	99.793	Callithrix_jacchus
ENSG00000110367	DDX6	100	99.793	ENSCAFG00000012442	DDX6	100	99.793	Canis_familiaris
ENSG00000110367	DDX6	100	88.542	ENSCAFG00020014681	-	100	86.458	Canis_lupus_dingo
ENSG00000110367	DDX6	100	99.793	ENSCAFG00020013150	DDX6	100	99.793	Canis_lupus_dingo
ENSG00000110367	DDX6	99	99.585	ENSCHIG00000026114	DDX6	99	99.585	Capra_hircus
ENSG00000110367	DDX6	100	99.793	ENSTSYG00000026313	DDX6	100	99.793	Carlito_syrichta
ENSG00000110367	DDX6	81	64.198	ENSCAPG00000013040	DDX6	100	64.198	Cavia_aperea
ENSG00000110367	DDX6	98	99.457	ENSCPOG00000010587	Ddx6	100	93.375	Cavia_porcellus
ENSG00000110367	DDX6	99	98.919	ENSCCAG00000021636	-	100	95.652	Cebus_capucinus
ENSG00000110367	DDX6	98	88.043	ENSCCAG00000029078	-	99	87.019	Cebus_capucinus
ENSG00000110367	DDX6	100	100.000	ENSCATG00000045025	DDX6	100	100.000	Cercocebus_atys
ENSG00000110367	DDX6	100	72.634	ENSCATG00000009414	-	100	71.575	Cercocebus_atys
ENSG00000110367	DDX6	100	99.586	ENSCLAG00000016749	DDX6	100	99.586	Chinchilla_lanigera
ENSG00000110367	DDX6	100	100.000	ENSCSAG00000002564	DDX6	100	100.000	Chlorocebus_sabaeus
ENSG00000110367	DDX6	86	99.760	ENSCHOG00000007565	DDX6	100	99.760	Choloepus_hoffmanni
ENSG00000110367	DDX6	100	98.758	ENSCPBG00000004323	DDX6	100	98.758	Chrysemys_picta_bellii
ENSG00000110367	DDX6	93	97.110	ENSCANG00000042664	DDX6	100	89.855	Colobus_angolensis_palliatus
ENSG00000110367	DDX6	100	99.586	ENSCGRG00001023465	Ddx6	100	99.586	Cricetulus_griseus_chok1gshd
ENSG00000110367	DDX6	100	99.586	ENSCGRG00000014165	Ddx6	100	99.586	Cricetulus_griseus_crigri
ENSG00000110367	DDX6	100	88.843	ENSCSEG00000006875	ddx6	100	88.843	Cynoglossus_semilaevis
ENSG00000110367	DDX6	99	88.382	ENSCVAG00000002540	ddx6	99	88.382	Cyprinodon_variegatus
ENSG00000110367	DDX6	99	89.441	ENSDARG00000061338	ddx6	99	89.234	Danio_rerio
ENSG00000110367	DDX6	98	99.457	ENSDNOG00000014447	DDX6	100	95.052	Dasypus_novemcinctus
ENSG00000110367	DDX6	88	91.294	ENSDORG00000001037	Ddx6	100	91.294	Dipodomys_ordii
ENSG00000110367	DDX6	65	99.612	ENSETEG00000007589	-	70	99.612	Echinops_telfairi
ENSG00000110367	DDX6	54	87.405	ENSEBUG00000010009	ddx6	71	87.405	Eptatretus_burgeri
ENSG00000110367	DDX6	71	70.149	ENSEBUG00000006566	-	96	66.667	Eptatretus_burgeri
ENSG00000110367	DDX6	100	99.793	ENSEASG00005004961	DDX6	100	99.793	Equus_asinus_asinus
ENSG00000110367	DDX6	100	99.793	ENSECAG00000000539	DDX6	100	99.793	Equus_caballus
ENSG00000110367	DDX6	98	98.913	ENSEEUG00000002824	DDX6	100	91.059	Erinaceus_europaeus
ENSG00000110367	DDX6	100	85.801	ENSELUG00000022660	ddx6	100	85.801	Esox_lucius
ENSG00000110367	DDX6	100	99.793	ENSFCAG00000029360	DDX6	100	99.793	Felis_catus
ENSG00000110367	DDX6	99	99.170	ENSFALG00000009831	DDX6	99	99.170	Ficedula_albicollis
ENSG00000110367	DDX6	100	99.586	ENSFDAG00000012457	DDX6	100	99.586	Fukomys_damarensis
ENSG00000110367	DDX6	99	88.382	ENSFHEG00000021202	ddx6	99	88.843	Fundulus_heteroclitus
ENSG00000110367	DDX6	99	86.777	ENSGMOG00000009542	ddx6	99	86.570	Gadus_morhua
ENSG00000110367	DDX6	99	99.378	ENSGALG00000033064	DDX6	99	99.378	Gallus_gallus
ENSG00000110367	DDX6	99	87.371	ENSGAFG00000020279	ddx6	99	87.578	Gambusia_affinis
ENSG00000110367	DDX6	100	87.603	ENSGACG00000012258	ddx6	100	87.603	Gasterosteus_aculeatus
ENSG00000110367	DDX6	100	98.758	ENSGAGG00000020608	DDX6	100	98.758	Gopherus_agassizii
ENSG00000110367	DDX6	100	77.479	ENSGGOG00000038856	-	100	77.479	Gorilla_gorilla
ENSG00000110367	DDX6	100	69.565	ENSGGOG00000023765	-	100	69.565	Gorilla_gorilla
ENSG00000110367	DDX6	100	89.648	ENSGGOG00000016751	DDX6	100	89.648	Gorilla_gorilla
ENSG00000110367	DDX6	100	89.648	ENSHBUG00000009651	ddx6	100	89.648	Haplochromis_burtoni
ENSG00000110367	DDX6	100	99.793	ENSHGLG00000004316	DDX6	100	99.793	Heterocephalus_glaber_female
ENSG00000110367	DDX6	100	99.793	ENSHGLG00100014595	DDX6	100	99.793	Heterocephalus_glaber_male
ENSG00000110367	DDX6	100	87.910	ENSHCOG00000012451	ddx6	100	88.320	Hippocampus_comes
ENSG00000110367	DDX6	99	87.992	ENSIPUG00000000616	ddx6	99	87.785	Ictalurus_punctatus
ENSG00000110367	DDX6	100	99.586	ENSSTOG00000014475	DDX6	100	99.586	Ictidomys_tridecemlineatus
ENSG00000110367	DDX6	100	99.586	ENSJJAG00000021630	Ddx6	100	99.586	Jaculus_jaculus
ENSG00000110367	DDX6	99	88.797	ENSKMAG00000003546	ddx6	99	88.797	Kryptolebias_marmoratus
ENSG00000110367	DDX6	100	83.231	ENSLBEG00000017823	ddx6	100	78.431	Labrus_bergylta
ENSG00000110367	DDX6	99	94.215	ENSLACG00000017153	DDX6	99	93.595	Latimeria_chalumnae
ENSG00000110367	DDX6	99	89.463	ENSLOCG00000000770	ddx6	99	89.669	Lepisosteus_oculatus
ENSG00000110367	DDX6	99	99.170	ENSLAFG00000011012	DDX6	99	99.170	Loxodonta_africana
ENSG00000110367	DDX6	100	100.000	ENSMFAG00000042472	DDX6	100	100.000	Macaca_fascicularis
ENSG00000110367	DDX6	98	75.000	ENSMMUG00000047408	-	100	71.429	Macaca_mulatta
ENSG00000110367	DDX6	100	100.000	ENSMMUG00000018651	DDX6	100	100.000	Macaca_mulatta
ENSG00000110367	DDX6	100	100.000	ENSMNEG00000033959	DDX6	100	100.000	Macaca_nemestrina
ENSG00000110367	DDX6	100	100.000	ENSMLEG00000028151	DDX6	100	100.000	Mandrillus_leucophaeus
ENSG00000110367	DDX6	100	88.391	ENSMAMG00000013732	ddx6	100	87.576	Mastacembelus_armatus
ENSG00000110367	DDX6	100	89.855	ENSMZEG00005024098	ddx6	100	89.855	Maylandia_zebra
ENSG00000110367	DDX6	99	99.378	ENSMGAG00000004123	DDX6	99	99.378	Meleagris_gallopavo
ENSG00000110367	DDX6	100	98.758	ENSMAUG00000008886	Ddx6	100	98.758	Mesocricetus_auratus
ENSG00000110367	DDX6	100	99.793	ENSMICG00000011519	DDX6	100	99.793	Microcebus_murinus
ENSG00000110367	DDX6	100	99.586	ENSMOCG00000002068	Ddx6	100	99.586	Microtus_ochrogaster
ENSG00000110367	DDX6	100	82.025	ENSMMOG00000001233	ddx6	100	81.818	Mola_mola
ENSG00000110367	DDX6	100	99.793	ENSMODG00000013375	DDX6	100	99.793	Monodelphis_domestica
ENSG00000110367	DDX6	100	84.917	ENSMALG00000009308	ddx6	100	84.711	Monopterus_albus
ENSG00000110367	DDX6	100	93.582	MGP_CAROLIEiJ_G0032122	Ddx6	100	93.582	Mus_caroli
ENSG00000110367	DDX6	100	97.723	ENSMUSG00000032097	Ddx6	100	97.723	Mus_musculus
ENSG00000110367	DDX6	100	97.308	MGP_PahariEiJ_G0014991	Ddx6	100	97.308	Mus_pahari
ENSG00000110367	DDX6	100	99.793	ENSMPUG00000004857	DDX6	100	99.793	Mustela_putorius_furo
ENSG00000110367	DDX6	100	99.379	ENSMLUG00000003671	DDX6	100	99.379	Myotis_lucifugus
ENSG00000110367	DDX6	100	99.586	ENSNGAG00000016848	Ddx6	100	99.586	Nannospalax_galili
ENSG00000110367	DDX6	100	80.745	ENSNBRG00000003507	ddx6	100	80.745	Neolamprologus_brichardi
ENSG00000110367	DDX6	89	82.530	ENSNBRG00000003540	ddx6	80	82.036	Neolamprologus_brichardi
ENSG00000110367	DDX6	100	100.000	ENSNLEG00000007372	DDX6	100	100.000	Nomascus_leucogenys
ENSG00000110367	DDX6	100	88.820	ENSMEUG00000010556	DDX6	100	88.820	Notamacropus_eugenii
ENSG00000110367	DDX6	81	82.353	ENSOPRG00000016112	DDX6	100	82.353	Ochotona_princeps
ENSG00000110367	DDX6	100	99.586	ENSODEG00000007950	DDX6	100	99.586	Octodon_degus
ENSG00000110367	DDX6	100	89.234	ENSONIG00000005756	ddx6	100	89.648	Oreochromis_niloticus
ENSG00000110367	DDX6	88	99.299	ENSOANG00000003751	DDX6	100	99.299	Ornithorhynchus_anatinus
ENSG00000110367	DDX6	100	99.379	ENSOCUG00000005849	DDX6	100	99.379	Oryctolagus_cuniculus
ENSG00000110367	DDX6	100	87.992	ENSORLG00000002506	ddx6	100	88.199	Oryzias_latipes
ENSG00000110367	DDX6	100	88.199	ENSORLG00020016534	ddx6	100	88.406	Oryzias_latipes_hni
ENSG00000110367	DDX6	100	87.992	ENSORLG00015005301	ddx6	100	88.199	Oryzias_latipes_hsok
ENSG00000110367	DDX6	100	88.199	ENSOMEG00000001347	ddx6	100	88.406	Oryzias_melastigma
ENSG00000110367	DDX6	100	99.793	ENSOGAG00000007978	DDX6	100	99.793	Otolemur_garnettii
ENSG00000110367	DDX6	99	99.585	ENSOARG00000011455	DDX6	99	99.585	Ovis_aries
ENSG00000110367	DDX6	100	68.116	ENSPPAG00000039963	-	100	67.909	Pan_paniscus
ENSG00000110367	DDX6	100	100.000	ENSPPAG00000034894	DDX6	100	100.000	Pan_paniscus
ENSG00000110367	DDX6	100	78.719	ENSPPAG00000040387	-	100	78.719	Pan_paniscus
ENSG00000110367	DDX6	100	99.793	ENSPPRG00000009039	DDX6	100	99.793	Panthera_pardus
ENSG00000110367	DDX6	100	99.793	ENSPTIG00000018551	DDX6	100	99.793	Panthera_tigris_altaica
ENSG00000110367	DDX6	100	100.000	ENSPTRG00000004353	DDX6	100	100.000	Pan_troglodytes
ENSG00000110367	DDX6	100	78.512	ENSPTRG00000050136	-	100	78.512	Pan_troglodytes
ENSG00000110367	DDX6	98	71.739	ENSPTRG00000043896	-	100	68.944	Pan_troglodytes
ENSG00000110367	DDX6	100	100.000	ENSPANG00000018963	DDX6	100	100.000	Papio_anubis
ENSG00000110367	DDX6	99	89.648	ENSPKIG00000013728	ddx6	99	89.648	Paramormyrops_kingsleyae
ENSG00000110367	DDX6	100	97.325	ENSPSIG00000013230	DDX6	100	97.325	Pelodiscus_sinensis
ENSG00000110367	DDX6	100	77.640	ENSPMGG00000023707	ddx6	100	77.847	Periophthalmus_magnuspinnatus
ENSG00000110367	DDX6	99	79.132	ENSPMAG00000007168	ddx6	99	78.882	Petromyzon_marinus
ENSG00000110367	DDX6	99	88.406	ENSPFOG00000010555	ddx6	99	88.406	Poecilia_formosa
ENSG00000110367	DDX6	99	88.199	ENSPLAG00000019684	ddx6	99	88.406	Poecilia_latipinna
ENSG00000110367	DDX6	99	88.406	ENSPMEG00000019775	ddx6	99	88.406	Poecilia_mexicana
ENSG00000110367	DDX6	99	87.785	ENSPREG00000016082	ddx6	99	87.992	Poecilia_reticulata
ENSG00000110367	DDX6	100	96.687	ENSPPYG00000003942	DDX6	100	96.687	Pongo_abelii
ENSG00000110367	DDX6	98	97.283	ENSPCAG00000004767	DDX6	100	90.062	Procavia_capensis
ENSG00000110367	DDX6	100	99.793	ENSPCOG00000020762	DDX6	100	99.793	Propithecus_coquereli
ENSG00000110367	DDX6	98	97.826	ENSPVAG00000005421	DDX6	100	91.925	Pteropus_vampyrus
ENSG00000110367	DDX6	100	89.648	ENSPNYG00000008538	ddx6	100	89.648	Pundamilia_nyererei
ENSG00000110367	DDX6	93	78.035	ENSPNAG00000010102	ddx6	100	69.980	Pygocentrus_nattereri
ENSG00000110367	DDX6	100	98.137	ENSRNOG00000053932	Ddx6	100	98.137	Rattus_norvegicus
ENSG00000110367	DDX6	100	69.530	ENSRBIG00000038129	-	100	69.325	Rhinopithecus_bieti
ENSG00000110367	DDX6	100	100.000	ENSRBIG00000032545	DDX6	100	100.000	Rhinopithecus_bieti
ENSG00000110367	DDX6	100	69.358	ENSRBIG00000027933	-	100	69.358	Rhinopithecus_bieti
ENSG00000110367	DDX6	100	72.464	ENSRROG00000034419	-	100	72.464	Rhinopithecus_roxellana
ENSG00000110367	DDX6	100	100.000	ENSRROG00000032478	DDX6	100	100.000	Rhinopithecus_roxellana
ENSG00000110367	DDX6	100	69.467	ENSRROG00000032664	-	100	69.467	Rhinopithecus_roxellana
ENSG00000110367	DDX6	100	99.793	ENSSBOG00000029671	DDX6	100	99.793	Saimiri_boliviensis_boliviensis
ENSG00000110367	DDX6	100	99.793	ENSSHAG00000011424	DDX6	100	99.793	Sarcophilus_harrisii
ENSG00000110367	DDX6	82	50.126	ENSSFOG00015005998	DDX6	97	49.239	Scleropages_formosus
ENSG00000110367	DDX6	99	89.855	ENSSFOG00015023211	ddx6	99	89.855	Scleropages_formosus
ENSG00000110367	DDX6	100	88.636	ENSSMAG00000001253	ddx6	100	88.430	Scophthalmus_maximus
ENSG00000110367	DDX6	100	89.876	ENSSDUG00000019695	ddx6	100	89.876	Seriola_dumerili
ENSG00000110367	DDX6	100	89.876	ENSSLDG00000006167	ddx6	100	89.876	Seriola_lalandi_dorsalis
ENSG00000110367	DDX6	100	99.793	ENSSARG00000003219	DDX6	100	99.793	Sorex_araneus
ENSG00000110367	DDX6	94	90.351	ENSSPUG00000004404	DDX6	93	95.059	Sphenodon_punctatus
ENSG00000110367	DDX6	100	89.669	ENSSPAG00000023258	ddx6	100	89.669	Stegastes_partitus
ENSG00000110367	DDX6	100	99.586	ENSSSCG00000015097	DDX6	100	99.586	Sus_scrofa
ENSG00000110367	DDX6	95	97.168	ENSTGUG00000017360	DDX6	100	97.168	Taeniopygia_guttata
ENSG00000110367	DDX6	100	88.430	ENSTRUG00000011848	ddx6	100	88.223	Takifugu_rubripes
ENSG00000110367	DDX6	100	89.256	ENSTNIG00000016295	ddx6	100	89.050	Tetraodon_nigroviridis
ENSG00000110367	DDX6	98	99.457	ENSTTRG00000004313	DDX6	100	96.687	Tursiops_truncatus
ENSG00000110367	DDX6	100	99.793	ENSUAMG00000027749	DDX6	100	99.793	Ursus_americanus
ENSG00000110367	DDX6	100	99.793	ENSUMAG00000000993	DDX6	100	99.793	Ursus_maritimus
ENSG00000110367	DDX6	100	97.516	ENSVPAG00000005601	DDX6	100	97.516	Vicugna_pacos
ENSG00000110367	DDX6	100	99.172	ENSVVUG00000024121	DDX6	100	99.172	Vulpes_vulpes
ENSG00000110367	DDX6	99	94.179	ENSXETG00000010061	ddx6	99	95.218	Xenopus_tropicalis
ENSG00000110367	DDX6	99	80.745	ENSXCOG00000008560	ddx6	99	80.952	Xiphophorus_couchianus
ENSG00000110367	DDX6	99	87.578	ENSXMAG00000007620	ddx6	99	87.785	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000792	heterochromatin	-	IEA	Component
GO:0000932	P-body	16699599.20616046.20826699.22915799.23125361.	IDA	Component
GO:0000932	P-body	22022269.	IMP	Component
GO:0001520	outer dense fiber	-	IEA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003724	RNA helicase activity	1579499.	TAS	Function
GO:0004386	helicase activity	1394235.1579499.	TAS	Function
GO:0005515	protein binding	16364915.16699599.16756390.17392519.19966221.20543818.20584987.20616046.24862572.25036637.25416956.26184334.26496610.27107012.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	26184334.	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	26184334.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005913	cell-cell adherens junction	-	IEA	Component
GO:0010494	cytoplasmic stress granule	17392519.26184334.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016442	RISC complex	20616046.	IDA	Component
GO:0019074	viral RNA genome packaging	22022269.	IMP	Process
GO:0019827	stem cell population maintenance	-	IEA	Process
GO:0019904	protein domain specific binding	24768540.	IPI	Function
GO:0033391	chromatoid body	-	IEA	Component
GO:0033962	cytoplasmic mRNA processing body assembly	20826699.	IDA	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	Component
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045665	negative regulation of neuron differentiation	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0048515	spermatid differentiation	-	IEA	Process
GO:0061830	concave side of sperm head	-	IEA	Component
GO:0097227	sperm annulus	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23932921	DDX6 post-transcriptionally down-regulates miR-143/145 expression through host gene NCR143/145 in cancer cells.	Biochim Biophys Acta	2013 Oct	Iio A	doi: 10.1016/j.bbagrm.2013.07.010
18769115	Knockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo.	Cancer Biol Ther	2008 Oct	Lin F	-
29987267	DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.	Int J Mol Sci	2018 Jul 9	Tajirika T	doi: 10.3390/ijms19072005.
29314290	Oncogene RNA helicase DDX6 promotes the process of c-Myc expression in gastric cancer cells.	Mol Carcinog	2018 May	Taniguchi K	doi: 10.1002/mc.22781

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr11	118765239	Nonsense_Mutation	novel	R206*	0.4
BLCA	chr11	118754766	Missense_Mutation	novel	K466N	0.17
BLCA	chr11	118754803	Missense_Mutation	NA	G454E	0.35
BLCA	chr11	118786086	Missense_Mutation	novel	Q56E	0.18
BRCA	chr11	118786212	Frame_Shift_Ins	novel	*L14Vfs9**	0.1
BRCA	chr11	118765253	Missense_Mutation	novel	G201A	0.05
BRCA	chr11	118758815	Missense_Mutation	NA	E318K	0.14
BRCA	chr11	118751068	3'Flank	novel		0.1
BRCA	chr11	118758995	Intron	novel		0.26
BRCA	chr11	118757177	Missense_Mutation	NA	M368I	0.57
BRCA	chr11	118755480	Missense_Mutation	NA	I400L	0.38
CESC	chr11	118751068	3'Flank	novel		0.14
CESC	chr11	118751068	3'Flank	novel		0.11
CESC	chr11	118751538	3'Flank	novel		0.5
CESC	chr11	118781165	Missense_Mutation	novel	K74E	0.28
CESC	chr11	118751068	3'Flank	novel		0.13
CESC	chr11	118757244	Frame_Shift_Ins	novel	*R346Lfs7**	0.15
CESC	chr11	118757245	Nonsense_Mutation	novel	Q345_R346insGE*	0.15
CHOL	chr11	118751104	3'Flank	novel		0.46
CHOL	chr11	118751068	3'Flank	novel		0.08
CHOL	chr11	118751047	3'Flank	novel		0.53
CHOL	chr11	118750264	3'Flank	novel		0.32
COAD	chr11	118763237	Missense_Mutation	NA	H239R	0.49
COAD	chr11	118755475	Missense_Mutation	novel	Q401H	0.28
COAD	chr11	118758933	Intron	novel		0.3
COAD	chr11	118756275	Missense_Mutation	novel	N387D	0.15
COAD	chr11	118779632	Splice_Region	NA	Q123Q	0.2
COAD	chr11	118781154	Frame_Shift_Del	NA	*K77Nfs7**	0.41
COAD	chr11	118786155	Nonsense_Mutation	novel	G33*	0.05
COAD	chr11	118756316	Missense_Mutation	NA	R373Q	0.15
ESCA	chr11	118790883	5'UTR	novel		0.47
ESCA	chr11	118790904	5'UTR	novel		0.29
ESCA	chr11	118750264	3'Flank	novel		0.3
ESCA	chr11	118751068	3'Flank	novel		0.14
ESCA	chr11	118750198	3'Flank	rs782094779		0.17
ESCA	chr11	118751067	3'Flank	novel		0.75
ESCA	chr11	118751068	3'Flank	novel		0.19
GBM	chr11	118765213	Missense_Mutation	novel	D214E	0.09
GBM	chr11	118765212	Missense_Mutation	novel	T215P	0.04
GBM	chr11	118755488	Missense_Mutation	NA	G397D	0.31
HNSC	chr11	118759955	Silent	rs376083867	S277S	0.35
HNSC	chr11	118768263	Silent	rs372116927	P153P	0.33
HNSC	chr11	118768264	Missense_Mutation	novel	P153L	0.33	DEAD
HNSC	chr11	118786162	Silent	novel	G30G	0.35
HNSC	chr11	118754750	Missense_Mutation	novel	E472Q	0.04
KIRC	chr11	118786189	Silent	NA	L21L	0.21
KIRP	chr11	118765246	Silent	novel	T203T	0.35
LGG	chr11	118759954	Missense_Mutation	novel	A278T	0.43
LIHC	chr11	118779641	Silent	novel	S120S	0.18
LIHC	chr11	118757274	Missense_Mutation	NA	Q336L	0.19
LUAD	chr11	118779689	Silent	NA	K104K	0.53
LUAD	chr11	118765338	Missense_Mutation	novel	T173A	0.16	DEAD
LUAD	chr11	118758778	Missense_Mutation	novel	S330F	0.19
LUSC	chr11	118781121	Splice_Region	rs781874399	S88S	0.23
LUSC	chr11	118768253	Missense_Mutation	rs782757060	R157W	0.33	DEAD
LUSC	chr11	118786105	Missense_Mutation	rs769816474	N49K	0.1
OV	chr11	118786233	Nonsense_Mutation	novel	E7*	0.08
OV	chr11	118758840	Frame_Shift_Ins	novel	*T310Yfs16**	0.04
OV	chr11	118786382	5'UTR	novel		0.19
OV	chr11	118757182	Missense_Mutation	NA	K367E	0.21
PAAD	chr11	118754762	Silent	novel	L468L	0.16
PRAD	chr11	118765349	Missense_Mutation	novel	V169G	0.18	DEAD
PRAD	chr11	118765220	Missense_Mutation	novel	L212R	0.25
READ	chr11	118756316	Missense_Mutation	NA	R373Q	0.16
SARC	chr11	118751068	3'Flank	novel		0.13
SARC	chr11	118759987	Missense_Mutation	novel	L267I	0.06
SARC	chr11	118751810	3'Flank	novel		0.33
SARC	chr11	118751962	3'Flank	novel		0.29
SKCM	chr11	118786147	Silent	novel	G35G	0.44
SKCM	chr11	118759985	Silent	novel	L267L	0.24
SKCM	chr11	118758896	Missense_Mutation	novel	H291Y	0.2
SKCM	chr11	118765221	Missense_Mutation	novel	L212F	0.16
STAD	chr11	118758804	Frame_Shift_Del	novel	*V322Yfs13**	0.4
STAD	chr11	118759008	Intron	novel		0.26
STAD	chr11	118754778	Silent	NA	S462S	0.13
STAD	chr11	118759977	Frame_Shift_Del	novel	*N270Tfs19**	0.23
TGCT	chr11	118756293	Silent	novel	R381R	0.29
THYM	chr11	118786293	5'UTR	novel		0.17
THYM	chr11	118750170	3'Flank	novel		0.29
UCEC	chr11	118786306	5'UTR	novel		0.25
UCEC	chr11	118751190	3'Flank	novel		0.13
UCEC	chr11	118751984	3'Flank	novel		0.55
UCEC	chr11	118758977	Intron	novel		0.41
UCEC	chr11	118756304	Missense_Mutation	novel	F377C	0.07
UCEC	chr11	118751123	3'Flank	novel		0.38
UCEC	chr11	118750193	3'Flank	rs376361455		0.42
UCEC	chr11	118750264	3'Flank	novel		0.58
UCEC	chr11	118755501	Missense_Mutation	NA	L393M	0.35
UCEC	chr11	118752054	3'Flank	novel		0.25
UCEC	chr11	118759996	Missense_Mutation	novel	I264V	0.29
UCEC	chr11	118765284	Missense_Mutation	rs750916819	M191V	0.09
UCEC	chr11	118750264	3'Flank	novel		0.75
UCEC	chr11	118750882	3'Flank	novel		0.59
UCEC	chr11	118749601	3'Flank	novel		0.12
UCEC	chr11	118750198	3'Flank	rs782094779		0.46
UCEC	chr11	118747795	3'UTR	novel		0.5
UCEC	chr11	118754837	Missense_Mutation	NA	R443C	0.41
UCEC	chr11	118765345	Missense_Mutation	novel	I170M	0.36	DEAD
UCEC	chr11	118781147	Missense_Mutation	novel	P80S	0.14
UCEC	chr11	118786331	5'UTR	novel		0.16
UCEC	chr11	118755457	Silent	novel	I407I	0.32
UCEC	chr11	118759935	Missense_Mutation	novel	V284A	0.44
UCEC	chr11	118786286	5'UTR	novel		0.12
UCEC	chr11	118751164	3'Flank	novel		0.43
UCEC	chr11	118756310	Missense_Mutation	novel	R375H	0.36
UCEC	chr11	118786217	Missense_Mutation	novel	M12T	0.18
UCEC	chr11	118751054	3'Flank	novel		0.31
UCEC	chr11	118749797	3'Flank	novel		0.28
UCEC	chr11	118749688	3'Flank	novel		0.34
UCEC	chr11	118751299	3'Flank	novel		0.67
UCEC	chr11	118750267	3'Flank	novel		0.42
UCEC	chr11	118750264	3'Flank	novel		1
UCEC	chr11	118754763	Silent	NA	S467S	0.3
UCEC	chr11	118749598	3'Flank	rs574563979		0.18
UCEC	chr11	118750198	3'Flank	rs782094779		0.48
UCEC	chr11	118747856	3'UTR	novel		0.42
UCEC	chr11	118756311	Missense_Mutation	novel	R375C	0.25
UCEC	chr11	118750023	3'Flank	novel		0.08
UCEC	chr11	118758973	Intron	novel		0.17
UCEC	chr11	118751047	3'Flank	novel		0.62
UCEC	chr11	118749946	3'Flank	novel		0.52
UCEC	chr11	118750198	3'Flank	rs782094779		0.11
UCEC	chr11	118751047	3'Flank	novel		0.58
UCEC	chr11	118758861	Missense_Mutation	NA	E302D	0.25
UCEC	chr11	118751654	3'Flank	novel		0.49
UCEC	chr11	118765332	Nonsense_Mutation	NA	E175*	0.2	DEAD
UCEC	chr11	118751054	3'Flank	rs557696047		0.37
UCEC	chr11	118750264	3'Flank	novel		0.7
UCEC	chr11	118759955	Silent	rs376083867	S277S	0.34
UCEC	chr11	118786333	5'UTR	novel		0.22
UCEC	chr11	118786220	Missense_Mutation	NA	I11T	0.4
UCEC	chr11	118759018	Intron	novel		0.31
UCEC	chr11	118750264	3'Flank	novel		0.73
UCEC	chr11	118765279	Silent	NA	G192G	0.21
UCEC	chr11	118751061	3'Flank	novel		0.43
UCEC	chr11	118756278	Missense_Mutation	rs782274778	R386C	0.46
UCEC	chr11	118781122	Missense_Mutation	rs782677081	S88L	0.38
UCEC	chr11	118751845	3'Flank	novel		0.29
UCEC	chr11	118786318	5'UTR	novel		0.14
UCEC	chr11	118750198	3'Flank	novel		0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2819	0.00015732
CESC	DEL	0.5085	1.0762e-32
CHOL	DEL	0.2778	0.048655
ESCA	AMP	0.0924	0.018342
KIRP	DEL	0.1007	2.839e-05
LIHC	DEL	0.2027	0.00030497
LUAD	DEL	0.157	4.2393e-06
PRAD	DEL	0.0772	0.00026046
READ	DEL	0.1879	0.054114
SARC	DEL	0.4358	1.8105e-09
STAD	DEL	0.1474	8.3734e-05
TGCT	DEL	0.7667	0.21504
UCS	DEL	0.375	0.086462
UVM	DEL	0.075	0.023516

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00014	Kaplan-Meier Survival Analysis
STAD	0.0066	Kaplan-Meier Survival Analysis
ESCA	0.027	Kaplan-Meier Survival Analysis
UCEC	0.041	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
CHOL	0.026	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742