EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000110851 (Gene tree)
Gene ID: 11108
Gene Symbol: PRDM4
Alias: PFM1
Full Name: PR/SET domain 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 28,407 bases
Position: chr12:107,732,866-107,761,272
Accession: 9348
RBP type: canonical RBP
Summary: The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000228437	zf-C2H2	PF00096.26	1.6e-18	1	2
ENSP00000228437	zf-C2H2	PF00096.26	1.6e-18	2	2
ENSP00000228437	zf-met	PF12874.7	0.00013	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000550659	PRDM4-206	837	-	ENSP00000449295	279 (aa)	-	H0YIF6
ENST00000549416	PRDM4-204	568	-	-	- (aa)	-	-
ENST00000228437	PRDM4-201	4210	XM_005268593	ENSP00000228437	801 (aa)	XP_005268650	Q9UKN5
ENST00000547188	PRDM4-202	640	-	ENSP00000448684	75 (aa)	-	F8VRG2
ENST00000550376	PRDM4-205	2591	-	ENSP00000446803	316 (aa)	-	F8VZQ2
ENST00000547268	PRDM4-203	585	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000110851's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04722	Neurotrophin signaling pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000110851	rs10861775	12	107750314	A	Male-pattern baldness	30573740	[0.019-0.032] unit increase	0.0257944	EFO_0007825

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000110851's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000110851	PRDM4	99	97.372	ENSAMEG00000016174	PRDM4	99	97.372	Ailuropoda_melanoleuca
ENSG00000110851	PRDM4	96	95.833	ENSAPLG00000009846	PRDM4	99	86.842	Anas_platyrhynchos
ENSG00000110851	PRDM4	100	100.000	ENSANAG00000024800	PRDM4	100	99.126	Aotus_nancymaae
ENSG00000110851	PRDM4	100	98.667	ENSBTAG00000012999	PRDM4	100	97.253	Bos_taurus
ENSG00000110851	PRDM4	100	100.000	ENSCJAG00000015261	PRDM4	100	98.627	Callithrix_jacchus
ENSG00000110851	PRDM4	100	98.667	ENSCAFG00000001788	PRDM4	100	97.378	Canis_familiaris
ENSG00000110851	PRDM4	100	98.667	ENSCAFG00020004916	PRDM4	100	97.378	Canis_lupus_dingo
ENSG00000110851	PRDM4	100	97.333	ENSCHIG00000019409	PRDM4	100	96.879	Capra_hircus
ENSG00000110851	PRDM4	100	100.000	ENSTSYG00000009248	PRDM4	100	97.628	Carlito_syrichta
ENSG00000110851	PRDM4	95	97.183	ENSCAPG00000013937	PRDM4	99	90.613	Cavia_aperea
ENSG00000110851	PRDM4	95	97.183	ENSCPOG00000022385	PRDM4	100	90.062	Cavia_porcellus
ENSG00000110851	PRDM4	100	100.000	ENSCCAG00000036033	PRDM4	100	99.251	Cebus_capucinus
ENSG00000110851	PRDM4	100	100.000	ENSCATG00000044797	PRDM4	100	99.376	Cercocebus_atys
ENSG00000110851	PRDM4	100	94.265	ENSCLAG00000007545	PRDM4	100	93.159	Chinchilla_lanigera
ENSG00000110851	PRDM4	100	100.000	ENSCSAG00000002896	PRDM4	100	99.625	Chlorocebus_sabaeus
ENSG00000110851	PRDM4	100	97.333	ENSCHOG00000001744	PRDM4	86	98.182	Choloepus_hoffmanni
ENSG00000110851	PRDM4	95	92.958	ENSCPBG00000023187	PRDM4	100	87.829	Chrysemys_picta_bellii
ENSG00000110851	PRDM4	100	100.000	ENSCANG00000021804	PRDM4	100	99.501	Colobus_angolensis_palliatus
ENSG00000110851	PRDM4	100	94.624	ENSCGRG00001015102	-	100	92.786	Cricetulus_griseus_chok1gshd
ENSG00000110851	PRDM4	100	94.624	ENSCGRG00000004044	-	100	92.774	Cricetulus_griseus_crigri
ENSG00000110851	PRDM4	100	96.504	ENSDNOG00000032478	PRDM4	100	96.504	Dasypus_novemcinctus
ENSG00000110851	PRDM4	99	82.183	ENSDORG00000015081	-	100	81.932	Dipodomys_ordii
ENSG00000110851	PRDM4	96	62.500	ENSEBUG00000003775	prdm4	99	46.291	Eptatretus_burgeri
ENSG00000110851	PRDM4	100	98.667	ENSECAG00000015423	PRDM4	100	97.378	Equus_caballus
ENSG00000110851	PRDM4	100	89.247	ENSEEUG00000006569	PRDM4	99	92.943	Erinaceus_europaeus
ENSG00000110851	PRDM4	95	70.423	ENSELUG00000015265	prdm4	99	60.753	Esox_lucius
ENSG00000110851	PRDM4	100	97.878	ENSFCAG00000022478	PRDM4	100	97.878	Felis_catus
ENSG00000110851	PRDM4	95	97.183	ENSFALG00000013342	PRDM4	100	87.077	Ficedula_albicollis
ENSG00000110851	PRDM4	100	93.333	ENSGALG00000012619	PRDM4	100	86.177	Gallus_gallus
ENSG00000110851	PRDM4	96	94.444	ENSGAGG00000002763	PRDM4	95	87.469	Gopherus_agassizii
ENSG00000110851	PRDM4	99	100.000	ENSGGOG00000001244	PRDM4	99	99.625	Gorilla_gorilla
ENSG00000110851	PRDM4	95	98.592	ENSHGLG00000004590	PRDM4	98	93.601	Heterocephalus_glaber_female
ENSG00000110851	PRDM4	95	98.592	ENSHGLG00100007464	PRDM4	100	92.547	Heterocephalus_glaber_male
ENSG00000110851	PRDM4	95	68.493	ENSIPUG00000024162	prdm4	93	61.749	Ictalurus_punctatus
ENSG00000110851	PRDM4	100	96.754	ENSSTOG00000016168	PRDM4	100	96.754	Ictidomys_tridecemlineatus
ENSG00000110851	PRDM4	99	94.595	ENSJJAG00000022448	-	95	93.280	Jaculus_jaculus
ENSG00000110851	PRDM4	98	75.824	ENSLACG00000007452	PRDM4	99	73.020	Latimeria_chalumnae
ENSG00000110851	PRDM4	68	60.784	ENSLOCG00000017092	prdm4	100	52.814	Lepisosteus_oculatus
ENSG00000110851	PRDM4	100	97.133	ENSLAFG00000001483	PRDM4	100	96.701	Loxodonta_africana
ENSG00000110851	PRDM4	100	100.000	ENSMFAG00000041862	PRDM4	100	99.750	Macaca_fascicularis
ENSG00000110851	PRDM4	100	100.000	ENSMMUG00000015550	PRDM4	100	99.750	Macaca_mulatta
ENSG00000110851	PRDM4	100	100.000	ENSMNEG00000032319	PRDM4	100	99.501	Macaca_nemestrina
ENSG00000110851	PRDM4	100	100.000	ENSMLEG00000039607	PRDM4	100	99.625	Mandrillus_leucophaeus
ENSG00000110851	PRDM4	95	95.775	ENSMGAG00000012815	PRDM4	100	78.875	Meleagris_gallopavo
ENSG00000110851	PRDM4	100	100.000	ENSMICG00000007807	PRDM4	100	96.629	Microcebus_murinus
ENSG00000110851	PRDM4	99	93.985	ENSMOCG00000000753	Prdm4	99	93.734	Microtus_ochrogaster
ENSG00000110851	PRDM4	100	94.624	ENSMUSG00000035529	Prdm4	100	94.354	Mus_musculus
ENSG00000110851	PRDM4	100	94.982	MGP_PahariEiJ_G0031398	Prdm4	100	94.028	Mus_pahari
ENSG00000110851	PRDM4	100	94.624	MGP_SPRETEiJ_G0016505	Prdm4	100	95.299	Mus_spretus
ENSG00000110851	PRDM4	100	95.341	ENSMPUG00000012238	PRDM4	99	91.272	Mustela_putorius_furo
ENSG00000110851	PRDM4	99	97.118	ENSMLUG00000000767	PRDM4	99	97.118	Myotis_lucifugus
ENSG00000110851	PRDM4	99	95.946	ENSNGAG00000018627	Prdm4	100	95.734	Nannospalax_galili
ENSG00000110851	PRDM4	100	99.625	ENSNLEG00000006748	PRDM4	100	99.625	Nomascus_leucogenys
ENSG00000110851	PRDM4	95	97.183	ENSMEUG00000004495	PRDM4	89	89.202	Notamacropus_eugenii
ENSG00000110851	PRDM4	95	98.592	ENSOPRG00000010192	PRDM4	89	95.238	Ochotona_princeps
ENSG00000110851	PRDM4	99	95.946	ENSODEG00000014750	PRDM4	99	90.375	Octodon_degus
ENSG00000110851	PRDM4	100	98.667	ENSOANG00000005526	PRDM4	100	90.886	Ornithorhynchus_anatinus
ENSG00000110851	PRDM4	95	100.000	ENSOCUG00000012859	PRDM4	96	96.710	Oryctolagus_cuniculus
ENSG00000110851	PRDM4	99	97.867	ENSOGAG00000011945	PRDM4	100	97.867	Otolemur_garnettii
ENSG00000110851	PRDM4	100	97.333	ENSOARG00000017955	PRDM4	100	96.629	Ovis_aries
ENSG00000110851	PRDM4	100	100.000	ENSPPAG00000038438	PRDM4	100	99.750	Pan_paniscus
ENSG00000110851	PRDM4	100	97.878	ENSPPRG00000004144	PRDM4	100	97.878	Panthera_pardus
ENSG00000110851	PRDM4	100	97.878	ENSPTIG00000005847	PRDM4	100	97.878	Panthera_tigris_altaica
ENSG00000110851	PRDM4	100	100.000	ENSPTRG00000005400	PRDM4	100	99.750	Pan_troglodytes
ENSG00000110851	PRDM4	100	100.000	ENSPANG00000022084	PRDM4	100	99.750	Papio_anubis
ENSG00000110851	PRDM4	97	72.603	ENSPKIG00000000875	prdm4	99	60.523	Paramormyrops_kingsleyae
ENSG00000110851	PRDM4	95	94.366	ENSPSIG00000012066	PRDM4	100	81.369	Pelodiscus_sinensis
ENSG00000110851	PRDM4	99	95.609	ENSPEMG00000014598	Prdm4	100	95.609	Peromyscus_maniculatus_bairdii
ENSG00000110851	PRDM4	100	94.667	ENSPCIG00000009471	PRDM4	100	89.055	Phascolarctos_cinereus
ENSG00000110851	PRDM4	100	100.000	ENSPPYG00000004913	PRDM4	100	99.625	Pongo_abelii
ENSG00000110851	PRDM4	100	93.907	ENSPCAG00000009987	PRDM4	83	95.833	Procavia_capensis
ENSG00000110851	PRDM4	100	100.000	ENSPCOG00000021060	PRDM4	100	96.879	Propithecus_coquereli
ENSG00000110851	PRDM4	100	97.333	ENSPVAG00000001596	PRDM4	100	96.883	Pteropus_vampyrus
ENSG00000110851	PRDM4	99	93.985	ENSRNOG00000004962	Prdm4	100	93.734	Rattus_norvegicus
ENSG00000110851	PRDM4	100	100.000	ENSRBIG00000035488	PRDM4	100	99.501	Rhinopithecus_bieti
ENSG00000110851	PRDM4	100	100.000	ENSRROG00000012779	PRDM4	100	99.625	Rhinopithecus_roxellana
ENSG00000110851	PRDM4	100	100.000	ENSSBOG00000000403	PRDM4	100	99.126	Saimiri_boliviensis_boliviensis
ENSG00000110851	PRDM4	96	75.000	ENSSFOG00015023358	prdm4	99	63.793	Scleropages_formosus
ENSG00000110851	PRDM4	100	98.667	ENSSSCG00000000160	PRDM4	100	97.129	Sus_scrofa
ENSG00000110851	PRDM4	96	97.222	ENSTGUG00000010962	-	99	86.967	Taeniopygia_guttata
ENSG00000110851	PRDM4	100	79.570	ENSTBEG00000001732	PRDM4	84	89.761	Tupaia_belangeri
ENSG00000110851	PRDM4	100	98.667	ENSTTRG00000011056	PRDM4	100	96.754	Tursiops_truncatus
ENSG00000110851	PRDM4	100	98.667	ENSUAMG00000022796	PRDM4	100	97.753	Ursus_americanus
ENSG00000110851	PRDM4	100	98.667	ENSUMAG00000017231	PRDM4	100	97.753	Ursus_maritimus
ENSG00000110851	PRDM4	99	97.616	ENSVPAG00000002215	PRDM4	100	97.616	Vicugna_pacos
ENSG00000110851	PRDM4	100	98.667	ENSVVUG00000023397	PRDM4	100	97.378	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006366	transcription by RNA polymerase II	-	IEA	Process
GO:0007165	signal transduction	10552934.	TAS	Process
GO:0008168	methyltransferase activity	-	IEA	Function
GO:0008270	zinc ion binding	10552934.	TAS	Function
GO:0008283	cell proliferation	10552934.	TAS	Process
GO:0031490	chromatin DNA binding	21873635.	IBA	Function
GO:0035097	histone methyltransferase complex	23048031.	NAS	Component
GO:0043565	sequence-specific DNA binding	21873635.	IBA	Function
GO:0043985	histone H4-R3 methylation	23048031.	NAS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:1990226	histone methyltransferase binding	21873635.	IBA	Function
GO:1990226	histone methyltransferase binding	23048031.	NAS	Function