EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000110880 (Gene tree)
Gene ID: 23603
Gene Symbol: CORO1C
Alias: coronin-3|HCRNN4
Full Name: coronin 1C
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 86,488 bases
Position: chr12:108,645,109-108,731,596
Accession: 2254
RBP type: non-canonical RBP
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000551550	CORO1C-217	547	-	ENSP00000448527	163 (aa)	-	F8VRE9
ENST00000547294	CORO1C-208	566	-	ENSP00000449330	181 (aa)	-	F8VVB7
ENST00000552030	CORO1C-218	547	-	-	- (aa)	-	-
ENST00000549772	CORO1C-212	1710	-	ENSP00000447534	480 (aa)	-	Q9ULV4
ENST00000547361	CORO1C-209	683	-	-	- (aa)	-	-
ENST00000420959	CORO1C-202	3921	XM_017019121	ENSP00000394496	527 (aa)	XP_016874610	Q9ULV4
ENST00000546571	CORO1C-205	899	-	ENSP00000448195	162 (aa)	-	F8VSA4
ENST00000541050	CORO1C-204	2487	-	ENSP00000438341	474 (aa)	-	Q9ULV4
ENST00000421578	CORO1C-203	1296	-	ENSP00000415554	369 (aa)	-	B4E3S0
ENST00000552871	CORO1C-219	587	-	ENSP00000449658	125 (aa)	-	F8VV53
ENST00000546705	CORO1C-206	577	-	ENSP00000447337	165 (aa)	-	H0YHL7
ENST00000261401	CORO1C-201	3892	XM_017019122	ENSP00000261401	474 (aa)	XP_016874611	Q9ULV4
ENST00000551044	CORO1C-215	567	-	ENSP00000447049	151 (aa)	-	F8W1H8
ENST00000551059	CORO1C-216	474	-	-	- (aa)	-	-
ENST00000547170	CORO1C-207	804	-	-	- (aa)	-	-
ENST00000549384	CORO1C-210	891	-	-	- (aa)	-	-
ENST00000550542	CORO1C-214	1245	-	ENSP00000448130	159 (aa)	-	F8VUX3
ENST00000550032	CORO1C-213	547	-	ENSP00000447989	169 (aa)	-	F8VTT6
ENST00000549387	CORO1C-211	873	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000110880's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000110880	Diabetes Mellitus, Type 2	3.553878E-5	17463248
ENSG00000110880	Cardiovascular Physiological Phenomena	2.2850000E-005	-
ENSG00000110880	Child Development Disorders, Pervasive	9.8000000E-005	-
ENSG00000110880	Cholesterol, HDL	3E-7	26879886

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000110880	rs750134	12	108667330	T	Low high density lipoprotein cholesterol levels	26879886	[1.08-2.33]	1.5873016	EFO_0004612
ENSG00000110880	rs4964273	12	108709897	T	Cognitive performance (MTAG)	30038396	[0.0081-0.0171] unit decrease	0.0126	EFO_0008354
ENSG00000110880	rs4964273	12	108709897	?	General cognitive ability	29844566	z-score decrease	5.128	EFO_0004337
ENSG00000110880	rs3741782	12	108701361	A	Coronary artery disease and LDL cholesterol levels (multivariate analysis)	30525989			EFO_0004611\|EFO_0000378

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000110880's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001755	neural crest cell migration	25074804.	IMP	Process
GO:0001932	regulation of protein phosphorylation	19913511.	IGI	Process
GO:0001933	negative regulation of protein phosphorylation	19913511.	IMP	Process
GO:0005515	protein binding	25074804.26655834.	IPI	Function
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	19913511.	IDA	Component
GO:0005938	cell cortex	-	IEA	Component
GO:0006909	phagocytosis	9778037.	TAS	Process
GO:0007165	signal transduction	9778037.	TAS	Process
GO:0010008	endosome membrane	30220460.	IDA	Component
GO:0010632	regulation of epithelial cell migration	19913511.	IGI	Process
GO:0010633	negative regulation of epithelial cell migration	19913511.	IMP	Process
GO:0010762	regulation of fibroblast migration	-	ISS	Process
GO:0015629	actin cytoskeleton	22364218.	IDA	Component
GO:0016197	endosomal transport	30220460.	IDA	Process
GO:0016328	lateral plasma membrane	25074804.	IDA	Component
GO:0016600	flotillin complex	-	ISS	Component
GO:0030017	sarcomere	-	IEA	Component
GO:0030027	lamellipodium	22364218.	IDA	Component
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0031982	vesicle	25074804.	IDA	Component
GO:0032587	ruffle membrane	-	IEA	Component
GO:0042383	sarcolemma	-	IEA	Component
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	19913511.	IMP	Process
GO:0045184	establishment of protein localization	-	ISS	Process
GO:0045202	synapse	-	IEA	Component
GO:0048365	Rac GTPase binding	-	IEA	Function
GO:0051015	actin filament binding	22364218.	IMP	Function
GO:0051893	regulation of focal adhesion assembly	19913511.	IGI	Process
GO:0051895	negative regulation of focal adhesion assembly	19913511.	IMP	Process
GO:0090148	membrane fission	30220460.	IDA	Process
GO:0090630	activation of GTPase activity	-	ISS	Process
GO:0097750	endosome membrane tubulation	30220460.	IDA	Process
GO:1900024	regulation of substrate adhesion-dependent cell spreading	19913511.	IGI	Process
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	19913511.	IMP	Process
GO:1900027	regulation of ruffle assembly	-	IEA	Process
GO:2000394	positive regulation of lamellipodium morphogenesis	19913511.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23292607	Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells.	Oncol Rep	2013 Mar	Wang ZG	doi: 10.3892/or.2012.2216
30150608	Coronin 1c and F-actin Promote Metastasis of Breast Cancer.	Med Sci Monit	2018 Aug 28	Shao J	doi: 10.12659/MSM.908929.
22974233	Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K.	Mol Cancer	2012 Sep 14	Ren G	doi: 10.1186/1476-4598-11-67.
28302118	YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro.	BMC Cancer	2017 Mar 16	Lim JP	doi: 10.1186/s12885-017-3187-7.
30065298	Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function.	Oncogene	2018 Dec	Castagnino A	doi: 10.1038/s41388-018-0422-x

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	108662083	Frame_Shift_Del	novel	*K131Efs36**	0.23
BLCA	chr12	108658896	Missense_Mutation	NA	W158G	0.25
BLCA	chr12	108678289	Missense_Mutation	novel	E101K	0.24
BLCA	chr12	108648820	Missense_Mutation	novel	D364N	0.49
BLCA	chr12	108701311	Missense_Mutation	NA	R3P	0.34
BLCA	chr12	108658749	Missense_Mutation	novel	E207Q	0.21
BLCA	chr12	108701288	Missense_Mutation	NA	R11W	0.06
BRCA	chr12	108657410	Missense_Mutation	NA	A215V	0.29
BRCA	chr12	108647337	3'UTR	novel		0.29
BRCA	chr12	108648746	Missense_Mutation	NA	I388M	0.23
BRCA	chr12	108657340	Silent	novel	S238S	1
BRCA	chr12	108647456	Missense_Mutation	NA	Q458E	0.12
BRCA	chr12	108662132	Silent	NA	L115L	0.15
BRCA	chr12	108678375	Missense_Mutation	NA	S72C	0.23
CESC	chr12	108648799	Missense_Mutation	rs762661543	A371T	0.38
CESC	chr12	108657369	Missense_Mutation	NA	D229N	0.08
CESC	chr12	108702891	Intron	novel		0.41
CESC	chr12	108657423	Missense_Mutation	NA	E211K	0.14
CESC	chr12	108702888	Intron	novel		0.13
COAD	chr12	108647446	Missense_Mutation	NA	R461H	0.13
COAD	chr12	108678387	Missense_Mutation	NA	R68Q	0.41
COAD	chr12	108658772	Missense_Mutation	novel	R199K	0.22
COAD	chr12	108647374	3'UTR	novel		0.39
COAD	chr12	108647265	3'UTR	rs558905344		0.28
COAD	chr12	108647259	3'UTR	novel		0.18
COAD	chr12	108701170	Missense_Mutation	NA	I50T	0.16
GBM	chr12	108647440	Missense_Mutation	novel	S463Y	0.05
GBM	chr12	108654370	Missense_Mutation	novel	T264S	0.06
GBM	chr12	108647268	3'UTR	novel		0.11
HNSC	chr12	108657331	Missense_Mutation	novel	S241R	0.12
HNSC	chr12	108657369	Missense_Mutation	NA	D229N	0.4
HNSC	chr12	108657304	Splice_Region	rs762555895	P250P	0.18
LGG	chr12	108701288	Missense_Mutation	NA	R11W	0.1
LIHC	chr12	108657306	Missense_Mutation	novel	P250T	0.29
LIHC	chr12	108657307	Missense_Mutation	novel	N249K	0.29
LUAD	chr12	108648697	Missense_Mutation	NA	V405F	0.07
LUAD	chr12	108657369	Missense_Mutation	NA	D229N	0.17
LUAD	chr12	108658892	Frame_Shift_Del	novel	*N153Mfs9**	0.19
LUAD	chr12	108652331	Missense_Mutation	NA	Q314H	0.1
LUAD	chr12	108658737	Splice_Site	novel	X210_splice	0.28
LUAD	chr12	108658739	Missense_Mutation	novel	A210V	0.28
LUAD	chr12	108701121	Splice_Region	novel		0.12
LUAD	chr12	108662156	Splice_Region	NA	V107V	0.33
LUAD	chr12	108652347	Missense_Mutation	NA	S309I	0.18
LUAD	chr12	108701169	Missense_Mutation	NA	I50M	0.27
LUAD	chr12	108658878	Nonsense_Mutation	novel	E164*	0.12
LUAD	chr12	108647325	3'UTR	novel		0.07
LUSC	chr12	108658817	Missense_Mutation	rs771989893	R184Q	0.27
LUSC	chr12	108658855	Silent	rs755025882	D171D	0.31
LUSC	chr12	108648787	Missense_Mutation	NA	E375K	0.25
LUSC	chr12	108701282	Missense_Mutation	NA	V13L	0.18
LUSC	chr12	108657327	Missense_Mutation	NA	R243W	0.32
LUSC	chr12	108648698	Silent	novel	V404V	0.17
OV	chr12	108648623	Silent	novel	T429T	0.06
READ	chr12	108652369	Missense_Mutation	NA	V302I	0.26
READ	chr12	108648650	Silent	novel	C420C	0.34
READ	chr12	108648752	Silent	novel	I386I	0.39
READ	chr12	108658866	Missense_Mutation	novel	N168H	0.13
SARC	chr12	108652373	Silent	rs748283648	P300P	0.2
SARC	chr12	108701260	Missense_Mutation	rs749438076	N20S	0.63
SKCM	chr12	108662085	Missense_Mutation	novel	K131T	0.19
SKCM	chr12	108662124	Missense_Mutation	NA	S118F	0.15
SKCM	chr12	108647445	Silent	NA	R461R	0.4
SKCM	chr12	108648744	Missense_Mutation	NA	S389F	0.88
SKCM	chr12	108648839	Silent	NA	F357F	0.28
SKCM	chr12	108652384	Missense_Mutation	NA	D297N	0.55
SKCM	chr12	108652376	Silent	NA	S299S	0.08
SKCM	chr12	108658844	Missense_Mutation	NA	D175V	0.46
SKCM	chr12	108652412	Silent	NA	D287D	0.35
SKCM	chr12	108652376	Silent	NA	S299S	0.35
STAD	chr12	108648647	Silent	NA	D421D	0.19
STAD	chr12	108647438	Missense_Mutation	NA	K464E	0.34
STAD	chr12	108652369	Missense_Mutation	NA	V302I	0.35
STAD	chr12	108652319	Silent	NA	G318G	0.05
STAD	chr12	108647373	3'UTR	novel		0.43
STAD	chr12	108647259	3'UTR	novel		0.45
STAD	chr12	108701250	Silent	NA	C23C	0.34
THCA	chr12	108647319	3'UTR	novel		0.06
UCEC	chr12	108701262	Missense_Mutation	NA	K19N	0.34
UCEC	chr12	108647207	3'UTR	novel		0.4
UCEC	chr12	108702868	Intron	novel		0.25
UCEC	chr12	108702957	Intron	novel		0.33
UCEC	chr12	108678378	Missense_Mutation	NA	K71T	0.39
UCEC	chr12	108662078	Silent	rs760519774	V133V	0.44
UCEC	chr12	108658858	Silent	rs768088134	D170D	0.34
UCEC	chr12	108648767	Missense_Mutation	novel	K381N	0.49
UCEC	chr12	108647339	3'UTR	novel		0.29
UCEC	chr12	108701237	Missense_Mutation	novel	R28W	0.39
UCEC	chr12	108647191	3'UTR	novel		0.26
UCEC	chr12	108647260	3'UTR	novel		0.31
UCEC	chr12	108678316	Missense_Mutation	NA	N92D	0.48
UCEC	chr12	108662078	Silent	rs760519774	V133V	0.17
UCEC	chr12	108646922	3'UTR	novel		0.88
UCEC	chr12	108652275	Missense_Mutation	NA	A333V	0.43
UCEC	chr12	108662106	Missense_Mutation	NA	V124A	0.46
UCEC	chr12	108652403	Silent	novel	I290I	0.35
UCEC	chr12	108658896	Missense_Mutation	novel	W158R	0.36
UCEC	chr12	108647207	3'UTR	novel		0.24
UCEC	chr12	108648839	Missense_Mutation	novel	F357L	0.38
UCEC	chr12	108652414	Missense_Mutation	novel	D287N	0.27
UCEC	chr12	108647190	3'UTR	novel		0.41
UCEC	chr12	108702984	Intron	rs374294256		0.24
UCEC	chr12	108657386	Missense_Mutation	novel	R223I	0.44
UCEC	chr12	108652385	Silent	rs773150683	T296T	0.38
UCEC	chr12	108647479	Missense_Mutation	novel	S450F	0.45
UCEC	chr12	108657302	Splice_Site	novel	X250_splice	0.37
UCEC	chr12	108648776	Silent	rs375038851	F378F	0.42
UCEC	chr12	108702984	Intron	rs374294256		0.18
UCEC	chr12	108678387	Missense_Mutation	NA	R68Q	0.36
UCEC	chr12	108662054	Silent	novel	T141T	0.29
UCEC	chr12	108654405	Silent	novel	N252N	0.41
UCEC	chr12	108662072	Silent	rs372909353	I135I	0.38
UCEC	chr12	108647208	3'UTR	novel		0.11
UCEC	chr12	108648776	Silent	rs375038851	F378F	0.4
UCEC	chr12	108647377	3'UTR	novel		0.14
UCEC	chr12	108647266	3'UTR	novel		0.28
UCEC	chr12	108678387	Missense_Mutation	NA	R68Q	0.18
UCEC	chr12	108657369	Missense_Mutation	NA	D229N	0.33
UCEC	chr12	108658739	Missense_Mutation	novel	A210V	0.27
UCEC	chr12	108652271	Splice_Site	NA	X334_splice	0.25
UCEC	chr12	108648772	Missense_Mutation	NA	G380C	0.23
UCEC	chr12	108662078	Silent	rs760519774	V133V	0.35
UCEC	chr12	108702884	Intron	novel		0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0222	0.20414
CHOL	DEL	0.2222	0.067545
HNSC	DEL	0.0613	0.22646
LUAD	DEL	0.1415	0.0059643
LUSC	DEL	0.0898	0.038823
PAAD	DEL	0.1848	0.0030251
PRAD	AMP	0.0589	0.016187
SKCM	DEL	0.1907	0.00079981

Survival Analysis

Cancer	P-value	Q-value
ACC	0.025	Kaplan-Meier Survival Analysis
HNSC	0.0099	Kaplan-Meier Survival Analysis
SKCM	0.0044	Kaplan-Meier Survival Analysis
PAAD	0.014	Kaplan-Meier Survival Analysis
BLCA	0.0016	Kaplan-Meier Survival Analysis
READ	0.037	Kaplan-Meier Survival Analysis
LAML	0.0022	Kaplan-Meier Survival Analysis
KICH	0.041	Kaplan-Meier Survival Analysis
GBM	0.01	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.0086	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis
UVM	0.00047	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742