EuRBPDB

Description

Ensembl ID: ENSG00000110917 (Gene tree)
Gene ID: 9761
Gene Symbol: MLEC
Alias: KIAA0152
Full Name: malectin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 14,996 bases
Position: chr12:120,686,869-120,701,864
Accession: 28973
RBP type: non-canonical RBP
Summary: This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000535413	MLEC-203	617	-	-	- (aa)	-	-
ENST00000412616	MLEC-202	841	-	ENSP00000440746	217 (aa)	-	F5GX14
ENST00000228506	MLEC-201	6626	-	ENSP00000228506	292 (aa)	-	Q14165
ENST00000545525	MLEC-205	549	XM_011539031	ENSP00000438950	146 (aa)	XP_011537333	F5H1S8
ENST00000535656	MLEC-204	543	-	ENSP00000441247	173 (aa)	-	H0YG07

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000110917	rs2005455	12	120690896	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000110917	MLEC	100	97.260	ENSMUSG00000048578	Mlec	100	92.517	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005783	endoplasmic reticulum	-	ISS	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005975	carbohydrate metabolic process	-	IEA	Process
GO:0006457	protein folding	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0019899	enzyme binding	22988243.	IPI	Function
GO:0030246	carbohydrate binding	-	ISS	Function
GO:0035579	specific granule membrane	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process