EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000111144 (Gene tree)
Gene ID: 4048
Gene Symbol: LTA4H
Alias: N
Full Name: leukotriene A4 hydrolase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 42,768 bases
Position: chr12:96,000,753-96,043,520
Accession: 6710
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000547982	LTA4H-205	986	-	-	- (aa)	-	-
ENST00000228740	LTA4H-201	2139	XM_011538349	ENSP00000228740	611 (aa)	XP_011536651	P09960
ENST00000537111	LTA4H-203	1881	-	-	- (aa)	-	-
ENST00000548375	LTA4H-206	639	-	-	- (aa)	-	-
ENST00000553041	LTA4H-210	6109	-	-	- (aa)	-	-
ENST00000552789	LTA4H-209	2025	-	ENSP00000449958	587 (aa)	-	P09960
ENST00000548852	LTA4H-207	1810	-	ENSP00000449340	132 (aa)	-	B4DEH5
ENST00000413268	LTA4H-202	1908	XM_005268871	ENSP00000395051	508 (aa)	XP_005268928	P09960
ENST00000547393	LTA4H-204	543	-	-	- (aa)	-	-
ENST00000552091	LTA4H-208	595	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000111144's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00590	Arachidonic acid metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000111144	Varicose Veins	2.49975621968999E-19	-
ENSG00000111144	Personality	1.17e-005	-
ENSG00000111144	Platelet Function Tests	5.9320979E-006	-
ENSG00000111144	Platelet Function Tests	6.1858652E-006	-
ENSG00000111144	Platelet Function Tests	9.3651473E-006	-
ENSG00000111144	Platelet Function Tests	6.8013827E-006	-
ENSG00000111144	Platelet Function Tests	6.9927571E-006	-
ENSG00000111144	Platelet Function Tests	1.5141900E-005	-
ENSG00000111144	Platelet Function Tests	2.5603000E-005	-
ENSG00000111144	Amino Acids	5E-11	27005778
ENSG00000111144	Metabolism	5E-11	27005778
ENSG00000111144	Proteins	5E-11	27005778

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000111144	rs2072510	12	96009421	?	Metabolite levels (small molecules and protein measures)	27005778	[0.048-0.089] unit decrease	0.0689075	EFO_0005664\|EFO_0004747\|EFO_0005134
ENSG00000111144	rs2247570	12	96028599	T	Blood protein levels	30072576	[0.071-0.177] unit decrease	0.124	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111144's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004177	aminopeptidase activity	9774412.15078870.18804029.	IDA	Function
GO:0004301	epoxide hydrolase activity	21873635.	IBA	Function
GO:0004301	epoxide hydrolase activity	15078870.	IDA	Function
GO:0004301	epoxide hydrolase activity	11675384.	IMP	Function
GO:0004301	epoxide hydrolase activity	11154734.	TAS	Function
GO:0004463	leukotriene-A4 hydrolase activity	21873635.	IBA	Function
GO:0004463	leukotriene-A4 hydrolase activity	9774412.15078870.	IDA	Function
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006508	proteolysis	-	IEA	Process
GO:0006691	leukotriene metabolic process	-	TAS	Process
GO:0008233	peptidase activity	1881903.	TAS	Function
GO:0008270	zinc ion binding	15078870.18804029.	IDA	Function
GO:0008270	zinc ion binding	11675384.	IMP	Function
GO:0019370	leukotriene biosynthetic process	21873635.	IBA	Process
GO:0019370	leukotriene biosynthetic process	9774412.15078870.	IDA	Process
GO:0019370	leukotriene biosynthetic process	11675384.	IMP	Process
GO:0042759	long-chain fatty acid biosynthetic process	-	TAS	Process
GO:0043171	peptide catabolic process	9774412.15078870.18804029.	IDA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044255	cellular lipid metabolic process	21873635.	IBA	Process
GO:0044267	cellular protein metabolic process	11675384.	IMP	Process
GO:0070006	metalloaminopeptidase activity	11675384.	IMP	Function
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:1904724	tertiary granule lumen	-	TAS	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component