EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000111530 (Gene tree)
Gene ID: 55832
Gene Symbol: CAND1
Alias: TIP120A|DKFZp434M1414|KIAA0829|TIP120
Full Name: cullin associated and neddylation dissociated 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 50,671 bases
Position: chr12:67,269,281-67,319,951
Accession: 30688
RBP type: non-canonical RBP
Summary: This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16036220	CAND1 enhances deneddylation of CUL1 by COP9 signalosome.	Biochem Biophys Res Commun	2005 Sep 2	Min KW	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000539434	CAND1-203	772	-	-	- (aa)	-	-
ENST00000541058	CAND1-206	663	-	-	- (aa)	-	-
ENST00000540319	CAND1-204	2786	-	ENSP00000445794	442 (aa)	-	H0YH27
ENST00000544619	CAND1-207	4091	-	ENSP00000444089	770 (aa)	-	A0A0C4DGH5
ENST00000535146	CAND1-201	560	-	-	- (aa)	-	-
ENST00000539109	CAND1-202	433	-	-	- (aa)	-	-
ENST00000540525	CAND1-205	527	-	ENSP00000437594	54 (aa)	-	F5H6I6
ENST00000545606	CAND1-208	11251	-	ENSP00000442318	1230 (aa)	-	Q86VP6

Gene Model

Click here to download ENSG00000111530's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000111530	rs118065693	12	67274047	?	Chronic sinus infection	28928442	[2.36-13.37] unit decrease	7.8681	EFO_0008419
ENSG00000111530	rs17781645	12	67279090	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000111530	rs710629	12	67304076	A	Educational attainment (years of education)	30038396	[0.0053-0.0111] unit increase	0.0082	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111530's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000111530	CAND1	100	88.889	FBgn0027568	Cand1	100	57.962	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000151	ubiquitin ligase complex	12609982.	IDA	Component
GO:0005515	protein binding	12504025.12504026.12609982.15537541.16861300.17290223.18826954.25435324.26496610.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10581176.21249194.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21249194.	IDA	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006879	cellular iron ion homeostasis	-	TAS	Process
GO:0010265	SCF complex assembly	21873635.	IBA	Process
GO:0010265	SCF complex assembly	15537541.21249194.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016567	protein ubiquitination	21873635.	IBA	Process
GO:0016567	protein ubiquitination	12609982.15537541.21249194.	IDA	Process
GO:0017025	TBP-class protein binding	-	IEA	Function
GO:0030154	cell differentiation	10581176.	IDA	Process
GO:0031461	cullin-RING ubiquitin ligase complex	15537541.21249194.22405651.	IDA	Component
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0043086	negative regulation of catalytic activity	12609982.	IDA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	-	IEA	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component