EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000111540 (Gene tree)
Gene ID: 5869
Gene Symbol: RAB5B
Alias: -
Full Name: RAB5B, member RAS oncogene family
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 22,771 bases
Position: chr12:55,973,913-55,996,683
Accession: 9784
RBP type: canonical RBP
Summary: RAB5B (RAB5B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000353444	MMR_HSR1	PF01926.23	0.00055	1	1
ENSP00000450168	MMR_HSR1	PF01926.23	0.00055	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000360299	RAB5B-201	5340	XM_005269051	ENSP00000353444	215 (aa)	XP_005269108	P61020
ENST00000551459	RAB5B-209	569	-	ENSP00000449554	100 (aa)	-	F8VVZ0
ENST00000549505	RAB5B-206	3148	-	ENSP00000450285	73 (aa)	-	F8VPW9
ENST00000549034	RAB5B-205	558	-	-	- (aa)	-	-
ENST00000628569	RAB5B-211	496	-	ENSP00000487368	73 (aa)	-	F8VPW9
ENST00000546810	RAB5B-203	589	-	-	- (aa)	-	-
ENST00000448789	RAB5B-202	1530	-	ENSP00000391319	174 (aa)	-	P61020
ENST00000549915	RAB5B-207	494	-	ENSP00000449762	79 (aa)	-	F8VWZ7
ENST00000550283	RAB5B-208	665	-	-	- (aa)	-	-
ENST00000553116	RAB5B-210	3322	-	ENSP00000450168	215 (aa)	-	P61020
ENST00000548068	RAB5B-204	596	-	ENSP00000447895	115 (aa)	-	F8VUA5

Gene Model

Click here to download ENSG00000111540's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04014	Ras signaling pathway	KEGG
hsa04144	Endocytosis	KEGG
hsa04145	Phagosome	KEGG
hsa04962	Vasopressin-regulated water reabsorption	KEGG
hsa05146	Amoebiasis	KEGG
hsa05152	Tuberculosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000111540	Polycystic Ovary Syndrome	9E-26	22885925

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000111540	rs705699	12	55991020	A	Sum eosinophil basophil counts	27863252	[0.018-0.032] unit increase	0.02494924	EFO_0005090\|EFO_0004842
ENSG00000111540	rs80223410	12	55974182	T	Educational attainment (years of education)	30038396	[0.0079-0.0157] unit decrease	0.0118	EFO_0004784
ENSG00000111540	rs773107	12	55975722	?	Autoimmune traits	30595370			EFO_0005140
ENSG00000111540	rs772920	12	55996580	?	Hypothyroidism	30595370			EFO_0004705
ENSG00000111540	rs772920	12	55996580	C	Lung function (FEV1)	30061609	[8.98-18.74] ml increase	13.86	EFO_0004314
ENSG00000111540	rs773110	12	55981353	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111540's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000111540	RAB5B	100	98.618	ENSAMEG00000003196	RAB5B	100	98.618	Ailuropoda_melanoleuca
ENSG00000111540	RAB5B	100	97.391	ENSACAG00000005380	RAB5B	100	96.279	Anolis_carolinensis
ENSG00000111540	RAB5B	100	100.000	ENSANAG00000033215	RAB5B	95	100.000	Aotus_nancymaae
ENSG00000111540	RAB5B	100	100.000	ENSBTAG00000014129	RAB5B	100	99.535	Bos_taurus
ENSG00000111540	RAB5B	100	100.000	ENSCJAG00000041780	RAB5B	95	100.000	Callithrix_jacchus
ENSG00000111540	RAB5B	100	100.000	ENSCAFG00000000087	RAB5B	100	100.000	Canis_familiaris
ENSG00000111540	RAB5B	100	100.000	ENSCAFG00020026094	RAB5B	100	100.000	Canis_lupus_dingo
ENSG00000111540	RAB5B	97	100.000	ENSCHIG00000010333	RAB5B	96	100.000	Capra_hircus
ENSG00000111540	RAB5B	100	100.000	ENSTSYG00000009576	RAB5B	100	99.535	Carlito_syrichta
ENSG00000111540	RAB5B	100	100.000	ENSCPOG00000034818	RAB5B	100	100.000	Cavia_porcellus
ENSG00000111540	RAB5B	100	100.000	ENSCCAG00000019480	RAB5B	100	99.070	Cebus_capucinus
ENSG00000111540	RAB5B	100	100.000	ENSCATG00000034978	RAB5B	98	99.441	Cercocebus_atys
ENSG00000111540	RAB5B	100	100.000	ENSCSAG00000005277	RAB5B	100	99.070	Chlorocebus_sabaeus
ENSG00000111540	RAB5B	100	97.391	ENSCPBG00000012712	RAB5B	100	96.279	Chrysemys_picta_bellii
ENSG00000111540	RAB5B	100	100.000	ENSCGRG00001000428	Rab5b	100	99.535	Cricetulus_griseus_chok1gshd
ENSG00000111540	RAB5B	100	100.000	ENSCGRG00000009508	-	100	99.535	Cricetulus_griseus_crigri
ENSG00000111540	RAB5B	100	100.000	ENSDORG00000025063	Rab5b	100	100.000	Dipodomys_ordii
ENSG00000111540	RAB5B	100	100.000	ENSECAG00000023306	RAB5B	100	99.535	Equus_caballus
ENSG00000111540	RAB5B	100	100.000	ENSEEUG00000006745	RAB5B	100	99.070	Erinaceus_europaeus
ENSG00000111540	RAB5B	100	100.000	ENSFDAG00000008326	RAB5B	100	100.000	Fukomys_damarensis
ENSG00000111540	RAB5B	100	100.000	ENSHGLG00000005995	RAB5B	100	99.070	Heterocephalus_glaber_female
ENSG00000111540	RAB5B	100	100.000	ENSHGLG00100012955	RAB5B	100	99.070	Heterocephalus_glaber_male
ENSG00000111540	RAB5B	100	99.130	ENSSTOG00000010536	RAB5B	100	98.605	Ictidomys_tridecemlineatus
ENSG00000111540	RAB5B	100	100.000	ENSJJAG00000019506	Rab5b	100	99.535	Jaculus_jaculus
ENSG00000111540	RAB5B	100	99.078	ENSLAFG00000018009	RAB5B	95	99.078	Loxodonta_africana
ENSG00000111540	RAB5B	100	100.000	ENSMFAG00000029992	RAB5B	100	99.070	Macaca_fascicularis
ENSG00000111540	RAB5B	100	100.000	ENSMMUG00000031853	RAB5B	100	99.070	Macaca_mulatta
ENSG00000111540	RAB5B	100	100.000	ENSMNEG00000005338	RAB5B	100	99.070	Macaca_nemestrina
ENSG00000111540	RAB5B	100	100.000	ENSMLEG00000034462	RAB5B	100	99.070	Mandrillus_leucophaeus
ENSG00000111540	RAB5B	100	100.000	ENSMAUG00000011613	Rab5b	100	100.000	Mesocricetus_auratus
ENSG00000111540	RAB5B	100	100.000	ENSMICG00000011086	RAB5B	100	99.535	Microcebus_murinus
ENSG00000111540	RAB5B	100	100.000	ENSMUSG00000000711	Rab5b	100	100.000	Mus_musculus
ENSG00000111540	RAB5B	100	100.000	MGP_PahariEiJ_G0031135	Rab5b	100	100.000	Mus_pahari
ENSG00000111540	RAB5B	100	99.535	MGP_SPRETEiJ_G0016774	Rab5b	100	99.535	Mus_spretus
ENSG00000111540	RAB5B	100	98.291	ENSMPUG00000000946	RAB5B	89	98.611	Mustela_putorius_furo
ENSG00000111540	RAB5B	100	100.000	ENSNLEG00000017570	-	100	100.000	Nomascus_leucogenys
ENSG00000111540	RAB5B	100	100.000	ENSOPRG00000007883	RAB5B	100	100.000	Ochotona_princeps
ENSG00000111540	RAB5B	100	99.535	ENSODEG00000003860	RAB5B	100	99.535	Octodon_degus
ENSG00000111540	RAB5B	100	100.000	ENSOCUG00000013895	RAB5B	95	100.000	Oryctolagus_cuniculus
ENSG00000111540	RAB5B	100	100.000	ENSOARG00000010651	RAB5B	95	100.000	Ovis_aries
ENSG00000111540	RAB5B	100	100.000	ENSPPAG00000035431	RAB5B	100	100.000	Pan_paniscus
ENSG00000111540	RAB5B	100	100.000	ENSPTRG00000005071	RAB5B	97	99.522	Pan_troglodytes
ENSG00000111540	RAB5B	99	98.131	ENSPANG00000021075	RAB5B	97	98.131	Papio_anubis
ENSG00000111540	RAB5B	100	100.000	ENSPCOG00000016461	RAB5B	100	100.000	Propithecus_coquereli
ENSG00000111540	RAB5B	100	100.000	ENSRNOG00000006130	Rab5b	100	99.070	Rattus_norvegicus
ENSG00000111540	RAB5B	100	100.000	ENSRBIG00000013165	RAB5B	100	99.070	Rhinopithecus_bieti
ENSG00000111540	RAB5B	100	100.000	ENSRROG00000037973	RAB5B	100	99.070	Rhinopithecus_roxellana
ENSG00000111540	RAB5B	100	91.304	ENSSBOG00000035419	RAB5B	100	83.256	Saimiri_boliviensis_boliviensis
ENSG00000111540	RAB5B	100	99.130	ENSSHAG00000007727	RAB5B	100	98.605	Sarcophilus_harrisii
ENSG00000111540	RAB5B	100	100.000	ENSSARG00000006237	RAB5B	100	100.000	Sorex_araneus
ENSG00000111540	RAB5B	100	97.391	ENSSPUG00000014873	RAB5B	100	96.279	Sphenodon_punctatus
ENSG00000111540	RAB5B	100	100.000	ENSTTRG00000015001	RAB5B	100	100.000	Tursiops_truncatus
ENSG00000111540	RAB5B	100	100.000	ENSUAMG00000014651	RAB5B	100	99.535	Ursus_americanus
ENSG00000111540	RAB5B	100	100.000	ENSUMAG00000016263	RAB5B	100	99.535	Ursus_maritimus
ENSG00000111540	RAB5B	100	100.000	ENSVVUG00000022054	RAB5B	81	100.000	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	17562788.	IDA	Function
GO:0005515	protein binding	10491193.17562788.18445495.25605758.27314038.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005768	endosome	21873635.	IBA	Component
GO:0005768	endosome	10491193.	IDA	Component
GO:0005769	early endosome	21873635.	IBA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006897	endocytosis	21873635.	IBA	Process
GO:0007032	endosome organization	-	IEA	Process
GO:0016020	membrane	1541686.	TAS	Component
GO:0019003	GDP binding	20937701.	IDA	Function
GO:0019882	antigen processing and presentation	19717423.	IMP	Process
GO:0030100	regulation of endocytosis	21873635.	IBA	Process
GO:0030139	endocytic vesicle	21873635.	IBA	Component
GO:0030667	secretory granule membrane	-	TAS	Component
GO:0030742	GTP-dependent protein binding	10491193.	IDA	Function
GO:0031901	early endosome membrane	-	TAS	Component
GO:0032482	Rab protein signal transduction	21873635.	IBA	Process
GO:0042470	melanosome	-	IEA	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0048227	plasma membrane to endosome transport	17562788.	IMP	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0070062	extracellular exosome	15326289.	IDA	Component
GO:0098993	anchored component of synaptic vesicle membrane	-	IEA	Component