EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000111602 (Gene tree)
Gene ID: 8914
Gene Symbol: TIMELESS
Alias: hTIM|TIM|TIM1
Full Name: timeless circadian regulator
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 33,044 bases
Position: chr12:56,416,373-56,449,416
Accession: 11813
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000553314	TIMELESS-202	511	-	-	- (aa)	-	-
ENST00000555808	TIMELESS-204	581	-	-	- (aa)	-	-
ENST00000557589	TIMELESS-205	2784	-	-	- (aa)	-	-
ENST00000553532	TIMELESS-203	5121	-	ENSP00000450607	1208 (aa)	-	Q9UNS1
ENST00000229201	TIMELESS-201	4376	-	ENSP00000229201	1207 (aa)	-	Q9UNS1

Gene Model

Click here to download ENSG00000111602's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000111602	Platelet Function Tests	1.4481750E-012	-
ENSG00000111602	Axial Length, Eye	4E-7	24144296
ENSG00000111602	Cytokines	6E-10	22610502
ENSG00000111602	Vaccine Potency	6E-10	22610502

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000111602	rs2291738	12	56421497	T	Axial length	24144296	[0.032-0.072] unit increase	0.0518	EFO_0005318
ENSG00000111602	rs11171846	12	56434272	A	Immune reponse to smallpox (secreted IFN-alpha)	22610502			EFO_0004645\|EFO_0004873

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111602's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000076	DNA replication checkpoint	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0000790	nuclear chromatin	17102137.	IDA	Component
GO:0002009	morphogenesis of an epithelium	-	ISS	Process
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0005515	protein binding	15798197.17102137.20124417.26344098.30356214.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9856465.	IC	Component
GO:0005634	nucleus	17102137.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006281	DNA repair	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	23797032.	IMP	Process
GO:0006974	cellular response to DNA damage stimulus	-	ISS	Process
GO:0007623	circadian rhythm	-	ISS	Process
GO:0009582	detection of abiotic stimulus	9856466.	TAS	Process
GO:0030324	lung development	-	IEA	Process
GO:0031298	replication fork protection complex	21873635.	IBA	Component
GO:0035861	site of double-strand break	26344098.30356214.	IDA	Component
GO:0042127	regulation of cell proliferation	17102137.	IMP	Process
GO:0042752	regulation of circadian rhythm	23418588.	IMP	Process
GO:0042803	protein homodimerization activity	-	IEA	Function
GO:0043111	replication fork arrest	21873635.	IBA	Process
GO:0044770	cell cycle phase transition	17102137.	IMP	Process
GO:0045892	negative regulation of transcription, DNA-templated	9856465.	IDA	Process
GO:0046982	protein heterodimerization activity	-	IEA	Function
GO:0048478	replication fork protection	21873635.	IBA	Process
GO:0048754	branching morphogenesis of an epithelial tube	-	IEA	Process
GO:0051301	cell division	-	IEA	Process
GO:0072711	cellular response to hydroxyurea	23797032.	IMP	Process
GO:0072719	cellular response to cisplatin	23797032.	IMP	Process
GO:1904976	cellular response to bleomycin	23797032.	IMP	Process
GO:1905168	positive regulation of double-strand break repair via homologous recombination	26344098.30356214.	IDA	Process
GO:2000781	positive regulation of double-strand break repair	23797032.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24161199	Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses.	BMC Cancer	2013 Oct 25	Mao Y	doi: 10.1186/1471-2407-13-498.
27909716	Aberrant TIMELESS expression is associated with poor clinical survival and lymph node metastasis in early-stage cervical carcinoma.	Int J Oncol	2017 Jan	Zhang W	doi: 10.3892/ijo.2016.3784
28464854	TIMELESS contributes to the progression of breast cancer through activation of MYC.	Breast Cancer Res	2017 May 2	Chi L	doi: 10.1186/s13058-017-0838-1.
22006848	Genetic and epigenetic associations of circadian gene TIMELESS and breast cancer risk.	Mol Carcinog	2012 Dec	Fu A	doi: 10.1002/mc.20862
23173913	TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival.	Cancer Sci	2013 Feb	Yoshida K	doi: 10.1111/cas.12068
30796221	Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner.	Nat Commun	2019 Feb 22	Bianco JN	doi: 10.1038/s41467-019-08886-8.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	56432366	Splice_Region	novel		0.67
BLCA	chr12	56423860	Missense_Mutation	rs765945106	Q635E	0.38
BLCA	chr12	56433034	Nonsense_Mutation	novel	Q175*	0.47
BLCA	chr12	56425126	Silent	rs761880221	K535K	0.65
BLCA	chr12	56418224	Missense_Mutation	novel	D1122N	0.23
BLCA	chr12	56428574	Silent	novel	V461V	0.19
BLCA	chr12	56428574	Silent	NA	V461V	0.23
BLCA	chr12	56428270	Missense_Mutation	NA	R515Q	0.22
BLCA	chr12	56428905	Missense_Mutation	NA	E428K	0.27
BLCA	chr12	56421969	Nonsense_Mutation	rs778017589	R858*	0.45
BLCA	chr12	56423813	Silent	novel	L650L	0.17
BLCA	chr12	56428972	Silent	novel	V405V	0.33
BLCA	chr12	56433596	Missense_Mutation	novel	E103A	0.61
BLCA	chr12	56428909	Silent	novel	R426R	0.49
BLCA	chr12	56422936	Silent	NA	V783V	0.05
BLCA	chr12	56433606	Silent	NA	L100L	0.13
BLCA	chr12	56422911	Missense_Mutation	NA	L792V	0.3
BLCA	chr12	56432384	Silent	novel	L224L	0.36
BLCA	chr12	56431598	Missense_Mutation	rs573398564	E232K	0.06
BLCA	chr12	56422157	Missense_Mutation	rs748267298	E825K	0.24
BLCA	chr12	56425038	Missense_Mutation	novel	E565Q	0.06
BRCA	chr12	56431571	Missense_Mutation	rs199809988	R241C	0.43
BRCA	chr12	56422881	Missense_Mutation	NA	E802Q	0.25
BRCA	chr12	56425142	Frame_Shift_Del	novel	*K530Efs18**	0.1
BRCA	chr12	56422011	Missense_Mutation	NA	D844Y	0.14
BRCA	chr12	56423864	Silent	NA	G633G	0.32
BRCA	chr12	56424902	Silent	rs748683827	L576L	0.38
BRCA	chr12	56423456	Missense_Mutation	rs780706303	V704I	0.17
BRCA	chr12	56433585	Missense_Mutation	rs751726906	R107W	0.12
BRCA	chr12	56423649	In_Frame_Ins	rs201615298	E678dup	0.19
BRCA	chr12	56421124	Missense_Mutation	rs374201861	A960V	0.12
BRCA	chr12	56429018	Missense_Mutation	rs780869332	R390Q	0.22
CESC	chr12	56433088	Missense_Mutation	NA	E157Q	0.15
CESC	chr12	56417659	3'UTR	novel		0.28
CESC	chr12	56421451	Nonsense_Mutation	NA	S923*	0.16
CESC	chr12	56423358	Silent	NA	L736L	0.34
CESC	chr12	56417591	3'UTR	novel		0.43
CESC	chr12	56418137	Missense_Mutation	NA	E1151K	0.29
CESC	chr12	56434219	5'UTR	novel		0.38
CESC	chr12	56423664	Silent	NA	E670E	0.38
CESC	chr12	56422872	Missense_Mutation	NA	E805K	0.35
COAD	chr12	56417536	3'UTR	novel		0.43
COAD	chr12	56418226	Missense_Mutation	novel	S1121C	0.25
COAD	chr12	56422976	Missense_Mutation	NA	A770V	0.37
COAD	chr12	56429062	Silent	NA	E375E	0.26
COAD	chr12	56433774	Splice_Region	novel	R84R	0.35
COAD	chr12	56434158	Missense_Mutation	novel	M5V	0.28
COAD	chr12	56418009	Splice_Site	NA	X1152_splice	0.1
COAD	chr12	56420589	Missense_Mutation	rs145031140	R1070W	0.4
COAD	chr12	56432482	Missense_Mutation	NA	A192S	0.26
COAD	chr12	56423649	Silent	NA	E675E	0.54
COAD	chr12	56432509	Missense_Mutation	rs781372283	A183T	0.22
COAD	chr12	56423420	Nonsense_Mutation	novel	Q716*	0.55
COAD	chr12	56420817	Silent	novel	E1035E	0.09
COAD	chr12	56428355	Nonsense_Mutation	rs747106203	R487*	0.15
COAD	chr12	56424887	Silent	NA	V581V	0.36
COAD	chr12	56421924	Missense_Mutation	novel	A873T	0.31
COAD	chr12	56420673	Missense_Mutation	rs745492833	V1042I	0.4
COAD	chr12	56423375	Missense_Mutation	rs770377436	R731W	0.27
COAD	chr12	56420604	Missense_Mutation	rs371723339	R1065C	0.42
ESCA	chr12	56432476	Missense_Mutation	novel	H194N	0.25
ESCA	chr12	56422185	Silent	rs760450039	S815S	0.56
ESCA	chr12	56420656	Silent	novel	L1047L	0.2
ESCA	chr12	56434153	Missense_Mutation	novel	M6I	0.4
GBM	chr12	56421965	Missense_Mutation	novel	T859K	0.06
GBM	chr12	56417694	3'UTR	novel		0.04
GBM	chr12	56422855	Silent	novel	L810L	0.07
GBM	chr12	56428572	Missense_Mutation	NA	R462K	0.45
GBM	chr12	56428271	Nonsense_Mutation	rs143827740	R515*	0.2
GBM	chr12	56420975	Missense_Mutation	novel	L1010M	0.2
GBM	chr12	56417617	3'UTR	novel		0.28
GBM	chr12	56432511	Missense_Mutation	rs372934828	D182G	0.27
HNSC	chr12	56434094	Missense_Mutation	novel	H26L	0.26
HNSC	chr12	56428603	Missense_Mutation	novel	E452K	0.12
HNSC	chr12	56421092	Missense_Mutation	novel	L971V	0.09
HNSC	chr12	56422872	Missense_Mutation	NA	E805K	0.41
HNSC	chr12	56433649	Silent	novel	L85L	0.3
HNSC	chr12	56424765	Missense_Mutation	novel	A622V	0.06
HNSC	chr12	56421384	Silent	rs113553695	K945K	0.52
HNSC	chr12	56418224	Missense_Mutation	novel	D1122H	0.03
HNSC	chr12	56421047	Missense_Mutation	NA	E986K	0.06
HNSC	chr12	56421404	Nonsense_Mutation	novel	E939*	0.05
KIRC	chr12	56422989	Missense_Mutation	NA	L766V	0.26
KIRC	chr12	56421083	Frame_Shift_Ins	novel	*E974Kfs31**	0.04
KIRP	chr12	56428886	Missense_Mutation	rs773667829	R434H	0.27
KIRP	chr12	56433918	Frame_Shift_Ins	novel	*K36Rfs11**	0.25
KIRP	chr12	56420638	Missense_Mutation	NA	E1053D	0.49
KIRP	chr12	56423664	Silent	NA	E670E	0.07
LAML	chr12	56420976	Silent	novel	S1009S	0.04
LAML	chr12	56431501	Missense_Mutation	novel	K264R	0.08
LGG	chr12	56417775	Missense_Mutation	novel	G1190R	0.44
LGG	chr12	56421408	Silent	rs765615967	V937V	0.05
LGG	chr12	56421968	Missense_Mutation	rs370232505	R858Q	0.45
LGG	chr12	56433905	Missense_Mutation	NA	R40P	0.1
LIHC	chr12	56420607	Silent	rs267603583	L1064L	0.41
LIHC	chr12	56434105	Silent	NA	G22G	0.38
LIHC	chr12	56418183	Missense_Mutation	novel	R1135S	0.46
LIHC	chr12	56428926	Missense_Mutation	NA	M421L	0.4
LIHC	chr12	56420592	Missense_Mutation	NA	V1069L	0.13
LIHC	chr12	56423664	Silent	NA	E670E	0.06
LIHC	chr12	56418229	Missense_Mutation	novel	G1120D	0.34
LUAD	chr12	56423456	Missense_Mutation	novel	V704F	0.15
LUAD	chr12	56420979	Missense_Mutation	NA	Q1008H	0.26
LUAD	chr12	56430214	Missense_Mutation	rs776504340	R326Q	0.16
LUAD	chr12	56421929	Missense_Mutation	NA	G871V	0.31
LUAD	chr12	56430892	Missense_Mutation	NA	G300C	0.17
LUAD	chr12	56428963	Silent	NA	F408F	0.32
LUAD	chr12	56421766	Nonsense_Mutation	NA	E896*	0.18
LUAD	chr12	56418134	Nonsense_Mutation	NA	E1152*	0.41
LUAD	chr12	56432486	Silent	NA	L190L	0.12
LUAD	chr12	56421416	Missense_Mutation	NA	G935W	0.2
LUAD	chr12	56418284	Nonsense_Mutation	novel	E1102*	0.25
LUSC	chr12	56430271	Missense_Mutation	novel	Y307C	0.22
LUSC	chr12	56430158	Missense_Mutation	novel	F345L	0.39
LUSC	chr12	56421484	Missense_Mutation	NA	G912V	0.11
LUSC	chr12	56423896	Splice_Site	novel	X623_splice	0.31
LUSC	chr12	56425021	Silent	novel	C570C	0.18
LUSC	chr12	56425133	Missense_Mutation	novel	R533K	0.24
LUSC	chr12	56420962	Splice_Site	novel	X1014_splice	0.18
LUSC	chr12	56429044	Silent	novel	A381A	0.16
LUSC	chr12	56417747	Missense_Mutation	novel	R1199L	0.17
LUSC	chr12	56428304	Nonsense_Mutation	novel	E504*	0.28
LUSC	chr12	56433852	Missense_Mutation	rs372802757	A58S	0.27
LUSC	chr12	56417757	Missense_Mutation	NA	K1196Q	0.57
LUSC	chr12	56432471	Silent	novel	L195L	0.28
LUSC	chr12	56423453	Nonsense_Mutation	rs777449396	R705*	0.34
LUSC	chr12	56425060	Silent	rs371945970	E557E	0.4
LUSC	chr12	56424907	Missense_Mutation	novel	E575K	0.16
MESO	chr12	56421020	Missense_Mutation	rs749613740	V995L	0.25
OV	chr12	56417699	3'UTR	novel		0.04
OV	chr12	56433837	Missense_Mutation	NA	S63C	0.29
OV	chr12	56430900	Missense_Mutation	NA	F297C	0.38
OV	chr12	56421372	Missense_Mutation	novel	K949N	0.13
OV	chr12	56433776	Missense_Mutation	novel	I83T	0.12
OV	chr12	56423591	Silent	NA	L695L	0.14
OV	chr12	56422855	Silent	novel	L810L	0.07
OV	chr12	56423298	Silent	NA	S756S	0.13
OV	chr12	56430961	Silent	NA	R277R	0.21
OV	chr12	56433549	Missense_Mutation	NA	A119P	0.43
OV	chr12	56433399	Missense_Mutation	novel	L137F	0.05
PAAD	chr12	56431585	Missense_Mutation	novel	G236E	0.05
PAAD	chr12	56418199	Missense_Mutation	rs145585280	R1130Q	0.18
PAAD	chr12	56433416	Missense_Mutation	novel	V132F	0.19
PCPG	chr12	56428997	Missense_Mutation	rs762811260	G397V	0.53
PRAD	chr12	56418214	Missense_Mutation	NA	H1125R	0.14
PRAD	chr12	56423686	Missense_Mutation	rs776587905	R663H	0.23
PRAD	chr12	56421963	Missense_Mutation	rs758367557	R860C	0.06
READ	chr12	56423703	Silent	NA	Q657Q	0.15
READ	chr12	56420839	Missense_Mutation	rs763159822	R1028Q	0.37
SARC	chr12	56433542	Missense_Mutation	novel	K121R	0.81
SARC	chr12	56420993	Missense_Mutation	novel	E1004K	0.33
SKCM	chr12	56430126	Silent	rs539747191	N355N	0.27
SKCM	chr12	56428316	Missense_Mutation	rs762709152	R500C	0.41
SKCM	chr12	56421361	Missense_Mutation	NA	S953F	0.16
SKCM	chr12	56430168	Silent	NA	F341F	0.38
SKCM	chr12	56428971	Missense_Mutation	rs765264874	R406C	0.32
SKCM	chr12	56418341	Missense_Mutation	novel	P1083S	0.38
SKCM	chr12	56420998	Missense_Mutation	novel	S1002L	0.36
SKCM	chr12	56428898	Missense_Mutation	NA	A430V	0.38
SKCM	chr12	56433040	Missense_Mutation	NA	L173F	0.27
SKCM	chr12	56433844	Silent	NA	I60I	0.17
SKCM	chr12	56423803	Missense_Mutation	NA	L654F	0.37
SKCM	chr12	56421769	Silent	NA	L895L	0.09
SKCM	chr12	56422123	Missense_Mutation	NA	A836V	0.21
SKCM	chr12	56420585	Missense_Mutation	NA	P1071L	0.25
SKCM	chr12	56429009	Missense_Mutation	NA	S393F	0.42
SKCM	chr12	56429097	Missense_Mutation	NA	H364Y	0.26
SKCM	chr12	56424821	Silent	novel	I603I	0.26
SKCM	chr12	56428319	Missense_Mutation	NA	L499F	0.17
SKCM	chr12	56428320	Silent	NA	F498F	0.17
SKCM	chr12	56417702	3'UTR	novel		0.17
SKCM	chr12	56418181	Missense_Mutation	novel	A1136V	0.25
SKCM	chr12	56430960	Missense_Mutation	NA	R277Q	0.41
SKCM	chr12	56432465	Silent	novel	G197G	0.38
SKCM	chr12	56420840	Nonsense_Mutation	rs372449809	R1028*	0.26
SKCM	chr12	56420841	Silent	novel	I1027I	0.26
SKCM	chr12	56420675	Missense_Mutation	novel	A1041V	0.23
STAD	chr12	56424843	Missense_Mutation	rs370688010	R596Q	0.25
STAD	chr12	56421778	Frame_Shift_Del	novel	*D892Ifs24**	0.21
STAD	chr12	56423664	Silent	NA	E670E	0.24
STAD	chr12	56422862	Missense_Mutation	NA	G808V	0.38
STAD	chr12	56428328	Missense_Mutation	rs550048328	R496C	0.27
STAD	chr12	56417627	3'UTR	novel		0.23
STAD	chr12	56428971	Missense_Mutation	rs765264874	R406C	0.44
STAD	chr12	56430124	Missense_Mutation	rs147921196	R356Q	0.34
STAD	chr12	56417923	Silent	NA	D1180D	0.11
STAD	chr12	56428548	Splice_Site	NA	X470_splice	0.3
STAD	chr12	56421015	Missense_Mutation	NA	Q996H	0.22
STAD	chr12	56418001	Silent	rs773988081	D1154D	0.37
STAD	chr12	56423667	Silent	rs576139603	E669E	0.25
STAD	chr12	56432376	Missense_Mutation	rs374029679	R227H	0.15
STAD	chr12	56423655	Silent	rs749887137	E673E	0.15
STAD	chr12	56433819	Missense_Mutation	NA	L69I	0.07
STAD	chr12	56417905	Splice_Site	NA	X1186_splice	0.18
STAD	chr12	56423585	Missense_Mutation	rs759412572	R697C	0.12
STAD	chr12	56424897	Missense_Mutation	NA	M578T	0.32
STAD	chr12	56430265	Missense_Mutation	NA	S309L	0.23
STAD	chr12	56418000	Missense_Mutation	rs150055938	A1155T	0.24
THCA	chr12	56421124	Missense_Mutation	rs374201861	A960V	0.28
THCA	chr12	56423593	Nonsense_Mutation	novel	Y694*	0.03
THYM	chr12	56423620	Nonsense_Mutation	novel	S685*	0.09
UCEC	chr12	56420625	Missense_Mutation	rs141490648	E1058K	0.34
UCEC	chr12	56430960	Missense_Mutation	NA	R277Q	0.39
UCEC	chr12	56417747	Missense_Mutation	rs757777309	R1199Q	0.09
UCEC	chr12	56434124	Missense_Mutation	novel	A16V	0.22
UCEC	chr12	56430967	Missense_Mutation	NA	H275Y	0.08
UCEC	chr12	56423669	Nonsense_Mutation	NA	E669*	0.37
UCEC	chr12	56418151	Missense_Mutation	novel	G1146D	0.41
UCEC	chr12	56429057	Missense_Mutation	rs759044561	Y377C	0.3
UCEC	chr12	56430246	Silent	rs755248274	P315P	0.39
UCEC	chr12	56422957	Missense_Mutation	novel	K776N	0.53
UCEC	chr12	56430194	Missense_Mutation	rs746965893	R333C	0.53
UCEC	chr12	56432464	Silent	NA	L198L	0.12
UCEC	chr12	56417752	Silent	NA	K1197K	0.24
UCEC	chr12	56421963	Missense_Mutation	rs758367557	R860C	0.14
UCEC	chr12	56422169	Missense_Mutation	rs768756941	T821A	0.24
UCEC	chr12	56423865	Missense_Mutation	NA	G633A	0.16
UCEC	chr12	56423456	Missense_Mutation	rs780706303	V704I	0.2
UCEC	chr12	56420604	Missense_Mutation	rs371723339	R1065C	0.39
UCEC	chr12	56420645	Missense_Mutation	novel	N1051S	0.23
UCEC	chr12	56421442	Missense_Mutation	rs537965247	R926Q	0.41
UCEC	chr12	56417960	Missense_Mutation	rs780603685	R1168Q	0.36
UCEC	chr12	56428637	Silent	novel	L440L	0.27
UCEC	chr12	56418190	Missense_Mutation	novel	A1133V	0.41
UCEC	chr12	56421963	Missense_Mutation	rs758367557	R860C	0.23
UCEC	chr12	56417606	3'UTR	novel		0.27
UCEC	chr12	56432396	Missense_Mutation	novel	E220D	0.5
UCEC	chr12	56424897	Missense_Mutation	NA	M578T	0.44
UCEC	chr12	56422139	Missense_Mutation	rs757661997	R831W	0.61
UCEC	chr12	56430193	Missense_Mutation	rs144344864	R333H	0.47
UCEC	chr12	56425114	Silent	rs113128353	V539V	0.42
UCEC	chr12	56428971	Missense_Mutation	rs765264874	R406C	0.4
UCEC	chr12	56433905	Missense_Mutation	rs527779087	R40H	0.41
UCEC	chr12	56420839	Missense_Mutation	rs763159822	R1028Q	0.45
UCEC	chr12	56433652	Missense_Mutation	novel	R84S	0.39
UCEC	chr12	56417960	Missense_Mutation	rs780603685	R1168Q	0.24
UCEC	chr12	56420983	Missense_Mutation	novel	G1007A	0.14
UCEC	chr12	56428404	Splice_Region	novel	N470N	0.4
UCEC	chr12	56421784	Missense_Mutation	novel	T890A	0.45
UCEC	chr12	56434197	5'UTR	rs536260378		0.28
UCEC	chr12	56420604	Missense_Mutation	rs371723339	R1065C	0.41
UCEC	chr12	56431522	Missense_Mutation	rs770327117	R257H	0.21
UCEC	chr12	56422872	Missense_Mutation	NA	E805K	0.33
UCEC	chr12	56430135	Silent	novel	N352N	0.23
UCEC	chr12	56430252	Silent	NA	K313K	0.34
UCEC	chr12	56433916	Missense_Mutation	novel	K36N	0.08
UCEC	chr12	56422158	Silent	rs756306792	P824P	0.46
UCEC	chr12	56431486	Missense_Mutation	novel	L269P	0.21
UCEC	chr12	56433841	Silent	novel	L61L	0.32
UCEC	chr12	56423813	Silent	NA	L650L	0.4
UCEC	chr12	56424763	Missense_Mutation	NA	R623W	0.47
UCEC	chr12	56418347	Nonsense_Mutation	novel	R1081*	0.13
UCEC	chr12	56430194	Missense_Mutation	rs746965893	R333C	0.18
UCEC	chr12	56433649	Silent	novel	L85L	0.17
UCEC	chr12	56433870	Silent	novel	R52R	0.37
UCEC	chr12	56432405	Silent	rs762836095	H217H	0.19
UCEC	chr12	56417741	Missense_Mutation	novel	Q1201P	0.36
UCS	chr12	56423347	Missense_Mutation	novel	A740G	0.25
UCS	chr12	56431562	Missense_Mutation	novel	Q244E	0.12

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0222	0.20414
DLBC	AMP	0.2083	0.085003
PCPG	AMP	0.0864	0.028953
READ	DEL	0.0727	0.064633

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0043	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.0065	Kaplan-Meier Survival Analysis
SARC	0.0032	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.00085	Kaplan-Meier Survival Analysis
PRAD	0.037	Kaplan-Meier Survival Analysis
KIRP	0.012	Kaplan-Meier Survival Analysis
PCPG	0.018	Kaplan-Meier Survival Analysis
CESC	0.0067	Kaplan-Meier Survival Analysis
KICH	0.00081	Kaplan-Meier Survival Analysis
UCEC	0.019	Kaplan-Meier Survival Analysis
LIHC	0.00097	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.033	Kaplan-Meier Survival Analysis
LUAD	0.0016	Kaplan-Meier Survival Analysis
UVM	0.0011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742