EuRBPDB

Description

Ensembl ID: ENSG00000111667 (Gene tree)
Gene ID: 8078
Gene Symbol: USP5
Alias: IsoT
Full Name: ubiquitin specific peptidase 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 14,515 bases
Position: chr12:6,852,118-6,866,632
Accession: 12628
RBP type: non-canonical RBP
Summary: Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000229268	USP5-201	3181	-	ENSP00000229268	858 (aa)	-	P45974
ENST00000542371	USP5-207	768	-	-	- (aa)	-	-
ENST00000542087	USP5-206	438	-	ENSP00000444668	137 (aa)	-	F5H571
ENST00000535080	USP5-203	534	-	-	- (aa)	-	-
ENST00000537267	USP5-204	2522	-	-	- (aa)	-	-
ENST00000541969	USP5-205	766	-	-	- (aa)	-	-
ENST00000389231	USP5-202	3083	-	ENSP00000373883	835 (aa)	-	P45974

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000111667	USP5	100	98.368	ENSMUSG00000038429	Usp5	100	98.368	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004197	cysteine-type endopeptidase activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	24424410.	IDA	Function
GO:0005515	protein binding	16189514.16712842.25416956.	IPI	Function
GO:0005764	lysosome	9827704.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0016579	protein deubiquitination	21873635.	IBA	Process
GO:0016579	protein deubiquitination	24424410.	IDA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	19098288.	IMP	Process
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	TAS	Function
GO:0043130	ubiquitin binding	24424410.	IDA	Function
GO:0071108	protein K48-linked deubiquitination	19098288.	IMP	Process