EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000111669 (Gene tree)
Gene ID: 7167
Gene Symbol: TPI1
Alias: N
Full Name: triosephosphate isomerase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 3,830 bases
Position: chr12:6,867,119-6,870,948
Accession: 12009
RBP type: non-canonical RBP
Summary: This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29463416	Irradiation of rainbow trout at early life stages results in a proteomic legacy in adult gills. Part A; proteomic responses in the irradiated fish and in non-irradiated bystander fish.	Environ Res	2018 May	Smith RW	doi: 10.1016/j.envres.2017.12.023

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000396705	TPI1-202	1231	-	ENSP00000379933	249 (aa)	-	P60174
ENST00000495834	TPI1-208	820	-	ENSP00000475829	98 (aa)	-	U3KQF3
ENST00000229270	TPI1-201	1763	-	ENSP00000229270	286 (aa)	-	P60174
ENST00000613953	TPI1-210	1460	-	ENSP00000484435	286 (aa)	-	P60174
ENST00000488464	TPI1-206	791	-	ENSP00000475620	167 (aa)	-	P60174
ENST00000462761	TPI1-203	374	-	ENSP00000475184	38 (aa)	-	U3KPS5
ENST00000493987	TPI1-207	839	-	ENSP00000475364	113 (aa)	-	U3KPZ0
ENST00000482209	TPI1-205	328	-	-	- (aa)	-	-
ENST00000535434	TPI1-209	1587	-	ENSP00000443599	167 (aa)	-	P60174
ENST00000474253	TPI1-204	427	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000111669's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00051	Fructose and mannose metabolism	KEGG
hsa00562	Inositol phosphate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111669's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000111669	TPI1	95	75.000	WBGene00006601	tpi-1	99	62.195	Caenorhabditis_elegans
ENSG00000111669	TPI1	100	71.053	FBgn0086355	Tpi	99	64.634	Drosophila_melanogaster
ENSG00000111669	TPI1	100	98.230	ENSMUSG00000023456	Tpi1	100	97.605	Mus_musculus
ENSG00000111669	TPI1	99	58.763	YDR050C		99	53.036	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004807	triose-phosphate isomerase activity	21873635.	IBA	Function
GO:0004807	triose-phosphate isomerase activity	18562316.	IDA	Function
GO:0004807	triose-phosphate isomerase activity	2876430.	NAS	Function
GO:0004807	triose-phosphate isomerase activity	2579079.	TAS	Function
GO:0005515	protein binding	20849852.21044950.23355646.	IPI	Function
GO:0005615	extracellular space	16502470.22664934.23580065.	HDA	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006094	gluconeogenesis	21873635.	IBA	Process
GO:0006094	gluconeogenesis	-	IEA	Process
GO:0006094	gluconeogenesis	-	TAS	Process
GO:0006096	glycolytic process	21873635.	IBA	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0008929	methylglyoxal synthase activity	-	ISS	Function
GO:0019242	methylglyoxal biosynthetic process	-	ISS	Process
GO:0019563	glycerol catabolic process	21873635.	IBA	Process
GO:0031625	ubiquitin protein ligase binding	19725078.	IPI	Function
GO:0042803	protein homodimerization activity	18562316.	IDA	Function
GO:0046166	glyceraldehyde-3-phosphate biosynthetic process	21873635.	IBA	Process
GO:0046166	glyceraldehyde-3-phosphate biosynthetic process	18562316.	IDA	Process
GO:0061621	canonical glycolysis	-	TAS	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
12051920	Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.	J Mol Biol	2002 May 31	Sundberg EJ	-
27908734	Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells.	Biochem Biophys Res Commun	2017 Jan 22	Jiang H	doi: 10.1016/j.bbrc.2016.11.156
20233700	[Identification and expression of two new secretory proteins associated with prostate cancer].	Yi Chuan	2010 Mar	Qian XL	-
28489783	Clinical significance and prognostic value of Triosephosphate isomerase expression in gastric cancer.	Medicine (Baltimore)	2017 May	Chen T	doi: 10.1097/MD.0000000000006865.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	6870413	3'UTR	novel		0.3
BLCA	chr12	6870503	3'UTR	novel		0.12
BLCA	chr12	6870268	Missense_Mutation	novel	S249F	0.17
BLCA	chr12	6867554	Silent	rs375712848	L33L	0.29
BRCA	chr12	6867546	Nonsense_Mutation	rs782622700	Q31*	0.36
BRCA	chr12	6870114	Silent	NA	Q240Q	0.31
BRCA	chr12	6870378	Missense_Mutation	NA	Q286K	0.56
BRCA	chr12	6869142	Missense_Mutation	novel	G132R	0.08
BRCA	chr12	6868861	Splice_Region	novel		0.22
CESC	chr12	6869301	Missense_Mutation	novel	G160E	0.52
CESC	chr12	6870536	3'UTR	novel		0.38
CESC	chr12	6867554	Silent	rs375712848	L33L	0.49
COAD	chr12	6867598	Missense_Mutation	NA	G48E	0.09
COAD	chr12	6867563	Missense_Mutation	rs782032967	S36R	0.38
COAD	chr12	6870318	Frame_Shift_Del	novel	*G266Afs43**	0.16
COAD	chr12	6870345	Missense_Mutation	NA	K275E	0.06
COAD	chr12	6869341	Missense_Mutation	NA	E173D	0.22
GBM	chr12	6870467	3'UTR	novel		0.2
GBM	chr12	6868934	Silent	novel	V99V	0.39
GBM	chr12	6870809	3'UTR	novel		0.09
HNSC	chr12	6870659	3'UTR	novel		0.2
HNSC	chr12	6867571	Missense_Mutation	rs781891860	A39V	0.32
HNSC	chr12	6870332	Silent	novel	G270G	0.29
HNSC	chr12	6870309	Missense_Mutation	novel	D263N	0.26
HNSC	chr12	6867543	Missense_Mutation	rs781876590	L30F	0.35
KIRC	chr12	6870458	3'UTR	NA		0.47
KIRC	chr12	6868893	Missense_Mutation	NA	I86V	0.38
KIRP	chr12	6867554	Silent	rs375712848	L33L	0.09
KIRP	chr12	6867558	Missense_Mutation	NA	S35P	0.47
KIRP	chr12	6870390	3'UTR	novel		0.1
LGG	chr12	6869151	Missense_Mutation	novel	E135K	0.45
LIHC	chr12	6869104	Missense_Mutation	novel	G119A	0.06
LUAD	chr12	6869269	Missense_Mutation	NA	Q149H	0.1
LUAD	chr12	6869368	Missense_Mutation	NA	F182L	0.33
LUAD	chr12	6869689	Splice_Region	NA	D190D	0.32
LUAD	chr12	6867563	Silent	rs782032967	S36S	0.21
LUAD	chr12	6867562	Missense_Mutation	novel	S36T	0.14
LUAD	chr12	6867651	Missense_Mutation	NA	L66V	0.25
LUAD	chr12	6870339	Missense_Mutation	novel	S273T	0.28
LUAD	chr12	6870340	Missense_Mutation	novel	S273Y	0.28
LUSC	chr12	6870382	Silent	novel	*287*	0.26
LUSC	chr12	6870124	Missense_Mutation	NA	I244V	0.36
LUSC	chr12	6870324	Missense_Mutation	NA	L268F	0.38
LUSC	chr12	6867644	Silent	NA	I63I	0.06
LUSC	chr12	6869287	Silent	novel	L155L	0.04
OV	chr12	6870063	Silent	rs369241009	H223H	0.11
OV	chr12	6870616	3'UTR	novel		0.55
PAAD	chr12	6867672	Missense_Mutation	novel	A73T	0.21
PAAD	chr12	6870364	Missense_Mutation	novel	I281S	0.14
PCPG	chr12	6867565	Missense_Mutation	novel	A37V	0.29
PRAD	chr12	6870412	3'UTR	novel		0.32
SKCM	chr12	6870629	3'UTR	novel		0.67
SKCM	chr12	6869299	Silent	rs138131191	L159L	0.41
SKCM	chr12	6869709	Missense_Mutation	NA	K197T	0.16
SKCM	chr12	6870493	3'UTR	novel		0.25
SKCM	chr12	6870391	3'UTR	rs782789697		0.11
STAD	chr12	6869714	Missense_Mutation	rs782391534	V199I	0.24
STAD	chr12	6869121	Missense_Mutation	novel	G125R	0.12
STAD	chr12	6870417	3'UTR	novel		0.23
UCEC	chr12	6870513	3'UTR	novel		0.43
UCEC	chr12	6869129	Silent	novel	T127T	0.19
UCEC	chr12	6870290	Missense_Mutation	novel	K256N	0.28
UCEC	chr12	6870642	3'UTR	novel		0.32
UCEC	chr12	6870789	3'UTR	novel		0.3
UCEC	chr12	6870104	Missense_Mutation	rs139532537	A237V	0.25
UCEC	chr12	6869172	Missense_Mutation	NA	E142K	0.3
UCEC	chr12	6870356	Missense_Mutation	novel	F278L	0.36
UCEC	chr12	6869278	Silent	novel	A152A	0.51
UCEC	chr12	6870104	Missense_Mutation	rs139532537	A237V	0.29
UCEC	chr12	6870511	3'UTR	novel		0.28
UCEC	chr12	6870692	3'UTR	novel		0.55
UCEC	chr12	6870788	3'UTR	novel		0.3
UCEC	chr12	6870718	3'UTR	rs782521774		0.17
UCEC	chr12	6870692	3'UTR	novel		0.36
UCEC	chr12	6869387	Missense_Mutation	novel	A189T	0.43
UCEC	chr12	6870122	Missense_Mutation	rs782417309	R243H	0.38
UCEC	chr12	6869757	Missense_Mutation	NA	T213N	0.27
UCEC	chr12	6870310	Missense_Mutation	rs750196839	D263G	0.19
UCEC	chr12	6869368	Silent	rs781865717	F182F	0.26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	DEL	0.0754	0.087189
DLBC	DEL	0.1042	0.11856
MESO	DEL	0.0805	0.17495
PAAD	DEL	0.125	0.0019175
READ	DEL	0.103	0.064633
TGCT	AMP	0.9467	3.5918e-21
THYM	AMP	0.0325	0.24554

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0032	Kaplan-Meier Survival Analysis
MESO	0.0039	Kaplan-Meier Survival Analysis
ACC	0.0012	Kaplan-Meier Survival Analysis
HNSC	0.012	Kaplan-Meier Survival Analysis
SKCM	0.00013	Kaplan-Meier Survival Analysis
ESCA	0.0075	Kaplan-Meier Survival Analysis
BLCA	0.026	Kaplan-Meier Survival Analysis
CESC	0.013	Kaplan-Meier Survival Analysis
LAML	0.00034	Kaplan-Meier Survival Analysis
KICH	0.0013	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.025	Kaplan-Meier Survival Analysis
CHOL	0.04	Kaplan-Meier Survival Analysis
LUAD	0.0003	Kaplan-Meier Survival Analysis
UVM	0.0011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742