EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000111801 (Gene tree)
Gene ID: 10384
Gene Symbol: BTN3A3
Alias: BTF3|BTN3.3
Full Name: butyrophilin subfamily 3 member A3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 12,944 bases
Position: chr6:26,440,472-26,453,415
Accession: 1140
RBP type: non-canonical RBP
Summary: The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474790	BTN3A3-205	587	-	-	- (aa)	-	-
ENST00000487627	BTN3A3-211	626	-	ENSP00000420339	100 (aa)	-	C9JNZ3
ENST00000497681	BTN3A3-215	542	-	-	- (aa)	-	-
ENST00000494393	BTN3A3-213	671	-	ENSP00000417234	137 (aa)	-	C9J3Q8
ENST00000490254	BTN3A3-212	765	-	ENSP00000419736	210 (aa)	-	C9JZT5
ENST00000361232	BTN3A3-202	2294	-	ENSP00000355238	535 (aa)	-	O00478
ENST00000482451	BTN3A3-208	626	-	ENSP00000419312	127 (aa)	-	C9JVU4
ENST00000480110	BTN3A3-207	4547	-	-	- (aa)	-	-
ENST00000477388	BTN3A3-206	560	-	-	- (aa)	-	-
ENST00000487272	BTN3A3-210	883	-	ENSP00000419445	250 (aa)	-	C9JUV8
ENST00000471353	BTN3A3-204	697	-	ENSP00000417717	140 (aa)	-	C9J877
ENST00000244519	BTN3A3-201	3002	-	ENSP00000244519	584 (aa)	-	O00478
ENST00000467524	BTN3A3-203	562	-	-	- (aa)	-	-
ENST00000483179	BTN3A3-209	1238	-	-	- (aa)	-	-
ENST00000496719	BTN3A3-214	1002	-	ENSP00000420147	237 (aa)	-	C9JQT8

Gene Model

Click here to download ENSG00000111801's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000111801	Platelet Function Tests	2.2932300E-005	-
ENSG00000111801	Platelet Function Tests	2.2932300E-005	-
ENSG00000111801	Platelet Function Tests	2.2932300E-005	-
ENSG00000111801	Platelet Function Tests	2.3041100E-005	-
ENSG00000111801	Platelet Function Tests	1.7106600E-005	-
ENSG00000111801	Platelet Function Tests	1.7106600E-005	-
ENSG00000111801	Platelet Function Tests	1.7106600E-005	-
ENSG00000111801	Platelet Function Tests	1.7188100E-005	-
ENSG00000111801	Platelet Function Tests	1.0221100E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000111801	rs13220495	6	26441412	T	Squamous cell lung carcinoma	28604730	[1.133133528-1.300253026]	1.2138206	EFO_0000708
ENSG00000111801	rs13220495	6	26441412	T	Diastolic blood pressure	30578418	[0.23-0.41] mmHg decrease	0.3191	EFO_0006336

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111801's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002456	T cell mediated immunity	22767497.	IMP	Process
GO:0005102	signaling receptor binding	21873635.	IBA	Function
GO:0005886	plasma membrane	22767497.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0009897	external side of plasma membrane	21873635.	IBA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0050776	regulation of immune response	21873635.	IBA	Process
GO:0050852	T cell receptor signaling pathway	21873635.	IBA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	26451673	Splice_Site	novel	X340_splice	0.29
BLCA	chr6	26450111	Missense_Mutation	novel	W332C	0.08
BLCA	chr6	26452316	Missense_Mutation	novel	L554V	0.27
BLCA	chr6	26443629	Missense_Mutation	NA	F19L	0.07
BLCA	chr6	26452078	Silent	novel	F474F	0.36
BLCA	chr6	26445926	Missense_Mutation	rs778094119	S219F	0.37
BLCA	chr6	26451991	Silent	rs143460142	L445L	0.41
BLCA	chr6	26452058	Missense_Mutation	novel	E468Q	0.04
BLCA	chr6	26443966	Missense_Mutation	NA	S32C	0.24
BLCA	chr6	26444270	Missense_Mutation	NA	F133L	0.26
BLCA	chr6	26448294	Silent	novel	G254G	0.11
BLCA	chr6	26448402	Missense_Mutation	novel	M290I	0.38
BLCA	chr6	26443610	Silent	novel	L12L	0.1
BRCA	chr6	26443441	Splice_Region	novel		0.4
BRCA	chr6	26452060	Missense_Mutation	NA	E468D	0.41
BRCA	chr6	26443591	Missense_Mutation	NA	S6Y	0.34
BRCA	chr6	26448263	Missense_Mutation	NA	S244T	0.2
BRCA	chr6	26444250	Missense_Mutation	NA	Y127H	0.35
BRCA	chr6	26451867	Missense_Mutation	NA	R404I	0.16
BRCA	chr6	26444007	Missense_Mutation	novel	E46K	0.06
CESC	chr6	26444138	Silent	NA	Q89Q	0.16
CESC	chr6	26445833	Missense_Mutation	rs749879449	P188L	0.41
CESC	chr6	26445902	Missense_Mutation	rs140844974	R211T	0.22
CESC	chr6	26445795	Silent	novel	P175P	0.4
CESC	chr6	26452069	Silent	novel	E471E	0.11
CESC	chr6	26444206	Missense_Mutation	rs776296722	R112Q	0.46
COAD	chr6	26451672	Splice_Region	novel		0.28
COAD	chr6	26451734	Missense_Mutation	rs149504053	R360G	0.6
COAD	chr6	26445786	Frame_Shift_Del	novel	*Q174Nfs4**	0.18
COAD	chr6	26443629	Missense_Mutation	NA	F19L	0.1
COAD	chr6	26451707	Missense_Mutation	rs574858167	A351T	0.15
COAD	chr6	26445967	Missense_Mutation	NA	A233T	0.23
COAD	chr6	26445811	Missense_Mutation	NA	D181N	0.2
COAD	chr6	26452134	Missense_Mutation	NA	E493G	0.18
ESCA	chr6	26452270	Silent	rs757126334	P538P	0.26
HNSC	chr6	26448727	Splice_Site	novel	X313_splice	0.4
HNSC	chr6	26452202	Missense_Mutation	novel	K516E	0.12
HNSC	chr6	26445944	Missense_Mutation	rs200625612	S225F	0.19
HNSC	chr6	26451692	Missense_Mutation	novel	P346T	0.34
HNSC	chr6	26452350	Missense_Mutation	novel	S565F	0.36
HNSC	chr6	26445724	Missense_Mutation	novel	I152F	0.15
HNSC	chr6	26451853	Frame_Shift_Ins	novel	*E400Sfs28**	0.07
HNSC	chr6	26452162	Missense_Mutation	novel	L502F	0.24
HNSC	chr6	26451772	Silent	novel	P372P	0.28
LGG	chr6	26451675	Missense_Mutation	rs746357036	A340V	0.46
LIHC	chr6	26452270	Silent	rs757126334	P538P	0.17
LUAD	chr6	26452098	Missense_Mutation	NA	S481C	0.16
LUAD	chr6	26444295	Nonsense_Mutation	NA	K142*	0.12
LUAD	chr6	26448754	Missense_Mutation	novel	R322S	0.25
LUAD	chr6	26448726	Splice_Site	NA	X313_splice	0.25
LUAD	chr6	26451829	Silent	novel	T391T	0.08
LUAD	chr6	26451975	Missense_Mutation	novel	N440S	0.07
LUAD	chr6	26451902	Missense_Mutation	rs531717427	V416M	0.14
LUAD	chr6	26451712	Silent	novel	I352I	0.12
LUSC	chr6	26451763	Silent	novel	R369R	0.39
LUSC	chr6	26444286	Missense_Mutation	NA	V139L	0.15
LUSC	chr6	26445763	Nonsense_Mutation	NA	E165*	0.09
LUSC	chr6	26452248	Missense_Mutation	NA	S531F	0.08
LUSC	chr6	26451989	Missense_Mutation	novel	L445I	0.2
LUSC	chr6	26452392	Missense_Mutation	rs144256388	R579H	0.17
LUSC	chr6	26445957	Silent	NA	L229L	0.53
LUSC	chr6	26452169	Missense_Mutation	novel	E505Q	0.49
LUSC	chr6	26452289	Missense_Mutation	novel	G545R	0.25
OV	chr6	26452250	Missense_Mutation	NA	L532V	0.14
OV	chr6	26451687	Missense_Mutation	NA	L344P	0.2
OV	chr6	26452527	3'UTR	novel		0.09
PRAD	chr6	26444055	Missense_Mutation	novel	T62A	0.17
PRAD	chr6	26452273	Silent	novel	G539G	0.09
PRAD	chr6	26451859	Silent	novel	V401V	0.12
READ	chr6	26452392	Missense_Mutation	rs144256388	R579H	0.38
READ	chr6	26444274	Missense_Mutation	rs746463161	E135K	0.4
READ	chr6	26445810	Silent	rs765497042	S180S	0.08
SARC	chr6	26444071	Frame_Shift_Del	novel	*W67Cfs53**	0.15
SKCM	chr6	26452028	Missense_Mutation	NA	P458S	0.16
SKCM	chr6	26452145	Missense_Mutation	rs372318760	P497S	0.36
SKCM	chr6	26452304	Missense_Mutation	novel	E550K	0.19
SKCM	chr6	26452228	Silent	rs545996762	P524P	0.22
SKCM	chr6	26443591	Missense_Mutation	novel	S6F	0.07
SKCM	chr6	26445871	Silent	NA	L201L	0.21
SKCM	chr6	26452048	Silent	NA	F464F	0.32
SKCM	chr6	26451808	Silent	NA	V384V	0.55
SKCM	chr6	26445944	Missense_Mutation	rs200625612	S225F	0.08
SKCM	chr6	26448358	Missense_Mutation	NA	E276Q	0.1
SKCM	chr6	26444163	Missense_Mutation	novel	S98A	0.18
SKCM	chr6	26444164	Missense_Mutation	rs138755245	S98L	0.18
SKCM	chr6	26444299	Missense_Mutation	NA	V143A	0.35
STAD	chr6	26444112	Missense_Mutation	novel	D81H	0.23
STAD	chr6	26452155	Missense_Mutation	NA	R500I	0.25
STAD	chr6	26448417	Silent	rs375083429	Y295Y	0.24
STAD	chr6	26451925	Silent	NA	V423V	0.26
STAD	chr6	26448309	Silent	rs368908067	S259S	0.2
STAD	chr6	26451817	Silent	NA	C387C	0.2
STAD	chr6	26451965	Missense_Mutation	NA	T437A	0.15
STAD	chr6	26451797	Missense_Mutation	rs200026955	R381C	0.24
THCA	chr6	26448425	Missense_Mutation	novel	T298K	0.39
THCA	chr6	26451787	Missense_Mutation	novel	R377S	0.18
UCEC	chr6	26443416	5'UTR	novel		0.46
UCEC	chr6	26444216	Silent	rs759288135	N115N	0.39
UCEC	chr6	26445830	Missense_Mutation	novel	I187N	0.08
UCEC	chr6	26452089	Missense_Mutation	NA	T478I	0.42
UCEC	chr6	26451746	Missense_Mutation	novel	R364C	0.44
UCEC	chr6	26448418	Missense_Mutation	rs144686528	A296T	0.41
UCEC	chr6	26452038	Missense_Mutation	novel	V461A	0.47
UCEC	chr6	26448418	Missense_Mutation	novel	A296S	0.07
UCEC	chr6	26444164	Missense_Mutation	rs138755245	S98L	0.21
UCEC	chr6	26444161	Frame_Shift_Ins	novel	*S98Qfs24**	0.04
UCEC	chr6	26451955	Silent	NA	T433T	0.2
UCEC	chr6	26448441	In_Frame_Ins	novel	S303_L304insV	0.06
UCEC	chr6	26444165	Silent	rs757781798	S98S	0.12
UCEC	chr6	26445951	Silent	rs200139388	L227L	0.14
UCEC	chr6	26448441	In_Frame_Ins	novel	S303_L304insV	0.05
UCEC	chr6	26444165	Silent	rs757781798	S98S	0.35
UCEC	chr6	26445778	Missense_Mutation	novel	G170C	0.3
UCEC	chr6	26451769	Silent	novel	L371L	0.23
UCEC	chr6	26452228	Silent	rs545996762	P524P	0.29
UCEC	chr6	26443442	Splice_Region	novel		0.33
UCEC	chr6	26445835	Missense_Mutation	novel	A189T	0.35
UCEC	chr6	26452086	Missense_Mutation	novel	A477D	0.47
UCEC	chr6	26452209	Missense_Mutation	novel	V518E	0.22
UCEC	chr6	26452420	3'UTR	novel		0.29
UCEC	chr6	26445810	Silent	rs765497042	S180S	0.16
UCEC	chr6	26448316	Missense_Mutation	novel	L262I	0.42
UCEC	chr6	26451675	Missense_Mutation	rs746357036	A340V	0.52
UCEC	chr6	26444012	Silent	rs774961102	D47D	0.35
UCEC	chr6	26451913	Frame_Shift_Ins	novel	*K420Vfs7**	0.04
UCEC	chr6	26451916	In_Frame_Del	novel	G421_W422del	0.05
UCEC	chr6	26443430	5'UTR	novel		0.39
UCEC	chr6	26443440	Splice_Region	novel		0.4
UCEC	chr6	26443624	Missense_Mutation	novel	S17F	0.38
UCEC	chr6	26452218	Missense_Mutation	novel	S521F	0.29
UCEC	chr6	26444205	Nonsense_Mutation	rs372313829	R112*	0.47
UCEC	chr6	26444205	Nonsense_Mutation	rs372313829	R112*	0.19
UCEC	chr6	26445854	Missense_Mutation	novel	V195A	0.28
UCEC	chr6	26444216	Silent	rs759288135	N115N	0.29
UCEC	chr6	26451735	Missense_Mutation	NA	R360M	0.39
UCEC	chr6	26445713	Missense_Mutation	NA	S148Y	0.51
UCEC	chr6	26452382	Missense_Mutation	NA	L576V	0.45
UCEC	chr6	26444164	Missense_Mutation	rs138755245	S98L	0.39
UCEC	chr6	26445703	Splice_Site	novel	X145_splice	0.17
UCEC	chr6	26445933	Silent	novel	I221I	0.19
UCEC	chr6	26448415	Missense_Mutation	novel	Y295N	0.27
UCEC	chr6	26452244	Missense_Mutation	novel	H530Y	0.06
UCEC	chr6	26451761	Missense_Mutation	rs551526423	R369W	0.33
UCEC	chr6	26451943	Silent	rs753121280	N429N	0.28
UCEC	chr6	26452403	Missense_Mutation	novel	L583F	0.35
UCS	chr6	26448424	Missense_Mutation	novel	T298A	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.1389	0.16947
LUSC	DEL	0.1896	0.002071
MESO	DEL	0.1149	0.20184
OV	DEL	0.1503	3.6941e-88
PAAD	DEL	0.2663	0.0001774
THCA	DEL	0.006	0.23456

Survival Analysis

Cancer	P-value	Q-value
STAD	0.04	Kaplan-Meier Survival Analysis
SARC	0.00012	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
BRCA	0.014	Kaplan-Meier Survival Analysis
PAAD	0.026	Kaplan-Meier Survival Analysis
BLCA	0.0046	Kaplan-Meier Survival Analysis
CESC	0.042	Kaplan-Meier Survival Analysis
LIHC	0.0033	Kaplan-Meier Survival Analysis
LGG	0.0037	Kaplan-Meier Survival Analysis
THCA	0.033	Kaplan-Meier Survival Analysis
LUAD	0.033	Kaplan-Meier Survival Analysis
UVM	0.0019	Kaplan-Meier Survival Analysis
OV	0.00085	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742