EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000111802 (Gene tree)
Gene ID: 51567
Gene Symbol: TDP2
Alias: TTRAP
Full Name: tyrosyl-DNA phosphodiesterase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 17,057 bases
Position: chr6:24,649,977-24,667,033
Accession: 17768
RBP type: canonical RBP
Summary: This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000345345	Exo_endo_phos	PF03372.23	3.7e-08	1	1
ENSP00000367440	Exo_endo_phos	PF03372.23	6.2e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000478285	TDP2-203	857	-	-	- (aa)	-	-
ENST00000478507	TDP2-204	573	-	-	- (aa)	-	-
ENST00000341060	TDP2-201	2120	-	ENSP00000345345	304 (aa)	-	X6R5A3
ENST00000480495	TDP2-205	714	-	-	- (aa)	-	-
ENST00000378198	TDP2-202	2071	-	ENSP00000367440	362 (aa)	-	O95551

Gene Model

Click here to download ENSG00000111802's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000111802	Hypertrophy, Left Ventricular	5.5490000E-005	-
ENSG00000111802	Colorectal Neoplasms	2E-7	26621817
ENSG00000111802	Endometrial Neoplasms	2E-7	26621817

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000111802	rs3181245	6	24651092	C	Colorectal or endometrial cancer	26621817	[1.07-1.16]	1.12	EFO_0005842\|EFO_0004230
ENSG00000111802	rs3181238	6	24654215	?	Serum alkaline phosphatase levels	29403010	[0.024-0.041] unit increase novel	0.03243	EFO_0004533

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111802's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000111802	TDP2	86	53.208	ENSAPOG00000018379	-	91	53.208	Acanthochromis_polyacanthus
ENSG00000111802	TDP2	92	86.738	ENSAMEG00000010230	TDP2	99	86.738	Ailuropoda_melanoleuca
ENSG00000111802	TDP2	60	52.717	ENSAOCG00000010081	-	81	52.717	Amphiprion_ocellaris
ENSG00000111802	TDP2	95	49.488	ENSAPEG00000004208	-	99	49.488	Amphiprion_percula
ENSG00000111802	TDP2	89	47.445	ENSATEG00000010663	-	89	47.445	Anabas_testudineus
ENSG00000111802	TDP2	93	65.970	ENSACAG00000002332	TDP2	92	65.680	Anolis_carolinensis
ENSG00000111802	TDP2	100	91.713	ENSANAG00000020033	TDP2	100	91.713	Aotus_nancymaae
ENSG00000111802	TDP2	88	53.333	ENSACLG00000016148	tdp2b	95	53.333	Astatotilapia_calliptera
ENSG00000111802	TDP2	92	48.582	ENSACLG00000016132	tdp2b	95	48.582	Astatotilapia_calliptera
ENSG00000111802	TDP2	97	48.822	ENSACLG00000016174	tdp2b	97	48.822	Astatotilapia_calliptera
ENSG00000111802	TDP2	91	56.679	ENSAMXG00000011775	tdp2b	95	51.934	Astyanax_mexicanus
ENSG00000111802	TDP2	91	48.410	ENSAMXG00000036549	tdp2a	92	48.410	Astyanax_mexicanus
ENSG00000111802	TDP2	94	85.714	ENSBTAG00000000365	TDP2	94	85.714	Bos_taurus
ENSG00000111802	TDP2	90	30.699	WBGene00013405	tdpt-1	85	30.699	Caenorhabditis_elegans
ENSG00000111802	TDP2	100	90.608	ENSCJAG00000021963	-	100	90.608	Callithrix_jacchus
ENSG00000111802	TDP2	100	91.989	ENSCJAG00000006074	TDP2	100	91.989	Callithrix_jacchus
ENSG00000111802	TDP2	92	87.814	ENSCAFG00000010428	TDP2	99	85.294	Canis_familiaris
ENSG00000111802	TDP2	92	87.814	ENSCAFG00020009994	TDP2	96	87.814	Canis_lupus_dingo
ENSG00000111802	TDP2	92	87.900	ENSCHIG00000015294	-	95	87.900	Capra_hircus
ENSG00000111802	TDP2	93	89.437	ENSTSYG00000037199	TDP2	100	89.644	Carlito_syrichta
ENSG00000111802	TDP2	100	85.635	ENSCPOG00000006390	TDP2	95	86.804	Cavia_porcellus
ENSG00000111802	TDP2	100	93.646	ENSCCAG00000022734	TDP2	100	93.646	Cebus_capucinus
ENSG00000111802	TDP2	100	95.724	ENSCATG00000022076	TDP2	100	95.724	Cercocebus_atys
ENSG00000111802	TDP2	100	83.978	ENSCLAG00000002072	TDP2	95	86.217	Chinchilla_lanigera
ENSG00000111802	TDP2	100	95.856	ENSCSAG00000007769	TDP2	100	95.856	Chlorocebus_sabaeus
ENSG00000111802	TDP2	95	69.096	ENSCPBG00000006551	TDP2	87	69.208	Chrysemys_picta_bellii
ENSG00000111802	TDP2	100	95.395	ENSCANG00000040122	TDP2	100	95.395	Colobus_angolensis_palliatus
ENSG00000111802	TDP2	91	73.741	ENSCGRG00001000384	Tdp2	92	69.208	Cricetulus_griseus_chok1gshd
ENSG00000111802	TDP2	91	73.741	ENSCGRG00000010250	Tdp2	94	67.155	Cricetulus_griseus_crigri
ENSG00000111802	TDP2	93	53.714	ENSCVAG00000003114	tdp2b	95	53.143	Cyprinodon_variegatus
ENSG00000111802	TDP2	84	47.692	ENSDARG00000069941	tdp2a	58	47.692	Danio_rerio
ENSG00000111802	TDP2	92	55.017	ENSDARG00000035954	tdp2b	94	51.648	Danio_rerio
ENSG00000111802	TDP2	100	85.912	ENSDNOG00000044082	TDP2	93	88.270	Dasypus_novemcinctus
ENSG00000111802	TDP2	91	85.971	ENSETEG00000019096	TDP2	100	85.971	Echinops_telfairi
ENSG00000111802	TDP2	87	53.008	ENSEBUG00000006535	tdp2a	62	53.008	Eptatretus_burgeri
ENSG00000111802	TDP2	94	87.390	ENSEASG00005007656	TDP2	94	87.390	Equus_asinus_asinus
ENSG00000111802	TDP2	94	87.390	ENSECAG00000014264	TDP2	94	87.390	Equus_caballus
ENSG00000111802	TDP2	100	80.387	ENSEEUG00000010776	TDP2	94	81.818	Erinaceus_europaeus
ENSG00000111802	TDP2	94	46.735	ENSELUG00000009321	tdp2a	94	46.333	Esox_lucius
ENSG00000111802	TDP2	92	53.039	ENSELUG00000016449	tdp2b	95	53.039	Esox_lucius
ENSG00000111802	TDP2	100	84.530	ENSFCAG00000025612	TDP2	94	86.217	Felis_catus
ENSG00000111802	TDP2	91	64.029	ENSFALG00000004710	TDP2	94	59.649	Ficedula_albicollis
ENSG00000111802	TDP2	96	85.616	ENSFDAG00000006512	TDP2	97	88.214	Fukomys_damarensis
ENSG00000111802	TDP2	81	51.613	ENSFHEG00000013560	-	84	51.613	Fundulus_heteroclitus
ENSG00000111802	TDP2	91	69.784	ENSGALG00000013637	TDP2	92	64.620	Gallus_gallus
ENSG00000111802	TDP2	97	68.466	ENSGAGG00000002853	TDP2	87	69.501	Gopherus_agassizii
ENSG00000111802	TDP2	100	99.448	ENSGGOG00000014237	TDP2	100	99.448	Gorilla_gorilla
ENSG00000111802	TDP2	66	56.436	ENSHBUG00000005421	-	83	57.711	Haplochromis_burtoni
ENSG00000111802	TDP2	91	56.475	ENSHBUG00000002714	tdp2b	95	54.467	Haplochromis_burtoni
ENSG00000111802	TDP2	100	83.978	ENSHGLG00000008655	TDP2	95	84.751	Heterocephalus_glaber_female
ENSG00000111802	TDP2	100	83.978	ENSHGLG00100019087	TDP2	95	84.751	Heterocephalus_glaber_male
ENSG00000111802	TDP2	94	53.463	ENSIPUG00000013691	tdp2b	94	53.824	Ictalurus_punctatus
ENSG00000111802	TDP2	98	64.326	ENSJJAG00000021685	Tdp2	97	66.272	Jaculus_jaculus
ENSG00000111802	TDP2	85	50.575	ENSKMAG00000015485	-	84	50.575	Kryptolebias_marmoratus
ENSG00000111802	TDP2	91	63.669	ENSLACG00000008852	TDP2	95	58.857	Latimeria_chalumnae
ENSG00000111802	TDP2	91	58.333	ENSLOCG00000005817	tdp2b	98	58.333	Lepisosteus_oculatus
ENSG00000111802	TDP2	94	87.097	ENSLAFG00000002567	TDP2	97	87.097	Loxodonta_africana
ENSG00000111802	TDP2	100	95.724	ENSMFAG00000045296	TDP2	100	95.724	Macaca_fascicularis
ENSG00000111802	TDP2	100	94.475	ENSMMUG00000009803	TDP2	100	94.475	Macaca_mulatta
ENSG00000111802	TDP2	100	95.395	ENSMNEG00000038003	TDP2	100	95.395	Macaca_nemestrina
ENSG00000111802	TDP2	100	96.382	ENSMLEG00000028883	TDP2	100	96.382	Mandrillus_leucophaeus
ENSG00000111802	TDP2	91	55.755	ENSMAMG00000013654	tdp2b	94	54.386	Mastacembelus_armatus
ENSG00000111802	TDP2	93	53.890	ENSMZEG00005003950	tdp2b	95	53.890	Maylandia_zebra
ENSG00000111802	TDP2	97	46.801	ENSMZEG00005004103	tdp2b	97	46.801	Maylandia_zebra
ENSG00000111802	TDP2	87	53.008	ENSMZEG00005004153	tdp2b	91	53.008	Maylandia_zebra
ENSG00000111802	TDP2	82	52.778	ENSMZEG00005004055	tdp2b	83	52.778	Maylandia_zebra
ENSG00000111802	TDP2	83	47.244	ENSMZEG00005003980	-	82	47.244	Maylandia_zebra
ENSG00000111802	TDP2	98	48.333	ENSMZEG00005004126	tdp2b	96	48.333	Maylandia_zebra
ENSG00000111802	TDP2	90	51.636	ENSMZEG00005004077	tdp2b	96	50.709	Maylandia_zebra
ENSG00000111802	TDP2	91	70.504	ENSMGAG00000008014	TDP2	91	65.689	Meleagris_gallopavo
ENSG00000111802	TDP2	91	73.022	ENSMAUG00000014451	Tdp2	92	68.328	Mesocricetus_auratus
ENSG00000111802	TDP2	100	88.705	ENSMICG00000000039	TDP2	100	87.789	Microcebus_murinus
ENSG00000111802	TDP2	91	74.820	ENSMOCG00000002823	Tdp2	92	70.381	Microtus_ochrogaster
ENSG00000111802	TDP2	89	65.152	ENSMODG00000011653	TDP2	95	67.203	Monodelphis_domestica
ENSG00000111802	TDP2	98	46.689	ENSMALG00000005368	-	98	46.689	Monopterus_albus
ENSG00000111802	TDP2	91	74.101	MGP_CAROLIEiJ_G0018354	Tdp2	91	68.035	Mus_caroli
ENSG00000111802	TDP2	91	75.180	ENSMUSG00000035958	Tdp2	91	68.915	Mus_musculus
ENSG00000111802	TDP2	91	73.741	MGP_PahariEiJ_G0019417	Tdp2	91	66.862	Mus_pahari
ENSG00000111802	TDP2	91	74.820	MGP_SPRETEiJ_G0019220	Tdp2	91	68.622	Mus_spretus
ENSG00000111802	TDP2	91	88.129	ENSMPUG00000004516	TDP2	95	84.257	Mustela_putorius_furo
ENSG00000111802	TDP2	91	82.079	ENSMLUG00000013506	TDP2	94	77.353	Myotis_lucifugus
ENSG00000111802	TDP2	98	64.407	ENSNGAG00000001375	Tdp2	92	65.588	Nannospalax_galili
ENSG00000111802	TDP2	100	98.619	ENSNLEG00000002447	TDP2	100	98.619	Nomascus_leucogenys
ENSG00000111802	TDP2	96	83.862	ENSOPRG00000016299	TDP2	97	84.164	Ochotona_princeps
ENSG00000111802	TDP2	92	91.039	ENSODEG00000014018	TDP2	95	91.039	Octodon_degus
ENSG00000111802	TDP2	98	85.311	ENSOCUG00000013773	TDP2	94	86.510	Oryctolagus_cuniculus
ENSG00000111802	TDP2	87	48.315	ENSORLG00000001661	-	97	48.315	Oryzias_latipes
ENSG00000111802	TDP2	87	48.315	ENSORLG00020004634	-	97	48.315	Oryzias_latipes_hni
ENSG00000111802	TDP2	87	43.446	ENSORLG00015008190	-	97	43.446	Oryzias_latipes_hsok
ENSG00000111802	TDP2	87	46.792	ENSOMEG00000015899	-	92	49.597	Oryzias_melastigma
ENSG00000111802	TDP2	100	85.635	ENSOGAG00000025303	TDP2	93	87.390	Otolemur_garnettii
ENSG00000111802	TDP2	100	99.448	ENSPPAG00000029023	TDP2	100	99.448	Pan_paniscus
ENSG00000111802	TDP2	100	83.978	ENSPPRG00000015398	TDP2	94	85.630	Panthera_pardus
ENSG00000111802	TDP2	99	82.178	ENSPTIG00000018574	TDP2	95	87.050	Panthera_tigris_altaica
ENSG00000111802	TDP2	100	99.448	ENSPTRG00000017778	TDP2	100	99.448	Pan_troglodytes
ENSG00000111802	TDP2	100	95.066	ENSPANG00000017590	TDP2	100	95.066	Papio_anubis
ENSG00000111802	TDP2	92	53.659	ENSPKIG00000006483	tdp2b	94	51.989	Paramormyrops_kingsleyae
ENSG00000111802	TDP2	92	71.326	ENSPSIG00000004948	TDP2	100	69.966	Pelodiscus_sinensis
ENSG00000111802	TDP2	91	74.820	ENSPEMG00000001788	Tdp2	91	70.088	Peromyscus_maniculatus_bairdii
ENSG00000111802	TDP2	81	47.148	ENSPMAG00000001570	tdp2b	96	47.529	Petromyzon_marinus
ENSG00000111802	TDP2	91	72.662	ENSPCIG00000007316	TDP2	89	68.035	Phascolarctos_cinereus
ENSG00000111802	TDP2	81	50.400	ENSPFOG00000017990	-	90	50.400	Poecilia_formosa
ENSG00000111802	TDP2	81	50.000	ENSPLAG00000019439	-	79	50.000	Poecilia_latipinna
ENSG00000111802	TDP2	81	50.800	ENSPMEG00000010824	-	94	46.528	Poecilia_mexicana
ENSG00000111802	TDP2	100	98.343	ENSPPYG00000016282	TDP2	92	98.343	Pongo_abelii
ENSG00000111802	TDP2	100	90.331	ENSPCOG00000021415	TDP2	100	90.331	Propithecus_coquereli
ENSG00000111802	TDP2	87	49.291	ENSPNYG00000011504	tdp2b	90	49.291	Pundamilia_nyererei
ENSG00000111802	TDP2	69	49.282	ENSPNYG00000001944	-	83	49.282	Pundamilia_nyererei
ENSG00000111802	TDP2	93	52.738	ENSPNYG00000011532	tdp2b	95	52.738	Pundamilia_nyererei
ENSG00000111802	TDP2	86	50.385	ENSPNAG00000022162	tdp2a	66	50.385	Pygocentrus_nattereri
ENSG00000111802	TDP2	94	71.777	ENSRNOG00000018246	Tdp2	92	68.328	Rattus_norvegicus
ENSG00000111802	TDP2	100	95.066	ENSRBIG00000037119	TDP2	100	95.066	Rhinopithecus_bieti
ENSG00000111802	TDP2	100	94.737	ENSRROG00000005025	TDP2	100	94.737	Rhinopithecus_roxellana
ENSG00000111802	TDP2	100	91.436	ENSSBOG00000028734	TDP2	100	90.789	Saimiri_boliviensis_boliviensis
ENSG00000111802	TDP2	99	65.489	ENSSHAG00000002506	TDP2	91	67.544	Sarcophilus_harrisii
ENSG00000111802	TDP2	84	52.756	ENSSFOG00015011322	-	71	53.175	Scleropages_formosus
ENSG00000111802	TDP2	91	79.211	ENSSARG00000013547	TDP2	100	79.211	Sorex_araneus
ENSG00000111802	TDP2	94	64.857	ENSSPUG00000008288	TDP2	95	64.857	Sphenodon_punctatus
ENSG00000111802	TDP2	100	86.188	ENSSSCG00000001092	TDP2	94	87.683	Sus_scrofa
ENSG00000111802	TDP2	86	68.199	ENSTGUG00000009035	TDP2	100	68.199	Taeniopygia_guttata
ENSG00000111802	TDP2	99	48.185	ENSTRUG00000012218	-	99	48.185	Takifugu_rubripes
ENSG00000111802	TDP2	93	53.561	ENSTRUG00000014347	tdp2b	96	53.258	Takifugu_rubripes
ENSG00000111802	TDP2	96	52.066	ENSTNIG00000017792	tdp2b	96	52.676	Tetraodon_nigroviridis
ENSG00000111802	TDP2	83	54.023	ENSTNIG00000010260	TDP2	99	54.023	Tetraodon_nigroviridis
ENSG00000111802	TDP2	100	84.530	ENSTTRG00000016376	TDP2	94	86.510	Tursiops_truncatus
ENSG00000111802	TDP2	99	82.392	ENSUAMG00000025939	TDP2	95	80.352	Ursus_americanus
ENSG00000111802	TDP2	100	80.921	ENSUMAG00000020111	TDP2	100	80.921	Ursus_maritimus
ENSG00000111802	TDP2	98	61.141	ENSXETG00000014826	tdp2	95	62.147	Xenopus_tropicalis
ENSG00000111802	TDP2	81	50.996	ENSXCOG00000010778	-	69	50.996	Xiphophorus_couchianus
ENSG00000111802	TDP2	81	50.996	ENSXMAG00000022252	-	72	50.996	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	22405347.22822062.	IDA	Function
GO:0000287	magnesium ion binding	19794497.	TAS	Function
GO:0003697	single-stranded DNA binding	21873635.	IBA	Function
GO:0003697	single-stranded DNA binding	22822062.	IDA	Function
GO:0003714	transcription corepressor activity	10764746.	TAS	Function
GO:0004518	nuclease activity	-	IEA	Function
GO:0005515	protein binding	18039968.	IPI	Function
GO:0005634	nucleus	22908287.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	22908287.	IDA	Component
GO:0006302	double-strand break repair	21873635.	IBA	Process
GO:0006302	double-strand break repair	19794497.	IDA	Process
GO:0006302	double-strand break repair	21030584.	IMP	Process
GO:0007166	cell surface receptor signaling pathway	10764746.	TAS	Process
GO:0016235	aggresome	-	IDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0016605	PML body	21873635.	IBA	Component
GO:0016605	PML body	19794497.	IDA	Component
GO:0030145	manganese ion binding	22822062.	IDA	Function
GO:0036317	tyrosyl-RNA phosphodiesterase activity	22908287.	IDA	Function
GO:0048666	neuron development	24658003.	IMP	Process
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	21873635.	IBA	Function
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	19794497.22405347.22822062.	IDA	Function
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	21030584.	IMP	Function
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21030584	TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.	J Biol Chem	2011 Jan 7	Zeng Z	doi: 10.1074/jbc.M110.181016
21478903	Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway.	Oncogene	2011 Sep 1	Li C	doi: 10.1038/onc.2011.94
26701725	ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells.	Oncotarget	2016 Feb 9	Bian K	doi: 10.18632/oncotarget.6682.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	24650826	Missense_Mutation	novel	H351Y	0.37	Exo_endo_phos
BLCA	chr6	24666748	Missense_Mutation	novel	D39N	0.23
BLCA	chr6	24650969	Missense_Mutation	novel	S303F	0.22	Exo_endo_phos
BLCA	chr6	24650910	Missense_Mutation	novel	A323S	0.13	Exo_endo_phos
BRCA	chr6	24650911	Silent	novel	A322A	0.49
BRCA	chr6	24666707	Nonsense_Mutation	NA	W52*	0.17
BRCA	chr6	24658661	Nonsense_Mutation	novel	E109*	0.09
BRCA	chr6	24666712	Missense_Mutation	novel	D51H	0.27
CESC	chr6	24653135	Missense_Mutation	NA	E219Q	0.41	Exo_endo_phos
CESC	chr6	24650958	Missense_Mutation	rs77273535	I307V	0.38	Exo_endo_phos
COAD	chr6	24653080	Missense_Mutation	NA	R237Q	0.36	Exo_endo_phos
COAD	chr6	24666792	Frame_Shift_Del	NA	*K24Sfs35**	0.09
COAD	chr6	24650651	3'UTR	novel		0.44
COAD	chr6	24653091	Silent	NA	H233H	0.33
COAD	chr6	24658714	Missense_Mutation	NA	E91A	0.29
COAD	chr6	24650786	3'UTR	novel		0.38
ESCA	chr6	24650976	Missense_Mutation	novel	M301V	0.52	Exo_endo_phos
ESCA	chr6	24666748	Missense_Mutation	novel	D39N	0.16
GBM	chr6	24657887	Missense_Mutation	NA	I148V	0.39	Exo_endo_phos
GBM	chr6	24650882	Missense_Mutation	novel	R332Q	0.44	Exo_endo_phos
GBM	chr6	24666581	Missense_Mutation	NA	V66M	0.26
HNSC	chr6	24657849	Silent	novel	Y160Y	0.16
KIRC	chr6	24650724	3'UTR	novel		0.41
KIRC	chr6	24658642	Missense_Mutation	NA	S115F	0.26
KIRP	chr6	24650754	3'UTR	novel		0.29
LGG	chr6	24650882	Frame_Shift_Del	novel	*R332Qfs8**	0.38	Exo_endo_phos
LIHC	chr6	24666756	Missense_Mutation	novel	A36V	0.44
LIHC	chr6	24650924	Missense_Mutation	novel	I318K	0.64	Exo_endo_phos
LUAD	chr6	24650850	Missense_Mutation	NA	D343Y	0.13	Exo_endo_phos
LUAD	chr6	24666595	Frame_Shift_Del	novel	*Y61Sfs27**	0.05
LUAD	chr6	24650852	Missense_Mutation	NA	L342P	0.29	Exo_endo_phos
LUAD	chr6	24650783	3'UTR	novel		0.08
LUSC	chr6	24658629	Missense_Mutation	novel	W119C	0.17	Exo_endo_phos
LUSC	chr6	24666705	Missense_Mutation	novel	E53A	0.1
LUSC	chr6	24654485	Missense_Mutation	novel	R188I	0.28	Exo_endo_phos
LUSC	chr6	24650683	3'UTR	novel		0.3
OV	chr6	24666611	Missense_Mutation	novel	R56W	0.16
OV	chr6	24666744	Missense_Mutation	NA	A40V	0.17
OV	chr6	24666570	Missense_Mutation	NA	S69R	0.62
OV	chr6	24666592	Missense_Mutation	novel	F62C	0.08
OV	chr6	24658634	Missense_Mutation	novel	T118A	0.06	Exo_endo_phos
PAAD	chr6	24654449	In_Frame_Del	novel	F199_P200del	0.11	Exo_endo_phos
PAAD	chr6	24650913	Missense_Mutation	rs752649752	A322T	0.2	Exo_endo_phos
READ	chr6	24650882	Missense_Mutation	novel	R332Q	0.48	Exo_endo_phos
READ	chr6	24666778	Missense_Mutation	NA	C29S	0.34
SKCM	chr6	24658604	Missense_Mutation	novel	N128H	0.27	Exo_endo_phos
SKCM	chr6	24666816	Missense_Mutation	novel	E16G	0.23
SKCM	chr6	24666814	Missense_Mutation	NA	E17K	0.29
SKCM	chr6	24654488	Missense_Mutation	NA	S187L	0.6	Exo_endo_phos
SKCM	chr6	24658678	Missense_Mutation	NA	S103F	0.28
SKCM	chr6	24650871	Missense_Mutation	NA	L336F	0.26	Exo_endo_phos
SKCM	chr6	24653115	Silent	NA	S225S	0.17
SKCM	chr6	24654427	Silent	NA	N207N	0.17
SKCM	chr6	24653123	Missense_Mutation	NA	M223V	0.4	Exo_endo_phos
STAD	chr6	24653081	Nonsense_Mutation	rs752399511	R237*	0.19	Exo_endo_phos
STAD	chr6	24653063	Frame_Shift_Del	novel	*M243Wfs3**	0.34	Exo_endo_phos
STAD	chr6	24650983	Silent	NA	D298D	0.05
STAD	chr6	24666839	Missense_Mutation	NA	E8D	0.28
STAD	chr6	24650853	Frame_Shift_Ins	novel	*L342Tfs5**	0.11	Exo_endo_phos
STAD	chr6	24654460	Missense_Mutation	NA	I196M	0.09	Exo_endo_phos
STAD	chr6	24653086	Missense_Mutation	rs375948102	A235V	0.68	Exo_endo_phos
STAD	chr6	24653087	Missense_Mutation	novel	A235T	0.68	Exo_endo_phos
STAD	chr6	24666769	Missense_Mutation	NA	F32L	0.15
UCEC	chr6	24650964	Missense_Mutation	NA	L305I	0.35	Exo_endo_phos
UCEC	chr6	24650928	Nonsense_Mutation	rs142438588	R317*	0.27	Exo_endo_phos
UCEC	chr6	24666561	Silent	novel	E72E	0.4
UCEC	chr6	24654437	Missense_Mutation	NA	M204R	0.31	Exo_endo_phos
UCEC	chr6	24658585	Missense_Mutation	rs772244923	R134Q	0.45	Exo_endo_phos
UCEC	chr6	24650937	Missense_Mutation	rs745911675	R314C	0.25	Exo_endo_phos
UCEC	chr6	24666601	Missense_Mutation	novel	N59S	0.11
UCEC	chr6	24653080	Missense_Mutation	novel	R237L	0.35	Exo_endo_phos
UCEC	chr6	24666792	Frame_Shift_Del	NA	*K24Sfs35**	0.44
UCEC	chr6	24652994	Missense_Mutation	NA	R266G	0.28	Exo_endo_phos
UCEC	chr6	24650937	Missense_Mutation	rs745911675	R314C	0.82	Exo_endo_phos
UCEC	chr6	24666792	Frame_Shift_Del	NA	*K24Sfs35**	0.43
UCEC	chr6	24650802	Missense_Mutation	novel	D359Y	0.45
UCEC	chr6	24650964	Missense_Mutation	NA	L305I	0.19	Exo_endo_phos
UCEC	chr6	24658585	Missense_Mutation	rs772244923	R134Q	0.28	Exo_endo_phos
UCEC	chr6	24650790	Nonstop_Mutation	novel	363Qext10	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1186	0.046699
SARC	DEL	0.214	0.014376

Survival Analysis

Cancer	P-value	Q-value
THYM	0.014	Kaplan-Meier Survival Analysis
KIRC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.027	Kaplan-Meier Survival Analysis
HNSC	0.033	Kaplan-Meier Survival Analysis
SKCM	0.00044	Kaplan-Meier Survival Analysis
PRAD	0.0014	Kaplan-Meier Survival Analysis
ESCA	0.012	Kaplan-Meier Survival Analysis
PAAD	0.028	Kaplan-Meier Survival Analysis
BLCA	0.0001	Kaplan-Meier Survival Analysis
LAML	0.036	Kaplan-Meier Survival Analysis
KICH	0.033	Kaplan-Meier Survival Analysis
LIHC	0.0041	Kaplan-Meier Survival Analysis
OV	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742