EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000111880 (Gene tree)
Gene ID: 8732
Gene Symbol: RNGTT
Alias: HCE|HCE1|hCAP
Full Name: RNA guanylyltransferase and 5'-phosphatase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 353,825 bases
Position: chr6:88,609,897-88,963,721
Accession: 10073
RBP type: canonical RBP
Summary: (RNA Guanylyltransferase And 5'-Phosphatase) is a Protein Coding gene. Diseases associated with RNGTT include Lymphomatous Meningitis and Cecum Adenocarcinoma. Among its related pathways are HIV Life Cycle and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP11.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000358497	mRNA_cap_enzyme	PF01331.19	5.1e-78	1	1
ENSP00000442609	mRNA_cap_enzyme	PF01331.19	3.5e-62	1	1
ENSP00000358487	mRNA_cap_enzyme	PF01331.19	6.3e-62	1	1
ENSP00000358487	mRNA_cap_C	PF03919.15	3.7e-19	1	1
ENSP00000358497	mRNA_cap_C	PF03919.15	3.9e-19	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000627296	RNGTT-204	2017	-	-	- (aa)	-	-
ENST00000369475	RNGTT-201	1725	-	ENSP00000358487	574 (aa)	-	O60942
ENST00000538899	RNGTT-203	1374	-	ENSP00000442609	457 (aa)	-	O60942
ENST00000369485	RNGTT-202	4553	XM_017011401	ENSP00000358497	597 (aa)	XP_016866890	O60942

Gene Model

Click here to download ENSG00000111880's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000111880	Blood Pressure	7.3279166E-005	-
ENSG00000111880	Platelet Function Tests	1.6980100E-005	-
ENSG00000111880	Erythrocyte Count	6.0500000E-006	-
ENSG00000111880	Colorectal Neoplasms	2E-7	26621817
ENSG00000111880	Endometrial Neoplasms	2E-7	26621817

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000111880	rs17503919	6	88856018	A	Colorectal or endometrial cancer	26621817	[1.11-1.25]	1.17	EFO_0005842\|EFO_0004230

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111880's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000111880	RNGTT	99	76.846	ENSAPOG00000008897	rngtt	98	77.381	Acanthochromis_polyacanthus
ENSG00000111880	RNGTT	100	98.660	ENSAMEG00000000368	RNGTT	100	98.660	Ailuropoda_melanoleuca
ENSG00000111880	RNGTT	99	70.625	ENSACIG00000009532	rngtt	95	74.896	Amphilophus_citrinellus
ENSG00000111880	RNGTT	79	75.738	ENSAOCG00000018488	rngtt	90	76.609	Amphiprion_ocellaris
ENSG00000111880	RNGTT	99	77.349	ENSAPEG00000008877	rngtt	98	78.061	Amphiprion_percula
ENSG00000111880	RNGTT	94	74.617	ENSATEG00000018015	rngtt	93	78.368	Anabas_testudineus
ENSG00000111880	RNGTT	98	87.223	ENSAPLG00000014978	RNGTT	98	87.394	Anas_platyrhynchos
ENSG00000111880	RNGTT	93	81.593	ENSACAG00000014716	RNGTT	98	81.593	Anolis_carolinensis
ENSG00000111880	RNGTT	100	90.506	ENSANAG00000022118	RNGTT	99	98.879	Aotus_nancymaae
ENSG00000111880	RNGTT	99	76.510	ENSACLG00000025133	rngtt	98	77.041	Astatotilapia_calliptera
ENSG00000111880	RNGTT	100	98.249	ENSBTAG00000002725	RNGTT	99	98.145	Bos_taurus
ENSG00000111880	RNGTT	99	38.446	WBGene00000466	cel-1	99	41.217	Caenorhabditis_elegans
ENSG00000111880	RNGTT	99	99.328	ENSCJAG00000000780	RNGTT	99	99.328	Callithrix_jacchus
ENSG00000111880	RNGTT	100	98.325	ENSCAFG00000003089	RNGTT	100	98.325	Canis_familiaris
ENSG00000111880	RNGTT	100	98.325	ENSCAFG00020015945	RNGTT	100	98.325	Canis_lupus_dingo
ENSG00000111880	RNGTT	99	97.976	ENSCHIG00000018488	RNGTT	99	97.976	Capra_hircus
ENSG00000111880	RNGTT	96	96.739	ENSTSYG00000006886	RNGTT	96	96.739	Carlito_syrichta
ENSG00000111880	RNGTT	88	96.721	ENSCAPG00000012521	RNGTT	81	96.721	Cavia_aperea
ENSG00000111880	RNGTT	98	91.482	ENSCPOG00000005124	RNGTT	98	91.837	Cavia_porcellus
ENSG00000111880	RNGTT	100	99.344	ENSCCAG00000030653	RNGTT	99	99.160	Cebus_capucinus
ENSG00000111880	RNGTT	100	99.781	ENSCATG00000045048	RNGTT	100	99.665	Cercocebus_atys
ENSG00000111880	RNGTT	100	96.482	ENSCLAG00000010675	RNGTT	100	96.482	Chinchilla_lanigera
ENSG00000111880	RNGTT	100	99.665	ENSCSAG00000017333	RNGTT	100	99.665	Chlorocebus_sabaeus
ENSG00000111880	RNGTT	80	100.000	ENSCHOG00000005246	RNGTT	100	74.957	Choloepus_hoffmanni
ENSG00000111880	RNGTT	100	86.364	ENSCPBG00000019915	RNGTT	98	86.949	Chrysemys_picta_bellii
ENSG00000111880	RNGTT	98	57.404	ENSCING00000001150	-	95	58.651	Ciona_intestinalis
ENSG00000111880	RNGTT	99	56.025	ENSCSAVG00000009934	-	99	60.573	Ciona_savignyi
ENSG00000111880	RNGTT	100	99.781	ENSCANG00000037275	RNGTT	100	99.497	Colobus_angolensis_palliatus
ENSG00000111880	RNGTT	99	95.777	ENSCGRG00001023707	-	98	95.726	Cricetulus_griseus_chok1gshd
ENSG00000111880	RNGTT	99	86.824	ENSCGRG00001013438	-	98	86.838	Cricetulus_griseus_chok1gshd
ENSG00000111880	RNGTT	98	93.857	ENSCGRG00000012687	-	98	95.560	Cricetulus_griseus_crigri
ENSG00000111880	RNGTT	99	86.318	ENSCGRG00000010662	-	98	86.325	Cricetulus_griseus_crigri
ENSG00000111880	RNGTT	99	73.244	ENSCSEG00000004052	rngtt	98	73.729	Cynoglossus_semilaevis
ENSG00000111880	RNGTT	99	76.975	ENSCVAG00000002956	rngtt	98	77.551	Cyprinodon_variegatus
ENSG00000111880	RNGTT	99	77.685	ENSDARG00000032261	rngtt	97	78.291	Danio_rerio
ENSG00000111880	RNGTT	97	97.927	ENSDNOG00000032165	RNGTT	92	97.927	Dasypus_novemcinctus
ENSG00000111880	RNGTT	100	97.487	ENSDORG00000011171	Rngtt	100	97.487	Dipodomys_ordii
ENSG00000111880	RNGTT	98	48.455	FBgn0030556	mRNA-cap	92	48.270	Drosophila_melanogaster
ENSG00000111880	RNGTT	94	94.316	ENSETEG00000018008	RNGTT	98	94.316	Echinops_telfairi
ENSG00000111880	RNGTT	51	72.043	ENSEBUG00000005986	rngtt	64	72.043	Eptatretus_burgeri
ENSG00000111880	RNGTT	100	98.660	ENSEASG00005005683	RNGTT	100	98.660	Equus_asinus_asinus
ENSG00000111880	RNGTT	100	98.827	ENSECAG00000012605	RNGTT	100	98.827	Equus_caballus
ENSG00000111880	RNGTT	81	100.000	ENSEEUG00000011671	RNGTT	84	100.000	Erinaceus_europaeus
ENSG00000111880	RNGTT	100	76.989	ENSELUG00000017127	rngtt	98	77.368	Esox_lucius
ENSG00000111880	RNGTT	100	98.780	ENSFCAG00000030695	RNGTT	100	98.780	Felis_catus
ENSG00000111880	RNGTT	98	87.606	ENSFALG00000002963	RNGTT	98	88.946	Ficedula_albicollis
ENSG00000111880	RNGTT	98	96.410	ENSFDAG00000008903	RNGTT	98	96.410	Fukomys_damarensis
ENSG00000111880	RNGTT	99	77.517	ENSFHEG00000020946	rngtt	98	78.061	Fundulus_heteroclitus
ENSG00000111880	RNGTT	98	88.435	ENSGALG00000015787	RNGTT	98	88.435	Gallus_gallus
ENSG00000111880	RNGTT	99	78.559	ENSGAFG00000001721	rngtt	94	79.545	Gambusia_affinis
ENSG00000111880	RNGTT	99	75.753	ENSGACG00000008281	rngtt	97	75.548	Gasterosteus_aculeatus
ENSG00000111880	RNGTT	100	86.364	ENSGAGG00000016170	RNGTT	98	86.949	Gopherus_agassizii
ENSG00000111880	RNGTT	100	100.000	ENSGGOG00000007863	RNGTT	100	100.000	Gorilla_gorilla
ENSG00000111880	RNGTT	99	76.510	ENSHBUG00000023823	rngtt	98	77.041	Haplochromis_burtoni
ENSG00000111880	RNGTT	100	96.650	ENSHGLG00000001236	RNGTT	100	96.650	Heterocephalus_glaber_female
ENSG00000111880	RNGTT	100	96.650	ENSHGLG00100003913	RNGTT	100	96.650	Heterocephalus_glaber_male
ENSG00000111880	RNGTT	99	78.188	ENSHCOG00000007195	rngtt	98	78.114	Hippocampus_comes
ENSG00000111880	RNGTT	100	76.304	ENSIPUG00000007731	rngtt	98	76.283	Ictalurus_punctatus
ENSG00000111880	RNGTT	100	97.822	ENSSTOG00000007145	RNGTT	100	97.822	Ictidomys_tridecemlineatus
ENSG00000111880	RNGTT	100	95.980	ENSJJAG00000019822	Rngtt	98	96.410	Jaculus_jaculus
ENSG00000111880	RNGTT	100	75.833	ENSKMAG00000019710	rngtt	98	76.701	Kryptolebias_marmoratus
ENSG00000111880	RNGTT	100	72.990	ENSLBEG00000012044	rngtt	95	77.297	Labrus_bergylta
ENSG00000111880	RNGTT	99	78.333	ENSLOCG00000016935	rngtt	98	78.716	Lepisosteus_oculatus
ENSG00000111880	RNGTT	100	97.320	ENSLAFG00000008130	RNGTT	100	97.320	Loxodonta_africana
ENSG00000111880	RNGTT	100	99.781	ENSMFAG00000030988	RNGTT	92	99.801	Macaca_fascicularis
ENSG00000111880	RNGTT	100	84.902	ENSMMUG00000020097	RNGTT	100	84.902	Macaca_mulatta
ENSG00000111880	RNGTT	100	99.781	ENSMNEG00000040764	RNGTT	100	99.665	Macaca_nemestrina
ENSG00000111880	RNGTT	100	99.781	ENSMLEG00000036501	RNGTT	100	99.665	Mandrillus_leucophaeus
ENSG00000111880	RNGTT	99	75.544	ENSMAMG00000003970	rngtt	98	76.061	Mastacembelus_armatus
ENSG00000111880	RNGTT	99	76.510	ENSMZEG00005002182	rngtt	98	77.041	Maylandia_zebra
ENSG00000111880	RNGTT	94	88.007	ENSMGAG00000013663	RNGTT	98	88.183	Meleagris_gallopavo
ENSG00000111880	RNGTT	99	95.439	ENSMAUG00000021153	Rngtt	98	95.385	Mesocricetus_auratus
ENSG00000111880	RNGTT	100	98.492	ENSMICG00000006070	RNGTT	100	98.492	Microcebus_murinus
ENSG00000111880	RNGTT	99	85.304	ENSMOCG00000000920	Rngtt	90	97.959	Microtus_ochrogaster
ENSG00000111880	RNGTT	99	74.204	ENSMMOG00000015633	rngtt	98	75.042	Mola_mola
ENSG00000111880	RNGTT	98	93.162	ENSMODG00000018289	-	98	93.162	Monodelphis_domestica
ENSG00000111880	RNGTT	100	76.790	ENSMALG00000022213	rngtt	98	76.231	Monopterus_albus
ENSG00000111880	RNGTT	99	95.777	MGP_CAROLIEiJ_G0025875	Rngtt	98	95.726	Mus_caroli
ENSG00000111880	RNGTT	99	95.608	ENSMUSG00000028274	Rngtt	98	95.556	Mus_musculus
ENSG00000111880	RNGTT	98	95.556	MGP_PahariEiJ_G0023998	Rngtt	98	95.556	Mus_pahari
ENSG00000111880	RNGTT	99	95.608	MGP_SPRETEiJ_G0026824	Rngtt	98	95.556	Mus_spretus
ENSG00000111880	RNGTT	100	98.492	ENSMPUG00000009351	RNGTT	100	98.492	Mustela_putorius_furo
ENSG00000111880	RNGTT	99	91.649	ENSMLUG00000003302	RNGTT	100	96.451	Myotis_lucifugus
ENSG00000111880	RNGTT	99	93.423	ENSNGAG00000021517	Rngtt	98	93.333	Nannospalax_galili
ENSG00000111880	RNGTT	99	76.678	ENSNBRG00000022540	rngtt	98	77.211	Neolamprologus_brichardi
ENSG00000111880	RNGTT	100	100.000	ENSNLEG00000013064	RNGTT	100	100.000	Nomascus_leucogenys
ENSG00000111880	RNGTT	56	92.254	ENSMEUG00000004467	-	78	92.254	Notamacropus_eugenii
ENSG00000111880	RNGTT	94	95.204	ENSOPRG00000000916	RNGTT	98	95.204	Ochotona_princeps
ENSG00000111880	RNGTT	98	96.233	ENSODEG00000007302	RNGTT	98	96.239	Octodon_degus
ENSG00000111880	RNGTT	99	77.685	ENSONIG00000005870	rngtt	98	78.231	Oreochromis_niloticus
ENSG00000111880	RNGTT	93	94.065	ENSOANG00000000533	RNGTT	98	94.065	Ornithorhynchus_anatinus
ENSG00000111880	RNGTT	100	96.817	ENSOCUG00000017081	RNGTT	100	96.817	Oryctolagus_cuniculus
ENSG00000111880	RNGTT	99	74.622	ENSORLG00000011486	rngtt	98	74.830	Oryzias_latipes
ENSG00000111880	RNGTT	99	74.664	ENSORLG00020017311	rngtt	98	74.830	Oryzias_latipes_hni
ENSG00000111880	RNGTT	99	74.497	ENSORLG00015000359	rngtt	98	74.660	Oryzias_latipes_hsok
ENSG00000111880	RNGTT	99	74.161	ENSOMEG00000022737	rngtt	98	74.150	Oryzias_melastigma
ENSG00000111880	RNGTT	93	98.113	ENSOGAG00000001690	RNGTT	99	98.113	Otolemur_garnettii
ENSG00000111880	RNGTT	96	97.902	ENSOARG00000012911	RNGTT	99	97.902	Ovis_aries
ENSG00000111880	RNGTT	100	100.000	ENSPPAG00000024828	RNGTT	100	100.000	Pan_paniscus
ENSG00000111880	RNGTT	100	98.606	ENSPPRG00000000245	RNGTT	100	98.606	Panthera_pardus
ENSG00000111880	RNGTT	100	98.606	ENSPTIG00000005384	RNGTT	100	98.606	Panthera_tigris_altaica
ENSG00000111880	RNGTT	100	100.000	ENSPTRG00000018413	RNGTT	100	100.000	Pan_troglodytes
ENSG00000111880	RNGTT	100	99.781	ENSPANG00000010454	RNGTT	100	99.665	Papio_anubis
ENSG00000111880	RNGTT	100	79.565	ENSPKIG00000017946	rngtt	98	78.092	Paramormyrops_kingsleyae
ENSG00000111880	RNGTT	94	87.698	ENSPSIG00000010976	RNGTT	98	87.698	Pelodiscus_sinensis
ENSG00000111880	RNGTT	94	69.301	ENSPMGG00000013700	rngtt	97	69.776	Periophthalmus_magnuspinnatus
ENSG00000111880	RNGTT	99	95.777	ENSPEMG00000018487	Rngtt	98	95.726	Peromyscus_maniculatus_bairdii
ENSG00000111880	RNGTT	87	63.119	ENSPMAG00000005449	rngtt	96	63.527	Petromyzon_marinus
ENSG00000111880	RNGTT	98	92.991	ENSPCIG00000021711	RNGTT	99	92.701	Phascolarctos_cinereus
ENSG00000111880	RNGTT	99	77.219	ENSPFOG00000018533	rngtt	98	77.419	Poecilia_formosa
ENSG00000111880	RNGTT	99	77.219	ENSPLAG00000019396	rngtt	98	77.419	Poecilia_latipinna
ENSG00000111880	RNGTT	99	77.219	ENSPMEG00000012393	rngtt	98	77.419	Poecilia_mexicana
ENSG00000111880	RNGTT	99	76.795	ENSPREG00000009255	rngtt	98	77.157	Poecilia_reticulata
ENSG00000111880	RNGTT	90	100.000	ENSPPYG00000016834	RNGTT	100	100.000	Pongo_abelii
ENSG00000111880	RNGTT	69	97.222	ENSPCAG00000014598	-	69	97.222	Procavia_capensis
ENSG00000111880	RNGTT	100	98.492	ENSPCOG00000017200	RNGTT	100	98.492	Propithecus_coquereli
ENSG00000111880	RNGTT	98	88.889	ENSPVAG00000017371	RNGTT	98	88.889	Pteropus_vampyrus
ENSG00000111880	RNGTT	99	76.510	ENSPNYG00000023388	rngtt	98	77.041	Pundamilia_nyererei
ENSG00000111880	RNGTT	99	76.884	ENSPNAG00000004948	rngtt	98	78.098	Pygocentrus_nattereri
ENSG00000111880	RNGTT	99	95.439	ENSRNOG00000007867	Rngtt	98	95.385	Rattus_norvegicus
ENSG00000111880	RNGTT	100	99.781	ENSRBIG00000031371	RNGTT	100	99.497	Rhinopithecus_bieti
ENSG00000111880	RNGTT	100	99.781	ENSRROG00000030932	RNGTT	100	99.497	Rhinopithecus_roxellana
ENSG00000111880	RNGTT	87	99.324	ENSSBOG00000021985	RNGTT	99	99.324	Saimiri_boliviensis_boliviensis
ENSG00000111880	RNGTT	93	93.165	ENSSHAG00000010187	RNGTT	98	93.165	Sarcophilus_harrisii
ENSG00000111880	RNGTT	100	81.304	ENSSFOG00015021884	rngtt	98	79.152	Scleropages_formosus
ENSG00000111880	RNGTT	100	76.407	ENSSMAG00000001713	rngtt	98	76.232	Scophthalmus_maximus
ENSG00000111880	RNGTT	99	78.356	ENSSDUG00000004268	rngtt	98	78.571	Seriola_dumerili
ENSG00000111880	RNGTT	99	78.188	ENSSLDG00000024223	rngtt	98	78.401	Seriola_lalandi_dorsalis
ENSG00000111880	RNGTT	81	95.455	ENSSARG00000010486	RNGTT	88	95.455	Sorex_araneus
ENSG00000111880	RNGTT	97	85.666	ENSSPUG00000001154	RNGTT	98	86.177	Sphenodon_punctatus
ENSG00000111880	RNGTT	99	77.685	ENSSPAG00000013510	rngtt	98	77.891	Stegastes_partitus
ENSG00000111880	RNGTT	100	97.990	ENSSSCG00000004311	RNGTT	100	97.990	Sus_scrofa
ENSG00000111880	RNGTT	98	87.606	ENSTGUG00000012427	RNGTT	98	88.946	Taeniopygia_guttata
ENSG00000111880	RNGTT	99	74.542	ENSTRUG00000017802	rngtt	98	75.722	Takifugu_rubripes
ENSG00000111880	RNGTT	97	75.300	ENSTNIG00000016410	rngtt	97	75.300	Tetraodon_nigroviridis
ENSG00000111880	RNGTT	100	79.564	ENSTBEG00000000862	RNGTT	100	79.564	Tupaia_belangeri
ENSG00000111880	RNGTT	85	100.000	ENSTTRG00000013936	RNGTT	88	100.000	Tursiops_truncatus
ENSG00000111880	RNGTT	78	96.056	ENSUAMG00000008784	RNGTT	94	98.837	Ursus_americanus
ENSG00000111880	RNGTT	100	98.492	ENSUMAG00000010518	RNGTT	100	98.492	Ursus_maritimus
ENSG00000111880	RNGTT	98	95.897	ENSVPAG00000004172	RNGTT	98	95.897	Vicugna_pacos
ENSG00000111880	RNGTT	100	98.432	ENSVVUG00000010152	RNGTT	100	98.432	Vulpes_vulpes
ENSG00000111880	RNGTT	99	82.609	ENSXETG00000005384	rngtt	98	82.082	Xenopus_tropicalis
ENSG00000111880	RNGTT	93	73.832	ENSXCOG00000001703	rngtt	85	73.660	Xiphophorus_couchianus
ENSG00000111880	RNGTT	99	77.926	ENSXMAG00000016967	rngtt	98	77.627	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004484	mRNA guanylyltransferase activity	21873635.	IBA	Function
GO:0004484	mRNA guanylyltransferase activity	9473487.	IDA	Function
GO:0004651	polynucleotide 5'-phosphatase activity	-	TAS	Function
GO:0004725	protein tyrosine phosphatase activity	-	IEA	Function
GO:0005515	protein binding	25137142.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005634	nucleus	9473487.	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006370	7-methylguanosine mRNA capping	21873635.	IBA	Process
GO:0006370	7-methylguanosine mRNA capping	9473487.	IDA	Process
GO:0006370	7-methylguanosine mRNA capping	-	TAS	Process
GO:0006396	RNA processing	21636784.	IDA	Process
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	-	IEA	Function
GO:0008192	RNA guanylyltransferase activity	21636784.	IDA	Function
GO:0016032	viral process	-	IEA	Process
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IEA	Process
GO:0050355	triphosphatase activity	9473487.	IDA	Function
GO:0098507	polynucleotide 5' dephosphorylation	-	IEA	Process