EuRBPDB

Description

Ensembl ID: ENSG00000112159 (Gene tree)
Gene ID: 23195
Gene Symbol: MDN1
Alias: KIAA0301|Rea1
Full Name: midasin AAA ATPase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 185,463 bases
Position: chr6:89,642,499-89,827,961
Accession: 18302
RBP type: non-canonical RBP
Summary: (Midasin AAA ATPase 1) is a Protein Coding gene. Diseases associated with MDN1 include Bone Ewing's Sarcoma. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include binding and unfolded protein binding. An important paralog of this gene is TCHHL1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000629399	MDN1-205	17400	-	ENSP00000486270	5596 (aa)	-	Q9NU22
ENST00000487831	MDN1-204	689	-	ENSP00000469327	62 (aa)	-	M0QXR3
ENST00000369393	MDN1-201	18413	XM_005248700	ENSP00000358400	5596 (aa)	XP_005248757	Q9NU22
ENST00000468568	MDN1-203	538	-	-	- (aa)	-	-
ENST00000439638	MDN1-202	3654	-	ENSP00000409664	1181 (aa)	-	Q5T795

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000112159	Body Weight	6.52747979314725E-6	17903300
ENSG00000112159	Personality Inventory	1.119e-005	-
ENSG00000112159	Personality Inventory	1.119e-005	-
ENSG00000112159	Personality Inventory	3.982e-006	-
ENSG00000112159	Personality Inventory	3.982e-006	-
ENSG00000112159	Electrocardiography	9E-7	27958378
ENSG00000112159	Sulfonylurea Compounds	9E-7	27958378

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000112159	rs10484885	6	89685297	?	QRS interval (sulfonylurea treatment interaction)	27958378	[2.13-4.87] ms increase	3.5	EFO_0005055\|EFO_0007922
ENSG00000112159	rs117472277	6	89661886	?	Mononucleosis	28928442	[0.097-0.241] unit increase	0.1694	EFO_0008403
ENSG00000112159	rs2748297	6	89716105	?	DNA methylation variation (age effect)	30348214			GO_0006306
ENSG00000112159	rs17293240	6	89686651	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000112159	MDN1	98	98.361	ENSMUSG00000058006	Mdn1	99	82.201	Mus_musculus
ENSG00000112159	MDN1	78	45.626	YLR106C	MDN1	78	42.735	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000027	ribosomal large subunit assembly	21873635.	IBA	Process
GO:0005515	protein binding	21326211.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005634	nucleus	12102729.	NAS	Component
GO:0005654	nucleoplasm	-	IEA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006364	rRNA processing	21873635.	IBA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016887	ATPase activity	12102729.	NAS	Function
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0051082	unfolded protein binding	12102729.	NAS	Function
GO:0065003	protein-containing complex assembly	12102729.	NAS	Process