EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000112210 (Gene tree)
Gene ID: 51715
Gene Symbol: RAB23
Alias: -
Full Name: RAB23, member RAS oncogene family
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 35,323 bases
Position: chr6:57,186,992-57,222,314
Accession: 14263
RBP type: canonical RBP
Summary: This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000320413	MMR_HSR1	PF01926.23	1.5e-05	1	1
ENSP00000417610	MMR_HSR1	PF01926.23	1.5e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000317483	RAB23-201	2546	-	ENSP00000320413	237 (aa)	-	Q9ULC3
ENST00000468148	RAB23-202	4837	-	ENSP00000417610	237 (aa)	-	Q9ULC3

Gene Model

Click here to download ENSG00000112210's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000112210	Anthropometry	7.2300000E-008	-
ENSG00000112210	Arteries	4.5540000E-006	-
ENSG00000112210	Platelet Function Tests	1.8004300E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000112210's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000112210	RAB23	99	84.615	ENSAPOG00000008892	rab23	99	84.615	Acanthochromis_polyacanthus
ENSG00000112210	RAB23	100	97.890	ENSAMEG00000006825	RAB23	100	97.890	Ailuropoda_melanoleuca
ENSG00000112210	RAB23	99	72.881	ENSACIG00000020496	rab23	99	72.881	Amphilophus_citrinellus
ENSG00000112210	RAB23	99	84.322	ENSAOCG00000004234	rab23	99	84.322	Amphiprion_ocellaris
ENSG00000112210	RAB23	99	84.322	ENSAPEG00000019758	rab23	99	84.322	Amphiprion_percula
ENSG00000112210	RAB23	99	83.051	ENSATEG00000020913	rab23	99	83.051	Anabas_testudineus
ENSG00000112210	RAB23	74	93.182	ENSAPLG00000003715	RAB23	99	93.182	Anas_platyrhynchos
ENSG00000112210	RAB23	100	90.336	ENSACAG00000006656	RAB23	100	90.336	Anolis_carolinensis
ENSG00000112210	RAB23	100	98.734	ENSANAG00000027052	-	100	98.734	Aotus_nancymaae
ENSG00000112210	RAB23	99	83.475	ENSACLG00000002819	rab23	99	83.475	Astatotilapia_calliptera
ENSG00000112210	RAB23	99	86.441	ENSAMXG00000014960	rab23	99	86.441	Astyanax_mexicanus
ENSG00000112210	RAB23	100	94.937	ENSBTAG00000005362	RAB23	100	94.937	Bos_taurus
ENSG00000112210	RAB23	100	98.734	ENSCJAG00000010247	RAB23	100	98.734	Callithrix_jacchus
ENSG00000112210	RAB23	100	97.046	ENSCAFG00000002459	RAB23	100	97.046	Canis_familiaris
ENSG00000112210	RAB23	100	97.046	ENSCAFG00020015900	RAB23	100	97.046	Canis_lupus_dingo
ENSG00000112210	RAB23	100	94.937	ENSCHIG00000009815	RAB23	100	94.937	Capra_hircus
ENSG00000112210	RAB23	99	98.305	ENSTSYG00000029126	RAB23	99	98.305	Carlito_syrichta
ENSG00000112210	RAB23	100	92.405	ENSCPOG00000030218	RAB23	100	92.405	Cavia_porcellus
ENSG00000112210	RAB23	100	98.312	ENSCCAG00000020364	RAB23	100	98.312	Cebus_capucinus
ENSG00000112210	RAB23	100	99.156	ENSCATG00000027876	RAB23	100	99.156	Cercocebus_atys
ENSG00000112210	RAB23	100	95.781	ENSCLAG00000000797	RAB23	100	95.781	Chinchilla_lanigera
ENSG00000112210	RAB23	100	98.312	ENSCSAG00000013438	RAB23	100	98.312	Chlorocebus_sabaeus
ENSG00000112210	RAB23	100	90.717	ENSCPBG00000022640	RAB23	100	90.717	Chrysemys_picta_bellii
ENSG00000112210	RAB23	99	65.702	ENSCING00000001155	-	99	67.355	Ciona_intestinalis
ENSG00000112210	RAB23	99	65.126	ENSCSAVG00000001356	-	99	65.546	Ciona_savignyi
ENSG00000112210	RAB23	100	98.312	ENSCANG00000031065	RAB23	100	98.312	Colobus_angolensis_palliatus
ENSG00000112210	RAB23	100	94.515	ENSCGRG00001008994	Rab23	100	94.515	Cricetulus_griseus_chok1gshd
ENSG00000112210	RAB23	99	93.644	ENSCGRG00000013630	Rab23	100	93.644	Cricetulus_griseus_crigri
ENSG00000112210	RAB23	99	73.305	ENSCSEG00000010565	rab23	99	73.305	Cynoglossus_semilaevis
ENSG00000112210	RAB23	99	83.898	ENSCVAG00000020501	rab23	99	83.898	Cyprinodon_variegatus
ENSG00000112210	RAB23	99	84.746	ENSDARG00000004151	rab23	99	84.746	Danio_rerio
ENSG00000112210	RAB23	100	93.671	ENSDNOG00000015501	RAB23	100	93.671	Dasypus_novemcinctus
ENSG00000112210	RAB23	99	94.915	ENSDORG00000028344	Rab23	99	94.915	Dipodomys_ordii
ENSG00000112210	RAB23	94	59.389	FBgn0037364	Rab23	82	59.389	Drosophila_melanogaster
ENSG00000112210	RAB23	97	65.948	ENSEBUG00000010861	-	92	65.948	Eptatretus_burgeri
ENSG00000112210	RAB23	100	96.624	ENSEASG00005003529	RAB23	100	96.624	Equus_asinus_asinus
ENSG00000112210	RAB23	100	96.203	ENSECAG00000013427	RAB23	100	96.203	Equus_caballus
ENSG00000112210	RAB23	99	94.915	ENSEEUG00000015045	RAB23	99	94.915	Erinaceus_europaeus
ENSG00000112210	RAB23	99	82.627	ENSELUG00000020788	rab23	99	83.475	Esox_lucius
ENSG00000112210	RAB23	100	97.890	ENSFCAG00000044358	RAB23	100	97.890	Felis_catus
ENSG00000112210	RAB23	100	89.451	ENSFALG00000001708	RAB23	100	89.451	Ficedula_albicollis
ENSG00000112210	RAB23	100	94.093	ENSFDAG00000014834	RAB23	100	94.093	Fukomys_damarensis
ENSG00000112210	RAB23	99	82.627	ENSFHEG00000023069	rab23	99	83.051	Fundulus_heteroclitus
ENSG00000112210	RAB23	99	84.746	ENSGMOG00000005102	rab23	99	84.746	Gadus_morhua
ENSG00000112210	RAB23	100	88.186	ENSGALG00000016279	RAB23	100	88.186	Gallus_gallus
ENSG00000112210	RAB23	100	81.435	ENSGAFG00000007684	rab23	99	82.203	Gambusia_affinis
ENSG00000112210	RAB23	99	83.475	ENSGACG00000006151	rab23	99	83.475	Gasterosteus_aculeatus
ENSG00000112210	RAB23	100	91.139	ENSGAGG00000012709	RAB23	100	91.139	Gopherus_agassizii
ENSG00000112210	RAB23	99	73.729	ENSHBUG00000007966	rab23	99	73.729	Haplochromis_burtoni
ENSG00000112210	RAB23	100	94.937	ENSHGLG00000013030	-	100	94.937	Heterocephalus_glaber_female
ENSG00000112210	RAB23	100	79.253	ENSHGLG00000009371	-	100	79.253	Heterocephalus_glaber_female
ENSG00000112210	RAB23	100	79.253	ENSHGLG00100017177	-	100	79.253	Heterocephalus_glaber_male
ENSG00000112210	RAB23	100	94.937	ENSHGLG00100005945	-	100	94.937	Heterocephalus_glaber_male
ENSG00000112210	RAB23	99	70.339	ENSHCOG00000013919	rab23	99	70.763	Hippocampus_comes
ENSG00000112210	RAB23	99	75.847	ENSIPUG00000016494	rab23	99	75.847	Ictalurus_punctatus
ENSG00000112210	RAB23	100	98.312	ENSSTOG00000010962	RAB23	100	98.312	Ictidomys_tridecemlineatus
ENSG00000112210	RAB23	100	95.781	ENSJJAG00000020094	Rab23	100	95.781	Jaculus_jaculus
ENSG00000112210	RAB23	99	83.051	ENSKMAG00000018270	rab23	99	83.051	Kryptolebias_marmoratus
ENSG00000112210	RAB23	99	82.627	ENSLBEG00000013176	rab23	99	82.627	Labrus_bergylta
ENSG00000112210	RAB23	99	88.559	ENSLACG00000004025	RAB23	99	88.559	Latimeria_chalumnae
ENSG00000112210	RAB23	99	87.029	ENSLOCG00000016999	rab23	99	87.029	Lepisosteus_oculatus
ENSG00000112210	RAB23	100	97.890	ENSLAFG00000007209	RAB23	100	97.890	Loxodonta_africana
ENSG00000112210	RAB23	100	99.156	ENSMFAG00000032369	RAB23	100	99.156	Macaca_fascicularis
ENSG00000112210	RAB23	100	99.156	ENSMMUG00000018003	RAB23	100	99.156	Macaca_mulatta
ENSG00000112210	RAB23	100	99.156	ENSMNEG00000037012	RAB23	100	99.156	Macaca_nemestrina
ENSG00000112210	RAB23	100	99.156	ENSMLEG00000042429	RAB23	100	99.156	Mandrillus_leucophaeus
ENSG00000112210	RAB23	99	84.746	ENSMAMG00000015456	rab23	99	84.746	Mastacembelus_armatus
ENSG00000112210	RAB23	99	83.475	ENSMZEG00005005441	rab23	99	83.475	Maylandia_zebra
ENSG00000112210	RAB23	100	88.186	ENSMGAG00000013882	RAB23	100	88.186	Meleagris_gallopavo
ENSG00000112210	RAB23	100	98.312	ENSMICG00000014037	RAB23	100	98.312	Microcebus_murinus
ENSG00000112210	RAB23	100	94.515	ENSMOCG00000000444	Rab23	100	94.515	Microtus_ochrogaster
ENSG00000112210	RAB23	99	73.729	ENSMMOG00000007703	rab23	99	73.729	Mola_mola
ENSG00000112210	RAB23	100	94.515	ENSMODG00000018720	RAB23	100	94.515	Monodelphis_domestica
ENSG00000112210	RAB23	99	83.898	ENSMALG00000002136	rab23	99	83.898	Monopterus_albus
ENSG00000112210	RAB23	100	94.515	MGP_CAROLIEiJ_G0014015	Rab23	100	94.515	Mus_caroli
ENSG00000112210	RAB23	100	93.249	ENSMUSG00000004768	Rab23	100	93.249	Mus_musculus
ENSG00000112210	RAB23	100	93.671	MGP_PahariEiJ_G0027261	Rab23	100	93.671	Mus_pahari
ENSG00000112210	RAB23	100	93.671	MGP_SPRETEiJ_G0014820	Rab23	100	93.671	Mus_spretus
ENSG00000112210	RAB23	100	86.555	ENSMPUG00000002642	RAB23	100	86.555	Mustela_putorius_furo
ENSG00000112210	RAB23	100	96.624	ENSMLUG00000004058	RAB23	100	96.624	Myotis_lucifugus
ENSG00000112210	RAB23	100	97.046	ENSNGAG00000018038	Rab23	100	97.046	Nannospalax_galili
ENSG00000112210	RAB23	99	83.475	ENSNBRG00000013691	rab23	99	83.475	Neolamprologus_brichardi
ENSG00000112210	RAB23	100	99.578	ENSNLEG00000027830	RAB23	100	99.578	Nomascus_leucogenys
ENSG00000112210	RAB23	100	93.249	ENSODEG00000016056	RAB23	100	93.249	Octodon_degus
ENSG00000112210	RAB23	99	82.700	ENSONIG00000009749	rab23	99	82.700	Oreochromis_niloticus
ENSG00000112210	RAB23	100	94.093	ENSOANG00000001398	RAB23	100	94.093	Ornithorhynchus_anatinus
ENSG00000112210	RAB23	100	97.468	ENSOCUG00000004816	RAB23	100	97.468	Oryctolagus_cuniculus
ENSG00000112210	RAB23	99	81.780	ENSORLG00000010115	rab23	99	81.780	Oryzias_latipes
ENSG00000112210	RAB23	99	81.780	ENSORLG00020020220	rab23	99	81.780	Oryzias_latipes_hni
ENSG00000112210	RAB23	99	80.932	ENSORLG00015004033	rab23	99	80.932	Oryzias_latipes_hsok
ENSG00000112210	RAB23	99	81.356	ENSOMEG00000001706	rab23	99	81.356	Oryzias_melastigma
ENSG00000112210	RAB23	100	97.890	ENSOGAG00000005675	RAB23	100	97.890	Otolemur_garnettii
ENSG00000112210	RAB23	100	94.937	ENSOARG00000005749	RAB23	100	94.937	Ovis_aries
ENSG00000112210	RAB23	100	99.156	ENSPPAG00000010023	RAB23	100	99.156	Pan_paniscus
ENSG00000112210	RAB23	100	97.468	ENSPPRG00000012453	RAB23	100	97.468	Panthera_pardus
ENSG00000112210	RAB23	100	97.890	ENSPTIG00000009435	RAB23	100	97.890	Panthera_tigris_altaica
ENSG00000112210	RAB23	100	99.578	ENSPTRG00000043341	RAB23	100	99.578	Pan_troglodytes
ENSG00000112210	RAB23	100	99.156	ENSPANG00000017772	RAB23	100	99.156	Papio_anubis
ENSG00000112210	RAB23	81	88.083	ENSPKIG00000024310	rab23	95	88.083	Paramormyrops_kingsleyae
ENSG00000112210	RAB23	100	90.717	ENSPSIG00000015579	RAB23	100	90.717	Pelodiscus_sinensis
ENSG00000112210	RAB23	99	71.610	ENSPMGG00000008577	rab23	99	71.610	Periophthalmus_magnuspinnatus
ENSG00000112210	RAB23	100	94.515	ENSPEMG00000023271	Rab23	100	94.515	Peromyscus_maniculatus_bairdii
ENSG00000112210	RAB23	99	68.220	ENSPMAG00000006835	-	99	68.220	Petromyzon_marinus
ENSG00000112210	RAB23	100	94.515	ENSPCIG00000007267	RAB23	100	94.515	Phascolarctos_cinereus
ENSG00000112210	RAB23	99	82.203	ENSPFOG00000011493	rab23	99	82.203	Poecilia_formosa
ENSG00000112210	RAB23	99	81.780	ENSPLAG00000011697	rab23	99	81.780	Poecilia_latipinna
ENSG00000112210	RAB23	99	82.203	ENSPMEG00000017300	rab23	99	82.203	Poecilia_mexicana
ENSG00000112210	RAB23	99	72.034	ENSPREG00000022509	rab23	99	72.034	Poecilia_reticulata
ENSG00000112210	RAB23	100	99.578	ENSPPYG00000016739	RAB23	100	99.578	Pongo_abelii
ENSG00000112210	RAB23	100	97.890	ENSPCOG00000028471	RAB23	100	97.890	Propithecus_coquereli
ENSG00000112210	RAB23	100	86.076	ENSPVAG00000017693	RAB23	100	86.076	Pteropus_vampyrus
ENSG00000112210	RAB23	99	83.475	ENSPNYG00000019639	rab23	99	83.475	Pundamilia_nyererei
ENSG00000112210	RAB23	99	87.288	ENSPNAG00000024728	rab23	99	87.288	Pygocentrus_nattereri
ENSG00000112210	RAB23	100	93.671	ENSRNOG00000012629	Rab23	100	93.671	Rattus_norvegicus
ENSG00000112210	RAB23	100	93.802	ENSRBIG00000030547	RAB23	100	93.802	Rhinopithecus_bieti
ENSG00000112210	RAB23	100	98.734	ENSRROG00000035920	RAB23	100	98.734	Rhinopithecus_roxellana
ENSG00000112210	RAB23	100	97.468	ENSSBOG00000033237	RAB23	100	97.468	Saimiri_boliviensis_boliviensis
ENSG00000112210	RAB23	100	94.093	ENSSHAG00000006379	RAB23	100	94.093	Sarcophilus_harrisii
ENSG00000112210	RAB23	99	85.593	ENSSFOG00015012604	rab23	99	85.593	Scleropages_formosus
ENSG00000112210	RAB23	99	83.051	ENSSMAG00000006341	rab23	99	83.051	Scophthalmus_maximus
ENSG00000112210	RAB23	99	83.898	ENSSDUG00000023508	rab23	99	83.898	Seriola_dumerili
ENSG00000112210	RAB23	99	83.898	ENSSLDG00000000287	rab23	99	83.898	Seriola_lalandi_dorsalis
ENSG00000112210	RAB23	100	95.359	ENSSARG00000013689	RAB23	100	95.359	Sorex_araneus
ENSG00000112210	RAB23	100	93.249	ENSSPUG00000006274	RAB23	100	93.249	Sphenodon_punctatus
ENSG00000112210	RAB23	99	84.322	ENSSPAG00000010373	rab23	99	84.322	Stegastes_partitus
ENSG00000112210	RAB23	100	94.515	ENSSSCG00000029539	RAB23	100	94.515	Sus_scrofa
ENSG00000112210	RAB23	100	89.451	ENSTGUG00000012794	RAB23	100	89.451	Taeniopygia_guttata
ENSG00000112210	RAB23	99	81.780	ENSTRUG00000015697	rab23	99	81.780	Takifugu_rubripes
ENSG00000112210	RAB23	99	83.475	ENSTNIG00000016575	rab23	99	83.475	Tetraodon_nigroviridis
ENSG00000112210	RAB23	100	97.468	ENSUAMG00000013367	RAB23	100	97.468	Ursus_americanus
ENSG00000112210	RAB23	100	97.468	ENSUMAG00000018629	RAB23	100	97.468	Ursus_maritimus
ENSG00000112210	RAB23	81	67.539	ENSVPAG00000006805	RAB23	100	67.539	Vicugna_pacos
ENSG00000112210	RAB23	100	96.624	ENSVVUG00000008535	RAB23	100	96.624	Vulpes_vulpes
ENSG00000112210	RAB23	99	81.435	ENSXETG00000004449	rab23	99	81.435	Xenopus_tropicalis
ENSG00000112210	RAB23	99	81.780	ENSXCOG00000011864	rab23	99	81.780	Xiphophorus_couchianus
ENSG00000112210	RAB23	99	82.203	ENSXMAG00000009387	rab23	99	82.203	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000045	autophagosome assembly	21873635.	IBA	Process
GO:0000045	autophagosome assembly	22452336.	IMP	Process
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	17646400.22365972.	IDA	Function
GO:0005515	protein binding	17646400.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005737	cytoplasm	22365972.	IDA	Component
GO:0005776	autophagosome	21873635.	IBA	Component
GO:0005776	autophagosome	22452336.	IDA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	17646400.	IDA	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006968	cellular defense response	22452336.	IMP	Process
GO:0010008	endosome membrane	21873635.	IBA	Component
GO:0030054	cell junction	-	IDA	Component
GO:0030670	phagocytic vesicle membrane	-	IEA	Component
GO:0032482	Rab protein signal transduction	21873635.	IBA	Process
GO:0042308	negative regulation of protein import into nucleus	22365972.	IMP	Process
GO:0045335	phagocytic vesicle	21255211.	IDA	Component
GO:0046039	GTP metabolic process	22365972.	IDA	Process
GO:0060271	cilium assembly	17646400.	IMP	Process
GO:0097094	craniofacial suture morphogenesis	17503333.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26238143	Effect of Rab23 on the proliferation and apoptosis in breast cancer.	Oncol Rep	2015 Oct	Liu Y	doi: 10.3892/or.2015.4152
26715272	Rab23 is overexpressed in human bladder cancer and promotes cancer cell proliferation and invasion.	Tumour Biol	2016 Jun	Jiang Y	doi: 10.1007/s13277-015-4590-9
18559507	Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.	Cancer Res	2008 Jun 15	Hou Q	doi: 10.1158/0008-5472.CAN-07-5870.
28277196	Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo.	Oncol Res	2017 Jan 26	Chang J	doi: 10.3727/096504016X14742891049118.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	57210280	Missense_Mutation	NA	F34C	0.22	MMR_HSR1
BRCA	chr6	57196581	Silent	NA	F89F	0.23
BRCA	chr6	57190496	Missense_Mutation	novel	N227H	0.05
BRCA	chr6	57190144	3'UTR	novel		0.71
BRCA	chr6	57210421	5'UTR	novel		0.1
BRCA	chr6	57190454	3'UTR	novel		0.16
CESC	chr6	57189887	3'UTR	novel		0.1
CESC	chr6	57210403	5'UTR	rs145059995		0.26
CESC	chr6	57196579	Missense_Mutation	NA	S90C	0.31	MMR_HSR1
COAD	chr6	57190396	3'UTR	novel		0.41
COAD	chr6	57210241	Frame_Shift_Del	NA	*L47Wfs14**	0.37	MMR_HSR1
COAD	chr6	57193927	Silent	novel	K163K	0.19
COAD	chr6	57194829	Missense_Mutation	NA	K141T	0.16
COAD	chr6	57207668	Silent	NA	G67G	0.27
COAD	chr6	57210253	Missense_Mutation	NA	G43E	0.07	MMR_HSR1
GBM	chr6	57210284	Missense_Mutation	novel	I33F	0.17	MMR_HSR1
HNSC	chr6	57196571	Missense_Mutation	novel	D93N	0.08	MMR_HSR1
HNSC	chr6	57210306	Missense_Mutation	novel	M25I	0.21	MMR_HSR1
KIRC	chr6	57210312	Silent	NA	S23S	0.14
KIRP	chr6	57190419	3'UTR	novel		0.37
LAML	chr6	57210343	Missense_Mutation	novel	V13G	0.05	MMR_HSR1
LAML	chr6	57193904	Missense_Mutation	NA	Q171R	0.2
LGG	chr6	57193892	Missense_Mutation	NA	Q175L	0.63
LIHC	chr6	57190600	Missense_Mutation	NA	G192V	0.34
LIHC	chr6	57194846	Missense_Mutation	novel	E135D	0.31
LUAD	chr6	57190526	Missense_Mutation	rs771703421	L217F	0.12
LUSC	chr6	57193842	Missense_Mutation	novel	G192S	0.27
LUSC	chr6	57207631	Nonsense_Mutation	rs762512079	R80*	0.14	MMR_HSR1
OV	chr6	57190500	Missense_Mutation	NA	K225N	0.23
READ	chr6	57210298	Missense_Mutation	rs376394715	R28Q	0.38	MMR_HSR1
READ	chr6	57190437	3'UTR	novel		0.34
READ	chr6	57207631	Nonsense_Mutation	rs762512079	R80*	0.27	MMR_HSR1
SKCM	chr6	57210396	5'UTR	novel		0.39
SKCM	chr6	57190530	Silent	novel	I215I	0.09
SKCM	chr6	57207630	Missense_Mutation	rs145669565	R80Q	0.41	MMR_HSR1
SKCM	chr6	57190465	Missense_Mutation	novel	P237L	0.21
STAD	chr6	57196520	Missense_Mutation	NA	E110K	0.4	MMR_HSR1
STAD	chr6	57190412	3'UTR	novel		0.06
STAD	chr6	57207647	Missense_Mutation	novel	I74M	0.3	MMR_HSR1
UCEC	chr6	57207630	Missense_Mutation	rs145669565	R80Q	0.29	MMR_HSR1
UCEC	chr6	57190357	3'UTR	novel		0.21
UCEC	chr6	57194833	Missense_Mutation	novel	A140T	0.15
UCEC	chr6	57190079	3'UTR	novel		0.33
UCEC	chr6	57190419	3'UTR	novel		0.28
UCEC	chr6	57190382	3'UTR	novel		0.08
UCEC	chr6	57196520	Missense_Mutation	NA	E110K	0.21	MMR_HSR1
UCEC	chr6	57190373	3'UTR	novel		0.16
UCEC	chr6	57210272	Missense_Mutation	novel	D37Y	0.16	MMR_HSR1
UCEC	chr6	57207701	Silent	NA	E56E	0.2
UCEC	chr6	57194829	Missense_Mutation	NA	K141T	0.62
UCEC	chr6	57210241	Frame_Shift_Del	NA	*L47Wfs14**	0.46	MMR_HSR1
UCEC	chr6	57190034	3'UTR	novel		0.42
UCEC	chr6	57190373	3'UTR	novel		0.37
UCEC	chr6	57196548	Silent	NA	V100V	0.1
UCEC	chr6	57207693	Missense_Mutation	novel	R59K	0.41	MMR_HSR1
UCEC	chr6	57190489	Missense_Mutation	novel	N229T	0.18
UCEC	chr6	57210251	Missense_Mutation	novel	V44I	0.14	MMR_HSR1
UCEC	chr6	57190410	3'UTR	novel		0.5
UCEC	chr6	57190387	3'UTR	novel		0.17
UCEC	chr6	57190401	3'UTR	novel		0.33
UCEC	chr6	57194805	Missense_Mutation	novel	R149I	0.42
UCEC	chr6	57207700	Missense_Mutation	NA	D57N	0.31	MMR_HSR1
UCEC	chr6	57210356	Missense_Mutation	rs150655349	A9T	0.21
UCEC	chr6	57207662	Silent	novel	E69E	0.18
UCEC	chr6	57210356	Missense_Mutation	rs150655349	A9T	0.43
UCEC	chr6	57189974	3'UTR	novel		0.4
UCEC	chr6	57189972	3'UTR	novel		0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0694	0.11427
LUAD	DEL	0.1105	0.0021365

Survival Analysis

Cancer	P-value	Q-value
STAD	0.045	Kaplan-Meier Survival Analysis
MESO	0.00021	Kaplan-Meier Survival Analysis
SKCM	0.0013	Kaplan-Meier Survival Analysis
KIRP	0.0013	Kaplan-Meier Survival Analysis
BLCA	0.00084	Kaplan-Meier Survival Analysis
KICH	0.00052	Kaplan-Meier Survival Analysis
GBM	0.013	Kaplan-Meier Survival Analysis
LIHC	0.024	Kaplan-Meier Survival Analysis
THCA	0.048	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

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Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742