EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000112357 (Gene tree)
Gene ID: 5191
Gene Symbol: PEX7
Alias: PTS2R|RD
Full Name: peroxisomal biogenesis factor 7
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 91,718 bases
Position: chr6:136,822,220-136,913,937
Accession: 8860
RBP type: canonical RBP
Summary: This gene encodes the cytosolic receptor for the set of peroxisomal matrix enzymes targeted to the organelle by the peroxisome targeting signal 2 (PTS2). Defects in this gene cause peroxisome biogenesis disorders (PBDs), which are characterized by multiple defects in peroxisome function. There are at least 14 complementation groups for PBDs, with more than one phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene have been associated with PBD complementation group 11 (PBD-CG11) disorders, rhizomelic chondrodysplasia punctata type 1 (RCDP1), and Refsum disease (RD). [provided by RefSeq, Oct 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000441004	eIF2A	PF08662.11	0.00047	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000318471	PEX7-201	1464	XM_005267019	ENSP00000315680	323 (aa)	XP_005267076	O00628
ENST00000541292	PEX7-203	945	-	ENSP00000441004	280 (aa)	-	O00628
ENST00000367756	PEX7-202	680	-	ENSP00000356730	122 (aa)	-	Q5TDQ5

Gene Model

Click here to download ENSG00000112357's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04146	Peroxisome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000112357	Diabetic Nephropathies	9.2000000E-005	16775037
ENSG00000112357	Diabetic Nephropathies	1.2200000E-004	16775037

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000112357's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000112357	PEX7	95	94.137	ENSAMEG00000010081	PEX7	100	94.137	Ailuropoda_melanoleuca
ENSG00000112357	PEX7	100	96.285	ENSANAG00000022204	PEX7	98	97.143	Aotus_nancymaae
ENSG00000112357	PEX7	96	70.645	ENSAMXG00000038326	pex7	97	71.548	Astyanax_mexicanus
ENSG00000112357	PEX7	100	90.712	ENSBTAG00000016791	PEX7	100	90.712	Bos_taurus
ENSG00000112357	PEX7	100	95.356	ENSCJAG00000008514	PEX7	100	90.714	Callithrix_jacchus
ENSG00000112357	PEX7	100	92.570	ENSCAFG00000000253	PEX7	100	92.570	Canis_familiaris
ENSG00000112357	PEX7	100	92.570	ENSCAFG00020022697	PEX7	100	92.570	Canis_lupus_dingo
ENSG00000112357	PEX7	100	90.712	ENSCHIG00000011508	PEX7	100	90.712	Capra_hircus
ENSG00000112357	PEX7	100	95.046	ENSCCAG00000037288	PEX7	100	95.046	Cebus_capucinus
ENSG00000112357	PEX7	100	97.214	ENSCATG00000030986	PEX7	100	97.214	Cercocebus_atys
ENSG00000112357	PEX7	87	97.163	ENSCSAG00000016896	PEX7	98	97.163	Chlorocebus_sabaeus
ENSG00000112357	PEX7	86	83.154	ENSCHOG00000002126	PEX7	100	83.154	Choloepus_hoffmanni
ENSG00000112357	PEX7	89	96.503	ENSCANG00000034712	PEX7	100	96.503	Colobus_angolensis_palliatus
ENSG00000112357	PEX7	86	91.398	ENSCGRG00000007885	Pex7	100	91.398	Cricetulus_griseus_crigri
ENSG00000112357	PEX7	96	68.710	ENSDARG00000042553	pex7	99	68.710	Danio_rerio
ENSG00000112357	PEX7	95	92.532	ENSETEG00000017799	PEX7	98	92.628	Echinops_telfairi
ENSG00000112357	PEX7	97	70.032	ENSELUG00000020404	pex7	98	70.032	Esox_lucius
ENSG00000112357	PEX7	100	92.570	ENSFCAG00000029046	PEX7	100	92.570	Felis_catus
ENSG00000112357	PEX7	97	88.217	ENSFDAG00000016466	PEX7	98	88.217	Fukomys_damarensis
ENSG00000112357	PEX7	98	68.671	ENSFHEG00000012075	pex7	98	68.671	Fundulus_heteroclitus
ENSG00000112357	PEX7	100	99.381	ENSGGOG00000002773	PEX7	100	99.381	Gorilla_gorilla
ENSG00000112357	PEX7	96	70.418	ENSIPUG00000005563	PEX7	97	70.418	Ictalurus_punctatus
ENSG00000112357	PEX7	96	69.453	ENSKMAG00000008299	pex7	96	69.453	Kryptolebias_marmoratus
ENSG00000112357	PEX7	99	91.925	ENSLAFG00000007598	PEX7	100	91.925	Loxodonta_africana
ENSG00000112357	PEX7	100	97.833	ENSMFAG00000036835	PEX7	100	97.833	Macaca_fascicularis
ENSG00000112357	PEX7	100	93.929	ENSMMUG00000016382	PEX7	100	98.697	Macaca_mulatta
ENSG00000112357	PEX7	100	96.285	ENSMNEG00000043251	PEX7	100	96.285	Macaca_nemestrina
ENSG00000112357	PEX7	86	98.566	ENSMLEG00000030496	PEX7	100	98.566	Mandrillus_leucophaeus
ENSG00000112357	PEX7	98	88.291	ENSMOCG00000016916	Pex7	99	88.291	Microtus_ochrogaster
ENSG00000112357	PEX7	99	87.578	ENSMODG00000017434	PEX7	99	87.578	Monodelphis_domestica
ENSG00000112357	PEX7	98	92.089	MGP_CAROLIEiJ_G0015153	Pex7	99	92.089	Mus_caroli
ENSG00000112357	PEX7	98	92.405	ENSMUSG00000020003	Pex7	99	92.405	Mus_musculus
ENSG00000112357	PEX7	98	91.139	MGP_PahariEiJ_G0023773	Pex7	99	91.139	Mus_pahari
ENSG00000112357	PEX7	98	92.089	MGP_SPRETEiJ_G0015961	Pex7	99	92.089	Mus_spretus
ENSG00000112357	PEX7	100	93.189	ENSMPUG00000014844	PEX7	100	93.189	Mustela_putorius_furo
ENSG00000112357	PEX7	89	91.078	ENSMLUG00000007080	PEX7	100	91.078	Myotis_lucifugus
ENSG00000112357	PEX7	98	90.506	ENSNGAG00000018527	Pex7	99	90.506	Nannospalax_galili
ENSG00000112357	PEX7	87	71.786	ENSNBRG00000005997	pex7	96	71.786	Neolamprologus_brichardi
ENSG00000112357	PEX7	100	95.666	ENSNLEG00000014868	PEX7	100	95.666	Nomascus_leucogenys
ENSG00000112357	PEX7	85	80.727	ENSMEUG00000002494	PEX7	99	80.727	Notamacropus_eugenii
ENSG00000112357	PEX7	97	71.019	ENSONIG00000018773	pex7	98	71.019	Oreochromis_niloticus
ENSG00000112357	PEX7	96	70.096	ENSORLG00000009259	pex7	95	70.096	Oryzias_latipes
ENSG00000112357	PEX7	96	70.096	ENSORLG00020001957	pex7	95	70.096	Oryzias_latipes_hni
ENSG00000112357	PEX7	96	70.096	ENSORLG00015016871	pex7	95	70.096	Oryzias_latipes_hsok
ENSG00000112357	PEX7	87	94.615	ENSOGAG00000000560	PEX7	99	94.615	Otolemur_garnettii
ENSG00000112357	PEX7	87	92.143	ENSOARG00000000382	PEX7	94	92.143	Ovis_aries
ENSG00000112357	PEX7	99	99.065	ENSPPAG00000029707	PEX7	99	99.065	Pan_paniscus
ENSG00000112357	PEX7	100	92.570	ENSPPRG00000002196	PEX7	100	92.570	Panthera_pardus
ENSG00000112357	PEX7	87	94.643	ENSPTIG00000009999	PEX7	94	94.643	Panthera_tigris_altaica
ENSG00000112357	PEX7	100	97.833	ENSPANG00000023965	PEX7	100	97.833	Papio_anubis
ENSG00000112357	PEX7	86	88.889	ENSPCIG00000027255	PEX7	93	88.889	Phascolarctos_cinereus
ENSG00000112357	PEX7	100	99.381	ENSPPYG00000017035	PEX7	100	99.381	Pongo_abelii
ENSG00000112357	PEX7	100	92.879	ENSPVAG00000009682	PEX7	100	92.879	Pteropus_vampyrus
ENSG00000112357	PEX7	96	71.935	ENSPNAG00000010142	pex7	97	71.935	Pygocentrus_nattereri
ENSG00000112357	PEX7	98	91.139	ENSRNOG00000012322	Pex7	99	91.139	Rattus_norvegicus
ENSG00000112357	PEX7	100	97.833	ENSRBIG00000031105	PEX7	100	97.833	Rhinopithecus_bieti
ENSG00000112357	PEX7	100	97.833	ENSRROG00000036829	PEX7	100	97.833	Rhinopithecus_roxellana
ENSG00000112357	PEX7	83	95.213	ENSSBOG00000029138	PEX7	89	96.552	Saimiri_boliviensis_boliviensis
ENSG00000112357	PEX7	99	85.981	ENSSHAG00000014094	PEX7	99	85.981	Sarcophilus_harrisii
ENSG00000112357	PEX7	100	85.449	ENSSARG00000003831	PEX7	100	85.449	Sorex_araneus
ENSG00000112357	PEX7	93	81.126	ENSSPUG00000011953	-	96	81.126	Sphenodon_punctatus
ENSG00000112357	PEX7	88	68.163	ENSSPAG00000000614	pex7	90	64.164	Stegastes_partitus
ENSG00000112357	PEX7	100	90.712	ENSSSCG00000004160	PEX7	100	90.712	Sus_scrofa
ENSG00000112357	PEX7	98	54.808	ENSTRUG00000014572	pex7	98	55.128	Takifugu_rubripes
ENSG00000112357	PEX7	93	87.708	ENSTTRG00000002549	PEX7	100	87.708	Tursiops_truncatus
ENSG00000112357	PEX7	100	84.830	ENSUAMG00000017510	PEX7	100	84.830	Ursus_americanus
ENSG00000112357	PEX7	87	93.929	ENSUMAG00000023831	PEX7	97	93.929	Ursus_maritimus
ENSG00000112357	PEX7	99	88.509	ENSVPAG00000003933	PEX7	99	88.509	Vicugna_pacos
ENSG00000112357	PEX7	100	92.879	ENSVVUG00000002175	PEX7	100	92.879	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001764	neuron migration	-	IEA	Process
GO:0001958	endochondral ossification	-	IEA	Process
GO:0005053	peroxisome matrix targeting signal-2 binding	9090381.9090383.11931631.	IDA	Function
GO:0005515	protein binding	30204880.	IPI	Function
GO:0005777	peroxisome	9090382.	IDA	Component
GO:0005778	peroxisomal membrane	-	TAS	Component
GO:0005782	peroxisomal matrix	11931631.	IDA	Component
GO:0005829	cytosol	11931631.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006625	protein targeting to peroxisome	-	TAS	Process
GO:0006635	fatty acid beta-oxidation	-	IEA	Process
GO:0007031	peroxisome organization	10022913.	IMP	Process
GO:0008611	ether lipid biosynthetic process	9090383.12522768.	IMP	Process
GO:0016558	protein import into peroxisome matrix	9090381.	IDA	Process
GO:0016558	protein import into peroxisome matrix	12522768.	IMP	Process
GO:0019899	enzyme binding	11931631.	IPI	Function
GO:0042803	protein homodimerization activity	11931631.	IDA	Function